• Journal of the Korean Recycled Construction Resources Institute
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• v.2 no.4
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• pp.297-306
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• 2014

Recently nano-materials are gaining more importance in the construction industry due to its enhanced energy efficiency, durability, economy, and sustainability. Nano-silica addition to cement based materials can control the degradation of the fundamental calcium-silicate-hydrate reaction of concrete caused by calcium leaching in water as well as block water penetration and therefore lead to improvements in durability. In this paper, the influence of synthesized nano silica from locally available rice husk on the mechanical properties and corrosion resistant properties of OPC (Ordinary Portland Cement) has been studied by conducting various experimental investigations. Micro structural properties have been assessed by conducting Scanning Electron Microscopy, Thermo gravimetry and Differential Thermal Analysis, X-Ray Diffraction analysis, and FTIR studies. The experimental results revealed that NS reacted with calcium hydroxide crystals in the cement paste and produces Calcium Silicate Hydrate gel which enhanced the strength and acts as a filler which filled the nano pores present in concrete. Hence the strength and corrosion resistant properties were enhanced than the control.

• Journal of Ocean Engineering and Technology
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• v.30 no.3
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• pp.186-193
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• 2016

Recently in Korea, a marine ranching project has continued to grow with the increasing needs of sea development. Management techniques, including settlement reduction and scour protection, have been required for constructing and maintaining the artificial reefs of this marine ranching project. The generation of settlement and scour can be influenced by ground characteristics. In this study, various laboratory tests (penetration test, two-dimensional water tank test) were performed to determine the settlement and scour characteristics of artificial reefs under various ground conditions. Three kinds of ground reinforcement were prepared: unreinforced, geogrid, and hybrid bamboo mat. Penetration test results showed that the normalized settlement ratio of ground reinforced with a hybrid bamboo mat was smaller than those of unreinforced ground and geogrid-reinforced ground. Two-dimensional water tank test results showed that the scour characteristics of ground reinforced with a geogrid were more reduced and stable than unreinforced ground. The amount of scour and ground settlement also decreased with increasing reinforced area.

• The Journal of Korean Physical Therapy
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• v.13 no.3
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• pp.719-726
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• 2001

Transdermal drug delivery offers various advantages over conventional drug delivery systems, such as avoidance gastrointestinal degradation and hepatic first-pass effect. encourages patient compliance. and possible sustained release of drugs. However, transdermal transport of drugs is low permeability of the stratum corneum, the superficial layer of the skin. Many physicochemical and biological factors influencing transdermal transport is described together with the corresponding experimental and clinical results. Phonophoresis is medical treatment with drugs introduced into the skin by ultrasound energy. Enhanced drug penetration is through to result from the biophysical alterations of skin structure by ultrasound waves. The frequency used for phonophoresis is usually from 20 kHz to 15MHz. Phonophoresis can be categorized in to three ranges: low-frequency range(below 1 MHz). therapeutic frequency range(1 to 3MHz), and high-frequency range(above 3 MHz). The depth of penetration of ultrasound into skin is inversely proportional to the frequency. Cavitation may cause mechanical stress. temperature elevation, or enhanced chemical reactivity causing drug transport. One theory is that ultrasound affects the permeation of the stratum corneum lipid structure as the limiting step in permeating through the skin. The range of indications for phonophoresis is wide. Aspecific classification of the range of indications is obtained by classification of pathological conditions. The continuous research is needed for many interesting issucs of phonophoretic transdermal delivory in new future.

• Archives of Pharmacal Research
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• v.29 no.10
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• pp.928-933
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• 2006

Percutaneous delivery of NSAIDs has advantages of avoiding hepatic first pass effect and delivering the drug for extended period of time at a sustained, concentrated level at the inflammation site that mainly acts at the joint and the related regions. To develop the new topical formulations of pranoprofen that have suitable bioadhesion, the gel was formulated using hydroxypropyl methylcellulose (HPMC) and poloxamer 407. The effects of temperature on drug release was performed at $32^{\circ}C$, $37^{\circ}C$ and $42^{\circ}C$ according to drug concentration of 0.04%, 0.08%, 0.12%, 0.16%, and 0.2% (w/w) using synthetic cellulose membrane at $37{\pm}0.5^{\circ}C$. The increase of temperature showed the increased drug release. The activation energy (Ea), which were calculated from the slope of lop P versus 1000/T plots was 11.22 kcal/ mol for 0.04%, 10.79 kcal/mol for 0.08%, 10.41 kcal/mol for 0.12% and 8.88 kcal/mol for 0.16% loading dose from the pranoprofen gel. To increase the drug permeation, some kinds of penetration enhancers such as the ethylene glycols, the propylene glycols, the glycerides, the non-ionic surfactants and the fatty acids were incorporated in the gel formulation. Among the various enhancers used, propylene glycol mono laurate showed the highest enhancing effects with the enhancement factor of 2.74. The results of this study suggest that development of topical gel formulation of pranoprofen containing an enhancer is feasible.

• Journal of Electrical Engineering and Technology
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• v.7 no.4
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• pp.486-492
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• 2012

This paper presents a novel objective function for distribution system reconfiguration for reliability enhancement. When islanding operations of distributed generators is prohibited, faults in the feeder interrupt the operation of distributed generators. For this reason, we include the customer interruption cost as well as the distributed generator interruption cost in the objective function in the network reconfiguration algorithm. The network reconfiguration in which genetic algorithms are used is implemented by MATLAB. The effect of the proposed objective function in the network reconfiguration is analyzed and compared with existing objective functions through case studies. The network reconfiguration considering the proposed objective function is suitable for a distribution system that has a high penetration of distributed generators.

• Proceedings of the Korea Concrete Institute Conference
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• 2002.05a
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• pp.569-574
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• 2002

Generally, the limestone powder is known to have some advantages in rheology of fresh concrete, resistance of material separation, and enhancement of strength at early ages. Recently, great attention is being paid to limestone blended cements in the manufacture of concrete, especially in the countries of Europe. The purpose of the present study is to establish the mechanical and durable properties of concrete containing slag and limestone powder. In this paper, the chloride ion penetration test, rapid carbonation test and rapid freezing-thawing test is carried out to study durability of concrete with various content of limestone powder. Futhermore, the strength of concrete is evaluated with various ages.

• Journal of Pharmaceutical Investigation
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• v.35 no.2
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• pp.81-87
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• 2005

We have prepared karaya gum patches containing ketoprofen and investigated the effect of short-time current pretreatment of skin on the permeability. Hairless mouse skin was treated with current before the patch was mounted on the skin. The effect of current density and current duration on the flux of ketoprofen was studied. The possibility of additive effect with penetration enhancer (PGML) was also investigated. Iontophoretic pretreatment of skin increased the passive flux up to 3 folds at 0.4 $mA/cm^2$ current density, when the matrix contained no PGML. As the duration of current-pretreatment and current density increased, flux increased. PGML increased the average passive flux markedly, about 6 to 12 folds, depending on the concentration in the patch. Current pretreatment further increased the flux from this PGML containing patch, exhibiting additive effect. These results indicate that short-duration current pretreatment of skin can be an useful method for the enhancement of ketoprofen permeability through skin.

• Journal of Pharmaceutical Investigation
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• v.33 no.2
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• pp.79-84
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• 2003

The effects of various pressure sensitive adhesives (PSA) and enhancers on the percutaneous absorption of tulobuterol were investigated. The permeation rate of tulobuterol through hairless mouse skin from various adhesives was evaluated using a flow-through diffusion cell system at $37^{\circ}C$. The permeability of tulobuterol was variable depending on the physicochemical property of the PSA. The permeation rate of tulobuterol from polyethylene oxide grafted acrylic adhesive matrix was higher than that from other PSA matrices. The flux of tulobuterol was $4.37{\pm}0.34\;{\mu}g/hr/cm^2$ from polyethylene oxide grafted acrylic adhesive matrix. When the effects of various enhancers on the percutaneous absorption of tulobuterol from grafted acrylic adhesive were evaluated, Plurol $oleique^{\circledR}$ showed higher flux than all other enhancers tested.

• Journal of Welding and Joining
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• v.22 no.6
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• pp.30-35
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• 2004

Laser welding is obviously an attractive method to join small, thin parts such as small stainless steel tubes, but it is very sensitive to the joint clearance and tolerance, and this makes laser welding difficult to obtain consistent welding qualities over time. Recently, Plasma Augmented Laser Welding(PALW) is being developed to solve these problems. In this study, plasma arc welding(PAW) was introduced to join conventional V-grooved butt joint of thin stainless steel strips using single laser heat source in manufacturing small stainless steel tubes. The effect of the welding speed enhancement is investigated by the experiments. Effects of welding directions, distance between the heat sources and intensity of arc heat source on the optimal welding speed was investigated. Through this research, it was confirmed that PALW process has higher welding speed and robustness than laser welding process.

• BMB Reports
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• v.46 no.1
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• pp.17-24
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• 2013

Transcutaneous immunization refers to the topical application of antigens onto the epidermis. Transcutaneous immunization targeting the Langerhans cells of the skin has received much attention due to its safe, needle-free, and noninvasive antigen delivery. The skin has important immunological functions with unique roles for antigen-presenting cells such as epidermal Langerhans cells and dermal dendritic cells. In recent years, novel vaccine delivery strategies have continually been developed; however, transcutaneous immunization has not yet been fully exploited due to the penetration barrier represented by the stratum corneum, which inhibits the transport of antigens and adjuvants. Herein we review recent achievements in transcutaneous immunization, focusing on the various strategies for the enhancement of antigen delivery and vaccination efficacy.