• Journal of Veterinary Science
• /
• v.22 no.5
• /
• pp.47.1-47.10
• /
• 2021

Background: Due to multiple similarities in the structure and physiology of human and pig skin, the pig model is extremely useful for biological drug testing after subcutaneous administration. Knowledge of the differences between subcutaneous injection sites could have a significant impact on the absorption phase and pharmacokinetic profiles of biological drugs. Objectives: This study aimed to analyze the impact of administration site on pharmacokinetics and selected biochemical and hematological parameters after a single subcutaneous administration of ustekinumab in pigs. Drug concentrations in blood plasma were analyzed by enzyme-linked immunosorbent assay. Pharmacokinetic analyses were performed based on raw data using Phoenix WinNonlin 8.1 software and ThothPro v 4.1. Methods: The study included 12 healthy, female, large white piglets. Each group received a single dose of ustekinumab given as a 1 mg/kg subcutaneous injection into the internal part of the inguinal fold or the external part of the inguinal fold. Results: The differences in absorption rate between the internal and external parts of the inguinal fold were not significant. However, the time of maximal concentration, clearance, area under the curve calculated between zero and mean residence time and mean residence time between groups were substantially different (p > 0.05). The relative bioavailability after administration of ustekinumab into the external part of the inguinal fold was 40.36% lower than after administration of ustekinumab into the internal part of the inguinal fold. Conclusions: Healthy breeding pigs are a relevant model to study the pharmacokinetic profile of subcutaneously administered ustekinumab.

• Journal of dental hygiene science
• /
• v.22 no.3
• /
• pp.171-179
• /
• 2022

Background: In this study, we investigated the changes and factors that affect daily health behaviors due to COVID-19 among adolescents. We intend to provide basic data so that a systematic and comprehensive health education program that includes physical and oral health can be made. Methods: This study was a secondary data analysis of the from the 2019 and 2020 Korea Youth Risk Behavior Web-based Survey. A final sample of 112,251 participants was anlayzed using chi-square test, and ordinal logistic regression. Results: In the case of tooth brushing, the frequency of 'never' increased in most general characteristics compared to before COVID-19. In the case of handwashing, it was found that handwashing behavior increased (increased) after COVID-19 compared to before COVID-19. As a result of confirming the factors affecting tooth brushing behavior before and after COVID-19, it was found that girls brushed teeth 2.2 times more regularly after lunch than boys. As a result of adjusting all other factors, regular tooth brushing behavior after COVID-19 was reduced by 0.79 times compared to before COVID-19. Conclusion: It is judged that it is necessary to operate a comprehensive health management program in the school so that the most basic tooth brushing for oral health and handwashing for health can become a habit. In addition, by confirming the impact of the COVID-19 pandemic on handwashing and tooth brushing behavior through this study, it is expected to be used in the development of policy data such as raising awareness of brushing and improving behaviors applicable in the current and upcoming new pandemic situations.

• Ocean and Polar Research
• /
• v.44 no.3
• /
• pp.249-260
• /
• 2022

This mini review examines the habitat connectivity and effectiveness of Korean Marine Protected Areas (MPAs) in the Yellow Sea Large Marine Ecosystem (YSLME) region. We first reemphasize that the Korean region of the YSLME is a single ecosystem (ecoregion) given the biophysical distribution patterns. The MPAs within the YSLME contribute about 50% to the total MPAs in Korea, accounting for about 10% of the territorial sea waters of Korea and 20% of the waters of YSLME on the Korean side. By area, national parks account for nearly 45% of the MPAs, followed by the wetland protected areas at 25%, with other types of MPA comprising the remaining 30%. Large MPA (> 100 km²) is the dominant type of MPA, accounting for 90% of the total area. We find that MPAs in the region are connected physically and perhaps also genetically. However, the level of protection was found to be low, and a no-take zone is rarely implemented. In addition, interrupted freshwater discharge caused by river-mouth dams poses a major hindrance to the physical connectivity of the MPAs. Restoration of the river-mouth dams and strengthened regulation on MPAs, with further expansion of MPAs in line with the current development of post-2020 global biodiversity frameworks, should be priorities for better management of marine resources. The newly revised law incorporating the concept of "Marine Ecosystem Axis Management" would reinforce the processes, and their effectiveness together with overall management of MPAs in Korea should be evaluated by designing appropriate measurement tools.

• The Plant Pathology Journal
• /
• v.39 no.1
• /
• pp.1-20
• /
• 2023

In the past, rice bakanae was considered an endemic disease that did not cause significant losses in Korea; however, the disease has recently become a serious threat due to climate change, changes in farming practices, and the emergence of fungicide-resistant strains. Since the bakanae outbreak in 2006, its incidence has gradually decreased due to the application of effective control measures such as hot water immersion methods and seed disinfectants. However, in 2013, a marked increase in bakanae incidence was observed, causing problems for rice farmers. Therefore, in this review, we present the potential risks from climate change based on an epidemiological understanding of the pathogen, host plant, and environment, which are the key elements influencing the incidence of bakanae. In addition, disease management options to reduce the disease pressure of bakanae below the economic threshold level are investigated, with a specific focus on resistant varieties, as well as chemical, biological, cultural, and physical control methods. Lastly, as more effective countermeasures to bakanae, we propose an integrated disease management option that combines different control methods, including advanced imaging technologies such as remote sensing. In this review, we revisit and examine bakanae, a traditional seed-borne fungal disease that has not gained considerable attention in the agricultural history of Korea. Based on the understanding of the present significance and anticipated risks of the disease, the findings of this study are expected to provide useful information for the establishment of an effective response strategy to bakanae in the era of climate change.

• Journal of Cadastre & Land InformatiX
• /
• v.52 no.2
• /
• pp.81-102
• /
• 2022

This study reviewed the concept of land registration and analyzed the land registration system in UK, Australia, USA, the Netherlands, France and Sweden. Land registration is a process of registering physical information and rights related to land in the land register for protection and regulation of land rights, taxation and dispute resolution. The land registration systems in the six countries were mainly analyzed in terms of policy, land register, objects and systems. As a result, first, the establishment of the land registration master plan is of paramount importance for sustainable development of land registration systems. Second, land register needs to be improved for 4D land management and service. Third, reduction of period and improvement of work efficiency for the cadastral resurveying should be considered. Last, a plan to improve public services by linking the geospatial technology with the land registration system is need.

• Nuclear Engineering and Technology
• /
• v.55 no.6
• /
• pp.2315-2324
• /
• 2023

Space nuclear reactors are becoming popular in deep space exploration owing to their advantages of high-power density and stability. Following the fourth-generation nuclear reactor technology, a conceptual design of the dual drum-controlled space molten salt reactor (D²-SMSR) is proposed. The reactor concept uses molten salt as fuel and heat pipes for cooling. A new reactivity control strategy that combines control drums and safety drums was adopted. Critical physical characteristics such as neutron energy spectrum, neutron flux distribution, power distribution and burnup depth were calculated. Flow and heat transfer characteristics such as natural convection, velocity and temperature distribution of the D²-SMSR under low gravity conditions were analyzed. The reactivity control effect of the dual-drums strategy was evaluated. Results showed that the D²-SMSR with a fast spectrum could operate for 10 years at the full power of 40 kWth. The D²-SMSR has a high heat transfer coefficient between molten salt and heat pipe, which means that the core has a good heat-exchange performance. The new reactivity control strategy can achieve shutdown with one safety drum or three control drums, ensuring high-security standards. The present study can provide a theoretical reference for the design of space nuclear reactors.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2022.11a
• /
• pp.377-379
• /
• 2022

POI refers to the point of Interest in Location-Based Social Networks (LBSNs). With the rapid development of mobile devices, GPS, and the Web (web2.0 and 3.0), LBSNs have attracted many users to share their information, physical location (real-time location), and interesting places. The tremendous demand of the user in LBSNs leads the recommendation systems (RSs) to become more widespread attention. Recommendation systems assist users in discovering interesting local attractions or facilities and help social network service (SNS) providers based on user locations. Therefore, it plays a vital role in LBSNs, namely POI recommendation system. In the machine learning model, most of the training data are stored in the centralized data storage, so information that belongs to the user will store in the centralized storage, and users may face privacy issues. Moreover, sharing the information may have safety concerns because of uploading or sharing their real-time location with others through social network media. According to the privacy concern issue, the paper proposes a recommendation model to prevent user privacy and eliminate traditional RS problems such as cold-start and data sparsity.

• Journal of radiological science and technology
• /
• v.46 no.5
• /
• pp.435-444
• /
• 2023

The purpose of this study was to analyze the factors that demographic factors, radiation knowledge level, and radiation awareness could be affecting the benefits of radiation. From July 2022 to July 2023, after receiving consent to participate by using the link of Naver through Social Network Service (SNS) for the general public, 312 people were surveyed by self-registration method without collecting personal information. The questionnaire consisted of a total of 25 questions following demographic factors (5 questions including age group by life cycle, sex, monthly household income, residence), radiation knowledge level (8 questions including basic physical, biological effects, radiation protection technology), radiation awareness (12 questions including risk, management, benefit). Independent sample T-test and ANOVA tests were performed for significant differences in the average radiation awareness between variables, and hierarchical regression was performed to identify influencing factors on radiation benefits. As a result, the benefit of radiation was significantly high among the radiation awareness, but the awareness of the danger of radiation was insufficient to the level of recognizing it as safe. Men had significantly higher awareness of radiation management and benefits than women, and the awareness of radiation management was significantly higher in the middle class with a monthly household income of 4.31 million won or more. The higher the knowledge level of radiation, the higher the awareness of the benefits of radiation. The factors that had a positive effect on radiation benefits were the high level of radiation knowledge and awareness of radiation management.

• International Journal of Computer Science & Network Security
• /
• v.24 no.6
• /
• pp.207-215
• /
• 2024

Cloud computing is now used by most companies, business centres and academic institutions to embrace new computer technology. Cloud Service Providers (CSPs) are limited to certain services, missing some of the assets requested by their customers, it means that different clouds need to interconnect to share resources and interoperate between them. The clouds may be interconnected in different characteristics and systems, and the network may be vulnerable to volatility or interference. While information technology and cloud computing are also advancing to accommodate the growing worldwide application, criminals use cyberspace to perform cybercrimes. Cloud services deployment is becoming highly prone to threats and intrusions. The unauthorised access or destruction of records yields significant catastrophic losses to organisations or agencies. Human intervention and Physical devices are not enough for protection and monitoring of cloud services; therefore, there is a need for more efficient design for cyber defence that is adaptable, flexible, robust and able to detect dangerous cybercrime such as a Denial of Service (DOS) and Distributed Denial of Service (DDOS) in heterogeneous cloud computing platforms and make essential real-time decisions for forensic investigation. This paper aims to develop a framework for digital forensic for the detection of cybercrime in a joined heterogeneous cloud setup. We developed a Digital Forensics model in this paper that can function in heterogeneous joint clouds. We used Unified Modeling Language (UML) specifically activity diagram in designing the proposed framework, then for deployment, we used an architectural modelling system in developing a framework. We developed an activity diagram that can accommodate the variability and complexities of the clouds when handling inter-cloud resources.

• Convergence Security Journal
• /
• v.23 no.5
• /
• pp.21-27
• /
• 2023

In the cloud computing environment, servers and applications can be set up within minutes, and recovery in case of fail ures has also become easier. Particularly, using virtual servers in the cloud is not only convenient but also cost-effective compared to the traditional approach of setting up physical servers just for temporary services. However, most of the und erlying networks and security systems that serve as the foundation for such servers and applications are primarily hardwa re-based, posing challenges when it comes to implementing cloud virtualization. Even within the cloud, there is a growing need for virtualization-based security and protection measures for elements like networks and security infrastructure. This paper discusses research on enhancing the security of cloud networks using network virtualization technology. I configured a secure network by leveraging virtualization technology, creating virtual servers and networks to provide various security benefits. Link virtualization and router virtualization were implemented to enhance security, utilizing the capabilities of virt ualization technology. The application of virtual firewall functionality to the configured network allowed for the isolation of the network. It is expected that based on these results, there will be a contribution towards overcoming security vulnerabil ities in the virtualized environment and proposing a management strategy for establishing a secure network.