• Title/Summary/Keyword: polyethylene glycol(PEG)

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Severe hyponatremia and seizures after bowel preparation with low-volume polyethylene glycol plus ascorbic acid solution (저용량 polyethylene glycol 용액에 아스코르빈산을 첨가한 장정결제로 대장내시경 전처치 후 발생한 발작을 동반한 저나트륨혈증)

  • Lee, Jae Young;Jang, Byung Ik;Nam, Yoon Jeong;Song, Jay;Kim, Min Cheol;Chung, Seung Min;Jang, Jong Geol;Cho, Jae Ho
    • Journal of Yeungnam Medical Science
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    • v.32 no.1
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    • pp.55-59
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    • 2015
  • The widely used polyethylene glycol (PEG)-based solutions have been proven effective for bowel preparation when 4 L of the solution is administered before colonoscopy. However, large volumes of the solutions are generally poorly tolerated. A new PEG-based solution consisting of 2 L of PEG and a high dose of ascorbic acid has recently become available. Electrolyte abnormalities caused by PEG-based solutions have rarely been reported. We report on a case of acute severe hyponatremia with associated generalized tonic-clonic seizures after bowel preparation with a low-volume PEG plus ascorbic acid solution in a 74-year-old woman with no history of seizures. She took a beta blocker, an angiotensin-converting enzyme inhibitor, and glimepiride for hypertension and diabetes mellitus. She showed general weakness, nausea, agitation, muscle cramping, and seizures after ingestion of the PEG plus ascorbic acid solution. Her serum sodium level was 112 mEq/L. Her symptoms improved after intravenous administration of hypertonic saline. Physicians should pay attention to screening for electrolytes and development of neurological symptoms during bowel preparation.

Change in Weight, Moisture Content, and Dimension at the Early Stage of Adsorption-desorption of Polyethylene Glycol-treated Woods (PEG처리재의 초기 흡·탈습과정에서 중량, 함수율 및 치수 변화)

  • Kwon, Gu-Joong;Kim, Nam-Hun;Chun, Kun-Woo
    • Journal of the Korean Wood Science and Technology
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    • v.37 no.6
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    • pp.497-504
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    • 2009
  • The characteristic changes in weight, moisture content, and dimension at the early adsorptiondesorption stage of PEG-treated Korean pine (Pinus koraiensis), Japanese larch (Larix kaempferi), mongolian oak (Quercus mongolica) and sargent cherry (Prunus sargentii) woods were investigated. The wood samples were treated with PEG 1000, 2000 and 4000, and conditioned at the relative 98%, 65% and 20% for humidities of one week. The weight of Korean pine, Japanese larch and sargent cherry woods treated with PEG 1000 and 2000 during the adsorption-desorption was significantly changed, but mongolian oak was slightly changed. Moisture content was highly Moisture content was highly fluctuated by the change of relative humidity in the three species except oak wood. Although the weight of PEG-treated wood; however, changes in dimension could be prevented by PEG treatment in all species tested.

The Stability of Piroxicam in Propylene Glycol (프로필렌글리콜에서의 피록시캄의 안정성)

  • Shin, Young-Shin;Shin, Young-Hee;Lee, Chi-Ho
    • Journal of Pharmaceutical Investigation
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    • v.18 no.4
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    • pp.203-208
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    • 1988
  • The stability and solubility of piroxicam in propylene glycol (PG), polyethylene glycol (PEC), and PG-water cosolvents have been studied by using high performance liquid chromatography. The degradation rate followed an apparent first-order kinetic and the reaction rate constants at 70, 80, and $90^{circ}C$ were determined. From these rate constants, the activation energy and the rate constant of piroxicam at $25^{circ}C$ in pure PG calculated by Arrhenius equation were 23.34 kcal/mole and $7.0\;{\times}\;10^{-4}\;day^{-1}$, respectively. Both of PG and PEG increased the solubility of the drug, but PEG was more effective.

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Intersubgeneric Protoplast Fusion of Pelargonium aridum (Ligularia) and P.zonale(Ciconium) (Pelargonium aridum과 P. zonale 아속간의 원형질체융합)

  • 유순남
    • Korean Journal of Plant Tissue Culture
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    • v.22 no.6
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    • pp.311-316
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    • 1995
  • In an attempt to obtain intersubgeneric somatic hybrids of Pelargonium aridum and P.zonale, protoplast isolated from the two species were fused by using polyethylene glycol(PEG) and electorfusion methods. Protoplast were isolated from cotyledon and leaf tissues using MS medium containing 550 mM sucrose, 0.7% cellulase (Onozuka R-10) and 0.4% Macerozyme. The optimum number of protoplasts per mL of culture medium was 6 x 10$^4$. Protoplast fused by the electrofusion method were more active than by PEG method. Heterokaryotically fused protoplasts formed calli when cultured in MS medium containing 550 mM glucose, 1 to 2 mg/L NAA and 0.5 to 1 mg/L BA.

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Detection of Macro-Aspartate Aminotransferase (AST) in an Asymptomatic Patient with Persistent Elevation of AST (지속적으로 AST가 증가된 무증상 환자에서 Macro-AST의 검출)

  • Yang, Eun Ju;Lim, Sung Soo;Shin, Kyeong Seob
    • Korean Journal of Clinical Laboratory Science
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    • v.53 no.2
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    • pp.188-192
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    • 2021
  • The persistent increase of aspartate aminotransferase (AST) due to the presence of a macro-AST can confuse diagnostic or therapeutic decisions in many clinical situations. In this study, we report a case of isolated and persistent AST-elevation without any clinical sign of dysfunction in organs such as the liver, skeletal muscle, cardiac muscle, etc. Despite various investigations, no definite cause for the elevation of AST could be found. With the help of polyethylene glycol (PEG) precipitation, we showed that macro-AST formation was responsible for the elevation of the AST titer in this case. Early recognition of macro-AST by PEG precipitation can prevent diagnostic confusion and unnecessary and even invasive tests.

The Effect of Operating Conditions on Cross-Flow Ultrafiltration with using Polyethylene Glycol (Polyethylene Glycol을 이용한 Cross-Flow Ultrafiltration에 있어서 운전조건의 영향)

  • Yoo, Kun-Woo;Seo, Hyung-Joon
    • Applied Chemistry for Engineering
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    • v.9 no.7
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    • pp.950-955
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    • 1998
  • The objective of this study was to investigate the effect of running time, operating pressure, feed concentration and circulation rate on the permeation flux and the rejection rate in cross-flow ultrafiltration of polyethylene glycol(PEG) solution of molecular weight($M_w$) 8000 and 20000. The membranes used for this study were MWCO(Molecular Weight Cut-off) of 6 K and 20 K. The experiments were performed at the operating pressures of 7, 14 and 28 psi, the circulation rates of 1000 mL/min and 2000 mL/min, and the feed concentration of 100 mg/L and 1000 mg/L. At a constant pressure, the permeation flux and the observed rejection($R_o$) appeared to be approximately constant within the range of running time, 0~480 min. The permeation flux increased with increasing the operating pressure, and it increased with decreasing the feed concentration and decreasing Mw of PEG at a given pressure. On the other hand, $R_o$ decreased slightly with increasing the operating pressure. However, $R_o$ increased with increasing the feed concentration and increasing of $M_w$ of PEG at a given pressure. The variation in circulation rates did not cause any significant influence on the permeation flux. Increasing of circulation rate caused the increase of $R_o$, and $\alpha$ was increased substantially with the decrease of $M_w$ of PEG. The dimensionless parameter. permeability ratio($\alpha$), which was used to investigate flux-pressure behavior, was increased with the increase in circulation rate and operating presure. The value of $\alpha$ was less than 1 in all cases. The estimated intrinsic rejection(R). which was obtained from mass transfer coefficient, was decreased with the increase of operating pressure. However R increased with the increase of linear velocity of feed and $M_w$ of PEG.

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Effects of PEG (Polyethylene Glycol) Concentration and Mixing Ratio of PEG/Gly (Glycerol) on the Physical Properties of Silk Fibroin Films (PEG(polyethylene glycol) 농도와 PEG/Gly(glycerol) 흔합비에 따른 견 피브로인 필름의 물성)

  • Ma, Yu-Hyun;Song, Kyung-Bin
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.35 no.1
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    • pp.121-125
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    • 2006
  • To study the effects of plasticizer concentration and its ratio on the physical properties of silk fibroin films, polyethylene glycol (PEG) was used at 4 different concentrations; 1, 2, 3, $4.5\%$ (w/v). Tensile strength (TS) and water vapor permeability (WVP) increased with the increase of PEG concentration, while opposite trend was observed for percent elongation of silk fibroin films. WVP of silk fibroin films increased from $2.54\;ng{\cdot}m/m^2spa$ for $1\%$ of PEG to $5.41\;ng{\cdot}m/m^2sPa$ for $4.5\%$. In addition, a mixture of PEG and glycerol (Gly) as a plasticizer was used at the ratio of 100:0, 75:25, 50:50, 25:75, and 0:100 (w/w). Percent elongation of the films was improved to $130.95\%$ when the ratio of 75:25 was used. On the contrary, WVP of silk fibroin films increased with the decrease of the ratio of PEG:Gly. Effect of the plasticizer concentration and its ratio on the color of silk fibroin films was negligible. These results suggest that mixture of PEG and Gly as a plasticizer provide more flexible than PEG alone in silk fibroin films, and the best ratio of PEG to Gly was 75:25.

Surface Immobilization of Amphiphilic Comb-like Polymer on Polydimethylsiloxane and in vitro Cytotoxicity Assay (양친성 빗 모양 고분자의 PDMS 표면 고정화 및 세포독성 평가)

  • Choi, Jaeyoo;Jung, Jaeyeon;Cheng, Jie;Lee, Jonghwan;Hyun, Jinho;Kim, Hyunjoong
    • Journal of Adhesion and Interface
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    • v.11 no.2
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    • pp.70-75
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    • 2010
  • It described the modification of polydimethylsiloxane (PDMS) with amphiphilic methyl methacrylate-based polyethylene glycol (PMMA-b-PEG) to enhance the hydrophilicity of a PDMS surface and cytotoxicity of it. PMMA-b-PEG solutions in water/ethanol mixture was spun-cast on the PDMS surface and the surface was characterized by long-term measurement of water contact angle. The morphology of PDMS surfaces coated with PMMA-b-PEG was characterized by field emission scanning electron microscopy and atomic force microscope. Cytotoxicity of the modified surfaces was investigated by MTT assay which would be necessary for the evaluation of tissue compatibility after implantation of the materials. Based on the MTT assay, PDMS coated with PMMA-b-PEG didn't show any significant cytotoxcity.

Fouling resistant membrane tailored by polyethylene glycol in oxidative environment for desalination

  • Kavaiya, Ashish R.;Raval, Hiren D.
    • Membrane and Water Treatment
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    • v.10 no.5
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    • pp.381-385
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    • 2019
  • Surface modification is very efficient and scalable approach to achieve improved membrane performance. We treated Reverse Osmosis Thin Film Composite (TFC RO) membrane with various concentrations of Polyethylene Glycol (PEG), a hydrophilic polymer after activation with sodium hypochlorite. This treatment resulted in an increment of the water flux by 43% and the salt rejection by 2.36% for the 3000 mg/l PEG-treated membrane. Further, these PEG-treated membranes were exposed to a mixture of 3000 mg/l PEG and 1000 mg/l sodium hypochlorite for 1 hour. Further modification of this membrane by PEG and sodium hypochlorite mixture increased the water permeance up to 133% when compared with the virgin TFC RO membrane. We characterized the treated membranes to understand the changes in wettability by contact angle analysis, changes in surface morphology and roughness by scanning electron microscope (SEM) and atomic force microscope (AFM) analysis.