• Natural Product Sciences
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• v.12 no.3
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• pp.153-156
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• 2006

The antisnake venom activity of Clerodendrum viscosum Vent. (Fam. Verbenaceae), a plant traditionally used in India for the treatment of snake bite was evaluated by in vitro and in vivo methods. While in vitro studies were performed using human blood, in vivo studies were carried out using mice administered three different i.p doses of the extract, 5 min before the administration of Naja naja snake venom. The results of the in vitro studies showed that the extract probably interacts with but does not stabilize membrane protein. In the in vivo studies the extract showed significant antisnake venom activity, which may be attributed to its possible interference with the acetylcholine receptor sites. Hence the present investigation justifies the traditional use of Clerodendrum viscosum (C. viscosum) as antisnake venom.

• Natural Product Sciences
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• v.9 no.4
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• pp.213-219
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• 2003

Five aromatic compounds, of which two are new glucosides, and six flavonols were isolated and identified for the first time from the flower heads and aerial shoots of Helichrysum conglobatum (Asteraceae). Their structures were established on the basis of chemical and spectroscopic methods including UV, MS, 1D- and 2D-NMR. Some fractions and isolates were screened for anti-microbial activities. This is the first report of the isolation of the chemical constituents of this species.

• Natural Product Sciences
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• v.10 no.1
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• pp.40-42
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• 2004

A simple quantitative HPLC method has been developed for differentiating two plants of Asteraceae family viz. S. costus and A. lappa by using a pharmacologically active constituent chlorogenic acid and symmetry C18 column clubbed with a binary gradient using acetonitrile: 0.1% phosphoric acid and detected using a PDA at 327 nm. Quantitatively chlorogenic acid was found to be more in A. lappa (0.140%) than in S. costus (0.087%).

• Korean Journal of Pharmacognosy
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• v.31 no.3
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• pp.357-363
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• 2000

The root of Actinidia arguta was extracted with methanol and the methanol extract was suspended in $H_2O$ and successively partitioned with n-hexane, $CH_2Cl_2$, EtOAc and n-BuOH. Repeated column chromatographic separation of the EtOAc extract resulted in the isolation of two flavonoids (compounds 2 and 3) and two triterpenes (compounds 1 and 4) and $CH_2Cl_2$, extract to afford three lignans (compounds 5-7). Their structures have been established by spectroscopic, means to be (+)-tormentoside(1), (-)-catechin(2), (-)-epicatechin(3), (+)-uscaphic $acid-28-O-[\beta}-D-glucopyranoside$(4), (+)-pinoresinol(5), (+)-medioresinol(6), and (-)-syringaresinol(7).

• Natural Product Sciences
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• v.9 no.3
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• pp.167-169
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• 2003

In the present study, Thespesia populnea was extracted with alcohol and water. The extracts were vacuum dried to yield the respective alcoholic and aqueous extracts. The extracts were screened for hypoglycemic, antidiabetic and antiulcer activities at the dose level of 500 mg/kg by standard methods. The extracts exhibited significant response for antidiabetic and antiulcer activities. The present study proved the claims of Thespesia populnea mentioned in the Indian System of Medicine.

• Natural Product Sciences
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• v.9 no.3
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• pp.195-199
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• 2003

The ethanolic (50% v/v) extracts of Peristrophe bicalyculata Nees. (Acanthaceae) were examined for anti-inflammatory and analgesic activities in experimental animals. P. bicalyculata in doses of 50, 100 and 200 mg/kg caused a dose dependent inhibition of swelling caused by carrageenin equivalent to 12.25-24.49% protection and 16.62-39.44% in cotton pellet induced granuloma in rats. There was a significant increase in the tail-flick reaction time in mice (18.05-76.43% protection) and analgesy-meter induced pain in rats (14.49-56.85%) protection). The extract of P. bicalyculata resulted in an inhibition of stretching episodes and the protection range of 14.49-56.85% respectively in acetic acid induced writhing.

• Natural Product Sciences
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• v.15 no.1
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• pp.22-26
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• 2009

Phytochemical investigation of the roots of Echiochilon fruticosum resulted in the isolation of two naphthoquinone derivatives. Compound 1 was identified as anhydroalkanin while compound 2 was identified as a new derivative 5-hydroxy 8-methoxy 2-(4-methylpent-1,3-dienyl) naphthalene-1,4-dione named as echiochiloquinone. In addition, caffeic acid 3, caffeic acid methyl ester 4 were isolated. The structures were determined by physical, chemical and spectral methods. The anti-inflammatory activity of the root extracts and compound 2 was evaluated utilizing both cotton pellet-induced and carragenin-induced rat paw edema. The ulcerogenic effect was also studied.

• Natural Product Sciences
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• v.9 no.2
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• pp.102-104
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• 2003

Aqueous and ethanolic extract of leaves of Canthium parviflorum were evaluated for wound healing and diuretic activities. Extract in the form of ointment is applied topically on excision wound in rats showed significant healing process as evidenced by increased rate of wound contraction as compared to control. The aqueous extract of 10% w/w ointment exhibited equivalent wound healing activity as Nitrofurazone oinment. Significant diuretic activity was exhibited by extracts. Graded dose response for both activities were observed for the extracts.

• Archives of Pharmacal Research
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• v.17 no.6
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• pp.393-397
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• 1994

Rhomobifoline and 5,6-dehydrolupanine were isolated for the frist time from the leaves and stems of A. foetida L. indigenous to Saudil Arabia. In addition, five other alkaloids, previously identified in A, foetidia L., namely N-methylcytisine, sparteine, anagyrine, lupanine and cytisine, were isolated. The isolated alkaloids were characterized by UV, $^1-NMR,{\;}^{13}H-NMR,{\;}^{13}C-NMR{\;}and{\;}Mass{\;}spectral{\;}data.{\;}^{13}C-NMR$ data of rhombifoline and 5,6-dehydroupanine are reported for the first time.

• Natural Product Sciences
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• v.13 no.4
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• pp.317-321
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• 2007

Phytochemical investigation of the aerial parts of Lotus ornithopodioloides L. resulted in the isolation of six known compounds. The structures were determined utilizing physical, chemical, spectral methods as well as direct comparison with reference materials whenever possible. The compounds were identified as: ${\beta}$-sitosterol; the two triterpenes oleanolic and betulinic acids; the two cyanogenic glycosides lotaustralin and linamarin in addition to the flavonol diglycoside kaempferitin.