Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Penetration Enhancement of β2-Selective Agonist, Tulobuterol, Across Hairless Mouse Skin

  • Published : 2003.06.20
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Abstract

The effects of various pressure sensitive adhesives (PSA) and enhancers on the percutaneous absorption of tulobuterol were investigated. The permeation rate of tulobuterol through hairless mouse skin from various adhesives was evaluated using a flow-through diffusion cell system at $37^{\circ}C$. The permeability of tulobuterol was variable depending on the physicochemical property of the PSA. The permeation rate of tulobuterol from polyethylene oxide grafted acrylic adhesive matrix was higher than that from other PSA matrices. The flux of tulobuterol was $4.37{\pm}0.34\;{\mu}g/hr/cm^2$ from polyethylene oxide grafted acrylic adhesive matrix. When the effects of various enhancers on the percutaneous absorption of tulobuterol from grafted acrylic adhesive were evaluated, Plurol $oleique^{\circledR}$ showed higher flux than all other enhancers tested.

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References

  1. C.K. Fan and P.J. Barnes, Respiratory and allergic disease,I. Br. Med. J, 296, 29-33 (1988) https://doi.org/10.1136/bmj.296.6614.29
  2. A.T.J. Miguel and L.N. Miguel, Tulobuterol in Childhood Asthma: Single Dose Ranging and Repeated Oral Dose Comparative studies, J. Int. Med. Res., 14, 228-235 (1986) https://doi.org/10.1177/030006058601400502
  3. D. Charpin, Acute and long-term effectiveness of tulobuterol inhaler, a New $\beta2$-agonist, in the treatment of asthma, Lung, Suppl. 194-201 (1990).
  4. K.R. Patel, Bronchodilating effect of inhaled tulobuterol. A new beta2 agonist in patients with asthma, Respiration, 46. Suppl 1. 116 (1984)
  5. K.R. Patel, Prolonged treatment with oral and inhaled tulobuterol does not induce airway tachyphylaxis, Lung, 168. Suppl.' 210-218 (1990) https://doi.org/10.1007/BF02718135
  6. B. Waldeck, Adrenoceptor agonists and asthma-l00 years of development, Eur. J. Pharmacol.; 445, 1-12 (2002)
  7. J.R.B.J. Brouwers, Advanced and controlled drug delivery systems in clinical disease management, Pharm. World Sci., 18, 153-162 (1996). https://doi.org/10.1007/BF00820726
  8. M. Guyot,F, Fawaz, Design and in vitro evaluation of adhesive matrix for transdermal delivery of propranolol, Int. J. Pharm., 204, 171-182 (2000)
  9. K.A. Walters, J. Hadgraft, Pharmaceutical Skin Penetration Enhancement, Marcel Dekker, New York. (1993)
  10. A. Naik, Y.N. Kalia and R.H. Guy, Transdermal drug delivery: Overcoming the skin barriers function, PSTT., 3, 318-325 (2000)
  11. H.S. Tan and W.R. Pfister, Pressure-sensitive adhesives for transdermal drug delivery systems, PSTT., 2, 60-69 (1999)
  12. T. Kokubo, K. Sugibayashi and Y. Morimoto, Interaction between drugs and pressure-sensitive adhesive in transdermal therapeutic system, Pharm. Res., 11, 104-107 (1994) https://doi.org/10.1023/A:1018906013527
  13. Y-J. Cho and H.-K. Choi, Enhancement of percutaneous absorption of ketoprofen: effect of vehicles and adhesive matrix, Int. J. Pharm., 169, 95-104 (1998).
  14. H.K. Choi and J.T. Angello, Mathmatical analysis and optimization of flowthrough diffusion cell system, Pharm. Res., 11, 595-599 (1994) https://doi.org/10.1023/A:1018991221647
  15. J.-H. Kim, Y-J. Cho and H.-K.Choi, Effect of vehicles and pressure sensitive adhesives on the permeation of tacrine across hairless mouse skin, Int. J. Pharm., 196, 105-113 (2000).
  16. H. Tan, S. Lydzinski, I. Zhang, K. Puwar and P. Foreman, Enhancer-Resistance acrylic pressure sensitive adhesive for transdermal system, Pharm. Res., 14. Suppl. S-318 (1997)
  17. H.-A. Cheong and H.-K. Choi, Enhanced percutaneous absorption of piroxicam via salt formation with ethanolamines, Pharm. Res., 19, 1375-1380 (2002) https://doi.org/10.1023/A:1020367212307
  18. E.-S. Park, S.-Y. Chang, M. Hahn and S.-C. Chi, Enhancing effect of polyoxyethylene alkyl ethers on the skin permeation of ibuprofen, Int. J Pharm., 209, 109-119 (2000)