• Communications for Statistical Applications and Methods
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• v.27 no.1
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• pp.1-14
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• 2020

Investigations of biosimilarity between reference drugs and test drugs required statistical tests; in addition, statistical tests to evaluate biosimilarity have been recently proposed. Ordinal outcome data has been observed in research; however, appropriate statistical tests to deal with ordinal endpoints for biosimilar have not yet been proposed. This paper extends existing design for ordinal endpoints. Using measure of nominal-ordinal association and relative distances between drugs are defined so that testing procedures are developed. Through simulation studies, we investigate type I error rate and power to show the performance of our suggested method. Furthermore, a comparison between the statistical tests and other designs is proviede to show significance of ordinal endpoints.

• Journal of Pharmacopuncture
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• v.18 no.1
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• pp.44-55
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• 2015

Objectives: Scolopendra subspinipes mutilans (S. subspinipes mutilans) is known as a traditional medicine and includes various amino acids, peptides and proteins. The amino acids in the pharmacopuncture extracted from S. subspinipes mutilans by using derivatization methods were analyzed quantitatively and qualitatively by using high performance liquid chromatography (HPLC) over a 12 month period to confirm its stability. Methods: Amino acids of pharmacopuncture extracted from S. subspinipes mutilans were derived by using O-phthaldialdehyde (OPA) & 9-fluorenyl methoxy carbonyl chloride (FMOC) reagent and were analyzed using HPLC. The amino acids were detected by using a diode array detector (DAD) and a fluorescence detector (FLD) to compare a mixed amino acid standard (STD) to the pharmacopuncture from centipedes. The stability tests on the pharmacopuncture from centipedes were done using HPLC for three conditions: a room temperature test chamber, an acceleration test chamber, and a cold test chamber. Results: The pharmacopuncture from centipedes was prepared by using the method of the Korean Pharmacopuncture Institute (KPI) and through quantitative analyses was shown to contain 9 amino acids of the 16 amino acids in the mixed amino acid STD. The amounts of the amino acids in the pharmacopuncture from centipedes were 34.37 ppm of aspartate, 123.72 ppm of arginine, 170.63 ppm of alanine, 59.55 ppm of leucine and 57 ppm of lysine. The relative standard deviation (RSD %) results for the pharmacopuncture from centipedes had a maximum value of 14.95% and minimum value of 1.795% on the room temperature test chamber, the acceleration test chamber and the cold test chamber stability tests. Conclusion: Stability tests on and quantitative and qualitative analyses of the amino acids in the pharmacopuncture extracted from centipedes by using derivatization methods were performed by using HPLC. Through research, we hope to determine the relationship between time and the concentrations of the amino acids in the pharmacopuncture extracted from centipedes.

• Research in Mathematical Education
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• v.19 no.2
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• pp.89-100
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• 2015

The study investigated pre-service teachers' knowledge and computational skills by using Triangular Arithmagon. Participants included 90 pre-service teachers from two schools in the United States and Taiwan. The Triangular Arithmagons Test (TAT) was used to measure pre-service teachers' performance in whole number, fractions, and decimals operations (i.e., addition, subtraction, multiplication, and division), each of which included level-1 (basic) and level-2 (advanced) tests. MANOVA analysis was performed to compare the performance between teachers from the United States and Taiwan. Results indicated that overall, pre-service teachers in Taiwan outperformed those in the United States, especially on the advanced-level tests. Pre-service teachers in the United States were found to have poor ability of solving complex operation problems. Different curriculum plans and teaching methods may lead to the performance gap between the two countries.

• International Journal of Highway Engineering
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• v.13 no.4
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• pp.93-101
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• 2011

The evaluation of various color coating methods for color maintenance of color asphalt pavement is conducted using the laboratory and field tests on the bus lane. The surface of color asphalt constructed on the bus lane is deteriorated such as changing color and decoloration and abrasion due to the passing of the traffic and time. The total of 9 coating methods were evaluated in this study. The laboratory tests included Ultra violet test, adhesion test and Taber abrasion test and the field tests were british pendulum test and visual survey. The results of tests showed that the different methods showed the their own engineering characteristics and it is dependant upon the main material used. The rubber epoxy material for the main material showed the satisfactory result among the methods tested. However, the performance of the coating methods after 100days are not satisfactory, decoloration, abrasion and peeling up are investigated and need to be studied for the further application in the field.

• Smart Structures and Systems
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• v.15 no.3
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• pp.555-576
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• 2015

The large number of long-span bridges constructed in China motivates the applications of structural health monitoring (SHM) technology. Many bridges have been equipped with sophisticated SHM systems in the mainland of China and in Hong Kong of China. Recently, SHM technology has been extended to field test systems. In this view, SHM can serve as a tool to develop the methods of life-cycle performance design, evaluation, maintenance and management of bridges; to develop new structural analysis methods through validation and feedback from SHM results; and to understand the behavior of bridges under natural and man-made disasters, rapidly assess the damage and loss of structures over large regions after disasters, e.g., earthquake, typhoon, flood, etc. It is hoped that combining analytical methods, numerical simulation, small-scale tests and accelerated durability tests with SHM could become the main engine driving the development of bridge engineering. This paper demonstrates the above viewpoint.

• Nuclear Engineering and Technology
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• v.46 no.6
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• pp.737-752
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• 2014

As condition-based maintenance (CBM) has risen as a new trend, there has been an active movement to apply information technology for effective implementation of CBM in power plants. This motivation is widespread in operations and maintenance, including monitoring, diagnosis, prognosis, and decision-making on asset management. Thermal efficiency analysis in nuclear power plants (NPPs) is a longstanding concern being updated with new methodologies in an advanced IT environment. It is also a prominent way to differentiate competitiveness in terms of operations and maintenance costs. Although thermal performance tests implemented using industrial codes and standards can provide officially trustworthy results, they are essentially resource-consuming and maybe even a hind-sighted technique rather than a foresighted one, considering their periodicity. Therefore, if more accurate performance monitoring can be achieved using advanced data analysis techniques, we can expect more optimized operations and maintenance. This paper proposes a framework and describes associated methodologies for in-situ thermal performance analysis, which differs from conventional performance monitoring. The methodologies are effective for monitoring, diagnosis, and prognosis in pursuit of CBM. Our enabling techniques cover the intelligent removal of random and systematic errors, deviation detection between a best condition and a currently measured condition, degradation diagnosis using a structured knowledge base, and prognosis for decision-making about maintenance tasks. We also discuss how our new methods can be incorporated with existing performance tests. We provide guidance and directions for developers and end-users interested in in-situ thermal performance management, particularly in NPPs with large steam turbines.

• Journal of the Earthquake Engineering Society of Korea
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• v.10 no.5 s.51
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• pp.107-115
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• 2006

The power supply system is one of the most important infrafacilities which should maintain their inherent function during and after earthquakes. This study was performed to analyze dynamic characteristics and seismic performance of Korean typical 154kV transformer porcelain bushing. For the purpose of this study, actual 154kV porcelain bushings were selected and tested on the shaking table. The vibration tests consist of modal identification tests, seismic performance tests, and fragility tests. The sine sweep waves, artificial earthquake waves, and continuous resonant sine waves were used as shaking table motions. This paper describes the test specimens, shaking facilities, and test methods. Natural frequencies and damping ratios of the bushing have been evaluated from the experimental data. The failure mode and the performance level of the Korean transformer bushing have been first identified in this study.

• International Journal of Highway Engineering
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• v.15 no.2
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• pp.65-71
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• 2013

PURPOSES : The objective of this study is to evaluate the effect of physical characteristics of emulsion asphalt and aggregate on performance of chip seal pavements. METHODS : In order to evaluate the performance of chip seal materials, the sweep tests and Vialit Plate Shock tests were conducted on the mixtures with five emulsion asphalt binders and three aggregate types. The sweep tests was intended to investigate the change of bonding properties between emulsion asphalt and aggregate with curing time. The Vialit Plate Shock test was used to evaluate the bonding properties of chip seal materials at low temperatures. RESULTS : Results from sweep tests showed that polymer modified emulsion asphalt can reduce the curing time by 1.5 hour comparing with typical emulsion asphalt. It is also found that the Flakiness Index of aggregates and absorption rate of binder are the major factors affecting the bonding properties of chip seal materials. The Vialit Plate Shock test results showed that the average aggregate loss of CRS-2 is ten times higher than CRS-2P No.2 indicating that the use of polymer additives in emulsion asphalt can improve the performance of chip seal materials in low temperature region. CONCLUSIONS : The use of polymer in emulsion asphalt can decrease the curing time of chip seal materials and increase the bonding properties between aggregates and asphalt binder. It is also concluded that the lower Flakiness Index and absorption rate of aggregates can improve the performance of chip seal pavement.

• Aerospace Engineering and Technology
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• v.6 no.1
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• pp.29-34
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• 2007

On the stage of combustor development process, many aerodynamic and combustion characteristics are found out not by only ideal design concept but by only useful tests which are top confidentiality of technically advanced engine development companies, RR and GE, etc. In this study, test techniques of one of that company are analysed and described about some unique tests for test low emission combustors.

• Proceedings of the KSR Conference
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• 1998.05a
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• pp.494-501
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• 1998

This Paper describes the evaluation methods and criteria used to verify running Performance of railway vehicle, and shows results of vehicle dynamics simulation and running performance tests for New Mugunghwa Coaches that were designed and manufactured by DHI in 1997. Through running performance test of New Mugunghwa Coaches, Vibration, Ride Comfort were measured on the condition of service operation. As a results, each simulation and test results meet the criteria proposed by Korean National Railroad(KNR) and Korea Railroad Research Institute(KRRI).