• 융합정보논문지
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• 제8권5호
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• pp.229-236
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• 2018

과거 기술사업화는 학계 및 연구계 중심으로 기술이전 또는 창업지원 등 좁은 의미로 해석되어 시행되었으며, 기술 사업화 단계에서 사업의 경험부족, 기술개발 실패, 판로 미확보 등이 실패원인으로 지적되어 왔다. 본 논문에서는 학계 연구소 보유기술의 직접사업화 지원 사업이 공공 자금 및 대기업 영업력을 기반으로, 사업화 기술과 자본, 판로, 정부정책 및 지원 등이 결합한 신개념의 기술사업화 모델을 제시하고, 보유기술을 직접사업화하기 위한 애로요인을 도출하였으며, 조사 및 분석을 통해 기술사업화 수행 주체의 요구요인과 보유역량과의 사이에 차이가 있고, 요구요인과 애로요인간에 상관관계가 있다는 유의미한 결론에 도달하였다. 이 결론을 기반으로, 대학 및 연구기관 보유기술에 대한 사업화의 효율성을 높이기 위한 일환으로 지원정책 개선 방안을 도출하였다.

• Journal of Korean Biological Nursing Science
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• 제5권1호
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• pp.35-44
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• 2003

Objectives : Though Tsutsugamushi disease has been reported with increasing frequencies in rural communities in Korea, it is not easy to find the nursing investigations. Methods : We have conducted a survey on 30 cases who had the fever as a chief complaint, then clinically ruled out the Tsutsugamushi disease in autumn of $2000{\sim}2001$. Data were collected retrospectively by investigation of the general characteristics, clinical and laboratory findings, their nursing care. Findings: Of 30 cases, 46.7% were farmers, and 60.0% had chances of exposure to fields or mountains. The characteristic symptoms and signs were febrile sense and chill(100.0%), headache(80.0%), and eschar(66.7%). Abnormal laboratory findings were anemia (23.3%), elevated AST(60.6%), ALT(63.3%), and abnormal urinalysis findings(50.0%). 53.3% were serologically confirmed as Tsutsugamushi disease. Therapeutic nursing cares were composed with warm up by blancket(50.0%), Ice bag(50.0%) and doxycycline antibiotic therapy(100.0%). Other nursing care for them included fluid therapy(100.0%) and nutritional support with regular(56.7%) or soft diet(43.3%). Conclusion: The above results indicate nurses who take care of acute febrile clients should make her responsible for the fever and pain management as well as give education for infection control for the community inhabitants.

• 한국치위생학회지
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• 제12권3호
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• pp.553-562
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• 2012

Objectives : The purpose of this study was to examine actual conditions of smoking and alcohol drinking behaviors among high school students, so that it could recognize possible harmful effects of smoking on oral health and could give positive motivations for students to quit smoking and drinking. Methods : This research was based on self-filling survey which 1,385 high school students in metropolitan area in Korea from September 5 to October 28, 2011. Surveyed data were analyzed by descriptive statistics, ${\chi}^2$-test and logistic analysis using SPSS WIN 12.0 program and its signification level was 0.05. Results : 1. As for smoking rate and drinking rate, boy students accounted for 11.6% and 25.4%, thereby having been higher than girl students(p<.001). It was the highest in over 180 cm(16.0%, 35.0%, p<.001) for height, in 60-under 70 kg for weight(13.4%, 23.5%, p<.001), and in a case of profession for mother's job(13.8%, 28.4%, p<.005). 2. The perceived oral symptoms had relationship with the less than 10 cigarettes of smoke (OR=2.41; 95% CI:1.31-4.41), more than 11 cigarettes of smoke (OR=3.16; 95% CI:1.42-7.00) and more than 1 bottle of alcohol (OR=1.75; 95% CI:1.00-3.06). Conclusions : This result implies that adolescents' smoking and drinking have correlation with oral health status, which makes uncomfortable sense felt given chewing along with the pain in teeth and gum. Based on the above findings, a school or community needs to reinforce education for preventing smoking and drinking and to offer environment available for practicing anti-smoking and anti-drinking plan, in order to reduce adolescents' smoking and drinking.

• Biomolecules & Therapeutics
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• 제20권6호
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• pp.550-555
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• 2012

TRPA1 and TRPV1 are members of the TRP superfamily of structurally related, nonselective cation channels. TRPA1 and TRPV1 are often co-expressed in sensory neurons and play an important role in somatosense such as cold, pain, and irritants. The first leaves of Kalopanax pictus Nakai (Araliaceae) have long been used as a culinary ingredient in Korea because of their unique chemesthetic flavor. In this study, we observed the intracellular $Ca^{2+}$ response to cultured cells expressing human TRPA1 (hTRPA1) and human TRPV1 (hTRPV1) by $Ca^{2+}$ imaging analysis to investigate the ability of the first leaves of K. pictus to activate the hTRPA1 and hTRPV1. An 80% ethanol extract of K. pictus (KPEx) increased intracellular $Ca^{2+}$ influx in a response time- and concentration-dependent manner via either hTRPA1 or hTRPV1. KPEx-induced response to hTRPA1 was markedly attenuated by ruthenium red, a general blocker of TRP channels, and HC-030031, a specific antagonist of TRPA1. In addition, the intracellular $Ca^{2+}$ influx attained with KPEx to hTRPV1 was mostly blocked by ruthenium red, and capsazepine, a specific antagonist of TRPV1. These results indicate that KPEx selectively activates both hTRPA1 and hTRPV1, which may provide evidence that the first leaves of K. pictus primarily activate TRPA1 and TRPV1 to induce their unique chemesthetic sense.

• Journal of Nutrition and Health
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• 제43권1호
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• pp.34-45
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• 2010

The purpose of this study was to evaluate the effects of routine haecho bibimbab (boiled rice with assorted seaweed mixtures) consumption on the bowel habits in humans. Forty free-living adults (female 38, male 2) participated in this study (mean age $41.2\;{\pm}\;7.5$). After a baseline survey on general characteristics, life style and dietary habits, the participants were asked to consume haecho bibimbab during two-week period for lunch. Habitual bowel movements were checked out every day by a questionnaire and nutrient intake was estimated by a 24-hour recalls before and after the study. After 2 weeks of clinical trial, the bowel habits had improved. Haecho bibimbab increased the number of bowel movements, changed hard stools into softer ones. It also lessen the sense of incomplete evacuation, and abdominal pain during defecation, increased water intake (p < 0.001) and improved gastrointestinal problem. The participants believed that haecho bibimbab was effective in improving their constipation symptoms and bowel habits (p < 0.01). Routine haecho bibimbab consumption tended to increase especially vitamin A, E and folate intake (p < 0.01). The present findings suggest that routine seaweed-based lunch meal (haecho bibimbab) consumption may improve bowel habits without side effects.

• 재활간호학회지
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• 제4권1호
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• pp.7-19
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• 2001

The Objectives of this research is to determine the effect of aerobic exercise program on health status and physical fitness in patients after the stem cell transplantation. This research design is one-group pretest-post test design. Sixteen subjects were selected from one university hospital in Seoul for the study, they was carried out aerobic exercise three to five times a week for 12 weeks. The period of data collection was from February to July, 2000. The collected data was analysed by descriptive analysis, paired t-test, content analysis SAS program was used for the statistical analysis. The results are as follows : 1. There was a significant improvement in the Physical functioning, Vitality and Reported change (t=2.39, p=0.03; t=2.35, p=0.03; t=2.58, p=0.02) but no change was observed in the Role physical, General health perception, Bodily pain, Social functioning, Role emotional and Mental health. 2. There was a significant improvement in the physical fitness (higher VO2 max, t=2.43, p=0.02; lower systolic pressure, t=-4.09, p=0.001; lower diastolic pressure, t=-3.43, p=0.002; lower pulse rate, t=-3.43, p=0.004; higher muscle sustaining power, t=2.79, p=0.015; higher muscle power, t=5.18 p=0.000; higher power of beginning, t=5.55, p=0.001; higher the sense of equilibrium, t=3.57, p=0.003; higher Hemoglobin, t=5.92, p=0.000; higher Hematocrit, t=5.38, p=0.000). Therefore, this study will provide a theoretical back ground for patients after stem cell transplantation to understand the importance of physical exercise and maintain physical exercise; and for other researches to refer to the results for exercise protocol of rehabilitation program.

• 동서간호학연구지
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• 제8권1호
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• pp.89-102
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• 2003

This study attempted to analyze the trend of studies related to IHD(Ischemic Heart Disease). This article reviewed 102 researches on IHD conducted from 1980 to 2003, by examining them according to their characteristics, such as sources by publication period, research design, nursing intervention, outcome of experimental research, and theme of qualitative research. The results were as follows : 1. The number of studies related to IHD has steadily increased year by year since 1985, and that of the articles was the highest during the post-2000 period. Especially, the majority of researches has published since 1995. 2. The 69 studies were degree of all 102 studies related to IHD, and the majority of articles' authors belonged to graduate school. Thirty three studies were non-degree articles. As for study design, the number of quantitative studies were 99 and that of qualitative studies were 3. Non-experimental research design were largely survey and correlational study. 3. Non-experimental study makes up a high proportion of the quantitative study. The most of experimental studies were accomplished after 2000. The main subjects were patients, chart records and general subjects. The majority number of subjects was like this : while the number of non-experimental study was between 51 and 100, that of experimental study was below 50. The number of subject of qualitative study is like this : the number of phenomenology study was 21 and 11, and that of case study is 14. 4. Nursing interventions used in the experimental study comprised teaching program, cardiac rehabilitation program, massage, relaxation, music therapy and providing of sense information. And the most nursing intervention effects included physiological effect, increased self-efficacy, relieved pain and increased quality of life. Most studies proved to have the affirmative effects. 5. The number of qualitative studies related to IHD is like this : the number of degree articles was 2 and that of non-degree articles was 1. Its themes included resources of hope, the experience of coronary artery angiography and the experience of admission at ICU(Intensive Care Unit).

• 동서간호학연구지
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• 제14권1호
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• pp.68-77
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• 2008

Purpose: This Study aims to explore the Wormwood smoke(Ssukjahun) experiences of women and to provide the data to develop Korean traditional nursing intervention for women. Methods: A sample of 15 women aged between 20 to 60 years with Ssukjahun experiences was interviewed and content analysis was used to analyze the data. Results: Six categories and Thirty attributes were derived for Ssukjahun experiences in women. The reason of Ssukjahun is related to illness included vaginitis, insomnia, mental depression, circulation down of hand and feet, repeat abortion, dysmenorrhea, hemorrhoids, disc, rheumatism, and asthma. The place of Ssukjahun was home, oriental hospital and Ssukjahun room. Also method of Ssukjahun included steam methods and burn the wormwood. The time-consuming of Ssukjahun was about 30 minutes. The response and effect in Ssukjahunincluded relax, decreasing rhinitis, weight reduction, feel better, increasing circulation, sleep well, reducing constipation, insomnia, hemorrhoid, back pain, asthma, and dysmenorrhea. The negative effect of Ssukjahun included vesicle, headache, itching sense, generalache, acne, and edema. However, women who did Ssukjahun believed that is the belligerent reaction because it is gone after several times. The preference of Ssukjahun than hospital treatment is related to side effect of medication, temporary method for reducing symptom. Recommends: It is recommended for nurses to understand experience of Ssukjahun in women. If Ssukjahun is to be own nursing intervention, it has to find solutions to encourage positive experiences and overcome negative experiences. Also it recommended research for experience of men.

• 한국간호교육학회지
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• 제10권1호
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• pp.149-160
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• 2004

The primary purpose of this study was to describe psychological aspects of menopausal women who have experiences on alternative therapies, such as pomegranate tree fluid, life pack, evening primerose, zacro syrup, zacro pill, multi-vitamin, oriental medicine instead of estrogen. In order to have insights on the participants behaviors, this qualitative research was conducted. The participants in this study were six women who have been taking at least one of the alternative therapies to relieve the menopausal symptom. Data had been collected from November 2002 to May 2003. The interview questions were about motivations to seek the alternative therapy, menopausal symptoms, feelings or positive effects after the treatment. The interviews were recorded and transcribed into written documents. The method described by Giorgi was utilized for data analysis. The study results were as follows : 1. The participants sought the alternative therapy based on their own information or by friends' recommendations. The motivations of taking the therapy were to live younger and healthier by reliving menopausal symptoms including somatic symptoms, such as irregular menstruation, flushing sense, cold sweating, insomnia, dull headache, vagina dryness, cystitis after sexual intercourse, joint pain, nervousness, depression, skin dryness, and suppression of activity. 2. The participants expressed that they became more active and felt better with disappearing menopausal symptoms after about 2 to 3 weeks treatment. 3. The participants did not want to accept the fact that they had menopause, which caused avoidance of having medical diagnosis and medical treatment. They also did not want to let their spouses know about their symptoms. 4. The major reason of taking the alternative therapy was to avoid the side effects of estrogen therapy in spite of high costs of the alternative way. 5. The participants suggested that menopausal women needed to be educated about physical and psychological symptoms of menopause. They also needed to be informed about how to manage it. In conclusion, accurate information about foods and drugs utilized for the alternative therapy was needed. Medically proved methods to recognize positive effects and side effects were also necessary. These goals could be achieved by continuous medical observations and further research.

• 대한약침학회지
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• 제14권1호
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• pp.5-24
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• 2011

Objective: This study was performed to analyse four weeks repeated -dose toxicity of Sweet Bee Venom (SBV-pure melittin, the major component of honey bee venom) in rats. Methods: All experiments were conducted under the regulations of Good Laboratory Practice (GLP) at Biotoxtech Company, a non-clinical study authorized institution. Male and female rats of 5 weeks old were chosen for the pilot study of four weeks repeated-dose toxicity and was injected at the level of 0.56 mg/kg body weight (eighty times higher than the clinical application dosage as the high dosage), followed by 0.28 and 0.14 mg/kg as midium and low dosage, respectively. Equal amount of normal saline was injected as the control group every day for four weeks. Results: 1. No mortality was witnessed in all of the experiment groups. 2. All experiment groups appealed pain sense in the treating time compared to the control group, and side effects such as hyperemia and movement disorder were observed around the area of injection in all experiment groups, and the higher dosage in treatment, the higher occurrence in side effects. 3. Concerning weight measurement, neither male nor female groups showed significant changes compared to the control group. 4. Concerning to the CBC and biochemistry, all experiment groups didn't show any significant changes compared to the control group. 5. Concerning weight measurement of organs, experiment groups didn't show any significant changes compared to the control group. 6. To verify abnormalities of organs and tissues, those such as cerebellum, cerebrum, liver, lung, kidney, and spinal cords were removed and we conducted histologocal observation with H-E staining. Concerning the histologocal observation of liver tissues, some fatty changes were observed around portal vein in 0.56 mg/kg experiment group. But another organs were not detected in any abnormalities. 7. The proper high dosage of SBV for the thirteen weeks repeated test in rats may be 0.28 mg/kg in one time. Conclusion: Above findings suggest that SBV is relatively safe treatment medium. Further studies on the subject should be conducted to yield more concrete evidences.