• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.273-273
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• 1996

Recently a novel in vivo approach in dogs, using a regional segmental intestinal perfusion technique, has been developed. The perfusion tube consists of a highly sophisticated multichannel tube with two inflatable occluding balloons, which are placed in 10cm apart. The tube was introduced orally from the stomach through the upper jejunum under the guidance of solid-state pH meter. In the present study, four healthy dogs were infused in the proximal jejunum on two periods. The two perfusion experiments used the same flow rate, 2 $m\ell$/min, and the same perfusion solution to determine the intrasubject variability. The mean (${\pm}$ S. E.) fractions of ranitidine absorbed calculated from the perfusion data were 21.32${\pm}$2.01% (n=3) (1st period), 27.88 ${\pm}$ 17.54% (n=4) (2nd period), respectively. The effective permeabilities (Peffs${\times}$10$\^$4/) of ranitidine were 1.51${\pm}$0.47cm/sec (n=3) (1st period), 1.50 ${\pm}$ 0.31 cm/sec (n=4) (2nd period), respectively. The pH and osmolarity of perfusion solution were 7.50 ${\pm}$ 0.03 and 300 ${\pm}$ 0.06 mOsm/L, There was no significant intrasubject variation. Mixing equilibrium (steady-state) was reached at about 50 min. l-Phenylalanine was absorbed almost completely. Intrinsic intestinal wall permeability of ranitidine showed low permeable characteristics, suggesting permeability-limited absorption. The absorption of 1-phenylalanine, an actively transported nutrient, was not inhibited by ranitidine. The low intestinal membrane permeability is one of the important factors responsible for the variable oral absorption of ranitidine. Supported by FDA Grant FD01462-04 and KOSEF Grant.

• Environmental Analysis Health and Toxicology
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• v.6 no.1_2
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• pp.7-23
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• 1991

The present study was undertaken to examine the effect of butylhydroxyanisole (BHA) on the lead poisoning in Wister female rats. All experimental rats except normal group were fed with diets formulated by adding BHA in a range of 0.1% to 3.2% and aqueous solution of 1% lead acetate ad libitum through the experimental period. The results obtained are summarized as follows: 1) Lead sedimentation in kidney tissue was decreased with increasing experimental period and BHA level of lead plus BHA-treated groups in comparison with that of lead-treated control group. 2) The weights of lung, spleen and left/right (L/R) kidney were significantly decreased in comparison with those of lead-treated control group after 2 weeks of experimental period, but no difference was shown with those of normal group. 3) The weights of lung, spleen and L/R kidney were increased in lead-treated control group as compared with normal group after 2 weeks of experimental period, but no difference was shown with increasing experimental period. 4) Water intake was remarkably decreased in lead-treated control group as compared with normal group, but water intake by increasing BHA level of lead plus BHA-treated groups showed no significant difference from that of normal group. 5) These results suggest that BHA is effective for reducing the toxic effect of lead in rats.

• Horticultural Science & Technology
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• v.35 no.4
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• pp.456-464
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• 2017

We examined the effect of nutrient solution concentration in the second half of growing period on the pre- and postharvest characteristics of two leaf lettuce cultivars, 'Geokchima' and 'Cheongchima'. Plants were grown hydroponically in a deep flow technique (DFT) system at different concentrations of National Horticulture Research Institute hydroponic nutrient solution: 1/2 strength (S), 1S, 2S, and 4S. Lettuce leaf growth, number of leaves, and shoot fresh weight of both cultivars were greatest in plants grown in the 1S treatment. Compared to other treatments, pigment and nutrient ion contents were greater in the 4S treatment. Growth of lettuce was greatest in the 1S treatment, and decreased at higher or lower concentrations of nutrient solution. However, postharvest characteristics such as fresh weight loss, leaf chlorophyll level, and external appearance were better in both cultivars when grown in 2S solution. Variations in weight loss and SPAD values were smallest in the 2S treatment. These results show that the optimal nutrient concentration for growth does not necessarily provide the optimal postharvest storability.

• KIEAE Journal
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• v.6 no.2
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• pp.43-50
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• 2006

A Double Facade System(DFS) is well known as an innovative solution of ecological facade in the west european countries. There are more than 200 various realized DFS in Germany. At the same time, the korean engineers have researched to find out the physical advantages of DFS in the moderate korean climate, which has a very humid summer with high temperature and a dry winter with low temperature. For example, the monthly mean temperature in Korea comes up to 28K, while that in Germany comes up to only 19K. That is, why a other solution of DFS is needed in Korea. This study has experimented the physical performance of the natural ventilation in the heating period. The preheating function of the cold air by DFS can improve no doubt the performance of the natural ventilation at the cold season as well as spring and autumn. The physical difference between single and double facade on natural ventilation has been tested at the newly constructed laboratory, which can turn $360^{\circ}$ to confirm the characteristic of a facade with the various directions. The results show the natural ventilation of the DFS has definitely much more comfortable than that of the single facade system. The air velocity of the inflow as well as the air temperature in the DFS provide a more stable condition than in the SFS. The theoretical limit(air velocity max 0.2m/s, air temperature min. $18^{\circ}C$, temperature difference between 100mm and 1700mm height max. 3K) on the indoor comfortableness doesn't go over in the DFS. On the other hand, the SFS showed an unstable condition with an excess of comfortableness limit on air velocity as well as temperature. In view of the researching results so far achieved, the research came to a conclusion, that the DFS can provide a more comfortable indoor condition by the preheating in the heating period than a SFS, and the period of natural ventilation in winter time could be definitely increased at the DFS.

• International Journal of Industrial Entomology and Biomaterials
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• v.34 no.2
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• pp.23-31
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• 2017

Bumblebees, more efficient than honeybees, provide important services for pollination especially in tomato, pepper, cucumber, strawberries and other crops grown under tunnel farming or glasshouse conditions to yield maximization. These bees require pollen and nectar to meet their dietary needs and maintain their colony structure, development and reproduction. Keeping in view their economic importance, the effect of five concentrations of sugar and honey solutions (1:1, 1:1.5, 1:2, 2:1,1.5:1) each as alternative to nectar were used to observe their effect on life history parameters of Bombus terrestris. The 1:1 ratio of sugar solution was found most effective followed by 1.5:1, 1:1.5, 1:2 and 2:1 and also more effective of all five concentrations of honey solutions on all three stages of colony development i.e., at colony initiation, colony development and colony maturation stages. At colony initiation stage, early pre-oviposition period ($6.40{\pm}0.97$ days), early emergence of first worker in the first batch ($25.40{\pm}1.21$ days) and maximum numbers of workers ($6.20{\pm}0.24$) emergence in the first batch were observed at 1:1 ratio of sugar solution. Colonies reared on 1:1 ratio of sugar solution reached earlier ($52.13{\pm}1.28$ days) at colony foundation stage with minimum mortality ($3.27{\pm}0.54$ workers). At colony maturation stage, maximum numbers of workers, sexual (males, queens) and maximum mother queen longevity was observed at the same 1:1 ratio of sugar solution. It can be suggested from present study that sugar solution as alternative of nectar at 1:1 ratio was better than other sugar concentration levels and also from those of honey solution.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.13 no.4
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• pp.317-322
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• 2003

Torsional oscillations of a system incorporating a Hooke's joint are investigated by adopting a nonlinear 2-degree-of-freedom model. Linear and Van der Pol transformations are applied to obtain the equations of motion to which the method of averaging can be readily applied. Various subharmonic and combination resonances are identified with the conditions of their occurrences. Applying the method of averaging leads to the reduced amplitude- and phase-equations of motion, of which constant and periodic solutions are obtained numerically. The periodic solution which emerges from Hopf bifurcation point experiences period doubling bifurcation leading to infinite solution rather than chaotic solution.

• Journal of the Korean Operations Research and Management Science Society
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• v.14 no.2
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• pp.67-74
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• 1989

This paper considers single-product production and inventory management problem where cumulative demands up to each time period are mutually independent random variables(known) having continuous probability distributions and the associated cost-minimizing production schedule (when to produce and how much to produce) need be determined in rolling horizon environment. For the problem, both the production cost and the inventory holding and backlogging costs are included in the whole system cost. The probability distributions of these costs are expressed in terms of random demands, and utilized to exploit a solution procedure for a production schedule which minimizes the expected unit time system cost and also reduces the probability of rist that, for the first-period of each production cycle (rolling horizon), the cost of the "production" option will exceed that of the "non-production" one. Numerical examples are presented for the solution procedure illustration.cedure illustration.

• Journal of Ginseng Research
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• v.8 no.2
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• pp.135-152
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• 1984

Solubility and degree of swelling of the starch were about 15% and 30%, respectively when the starch in agueous solution was heated at 90$^{\circ}C$ for 30minutes. The starch showed no singnificant differences in the degree of swelling and soblubility with a growing period of ginseng. The starch was begun gelatinize at 50-55$^{\circ}C$ and completed at 65-70$^{\circ}C$ by the amy tical methods of X-ray diffraction, disappearance of crystalinity. Brabender angly lographic analysis and amylase digestion test. The maximum and minimum peak viscosities of 10% starch solution were 5.500 B.U and 1960 B.U, respectively. The starch showed no significant differences in pasting temperature, maximum and minimum viscosities on amylogram with a growing period of ginseng. The intrinsic viscosities of the starch and amylose were 0.54 and 1.5-1.9, respectively.

• Transactions of the Korean Society of Mechanical Engineers
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• v.17 no.11
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• pp.2684-2693
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• 1993

The free vibration and dynamic response of cross-ply for CFRP and GFRP laminated circular cylindrical shells under dynamic loadings are investigated by using the first-order shear deformation shell theory. The modal analysis technique is used to develop the analytical solutions of simply supported cylindrical shells under dynamic load. The analysis is based on an expansion of the loads, displacements and rotations in a double Fourier series which satisfies the and boundary conditions of simply support. Analytical solution is assumed to be separable into a function of time and a function of position. In this paper, the considered load forces are step pulse, sine pulse, triangular(1, 2, 3) pulse and exponential pulse. The solution for a given loading pulse can be found by involving the convolution integral. The results show that the dynamic response are governed primarily by the natural period of the structure.

• Journal of The Korean Society of Grassland and Forage Science
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• v.10 no.3
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• pp.121-128
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• 1990

Germination of Italian ryegrass and sorghum were measured at a range of temperatures and with PEG treatment at several different levels of concentration and treatment period to evaluate the effects of osmoconditioning with polyethylene glycol(PEG-8000). The results obtained are summarized as follows: 1. Cumulative germination percentage of intact Italian ryegrass seeds did not show much difference among temperatures, while that of sorghum seeds decreased markedly at low temperature. 2. Italian ryegrass seeds osmoconditioned with 20% PEG solution for two days at 10^{\circ}C.$ accelerated germination at 10^{\circ}C.$, with injurious effect of osmoconditioning at higher temperature for many days. 3. Osmoconditioning with 20% PEG solution for two or four days at 10^{\circ}C.$ increased germination of sorghum seeds, while the seeds treated at higher temperatures for long period suppressed germination.