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http://dx.doi.org/10.4333/KPS.2003.33.2.079

Penetration Enhancement of β2-Selective Agonist, Tulobuterol, Across Hairless Mouse Skin  

Kim, Byung-Do (College of Pharmacy, Chosun University)
Choi, Hoo-Kyun (College of Pharmacy, Chosun University)
Publication Information
Journal of Pharmaceutical Investigation / v.33, no.2, 2003 , pp. 79-84 More about this Journal
Abstract
The effects of various pressure sensitive adhesives (PSA) and enhancers on the percutaneous absorption of tulobuterol were investigated. The permeation rate of tulobuterol through hairless mouse skin from various adhesives was evaluated using a flow-through diffusion cell system at $37^{\circ}C$. The permeability of tulobuterol was variable depending on the physicochemical property of the PSA. The permeation rate of tulobuterol from polyethylene oxide grafted acrylic adhesive matrix was higher than that from other PSA matrices. The flux of tulobuterol was $4.37{\pm}0.34\;{\mu}g/hr/cm^2$ from polyethylene oxide grafted acrylic adhesive matrix. When the effects of various enhancers on the percutaneous absorption of tulobuterol from grafted acrylic adhesive were evaluated, Plurol $oleique^{\circledR}$ showed higher flux than all other enhancers tested.
Keywords
Tulobuterol; Enhancer; Pressure sensitive adhesive; Transdermal drug delivery;
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