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Preliminary Study on the Antisnake Venom Activity of Alcoholic Root Extract of Clerodendrum viscosum (Vent.) in Naja naja Venom  

Lobo, Richard (Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences)
Punitha, I.S.R. (Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences)
Rajendran, K. (Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences)
Shirwaikar, Arun (Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences)
Shirwaikar, Annie (Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences)
Publication Information
Natural Product Sciences / v.12, no.3, 2006 , pp. 153-156 More about this Journal
Abstract
The antisnake venom activity of Clerodendrum viscosum Vent. (Fam. Verbenaceae), a plant traditionally used in India for the treatment of snake bite was evaluated by in vitro and in vivo methods. While in vitro studies were performed using human blood, in vivo studies were carried out using mice administered three different i.p doses of the extract, 5 min before the administration of Naja naja snake venom. The results of the in vitro studies showed that the extract probably interacts with but does not stabilize membrane protein. In the in vivo studies the extract showed significant antisnake venom activity, which may be attributed to its possible interference with the acetylcholine receptor sites. Hence the present investigation justifies the traditional use of Clerodendrum viscosum (C. viscosum) as antisnake venom.
Keywords
Clerodendrum viscosum; Naja naja; snake venom; verbenacease; alcoholic extract;
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