• Applied Biological Chemistry
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• 제46권4호
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• pp.344-347
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• 2003

본 연구에서는 PCR을 이용하여 국내시장에 유통중인 원료콩과 가공식품에 epsps 또는 pat 유전자가 삽입된 유전자재조합 콩(GMS)의 사용여부를 모니터링하였다. 이러한 GMS의 검출을 위해 3쌍의 primer set을 제작하였고, 각각의 primer들은 GMS에 삽입된 유전자와 특이적으로 반응하여 PCR산물을 생성하였다. 2001년 표시제가 시행되기 이전에 생산된 콩 가공식품과 이후의 제품에 대해 각각 모니터링을 수행하였으며, 표시제 이전에 생산된 제품의 경우 대부분의 미국산 원료에서 epsps가삽입된 CMS가 검출되었으나, 표시제 이후에는 검출되지 않았다.

• 한국실내디자인학회논문집
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• 제25권5호
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• pp.121-129
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• 2016

With the ingenious properties of unconstrained formativeness and frank expression of materiality the exposed concrete became popular with numerous architectures. The application of the exposed concrete has expanded to indoor environments such as commercial and residential spaces beyond the building exteriors with the uncompromising nature of its materiality. The purpose of this study is to conduct sensibility evaluation of the exposed concrete finish in interior spaces. The sensibility evaluation is conducted through a survey on a set of space models of the exposed concrete finish. The three rendered space models were evaluated by emotional vocabulary of 18 pairs of words. The result were as follows: First, the emotions derived from the exposed concrete finish are 'modern', 'cold', 'simple', 'restrained', 'rough', 'dark', 'new', 'chic', 'familiar' and 'eco-friendly'. Second, three sets of space models with alternative materials on walls and floors in exposed concrete interior space showed clear difference in sensibility. A space with the exposed concrete finish on the floor, the walls and the ceiling showed the results of 'cold', 'dark', 'rational' and 'masculine'. In the exposed concrete finish environment with wood flooring 'comfortable', 'warm', 'bright' senses and with white paint finish on the wall 'bright', 'practical', 'ordinary' and 'restrained' senses were obtained. Third, all three images achieved senses of 'chic', 'modern', 'new', 'pleasant', 'environment friendly' and 'satisfactory'. The modernity and stylish expressions of the exposed concrete finish were kept with the application of different material finishes as well as complementing its cold and rough expressions with warmth and brightness.

• 대한의용생체공학회:의공학회지
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• 제28권5호
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• pp.601-608
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• 2007

2 Dimensional Gel Electrophoresis(2DGE) is an essentialmethodology for analysis on the expression of various proteins. For example, information for the location, mass, expression, size and shape of the proteins obtained by 2DGE can be used for diagnosis, prognosis and biological progress by comparison of patients with the normal persons. Protein spot matching for this purpose is comparative analysis of protein expression pattern for the 2DGE images generated under different conditions. However, visual analysis of protein spots which are more than several hundreds included in a 2DGE image requires long time and heavy effort. Furthermore, geometrical distortion makes the spot matching for the same protein harder. In this paper, an iterative algorithm is introduced for more efficient spot matching. Proposed method is first performing global matching step, which reduces the geometrical difference between the landmarks and the spot to be matched. Thus, movement for a spot is defined by a weighted sum of the movement of the landmark spots. Weight for the summation is defined by the inverse of the distance from the spots to the landmarks. This movement is iteratively performed until the total sum of the difference between the corresponding landmarks is larger than a pre-selected value. Due to local distortion generally occurred in 2DGE images, there are many regions in whichmany spot pairs are miss-matched. In the second stage, the same spot matching algorithm is applied to such local regions with the additional landmarks for those regions. In other words, the same method is applied with the expanded landmark set to which additional landmarks are added. Our proposed algorithm for spot matching empirically proved reliable analysis of protein separation image by producing higher accuracy.

• 대한수학회지
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• 제48권1호
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• pp.105-115
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• 2011

Let f be a function which assigns a positive integer f(v) to each vertex v $\in$ V (G), let r, s and t be non-negative integers. An f-coloring of G is an edge-coloring of G such that each vertex v $\in$ V (G) has at most f(v) incident edges colored with the same color. The minimum number of colors needed to f-color G is called the f-chromatic index of G and denoted by ${\chi}'_f$(G). An [r, s, t; f]-coloring of a graph G is a mapping c from V(G) $\bigcup$ E(G) to the color set C = {0, 1, $\ldots$; k - 1} such that |c($v_i$) - c($v_j$ )| $\geq$ r for every two adjacent vertices $v_i$ and $v_j$, |c($e_i$ - c($e_j$)| $\geq$ s and ${\alpha}(v_i)$ $\leq$ f($v_i$) for all $v_i$ $\in$ V (G), ${\alpha}$ $\in$ C where ${\alpha}(v_i)$ denotes the number of ${\alpha}$-edges incident with the vertex $v_i$ and $e_i$, $e_j$ are edges which are incident with $v_i$ but colored with different colors, |c($e_i$)-c($v_j$)| $\geq$ t for all pairs of incident vertices and edges. The minimum k such that G has an [r, s, t; f]-coloring with k colors is defined as the [r, s, t; f]-chromatic number and denoted by ${\chi}_{r,s,t;f}$ (G). In this paper, we present some general bounds for [r, s, t; f]-coloring firstly. After that, we obtain some important properties under the restriction min{r, s, t} = 0 or min{r, s, t} = 1. Finally, we present some problems for further research.

• 정보처리학회논문지B
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• 제16B권5호
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• pp.359-366
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• 2009

구조적 생물 정보학 분야는 단백질의 3차원 구조를 대상으로 단백질을 연구하는 분야이며, 본 논문에서는 구조적 생물 정보학 분야의 핵심 연구 주제중의 하나인 Flexible 단백질 구조 정렬에 관한 새로운 알고리즘을 제시한다. Flexible 단백질 구조 정렬을 위하여, 단백질의 3차원 구조의 지역적인 유사성을 이용하여 두 단백질의 유사한 부분 구조를 추출해 내고, 이 추출된 유사 구조간에 연결 가능성을 검색하여 정렬이 가능한 모든 유사 구조를 찾고, 이 유사 구조에 꺽임점을 도입하여 Flexible 단백질 구조 정렬을 수행하였다. 이 과정에서 단백질의 지역적 유사성을 정확히 비교하기 위하여 RDA를 이용한 방법을 제안하였고, Flexible 단백질 구조 정렬시 신뢰성 있는 꺽임점 위치 선정 방법과 그래프를 이용한 최적화 방법을 제안하였다. 성능 평가를 위하여 다양한 방법으로 Flexible 단백질 구조 정렬의 성능 평가를 수행하였고, 기존의 방법인 DALI, CE, FATCAT 보다 성능의 우수함을 나타내었다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6419-6425
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• 2013

Background: Neoadjuvant chemotherapy (NACT) is a treatment modality whereby chemotherapy is used as the initial treatment of HNSCC in patients presenting with advanced cancer that cannot be treated by other means. It leads to shrinkage of tumours to an operable size without significant compromise to essential oro-facial organs of the patients. The molecular mechanisms behind shrinkage due to NACT is not well elucidated. Materials and Methods: Eleven pairs of primary HNSCCs and adjacent normal epithelium, before and after chemotherapy were screened for cell proliferation and apoptosis. This was followed by immunohistochemical analysis of some cell cycle (LIMD1, RBSP3, CDC25A, CCND1, cMYC, RB, pRB), DNA repair (MLH1, p53) and apoptosis (BAX, BCL2) associated proteins in the same set of samples. Results: Significant decrease in proliferation index and increase in apoptotic index was observed in post-therapy tumors compared to pre-therapy. Increase in the RB/pRB ratio, along with higher expression of RBSP3 and LIMD1 and lower expression of cMYC were observed in post-therapy tumours, while CCND1 and CDC25A remained unchanged. While MLH1 remained unchanged, p53 showed higher expression in post-therapy tumors, indicating inhibition of cell proliferation and induction of apoptosis. Increase in the BAX/BCL2 ratio was observed in post-therapy tumours, indicating up-regulation of apoptosis in response to therapy. Conclusions: Thus, modulation of the G1/S cell cycle regulatory proteins and apoptosis associated proteins might play an important role in tumour shrinkage due to NACT.

• Spatial Information Research
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• 제18권1호
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• pp.77-87
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• 2010

시공간 조인은 이동객체와 같이 시공간의 특성을 가지는 데이터를 처리할 때 요구되는 중요한 연산자로, 이동객체들의 움직임을 분석하거나 이동객체들의 시공간적 패턴을 찾는 것과 같이 다양하게 활용된다. 현재까지 실외공간에서의 시공간 조인 질의에 관한 연구는 많이 진행되어왔다. 최근에는 실내측위기술이 발전함에 따라 실외뿐만 아니라 실내에서도 다양한 위치기반 서비스가 점진적으로 제공되고 있으며, 특히 이동객체를 중심으로 다양한 응용 서비스들을 필요로 하게 된다. 하지만 실내공간에서의 시공간 조인에 관한 연구는 아직 전무하다. 본 논문에서는 실내공간에서 실시간으로 갱신되는 이동객체에 대한 연속 시공간 셀프조인 질의와 질의처리 방법론을 제안하였다. 연속 시공간 셀프조인 질의는 주어지는 특정 시간과 공간의 조건을 만족하는 모든 쌍들을 시간이 지남에 따라 지속적으로 갱신하는 질의이다. 본 논문에서는 방이나 복도와 같이 특정한 기호를 중심으로 이동객체의 위치를 표현하며 이러한 특징을 가지는 공간을 기호공간이라 한다. 그리고 방대한 스트림데이터를 효과적으로 필터링하고 관리하기 위한 후보쌍 버퍼 테이블이라는 자료구조와 이를 활용한 질의처리 방법론을 제안하였으며 실험을 통해 타당성을 검증하였다.

• 한국자원식물학회지
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• 제24권3호
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• pp.272-279
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• 2011

It is very crucial to evaluate the genetic diversity of peanut genetic resources for identification of peanut germplasm accessions and variety improvement. Cultivated peanut generally has two subspecies, hypogaea and fastigiata. In this study, we identified peanut into three plant types, virginia (var. hypogaea), spanish (var. vulgaris), and valencia (var. fastigiata). Former one belongs to ssp. hypogaea and latter two are involved in ssp. fastigiata. Twenty SSR markers were used to assess the genetic variation of three sets, hypogaea, vulgaris, and fastigiata, respectively. Out of variety-specific SSR primers tried in this study, ten pairs of SSR primers showed polymorphisms. Each accession could be identified by a specific set of polymorphic SSR primers, and allele number was evaluated among accessions, with an average of 6.7 in var. hypogaea and 5.4 in var. vulgaris and fastigiata. For evaluation of genetic diversity, gene diversity ranged from 0.336 to 0.844 and PIC (polymorphism information contents) ranged from 0.324 to 0.827 were investigated. Dendrograms based on genetic distances were constructed, which showed the existence of three different clusters. And these three different clusters might be associated with the genes involved in three plant types. The results also suggested that there were plentiful SSR polymorphisms among peanut germplasm accessions in RDA (Rural Development Administration, Korea) Genebank and SSRs might play an important role in evaluating peanut accessions and cultivar improvement.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권3호
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• pp.950-975
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• 2016

Device-to-Device (D2D) communication underlaying cellular networks is a promising add-on component for future radio communication systems. It provides more access opportunities for local device pairs and enhances system throughput (ST), especially when mobile relays (MR) are further enabled to facilitate D2D links when the channel condition of their desired links is unfavorable. However, mutual interference is inevitable due to spectral reuse, and moreover, selecting a suitable transmission mode to benefit the correlated resource allocation (RA) is another difficult problem. We aim to optimize ST of the hybrid system via joint consideration of mode selection (MS) and RA, which includes admission control (AC), power control (PC), channel assignment (CA) and relay selection (RS). However, the original problem is generally NP-hard; therefore, we decompose it into two parts where a hierarchical structure exists: (i) PC is mode-dependent, but its optimality can be perfectly addressed for any given mode with additional AC design to achieve individual quality-of-service requirements. (ii) Based on that optimality, the joint design of MS, CA and RS can be viewed from the graph perspective and transferred into the maximum weighted independent set problem, which is then approximated by our greedy algorithm in polynomial-time. Thanks to the numerical results, we elucidate the efficacy of our mechanism and observe a resulting gain in MR-aided D2D communication.

• 대한원격탐사학회지
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• 제36권5_2호
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• pp.949-959
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• 2020

본 논문에서는 CAS500-1/2를 이용한 산출물 생성에 관련한 선행연구로 KOMPSAT-3A 스트립영상을 사용한 비접근 지역의 도엽별 DSM을 생성하는 방법을 제안한다. 제안 기법은 1:5000 도엽정보의 입력을 통한 영역 설정을 통해 도엽별로 산출물이 나올 수 있도록 설계됐으며, 강인한 스테레오 영상정합 기법인 MDR을 적용하여 스테레오 페어에서도 최적의 DSM이 나오도록 설정했다. 스트립 영상이 분할된 여러 장의 단위 영상으로 들어오는 것을 고려하여 하나의 도엽에 여러 쌍의 영상 페어를 처리하여 통합하는 방식으로 DSM의 생성을 시도했으며, 처리결과 도엽 간의 접합부분에서 이격 발생을 최소화한 DSM의 생성이 가능함을 확인할 수 있었다. 최종적으로 GCP와의 비교를 통한 정확도 검증결과 5 m 이내의 정확도가 나타나는 것을 확인할 수 있었다.