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Ethnopharmacological Evaluation of Peristrophe bicalyculata Nees. for Anti-inflammatory and Analgesic Activity  

Rathi, Anshu (Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute, (Council of Scientific Industrial Research))
Rao, Ch.V. (Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute, (Council of Scientific Industrial Research))
Khatoon, S. (Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute, (Council of Scientific Industrial Research))
Mehrotra, S. (Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute, (Council of Scientific Industrial Research))
Publication Information
Natural Product Sciences / v.9, no.3, 2003 , pp. 195-199 More about this Journal
Abstract
The ethanolic (50% v/v) extracts of Peristrophe bicalyculata Nees. (Acanthaceae) were examined for anti-inflammatory and analgesic activities in experimental animals. P. bicalyculata in doses of 50, 100 and 200 mg/kg caused a dose dependent inhibition of swelling caused by carrageenin equivalent to 12.25-24.49% protection and 16.62-39.44% in cotton pellet induced granuloma in rats. There was a significant increase in the tail-flick reaction time in mice (18.05-76.43% protection) and analgesy-meter induced pain in rats (14.49-56.85%) protection). The extract of P. bicalyculata resulted in an inhibition of stretching episodes and the protection range of 14.49-56.85% respectively in acetic acid induced writhing.
Keywords
Peristrophe bicalyculata; pain; inflammation;
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1 Collier, H. O J., Dinneen, L. c., Johnson, C. A., and Schneider, C., The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br. J. Phannacol. 32, 295310 (1968)
2 Deraedt., R., Jougney, S., Delevalacee, E, and Falthour, M., Release of prostaglandin E and F in an algogenic reaction and its inhibition. European J. Pharmacol. 51, 17-24 (1980)
3 Jain, S. K., Dictionary of Indian folk medicine and Ethnobotany, Deep Publication, (1991), pp. 140
4 Miller, L. C. and Tainter, M. L., Evaluation of EDso and its error by means of logarithmic probic graph papers. Proc. Soc. Exp. BioI. Med. 57, 261-264 (1994)
5 Zimmerman, M., Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16, 109-110. (1983)   DOI   PUBMED   ScienceOn
6 Kirtikar, K. R., and Basu, BD., Indian medicinal plants, Leader Press, Allahabad, (1975) pp 1889
7 Trease, G. E., Evans, W. C., Pharmacognosy. Baillier Tindall Press, Londan, (1983) pp 309-706
8 Bhattacharya, S. K., Raina, M. K., Banerjee, D., and Neogy, N. C, Potentiation of morphine and pethidine analgesia by some monoamine oxidase inhibitor. Indian J. Exp. Biol. 9,257-262 (1971)
9 Vogel G. H., and Vogel W. H., Drug discovery and evaluation, Springer Verlag, Berlin (1998) pp. 413
10 Winter, C. A., Risley, E. A., and Nuss, G. w., Carrageenin induced oedema in hind paw of the rats as an assay for anti inflammatory drugs. Proc. Soc. Exp. Bio. Med. 111,544-547 (1962)   DOI
11 Meier, R., Schuler W., Desaulles, P., and Zur Frage, des Mechananismus der Hemrnung des Bindegewebswachstums durch Cortisone. Experientia. 6,469. (1950)   DOI   PUBMED   ScienceOn
12 Di Rosa, M., Biological properties of Carrageenin. J. Phann. Phannacol. 24, 89-102 (1972)
13 Sheth, U. K., Dadkar, N. K., Kamat, G., Usha, G., Miscellaneous topics. In selected topics in experimental Pharmacology. Pare & Botany, The Kothari Book Depot, (1972) pp 194
14 Nakamura, H., Shimoda, A., Ishi, K., and Kadokawa, T., Central and peripheral analgesic action of non steroidal anti inflammatory drugs in mice and rats.Arch Int. Phannacodyn. 282, 16-25, (1986)
15 Padmanabha pillai, N., Ramaswamy, S., Gopalakrishinan, V., and Ghosh, M.N., Effect of cholinergic drugs on acute and chronic morphine dependence. Arch. Int. Pharmacodyn. 257, 147-154, (1982)
16 Anonymous. The Wealth of India. Vol VII, Pill, Council of Scientific and Industrial Research, New Delhi, 1991, pp. 313
17 Davies, O. L., Raventos, J., and Walpole, A. L., A method for evaluation of analgesic activity using rats. Br. J. Pharmacol. 1, 255-261 (1946)
18 Bentley, G. A., Newton, S. H., Starr, J., Studies on the antinociceptive action of a against drugs and their interaction with opioid mechanisms. Br. J. Pharmacol. 79, 125-134 (1983)   DOI   ScienceOn
19 Chopra, R. N., Nayar, S. L., and Chopra, J. C., Glossary of Indian Medicinal Plants. Council of Scientific and Industrial Research, New Delhi, 1956, pp 94
20 Vinegar R., Schrieber w., and Hugo R., Biphasic development of carrageenin oedema in rats. J. Phannacol. Exp. Therap. 166, 96 (1969)
21 Bapalala, G. V., Nighantu Adarsh. V-II, Chowkhamba Bharati Academy Publishers. lind Edition 1999, pp. 225
22 Chopra, J. C, and Chopra, C. L., Antibacterial properties of Peristrophe bicalyculata. Indian J. Med. Res. 47, 161-163 (1959)
23 Winter, C. A., and Porter, C. C, Effect of alteration in side chain upon anti-inflammatory and liver glycogen activities in hydrocortisone esters. J. Am. Phann. Assoc. Sci. 46,515 (1957)
24 Crunkhorn, P., and Meacock, S. C .R., Mediator of inflammation induced in the paw by carrageenin. Br. J. Phannacol. 42, 392 (1971)
25 Singh R. S., Pandey R. P., Singh B. K., Singh R. G., Aliphatic from Peristrophe bicalyculata. Fitoterpia. 71, 80-81, (2000)   DOI   ScienceOn
26 Phadke, J D., and Anderson, L .A., Ethnopharmacology and Western medicine. J. Ethnophannacol. 25, 61. (1988)
27 Witkin, L. B., Huebner, C. E, Galdi, EO., Keefe, E., Spitaletta, P., and Plumer, A.J.,Pharmacognosy of 2 amino indanehydrochloride (SU 8629); A potent non nacrotic analgelic. J. Pharmacol. Exp. Therap. 133,400-408 (1961)
28 Rodriguez Alia, R. E., Antinocicptive activity of glycosidic enkephalin analogues. Psychopharmacol. 101, 222-225 (1990)   DOI