• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4121-4126
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• 2013

Objective: Low dose radiation may stimulate the growth and development of animals, increase life span, enhance fertility, and downgrade the incidence of tumor occurrence.The aim of this study was to investigate the antitumor effect and hormesis in an erythrocyte system induced by low-dose radiation. Methods: Kunming strain male mice were subcutaneously implanted with S180 sarcoma cells in the right inguen as an experimental in situ animal model. Six hours before implantation, the mice were given 75mGy whole body X-ray radiation. Tumor growth was observed 5 days later, and the tumor volume was calculated every other day. Fifteen days later, all mice were killed to measure the tumor weight, and to observe necrotic areas and tumor-infiltration-lymphoreticular cells (TILs). At the same time, erythrocyte immune function and the level of 2,3-diphosphoglyceric acid (2,3-DPG) were determined. Immunohistochemical staining was used to detect the expression of EPO and VEGFR of tumor tissues. Results: The mice pre-exposed to low dose radiation had a lower tumor formation rate than those without low dose radiation (P < 0.05). The tumor growth slowed down significantly in mice pre-exposed to low dose radiation; the average tumor weight in mice pre-exposed to low dose radiation was lighter too (P < 0.05). The tumor necrosis areas were larger and TILs were more in the radiation group than those of the group without radiation. The erythrocyte immune function, the level of 2,3-DPG in the low dose radiation group were higher than those of the group without radiation (P < 0.05). After irradiation the expression of EPO of tumor tissues in LDR group decreased with time. LDR-24h, LDR-48h and LDR-72h groups were all statistically significantly different from sham-irradiation group. The expression of VEGFR also decreased, and LDR-24h group was the lowest (P < 0.05). Conclusion: Low dose radiation could markedly increase the anti-tumor ability of the organism and improve the erythrocyte immune function and the ability of carrying $O_2$. Low-dose total body irradiation, within a certain period of time, can decrease the expression of hypoxia factor EPO and VEGFR, which may improve the situation of tumor hypoxia and radiosensitivity of tumor itself.

• 한국가스학회지
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• 제26권6호
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• pp.16-23
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• 2022

본 연구에서는 디스크와 인장시험 등을 통해 수소취성에 대한 재료 특성을 평가하고자 하였다. 이를 위해 니켈 당량이 28.5 이상인 합금 조성과, 이와 유사한 상용 합금 조성 2종에 대해 합금을 제조하였고, 각 합금은 진공유도용해로(Vacuum Induction Melting, VIM)에서 개발 합금(이하 #1)과 상용 배관(이하 각각 #2, #3)을 재용해하여 주조재로 제조하였고, 주조 합금은 단조 및 압연하여 판재로 제조하였다. 디스크형태의 시편은 0.1~1000 bar/min의 속도로 수소와 헬륨으로 가압하여 파열압력을 측정하여 수소에 대한 특성을 평가하였고, 전기화학적 방법으로 수소처리한 인장시편과 비교군에 대해 항복강도, 인장강도, 연신률, 단면적 감소율을 확인하였다. 또한 인장시편은 주사전사현미경을 통해 파단면을 확인하였다. 디스크파열시험과 수소처리 한 시편의 인장시험을 통해, 본 연구를 통해 개발된 강종의 경우 상용 강종과 비교하여 유사한 수소취성 특성을 갖고 있음을 확인하였고, 파단면 또한 미세한 두께의 벽개파괴 특성을 보였지만 기계적 강도에 큰 영향을 미치지 않음에 따라 개발된 고질소 스테인리스강은 내수소취성이 우수한 것으로 평가 할 수 있었다.

• Steel and Composite Structures
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• 제27권1호
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• pp.13-25
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• 2018

The main objective of this study is to develop a dual approach for geometrically nonlinear finite element analysis of plane truss structures. The geometric nonlinearity is considered using the Total Lagrangian formulation. The nonlinear solution is obtained by introducing and minimizing an objective function subjected to displacement-type constraints. The proposed method can fully trace the whole equilibrium path of geometrically nonlinear plane truss structures not only before the limit point but also after it. No stiffness matrix is used in the main approach and the solution is acquired only based on the direct classical stress-strain formulations. As a result, produced errors caused by linearization and approximation of the main equilibrium equation will be eliminated. The suggested algorithm can predict both pre- and post-buckling behavior of the steel plane truss structures as well as any arbitrary point of equilibrium path. In addition, an equilibrium path with multiple limit points and snap-back phenomenon can be followed in this approach. To demonstrate the accuracy, efficiency and robustness of the proposed procedure, numerical results of the suggested approach are compared with theoretical solution, modified arc-length method, and those of reported in the literature.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2010년도 추계 학술발표회
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• pp.467-472
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• 2010

Individual vacuum pressure method is soft ground improvement technique, in which a vacuum pressure can be directly applied to the vertical drain board to promote consolidation and strengthening the soft ground. This method does not require a surcharge load, different to embankment or pre-loading method. In this study, given the inner displacement of the ground where the individual vacuum pressure is applied, this dissertation aimed to reproduce the state of stress in the ground that is subject to the constraints created by the depth of improvement area. Modified Cam Clay theory which made it possible to take into account the isotropic displacement of the ground was applied to the NAP-IVP used simulation; the conception of equivalent permeability proposed by Hird was also applied so that the 3-dimensional real construction effect of drain materials could be reflected in the analysis.

• 대한안전경영과학회지
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• 제6권2호
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• pp.35-48
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• 2004

The purpose of this study is to find injurious factors and to propose an improvement plan on workers' musculoskeletal disorders at a bakery workplace through analyzing the symptom, work posture and quantitative estimate. For this study, a survey and ergonomic estimate methods were adopted. According to the survey, it was analyzed that 429 workers corresponding to 68.2% of the response have been experienced the symptoms of musculoskeletal disorders such as an ache, prickle and numbness. The result of QEC analysis shows that shoulder and waist are highly exposed to musculoskeletal disease. The result of RULA analysis shows that injurious factors of muscle, weight and repeated operations are a little higher than those of operation posture. The result of SI estimate shows that pre-treatment of making bread requiring highly repeated operation gets the highest point of 81, on the other hand, chocolate-coating job requiring relatively low speed and short time gets the point of 4.5. Based on the analyzed results, improvement plan to prevent the musculoskeletal disorders against injurious working process of a bakery workplace. The goal of this study is to propose the improved scheme that prevents the workers against musculoskeletal disorders. A questionnaire and an ergonomic assessment method were adopted to analyze the symptoms of workers' musculoskeletal disorders, and an analysis of working postures and a quantitative assessment on various processes were performed to find out harmful factors of workplace.

• 대한기계학회논문집
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• 제18권11호
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• pp.2913-2921
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• 1994

In SMA(shape memory alloy), the degradation by fatigue is one of the most important problems to be overcome, when SMA is used for robot-actuator material. The actuator is operated repeatitively for long time and its repeating operation develops the fatigue degradation of SMA. The fatigue degradation changes the transformation temperature and deformation behavior and results in inaccurate operation control of robot. Accordingly, the changing behavior of transformation temperature and deformation which results from repeating operation is to be investigated in advance and the scheme to resolve those problems have to be made for the design of actuator. In this study, the fatigue tests were carried out on SMA specimens prepared to have different condition of aging time and pre-strain with the direct-current heating-cooling method, which was a general method of operation in robot actuators. The behavior of transformation temperature and deformation were examined and analyzed in each specimen and the study was performed to establish the optimistic manufacturing condition of SMA against the fatigue degradation.

• 한국생산제조학회지
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• 제9권4호
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• pp.48-55
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• 2000

For the Tailor Welded Blank sheet used for automobile body panel, the characteristics of fatigue strength and crack propagation behavior were studied. The thickness of specimens was joined to be same (0.9mm+0.9mm) and different (0.9mm+2.0mm) .As a base test, mechanical properties around weld zone were examined . The results indicated that there were no significant decreases in mechanical properties , but hardness around weld bead was 2.3 times greater than base material . The fatigue strength was the highest when the loading direction was parallel to the welding direction, which was about 85% of tensile strength of base material. It was decreased by 8.5% when the thickness of specimens and base metal was different, and it was increased by 25% when pres-strain was applied. The crack propagation rate was noticeably decreased around weld line and rapidly increased as it passed through weld line. Reviewing the shape of the crack propagation , crack width around weld line was around the weld zone due to retardation of crack growth , but is became narrow passing weld line due to decreased toughness.

• 한국강구조학회 논문집
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• 제20권3호
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• pp.445-454
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• 2008

철골모멘트접합부에 관한 이전의 연구에 의하면 RHS 기둥과 기존의 스캘럽을 가진 접합부실험체의 변형능력은 매우 열등했고, 보단부의 응력집중은 보에서 기둥으로 전달되는 모멘트의 전달효율에 영향을 받는다는 사실을 실험이나 해석적으로 밝혔다. 본 연구는 보강된 RBS 접합부와 용접수평스티프너를 사용한 효고현남부지진 이전에 지어진 모멘트 접합부를 내진보강하는데 주안점을 두었다. 이러한 내진보강은 시공성과 경제성을 고려하여 보의 하부플랜지에만 실시하였다. 접합부의 내진보강방법을 발견하고 이를 향상시키기 위해서 비선형유한요소해석을 통해서 다양한 변수를 바탕으로 한 파라메타 연구를 실시하였다.

• Journal of Microbiology and Biotechnology
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• 제19권10호
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• pp.1161-1168
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• 2009

Ethanol production by the simultaneous saccharification and fermentation (SSF) of low-value rice wine cake (RWC) without cooking was investigated. RWC is the filtered solid waste of fermented rice wine mash and contains 53% raw starch. For the SSF, the RWC slurry was mixed with the raw-starch-digesting enzyme of Rhizopus sp. and yeast, where the yeast strain was selected from 300 strains and identified as Saccharomyces cerevisiae KV25. The highest efficiency (94%) of ethanol production was achieved when the uncooked RWC slurry contained 23.03% starch. The optimal SSF conditions were determined as 1.125 units of the raw-starch-digesting enzyme per gram of RWC, a fermentation temperature of $30^{\circ}C$, slurry pH of 4.5, 36-h-old seeding culture, initial yeast cell number of $2{\times}10^7$ per ml of slurry, 17 mM of urea as the nitrogen additive, 0.25 mM of $Cu^{2+}$ as the metal ion additive, and a fermentation time of 90 h. Under these optimal conditions, the ethanol production resulting from the SSF of the uncooked RWC slurry was improved to 16.8% (v/v) from 15.1% (v/v) of pre-optimization.

• 한국안전학회지
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• 제29권5호
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• pp.15-21
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• 2014

The aim of this work is conduct the study on light weight and structural performance improvement of the composite wind power blade. GFRP (Glass Fiber Reinforced Plastic) pre-empted by CFRP(Carbon Fiber Reinforced Plastic), the major material of wind power blade, was identified the superiority of mechanical performance through the tensile and fatigue test. SENT(Single Edge Notched Tension) specimen fracture test was conducted on the specimen that laminated together 2 ply CFRP with 4 ply GFRP through DIC(Digital Image Correlation) analysis. The SENT specimen thickness and $a_0/W$ ratio is 1.45 mm and 0.2, respectively. The fracture test accomplished with displacement control with 0.1 mm/min at the room temperature. The experimental apparatus used for the fracture test consisted of a 50kN universal dynamic tester and CCD camera connected to a personal computer (PC), which was used to record images of the specimen surface. Following data acquisition, the images and load-displacements were transferred to the PC, on which the DIC software was implement. The experiment and DIC analysis results show that CFRP/GFRP laminated composite exhibits improvement of the strength, compared with that of the existing blade material. This study shows the result that the strength of CFRP rotor blade of wind turbine satisfies through the experimental and DIC method.