• Journal of Nutrition and Health
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• v.30 no.6
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• pp.658-668
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• 1997

Path of a small hydrophobic molecule through the aqueous cytoplasma is not linear. Partition may favor membrane binding by several orders of magnitude : thus significant membrane association will markedly decrease the cytosolic transport rate. The presence of high concentration of soluble binding proteins for these hydrophobic molecules would compete with membrane association and thereby increase transport rate. For long chain fatty acid molecules, a family of cytosolic binding proteins collectively known as the fatty acid binding proteins(FABP), are thought to act as intracellular transport proteins. This paper examines the mechanism of transfer of fluorescent antyroyloxy-labeled fatty acids(AOFA) from purified FABPs to phosholipid membranes. With the exception of the liver FABP, AOFA is transferred from FABP by collisional interaction of the protein with a acceptor membrane. The rate of transfer increased markedly when membranes contain anionic phospholipids. This suggests that positively charged residues on the surface of the FABP may interact with the membranes. Neutralization of the surface lysine residues of adipocyte FABP decreased fatty acid transfer rate, and transfer was found to proceed via aqueous diffusion rather than collisional interaction. Site specific mutagenesis has further shown that the helix-turn-helix domain of the FABP is critical for interaction with anionic acceptor membranes. Thus cytosolic FABP may function in intracellular transport of fatty acid to decrease their membranes association as well as to target fatty acid to specific subcellular sites of utilization.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.28 no.9
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• pp.1032-1041
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• 2004

In this study we decompose the 3-dimensional velocity field of isotropic turbulent flow into the coherent and the incoherent structure using the discrete wavelet. It is shown that the coherent structure, 3% wavelet modes, has 98% energy and 88% enstrophy and its statistical characteristics are almost same as the original turbulence structure. And it is confirmed that the role of the coherent structure is that it produces the turbulent kinetic energy at the inertia range then transfers energy to the dissipation range. The incoherent structure, with residual wavelet modes, is uncorrelated and has the Gaussian probability density function but it dissipates the kinetic energy in dissipation range. On the procedure, we propose a new but easy way to get the threshold by applying the energy partition percentage concept about coherent structure. The vorticity field extracted from the wavelet-decomposed velocity field has the same structure as the result of the precedent studies which decomposed vorticity field directly using wavelet. Therefore it has been shown that velocity and vorticity field are on the interactive condition.

• International Journal of CAD/CAM
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• v.6 no.1
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• pp.59-64
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• 2006

A new method to obtain explicit re-parameterization that preserves the curve degree and parametric domain is presented in this paper. The re-parameterization brings a curve very close to the arc length parameterization under $L_2$ norm but with less segmentation. The re-parameterization functions we used are $C^1$ continuous piecewise rational linear functions, which provide more flexibility and can be easily identified by solving a quadratic equation. Based on the outstanding performance of Mobius transformation on modifying pieces with monotonic parametric speed, we first create a partition of the original curve, in which the parametric speed of each segment is of monotonic variation. The values of new parameters corresponding to the subdivision points are specified a priori as the ratio of its cumulative arc length and its total arc length. $C^1$ continuity conditions are imposed to each segment, thus, with respect to the new parameters, the objective function is linear and admits a closed-form optimization. Illustrative examples are also given to assess the performance of our new method.

• YAKHAK HOEJI
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• v.35 no.1
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• pp.45-60
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• 1991

lonophores, uniquely, create specific pathways of ion permeability in model and cell membranes. Calcium-transporting ionophores of microbiological origin, such as A23187 and ionomycin, have been used as experimental tools to elucidate the physiological role of calcium as a second messenger in many cell types. These ionophores are believed to bypass the initial ligand-receptor step in the activation of cells by increasing membrane permeability to calcium. In this report, we shall discuss several naturally occurring substances that share some properties of calcium-ionophores, primarily concentrating on oxidized fatty acids. We have previously demonstrated that oxidized linoteic and arachidonic acids, obtained either by lipoxygenase catalysis or nonenzymatic processes, significantly promote calcium translocation in a two-phase partition model and modulate calcium-transporting function in the isolated sarcoplasmic reticulum vesicles obtained from mammalian hearts. We have also confirmed that calcium-ionophoric properties are due not to their general amphiphilic nature of certain lipids, but to distinct structural characteristics. Although there are some skeptical views on the occurrence of ionophores in higher organisms, increasing evidence suggests that membrane lipids or their derivatives may serve as physiological calcium-ionophores. Abnormal accumulation of lipid peroxidation products(particularly end products), however, may be associated with the general oxidative damages as seen in many pathological conditions.

• Journal of the Korean Mathematical Society
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• v.57 no.2
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• pp.451-470
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• 2020

Let C[0, T] denote an analogue of Wiener space, the space of real-valued continuous functions on the interval [0, T]. For a partition 0 = t₀ < t₁ < ⋯ < t_n < t_n+1 = T of [0, T], define X_n : C[0, T] → ℝⁿ⁺¹ by X_n(x) = (x(t₀), x(t₁), …, x(t_n)). In this paper we derive a simple evaluation formula for Radon-Nikodym derivatives similar to the conditional expectations of functions on C[0, T] with the conditioning function X_n which has a drift and does not contain the present position of paths. As applications of the formula with X_n, we evaluate the Radon-Nikodym derivatives of the functions ∫₀^T[x(t)]^mdλ(t)(m∈ℕ) and [∫₀^Tx(t)dλ(t)]² on C[0, T], where λ is a complex-valued Borel measure on [0, T]. Finally we derive two translation theorems for the Radon-Nikodym derivatives of the functions on C[0, T].

• Journal of Pharmaceutical Investigation
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• v.30 no.1
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• pp.33-37
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• 2000

One of the methods to increase the solubility of a drug is to use complexation with a cyclodextrin. Due to the hydrophobic nature of the interior cavity of the cyclodextrin, it has been known that undissociated lipophilic drugs can be included within the cyclodextrin by hydrophobic interaction. Recently, inclusion of hydrophilic or dissociated form of a drug has been investigated. In this study, the synergism of pH and complexation with $hydroxypropy-{\beta}-cyclodextrin\;(HP\;{\beta}\;CD)$ to increase the solubility of two oxicam derivatives was investigated. In addition, the effect of partition coefficient of dissociated and undissociated form of the drug on the extent of complexation with HP ${\beta}$ CD was studied. The solubility was measured by equilibrium solubility method. The solubility of tenoxicam and piroxicam increased exponentially with an increase in solution pH above the pKa of the drug in the presence and absence of HP ${\beta}$ CD. The solubility of the drugs increased linearly as a function of HP ${\beta}CD$ concentration at fixed pH. Although the stability constant of ionized species is less than that of the unionized species, the concentration of the ionized drug complex is greater than that of the unionized drug complex due to higher concentration of ionized species at pH 7.3.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 1998.06b
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• pp.165-170
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• 1998

This paper presents a new prediction method RBP region-based prediction model where the context used for prediction contains regions instead of individual pixels. There is a meaningful property that RBP can partition a cartoon image into two distinctive types of regions, one containing full-color backgrounds and the other containing boundaries, edges and home-chromatic areas. With the development of computer techniques, synthetic images created with CG (computer graphics) becomes attactive. Like the demand on data compression, it is imperative to efficiently compress synthetic images such as cartoon animation generated with CG for storage of finite capacity and transmission of narrow bandwidth. This paper a lossy compression method to full-color regions and a lossless compression method to homo-chromatic and boundaries regions. Two criteria for partitioning are described, constant criterion and variable criterion. The latter criterion, in form of a linear function, gives the different threshold for classification in terms of contents of the image of interest. We carry out experiments by applying our method to a sequence of cartoon animation. We carry out experiments by applying our method to a sequence of cartoon animation. Compared with the available image compression standard MPEG-1, our method gives the superior results in both compression ratio and complexity.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.32 no.3
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• pp.241-248
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• 1996

The relationship between width of line target and distance at the limit of discrimination was examined by means of the behavioral method, for filefish Stephanolepis cirrhifer from 11 to 15cm body length. Target distance was distance from beginning of partition board to target plate, and was varied from 50cm to 200cm. The target plate was made of white acrylic resin with a vertical black line in the center. The width of line target was varied from 0.2mm to 8.0mm. Fish were trained to respond to a line target and the width of line target reduced until the minimum width required to elicit a response was established. Rate of success was expressed as the percentage of target choices in 90 trials. The line acuity of filefish was found to be 0.58 at a target distance of 50cm. The rate of success decreased slowly as line target width decreased from 8.0mm to 1.5mm, and decreased suddenly for target widths less than about 1.5mm. The width of the line target D(mm) at the limit of discrimination was shown to be an exponential function of the target distance L(cm) as follows : D=exp(9.947$\times$$10^-3$.L+0.146)

• Macromolecular Research
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• v.15 no.7
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• pp.623-632
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• 2007

Thermosensitive nanoparticles were prepared via the self-assembly of two different $poly({\varepsilon}-caprolactone)$-based block copolymers of poly(N-isopropylacrylamide)-b-$poly({\varepsilon}-caprolactone)$ (PNPCL) and poly(ethylene glycol)-b-$poly({\varepsilon}-caprolactone)$ (PEGCL). The self-aggregation and thermosensitive behaviors of the mixed nanoparticles were investigated using $^1H-NMR$, turbidimetry, differential scanning microcalorimetry (micro-DSC), dynamic light scattering (DLS), and fluorescence spectroscopy. The copolymer mixtures (mixed nanoparticles, M1-M5, with different PNPCL content) formed nano-sized self-aggregates in an aqueous environment via the intra- and/or intermolecular association of hydrophobic PCL chains. The microscopic investigation of the mixed nanoparticles showed that the critical aggregation concentration (cac), the partition equilibrium constants $(K_v)$ of pyrene, and the aggregation number of PCL chains per one hydrophobic microdomain varied in accordance with the compositions of the mixed nanoparticles. Furthermore, the PNPCL harboring mixed nanoparticles evidenced phase transition behavior, originated by coil to the globule transition of PNiPAAm block upon heating, thereby resulting in the turbidity change, endothermic heat exchange, and particle size reduction upon heating. The drug release tests showed that the formation of the thermosensitive hydrogel layer enhanced the sustained drug release patterns by functioning as an additional diffusion barrier.

• Journal of the Korean Chemical Society
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• v.11 no.4
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• pp.143-149
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• 1967

The Transient State Theory of Significant Liquid Structure is applied to a binary liquid solution of benzene and carbon tetrachloride, which gives slightly positive deviation from Raoults law. The partition function for the solution is derived according to the proposed theory. The various thermodynamic properties such as total and partial vapor pressures, molar volumes, entropies of mixing, and compressibilities are calculated at three different temperatures, 298.15^{\circ}K$, 313.15^{\circ}K$ and 343.1515^{\circ}K$. The calculated values agree satisfactorily with experimental data.