• The Korean Journal of Physiology and Pharmacology
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• 제27권1호
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• pp.113-125
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• 2023

It has been reported that stressful events in early life influence behavior in adulthood and are associated with different psychiatric disorders, such as major depression, post-traumatic stress disorder, bipolar disorder, and anxiety disorder. Maternal separation (MS) is a representative animal model for reproducing childhood stress. It is used as an animal model for depression, and has well-known effects, such as increasing anxiety behavior and causing abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis. This study investigated the effect of MS on anxiety or aggression-like behavior and the number of GABAergic neurons in the hippocampus. Mice were separated from their dams for four hours per day for 19 d from postnatal day two. Elevated plus maze (EPM) test, resident-intruder (RI) test, and counted glutamic acid decarboxylase 67 (GAD67) or parvalbumin (PV) positive cells in the hippocampus were executed using immunohistochemistry. The maternal segregation group exhibited increased anxiety and aggression in the EPM test and the RI test. GAD67-positive neurons were increased in the hippocampal regions we observed: dentate gyrus (DG), CA3, CA1, subiculum, presubiculum, and parasubiculum. PV-positive neurons were increased in the DG, CA3, presubiculum, and parasubiculum. Consistent with behavioral changes, corticosterone was increased in the MS group, suggesting that the behavioral changes induced by MS were expressed through the effect on the HPA axis. Altogether, MS alters anxiety and aggression levels, possibly through alteration of cytoarchitecture and output of the ventral hippocampus that induces the dysfunction of the HPA axis.

• 보건행정학회지
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• 제34권2호
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• pp.129-140
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• 2024

연구배경: 트라우마가 초래한 정신건강 문제는 사건의 특성에 따라 다르게 나타날 수 있다. 특히 성적 외상사건 경험자는 다른 유형의 외상사건을 경험한 사람들보다 정신건강 결과가 부정적이라고 알려져 있을 뿐만 아니라, 디지털 성범죄 등 성적 사건에 노출될 수 있는 새로운 형태의 위협이 커지고 있다. 이 연구는 성적 트라우마 사건을 중심으로 트라우마 사건의 유형이 정신건강의 차이를 유발하는지 확인하고, 자살생각과 잠재적 post-traumatic stress disorder (PTSD) 위험수준에 영향을 미치는 요인을 확인하고자 하였다. 방법: 전국 20대부터 50대까지 성인을 대상으로 실시한 온라인 설문조사를 토대로, 경험한 트라우마 사건의 유형에 따라 분석대상자를 구분하였다(성적 트라우마 경험자, 비성적 트라우마 경험자). 성적 트라우마 사건 경험 여부를 제외하고 정신건강(자살생각, 잠재적 PTSD 위험수준)에 영향을 미칠 수 있는 인구사회학적 요인(성, 연령, 주관적 경제수준, 결혼상태)과 회복 보호요인(사회적 지지, 회복 가능성 인지, 아동기 보호경험)을 공변량으로 propensity score matching (PSM)을 실시하였다. 이후 정신건강에 영향을 미치는 요인을 확인하기 위해 이분형 로지스틱 회귀분석을 하였다. 결과: PSM 후에도 성적 트라우마 경험자는 비성적 트라우마 경험자보다 자살생각과 잠재적 PTSD 위험수준이 부정적이었다. 이분형 로지스틱 회귀분석 결과, 성적 트라우마 경험자는 비성적 트라우마 경험자보다 자살생각이 1.9배(odds ratio [OR], 1.911), 잠재적 PTSD 위험수준은 2.5배(OR, 2.472) 높았다. 또한 트라우마 회복 인식, 사회적 지지, 아동기 보호 경험과 같은 회복 보호요인이 부정적일수록 자살생각과 잠재적 PTSD 위험수준의 가능성이 높아졌다. 결론: 이 연구는 성적 트라우마 경험에 대한 이해와 지원의 중요성을 강조하고, 성적 트라우마 경험자의 자살생각과 잠재적 PTSD 위험을 완화하고 회복을 돕기 위해 회복 보호요인을 촉진하는 전략의 필요성을 시사한다.

• 정신신체의학
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• 제6권1호
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• pp.28-34
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• 1998

Objective: This study was designed to evaluate the etiological factors of the PTSD(post traumatic stress disorder) by examining the relationship between severity of physical trauma and subsequent the severity of PTSD symptom in traffic accident related PTSD patients. Method: Subjects were 21 psychiatric inpatients with history of traffic accident related PTSD(DSM-IV criteria), the purpose of evaluation of mental disability and no evidence of organic brain leisons. The severity of physical trauma was assessed by McBride number of nonpsychiatric department and the presence / absence of loss of conciousness. The severity of PTSD symptom was assessed by Hovens' self rating inventory for PTSD. And then we evaluated the correlation between these two factors. And we also evaluated relationship between severity of PTSD symtom and clinical variables. Results : There were no significant relationship between McBride number of nonpsychiatric department severity and symptomatic severity(r= 0.17, p<0.05), the presence / absence of loss of conciousness and symptomatic severity(p>0.05). And significant relationship between symptomatic severity and clinical varibles such as sex, education level, marital status(p<0.05). Conclusions : These data did not support data of previous studies that traumatic severity was correlated with symptom severity but, suggested that other variables affecting the severity of PTSD symptom is more important indirectly. And that the 'trauma' in PTSD is psychological meaning rather than physical meaning is also suggested.

• 한국콘텐츠학회논문지
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• 제13권11호
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• pp.297-305
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• 2013

본 논문은 현기영의 "순이삼촌"을 중심으로 역사적 트라우마에 따른 외상후 스트레스 장애(PTSD)의 치료과정을 탐구한 것이다. 주된 연구방법으로는 주디스 허먼의 이론을 적용하였으며, 논의된 결과는 다음과 같다. 첫째, 순이삼촌은 제주4 3사건 당시의 집단 학살 현장에서 기적적으로 살아남았다. 그러나 30년 동안의 유예된 삶을 살면서 그녀는 역사적 트라우마에 시달린다. 이를 치료하기 위해서는 그녀의 외상 증세인 환청, 결벽증 등과 같은 원인을 알아야 한다. 또한 국가 사회적으로 피해자가 치료를 받을 수 있는 도움이 필요하고, 역사 정의가 바로 서야 한다. 둘째, 순이삼촌은 북촌 일대에서 행해지는 제삿날이나 '옴팡밭'에서 일할 때 발견되는 '흰 뼈'와 '납탄환' 등으로 인해 외상을 재경험한다. 이를 치료하기 위해서는 애도가 필요하다. 애도의 과정은 그녀에게 심적 고통을 야기하는 외상 당시의 체험과 증언을 해야 하고, 이를 말할 때 자신의 정서를 솔직하게 고백해야 한다.셋째, 역사적 트라우마를 해소하기 위해서는 자신뿐만 아니라 피해자와 공동체 사이의 연결 복구가 이루어져야 한다. 이러한 과정을 통해 개인은 자기서사에서 집단서사로 치료의 장이 확장됨을 경험하면서 동시에 슬픔을 극복할 수 있는 자신감을 얻는다. 그 결과 외상치료는 회복단계에 도달한다.

• 동의신경정신과학회지
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• 제25권1호
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• pp.73-84
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• 2014

The purpose of this study was to introduce a PTSD patient who experienced significant effects of mindfulness meditation and Ii-Gyeung-Byun-Qi therapy. Our psychotherapy was executed five times a week for the 14-year-old male patient who attended middle school and was diagnosed by DSM-IV Diagnostic Criteria for PTSD, and then the MMPI-A was evaluated to determine the effects after 3 months. The results showed normal profiles of MMPI-A validity scales and Clinical Scales profile after his treatment, positive changes in content scales, and significant decreases of PSYC (psychoticism) and NEGE (negative emotionality) in PSY-5 scales. This study made through a case report on the treated psychotherapy for PTSD by the applications of modern psychological techniques in the Korean psychotherapy. We expected that this case report will have a role in development of standardized psychotherapy programs for PTSD.

• 한국보육지원학회지
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• 제16권1호
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• pp.1-20
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• 2020

Objective: The purpose of this study was to explore the application of the multidisciplinary model, which is customized evidence-based counseling for abused preschool children done by a day care center teacher. Methods: The participants were 16 preschool children which were abused by a day care center teacher and their parents. The data were analyzed by using the Wilcoxon Signed-rank test. Results: The multidisciplinary cooperative service model based on customized evidence-based counseling for abused preschool children, their parents, and day care center teachers was developed. Based on this model, customized evidence-based Post-Traumatic Stress Disorder (PTSD) emergency intervention was provided to preschool children abused by a day care teacher in Incheon. The multidisciplinary cooperative emergency intervention service proved to be effective in reducing emotional and behavioral problems of abused preschool children and enhancing the mental health of parents. Conclusion/Implications: The results of this study indicated that the customized evidence-based counseling for abused preschool children done by a day care center teacher using the multidisciplinary cooperative linkage system would be effective, and that child abuse prevention by day care center teachers and intervention services should be provided systematically at the national level.

• Journal of Korean Neurosurgical Society
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• 제45권4호
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• pp.246-248
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• 2009

Atlantoaxial rotatory fixation (AARF) in adult is a rare disorder that occurs followed by a trauma. The patients were presented with painful torticollis and a typical 'cock robin' position of the head. The clinical diagnosis is generally difficult and often made in the late stage. In some cases, an irreducible or chronic fixation develops. We reported a case of AARF in adult patient which was treated by immobilization with conservative treatment. A 25-year-old female was presented with a posterior neck pain and limitation of motion of cervical spine after a traffic accident. She had no neurological deficit but suffered from severe defect on the scalp and multiple thoracic compression fractures. Plain radiographs demonstrated torticollis, lateral shift of odontoid process to one side and widening of one side of C1-C2 joint space. Immobilization with a Holter traction were performed and analgesics and muscle relaxants were given. Posterior neck pain and limitation of the cervical spine' motion were resolved. Plain cervical radiographs taken at one month after the injury showed that torticollis disappeared and the dens were in the midline position. The authors reported a case of type I post-traumatic AARF that was successfully treated by immobilization alone.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.507-512
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• 2015

Background: This pilot study looked into the physical, social, psychological and economic issues of Indian adult cancer survivors. Materials and Methods: Assumed cancer free patients, after cancer directed therapy (CDT), were assessed on the basis of a questionnaire developed by the investigators. The mental status of the survivors was elicited by modified MINI international neuro-psychiatric interview. This cross sectional assessment was conducted as a direct interaction with each patient for 30 to 45 minutes at a cancer hospital in 2012. Results: Thirty one adult cancer survivors participated in this study. Median age was 53 years with a median follow up duration of 21.8 months (Range 2.3-194.1 months). The majority (68%) did not receive financial support for treatment. Median interval after CDT to start of activity of daily living was 1.5 months (range: 0-24 months). Fatigue and loss of appetite were reported by 52% and 29% respectively. The cancer diagnosis and its treatment adversely impacted the financial condition in 42% of patients. Nineteen percent each showed social anxiety and post-traumatic stress disorder and another 13% patients reported depression. Conclusions: This prospective assessment highlights survivorship issues and the need to address those issues particularly in the context of developing countries where resources and manpower are limited.

• 대한간호학회지
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• 제46권2호
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• pp.159-167
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• 2016

Purpose: This article provides an overview of current knowledge on the impact of caregiving on the psychological and physical health of family caregivers of intensive care unit (ICU) survivors and suggestions for future research. Methods: Review of selected papers published in English between January 2000 and October 2015 reporting psychological and physical health outcomes in family caregivers of ICU survivors. Results: In family caregivers of ICU survivors followed up to five years after patients' discharge from an ICU, psychological symptoms, manifested as depression, anxiety and post-traumatic stress disorder, were highly prevalent. Poor self-care, sleep disturbances and fatigue were identified as common physical health problems in family caregivers. Studies to date are mainly descriptive; few interventions have targeted family caregivers. Further, studies that elicit unique needs of families from diverse cultures are lacking. Conclusion: Studies to date have described the impact of caregiving on the psychological and physical health in family caregivers of ICU survivors. Few studies have tested interventions to support unique needs in this population. Therefore, evidence for best strategies is lacking. Future research is needed to identify ICU caregivers at greatest risk for distress, time points to target interventions with maximal efficacy, needs of those from diverse cultures and test interventions to mitigate family caregivers' burden.

• 동의신경정신과학회지
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• 제31권3호
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• pp.157-168
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• 2020

The number of disasters caused by natural or human-made events such as earthquakes, tsunamis, floods, typhoons, industrial disasters, and the recent outbreak of COVID-19 has increased and the damage caused by such disasters is increasing every year. Disasters can cause physical destruction and also have unexpected psychological impacts, such as post-traumatic stress disorder (PTSD). Ear acupuncture is a treatment modality that can be helpful for both physical and mental health problems. Since ear acupuncture is a cost-effective, flexible, and safe treatment tool, it has the potential to provide medical assistance in disasters. The National Acupuncture Detoxification Association (NADA) auricular acupuncture protocol, originally developed for addiction treatment, has been used for mental illness and behavioral symptoms in both community health settings and in a variety of disaster, terror, and refugee settings. In this review, we introduced the NADA protocol, including its history, features, training, clinical evidence, and cases in disaster settings, suggesting that the NADA protocol could be utilized as a disaster medical support model in Korean medicine.