Browse > Article
http://dx.doi.org/10.4333/KPS.2005.35.2.081

Current Pretreatment of Skin and Its Effect on the Permeability  

Lee, Jung-Hwa (College of Pharmacy, Sookmyung Women's University)
Oh, Seaung-Youl (College of Pharmacy, Sookmyung Women's University)
Publication Information
Journal of Pharmaceutical Investigation / v.35, no.2, 2005 , pp. 81-87 More about this Journal
Abstract
We have prepared karaya gum patches containing ketoprofen and investigated the effect of short-time current pretreatment of skin on the permeability. Hairless mouse skin was treated with current before the patch was mounted on the skin. The effect of current density and current duration on the flux of ketoprofen was studied. The possibility of additive effect with penetration enhancer (PGML) was also investigated. Iontophoretic pretreatment of skin increased the passive flux up to 3 folds at 0.4 $mA/cm^2$ current density, when the matrix contained no PGML. As the duration of current-pretreatment and current density increased, flux increased. PGML increased the average passive flux markedly, about 6 to 12 folds, depending on the concentration in the patch. Current pretreatment further increased the flux from this PGML containing patch, exhibiting additive effect. These results indicate that short-duration current pretreatment of skin can be an useful method for the enhancement of ketoprofen permeability through skin.
Keywords
Ketoprofen; Current-pretreatment; PGML; Flux; Additive effect;
Citations & Related Records
연도 인용수 순위
  • Reference
1 M.J. Pikal, Transport mechanisms in iontophoresis. I. A theoretical model for the effect of electroosmotic flow on flux enhancement in transdermal iontophoresis, Pharm. Res., 7, 118-126 (1990)   DOI   ScienceOn
2 H.A.E. Benson, J.C. McElnay, R. Harland and J. Hadgraft, Influence of ultrasound on the percutaneous absorption of nicotinate esters, Pharm. Res., 8, 204-209 (1991)   DOI   ScienceOn
3 S.L. Chang, G.A. Hofmann, L. Zhang, L.J. Deftos and A.K. Banga, The effect of electroporation on iontophoretic transdermal delivery of calcium regulating hormones. J. Controlled Release, 66, 127-33 (2000)   DOI   ScienceOn
4 S. Le Duc, Electric ions and their use in medicine, Rebman, London, England (1908)
5 P.G. Green, R.S. Hinz, A. Kim, C. Cullander, G. Yamane, F.C. Szoka Jr. and R.H. Guy, Transdermal iontophoresis of amino acids and peptides ill vitro, J. Controlled Release, 21, 187-190 (1992)   DOI   ScienceOn
6 R.R. Bumette, J. Hadgraft and R.H. Guy, Iontophoresis: In Transdermal Drug Delivery, R.H. Guy and J. Hadgraft (Ed.), Marcel Dekker Inc., New York, U.S.A., 247-291 (1989)
7 G. Hritzo, Management of postsurgical hyperhidrosis with direct current and tap water: a case report, J. Hand Ther., 17, 42 (2004)
8 R,R. Bumette and T.M. Bagniefski, Influence of constant current iontophoresis on the impedance and passive Na+ permeability of excised mouse skin, J. Pharm. Sci., 77, 492-497 (1988)   DOI
9 S.Y. Oh and R.H. Guy, Effect of iontophoresis on the electrical properties of human skin in vivo, Int. J. Pharm., 124, 137-142 (1995)   DOI   ScienceOn
10 S.Y. Oh and R.H. Guy, Effect of enhancers on the electrical properties of skin: The effect of Azone and ethanol, J. Kor. Pharm. Sci., 24, S41-S47 (1994)
11 S.Y. Oh and R.H. Guy, The effect of oleic acid and propylene glycol on the electrical properties of skin, J. Kor. Pharm. Sci., 24, 281-287 (1994)
12 S.C. Chi and H.W. Jun, Anti-inflammatory activity of ketoprofen gel on carrageenan induced paw edema in rats, J. Pharm. Sci., 79, 974-977 (1990)   DOI
13 G.R. Hanson, Analgesic, antipyretic and anti-inflammatory drug, In Remington: The Science and practice of pharmacy, 19th Ed., A.R. Gennaro (Ed.), Mack Publishing Company, Easton, U.S.A., p. 1214 (1995)
14 J. Jacobs A.G. Golstein, M.E. Kelly and B.S. Bloom, NSAIDs dosing schedules and compliance, Drug Intell. Clin. Pharm., 22, 726-727 (1988)
15 P. Singh and H.I. Maibach, Iontophoresis in drug delivery: basic principles and applications, Crit. Rev. Ther. Drug Carrier Syst., 11, 161-213 (1994)
16 W.T. Zempsky and T.M. Parkinson, Lidocaine iontophoresis for topical anesthesia before dermatologic procedures in children: a randomized controlled trial, Pediatr. Dermatol., 20, 364 (2003)   DOI   ScienceOn
17 S.Y. Kim and S.Y. Oh, Iontophoretic Delivery of Vitamine C 2-phosphate, J. Kor. Pharm. Sci., 34,.201-207 (2004)
18 A. Sieg, R.H. Guy and M.B. Delgado-Charro, Reverse iontophoresis for noninvasive glucose monitoring, The Internal Standard Concept, 92, 2295-2302 (2003)
19 M.F. Cuthbert, Adverse reactions to non-steroidal antirheumatic drugs, Curr. Med. Res. Opin., 2, 600-609 (1974)   DOI   ScienceOn
20 K. Sugibayashi, K. Nakayama, T. Seki, K. Hosoya and Y. Morimoto, Mechanism of skin penetration-enhancing effect by laurocapram, J. Pharm. Sci., 81, 58 (1992)   DOI
21 S.D. Roy, E. Roos and K. Sharma, Transdermal delivery of buprenorphine through cadaver skin, J. Pharm. Sci., 83(2), 126-30 (1994)   DOI   ScienceOn
22 H.S. Gwak, I.K. Chun, Effect of vehicles and penetration enhancers on the in vitro percutaneous absorption of tenoxicam through hairless mouse skin, Int. J. Pharm., 236, 57-64 (2002)   DOI   ScienceOn
23 S. Chong, H.L. Fung, J. Hadgraft and R.H. Guy, Transdermal drug delivery systems: pharmacokinetics, clinical efficacy, and tolerance development : In Transdermal Drug Delivery, Developmental Issues and Research Initiatives, J. Hadgraft and R.H. Guy (Ed.), Marcel Dekker, New York, U.S.A., p 135 (1989)
24 M.C. Audet, M. Moreau, W.D. Koltun, A.S. Waldbaum, G. Shangold, A.C Fisher and G.W.Creasy, Evaluation of contraceptive efficacy and cycle control of a transdermal contraceptive patch vs. an oral contraceptive: a randomized controlled trial, JAMA, 285(18), 2347-2354 (2001)   DOI   ScienceOn
25 Electronic Orange Book, Food and Drug Administration, December 2004
26 Retail and Provider Perspective, IMS Health, 2001
27 E.F. Sherertz, K.B. Sloan and R.G. McTiernan, Transdermal delivery of 5-fluorouracil through skin of hairless mice and humans in vitro: a comparison of the effect of formulations and a prodrug, Arch. Dermatol. Res., 282(7), 463-468 (1990)   DOI   ScienceOn
28 R.R. Burnette and B. Ongpipattanakul, Characterization of the pore transport properties and tissue alteration of excised hwnan skin during iontophoresis, J. Pharm. Sci., 76, 765-773 (1987)   DOI
29 J. Jona, J. Audett and N. Singh, Transdermal patch and method for administering 17-deacetyl norgestirnate alone or in combination with an estrogen, United States Patent: 6,071,531
30 R.O. Potts, G.M. Golden, M.L. Francoeur, V.H.W. Mak and R.H. Guy, Mechanism and enhancement of solute transport across the stratum corneum, J. Controlled Release, 15, 249-260 (1991)   DOI   ScienceOn
31 M.A. Ashburn, J. Streisand, J. Zhang, G. Love, M. Rowin, S. Niu, J.K. Kievit, J.R. Kroep and M.J. Mertens, The iontophoresis of fentanyl citrate in humans, Anesthesiology, 82, 1146-53 (1995)   DOI   ScienceOn
32 P.M. Farrell and R.E. Koscik, Sweat chloride concentrations in infants homozygous or heterozygous for F508 cystic fibrosis, Pediatrics, 97, 524-528 (1996)
33 C. Cullander and R.H. Guy, Sites of iontophoretic current flow into the skin: Identification and characterization with the vibrating probe electrode, J. Invest. Dermatol., 97, 55-64 (1991)   DOI   ScienceOn
34 S.l. Yum, Permeation enhancement with ethanol : In Drug permeation enhancement, Hsieh, D.S. (Ed.), Marcel Dekker: New York, U.S.A., pp. 3-17 (1994)
35 T. Yamamoto and Y. Yamamoto, Electrical properties of the epidermal stratum corneum, Med. Biol. Eng., March, 151-158 (1976)
36 E.R. Scott, H.S. White and J.B. Phipps, Direct imaging of ionic pathways in stratum corneum using scanning electrochemical microscopy, Solid State Ionics, 53-56, 176-183 (1992)
37 S.Y. Oh, L. Leung, D. Bommannan, R.H. Guy and R.O. Potts, Effect of current, ionic strength and temperature on the electrical properties of skin, J. Controlled Release, 27, 115-125, (1993)   DOI   ScienceOn