• Journal of Chest Surgery
• /
• 제39권2호
• /
• pp.150-153
• /
• 2006

심방 중격 결손에 대한 경피적 카테타 폐쇄술은 적절한 환자에서 치료적 대안으로 이용되며, 미용적으로 우수하고, 덜 침습적이며, 재원 기간이 짧으나, 응급 수술이 요구되는 치명적인 합병증이 발생할 수 있다. 저자들은 Amplatzer septal occluder에 의한 심방 중격 결손의 경피적 카테터 폐쇄술 시행 후 발생한 대동맥-우심방루를 경험하였다. 시술 2개월 후에 호흡곤란, 심계항진과 용혈에 의한 황달로 발견되어, 대동맥의 무관상동맥동과 우심방 사이의 누공을 일차 봉합하고, 심방 중격 결손은 팻취로 봉합하는 응급수술을 시행하였다. 이 합병증은 우심방 원반(disk)이 대동맥으로 침식(erosion)하여 발생하였다.

• Journal of Chest Surgery
• /
• 제30권12호
• /
• pp.1251-1253
• /
• 1997

개심 수술후 위장관 계통의 합병증은 드물게 발생하지만 사망률은 매우 높은 심각한 합병증 중의 하나이 며 특히 십이지장의 합병증은 그 빈도가 매우 드문 것으로 알려져 있다. 본원에서는 개심 수술후 십이지장 출혈 1례, 십이지장 궤양 천공 2례를 치험하였다. 출혈의 경우 빈맥, 현기증, 흑색변 등의 증상이 임상적 의 심의 단서가 되었으며, 천공의 경우는 복통을 동반한 복부 팽만, 빈맥, 저혈압, 핍뇨 등이 임상적 단서가 되 었고 복막펀자술로 확진을 내릴 수 있었다. 십이지장 출혈의 경우 항제산제의 복용, 수혈 등 보존적인 방법 으로 치료되었으나 십이지장 천공의 경우에는 2례 모두에서 응급 개복수술을 필요로 하였고 1례는 병발되는 합병증으로 가퇴원하였으며, 나머지 1례에서는 장기간의 중환자실 처치를 필요로 하였다. 따라서 수술전 과 거력상 위장관 계통의 증상, 장시간의 심폐바이패스 사용등 위십이지장궤양의 위험인자가 있는 환자들에서 는 개심수술후 항궤양 약물의 예방적 사용뿐만 아니라 십이지장 합병증에 대한 임상적 의심, 조기 진단과 시의 적절한 치료가 십이지장 합병증의 이환율과 사망률을 줄이는데 필요한 것으로 생각된다.

• 대한핵의학회지
• /
• 제7권1호
• /
• pp.15-29
• /
• 1973

To attain a simple and reliable method of evaluating the thyroid function the reliability of the clinical manifestation and the conventional thyroid function tests in diagnosing the hyperthyroidism was studied. The subjects included 184 patients with hyperthyroidism and 66 cases with euthyroidism, who were treated at the Thyroid Clinic, Seoul National University Hospital, from July 1971 through August 1972. The observed results were as follows: 1. In the cases of hyperthyroidism, 19% of the patients were male and 81% female; in the cases of euthyroidism, 7.6% of the patients were male and 92.4% female. The majority of the patients were in 2nd to 4th decades of their lives. 2. There were objective signs clearly manifested in hyperthyroidism which were rare or absent in the euthyroid state. These clinical signs included wide pulse pressure, tachycardia, systolic murmur, exophthalmos, tremor, and warm skin. In the hyperthyroid state 91.3% of the cases manifested two or more of the above signs, whereas in the euthyroid state no patients manifested any two of the above signs. 3. The most frequent complaints of the patients with thyroid disease were palpitation, weight loss, increased appetite, heat intolerance, perspiration, hunger feeling; nervousness, exertional dyspnea, etc. There was no clear difference in the incidence of the symptoms between hyperthyroidism and euthyroidism. 4. In the diagnosis of hyperthyroidism, the reliability of thyroid ?unction tests was as follows; $T_7$ was 92.4% reliable, $^{125}IT_3$ resin uptake rate 91.6% reliable, $^{131}I$ thyroid uptake rate in 24 hrs. 89.4% reliable, serum $T_4$ level 85.9% reliable and BMR 75.5% reliable. Therefore the careful observation of the clinical manifestation of the disease is a simple and reliable way of making a correct diagnosis of either hyperthyroidism or euthyroidism. 5. In hyperthyroidism there shows no correlationship between the results of the thyroid function test and clinical signs but a high BMR was associated with both tachycardia and systolic murmur.

• 동의생리병리학회지
• /
• 제25권4호
• /
• pp.628-634
• /
• 2011

The roots of Polygala tenuifolia Willd. is a well-known traditional medicine used as expectorant, tonic, tranquilizer in Asia including China and Korea. And also have been used to treat amnesia, neurasthenia, palpitation, insomnia, and disorientation. Glutamate-induced oxidative injury contributes to neuronal degeneration in many central nervous system (CNS) diseases, such as Parkinson's disease, Alzheimer's disease, epilepsy and ischemia. Inducible heme oxygenase (HO)-1 acts against oxidants that are thought to play a role in the pathogenesis of these diseases. NNMBS269, acid hydrolysis EtOAc fraction of the P. tenuifolia showed dominant neuroprotective effects on glutamate-induced neurotoxicity in mouse hippocampal HT22 cells while general EtOAc fraction of the P. tenuifolia (NNMBS268) not shown. NNMBS269 induced the expression of HO-1 protein that has been proposed to play an important cellular defense role against oxidant injury. In addition increased HO activity. In mouse hippocampal HT22 cells, NNMBS269 makes the nuclear accumulation of nuclear factor E2-related factor 2 (Nrf2). In conclusion, acid hydrolysis EtOAc fraction the P. enuifolia. (NNMBS269) significantly protect glutamate-induced oxidative damage by induction of HO-1 via Nrf2 translocation in mouse hippocampal HT22 cells.

• Journal of Chest Surgery
• /
• 제25권2호
• /
• pp.176-182
• /
• 1992

From April 1977 to March 1991, 44 patients have undergone excision of intracardiac myx-omas, 36 cases were located in the left atrium[81.6%], 3 cases in the right atrium[6.6%], 2 cases in the right ventricle[4.5%], 3 cases in the left ventricle[6.6%], There were 32 female and 12 male. The mean age of patients was 39.6$\pm$12.3 years[ranged 11 to 67 years]. The major preoperative symptoms included exertional dyspnea in 35[79.6%], palpitation in 23[52.3%], syncopal episodes in 9[20.4%], and signs of systemic illness; low-grade fever, weight loss, arthralgia, headache and so on. The diagnosis was made by echocardiography alone in 7[15.9%], and by combination of angiography and echocardiography in 37[84.1%]. The weight of the tumor ranged from 15 to 115gm[mean weight, 47.6$\pm$27.6gm], and the volum of the tumor was 129.1cm3[$\pm$149.0]. Follow-up time ranged from 0.6 to 9 years[mean follow-up, 65$\pm$3.22 years]. There were no early and late deaths during the follow-up period. Tumor recurred in one patient with left atrial myxoma 8 years later, who underwent successful reoperation. Postoperative complications occurred in 12 patients: episodes of sup-raventricular arrhythmia in 7, convulsion in 2, wound problem in 2, tricuspid valve regurgitation in 1, massive bleeding in 1, and intubation granuloma in one. In conclusion, surgical excision of the myxoma can be considered curative with excellent long-term result.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제8권1호
• /
• pp.96-101
• /
• 2005

덤핑 증후군은 소아의 위공장 경관식이의 합병증으로 발생할 수 있는 질환으로, 19개월된 여아에서 식후 나타나는 특징적인 임상증상과 당부하 검사상 조기 고혈당 후 나타나는 후기 저혈당으로 진단할 수 있었으며, 생옥수수 전분을 포함한 식이요법만으로도 증상의 호전과 영양상태의 호전을 보일 수 있었다.

• 동아시아식생활학회지
• /
• 제24권6호
• /
• pp.924-932
• /
• 2014

This study investigated intake of energy drinks, side effects and willingness to stop intake of 255 high school students in Gyeoungbuk region. The data were collected by the self-administered questionnaire. Frequency, t test, one-way ANOVA, Duncan's multiple range test, and ${\chi}^2$ test were conducted by SPSS Window V.21.0. About 78% of the respondents had experience of intake of energy drinks. The respondents were aware of energy drinks from 'advertisements on mass media (44.3%)', 'friends (32.2%)', and 'looking in stores (16.9%)'. The mean of the amount of energy drink intake per day was 30.62 mg. Forty-four percent of the respondents had energy drinks during an examination period, and 37% took it at home. The main reasons for intake of energy drinks were 'to fight off sleepiness', 'to recover from fatigue', and 'good taste' in order. Many respondents answered that energy drinks did not much help to increase concentration or learning ability. About 72% of the respondents experienced 'not feel sleepy' after having energy drinks. Half of the respondents experienced side effects such as palpitation, insomnia, and increase of urination. Most respondents had willingness to stop having energy drinks if it had bad effect on health.

• 대한한의학회지
• /
• 제30권1호
• /
• pp.40-50
• /
• 2009

Objectives: The clinical document forms, a format for collecting clinical data, is the most fundamental object of standardization. Doctors must have a mutual understanding of the clinical chart. Methods: Clinical document forms were developed by investigating existing conditions in hospitals and conducting demand surveys, doing literature research, and seeking expert advice for the improvement of version 1.0. In addition, an organization of a network of 19 Oriental medical doctors and nurses, 190 patients, and users of collected and assessed data was formed to come up with version 2.0. Results: The overall format was divided into different portions that the patient, nurse, and doctor must fill out, respectively. The patient's section consists of demographic data, lifestyle details, history, and symptoms. The data to be supplied by the nurse include the patient's vital signs and anthropometric parameters. As for the doctors, they are to supply data regarding the patient's palpitation, the detailed symptoms of the patient's head, ophthalmological and otorhinolaryngological symptoms (mouth), respiration, circulatory organ and chest conditions, digestive-organ conditions (thirst), neuropsychiatric conditions, reproductive system, musculoskeletal system, skin (depilation), etc. Conclusions: Common clinical chart development is the prior question to Traditional Korean Medicine standardization. A web-based clinical document format should be developed to support diagnosis and treatment, and furthermore EMR (electronic medical record system) and EHR (electronic health record) developed. Clinical information could be shared through a network of medical institutions and be useful Traditional Korean Medicine for evidence-based medicine.

• 혜화의학회지
• /
• 제26권1호
• /
• pp.1-10
• /
• 2017

Objectives: The aim of this study is (1) to investigate the historic changes and pharmacological efficacies of Woohwangchungsim-won and (2) to discuss the necessities for Woohwangchungsim-won's clinical applications. Methods: This study was performed through (1) investigating the ancient literature records related with Woohwangchungsim-won and analyzing Woohwangchungsim-won's composition, dosage and indications, (2) searching articles about Woohwangchungsim-won on 10 major Korean web and 3 major foreign web article search engines and analyzing Woohwangchungsim-won's pharmacological efficacies and indications. Results: Woohwangchungsim-wom has been used for cerebrovascular diseases such as stroke and palpitation. Also, there are some ancient literature records of Woohwangchungsim-won's clinical applications in neuropsychiatric disorders such as depression and bipolar disorder. In addition, there have been a number of experimental studies which demonstrate Woohwangchungsim-won's neuroprotective effect on cerebral cortex and hippocampus injury. So, it is possible to infer that Woohwangchungsim-won can be used for the treatments of neuropsychiatric disorders associated with neuronal cell death in cerebral cortex and hippocampus. But there have been no or less experimental studies which demonstrate the pharmacological efficacy of Woohwangchungsim-won on such disease. Conclusion: It is necessary that further experimental studies which demonstrate Woohwangchungsim-won's pharmacological efficacy on neuropsychiatric disorders should be done and Woohwangchungsim-won's clinical applications should be expanded on the basis of those related experimental results.

• 대한본초학회지
• /
• 제20권3호
• /
• pp.43-49
• /
• 2005

Objectives : The present study was carried out to determine if Glycyrrhizae Radix extract exerts beneficial effect against the ischemia-induced acute renal failure in rabbits. Glycyrrhizae Radix was known to reinforce the function of the spleen and replenish Qi, remove heat and counteract toxicity, dispel phlegm and relieve cough, alleviate spasmodic pain, and to moderate drug actions. It's indications are weakness of the spleen and the stomach marked by lassitude and weakness; cardiac palpitation and shortness of breath; cough with much phlegm: spasmodic pain in the epigastrium, abdomen and limbs: carbuncles and sores. It is often used for reducing the toxic or drastic actions of other drugs. Methods : Antioxidative effect of 3% concentration of Glycyrrhizae Radix extract was measured. Rabbits were treated with Glycyrrhizae Radix extract via i.v., followed by renal ischemia/reperfusion, and the changes of urine volume, serum creatinine levels, glomerular filtration rate(GFR), fractional Na+ excretion$(FE\;Na^+)\;and\;K^+\;excretion(FE\;K^+)$ in ischemia/reperfusion induced acute renal failure were measured. Results : Renal ischemia/reperfusion caused increase of serum creatinine level, which was accompanied by a reduction in glomerular filtration rate(GFR). The fractional excretion of $Na^+\;and\;K^+$ increased in ischemia-induced animals, which was partially prevented by Glycyrrhizae Radix extract treatment. Conclusions : These results indicate that lipid peroxidation plays a critical role in ischemia-induced acute renal failure. Glycyrrhizae Radix extract exerts the protective effect against acute renal failure induced by renal ischemia/reperfusion, and its effect may be attributed to an antioxidant action.