• Asian Pacific Journal of Cancer Prevention
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• 제15권21호
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• pp.9137-9142
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• 2014

Background: To explore the expression of DcR3 protein and its clinicopathological significance in bladder urothelial carcinomas (BUC). Materials and Methods: Immunohistochemistry was performed to detect the expression of DcR3, caspase-3, Bcl-2, VEGF, Ki-67, PCNA and P53 in 166 BUC and 56 normal bladder tissues. Western blotting was used to detect the expression of DcR3 in the supernatants of cultured BUC cells. Results: Overexpression of DcR3 was found in BUC tissues and cell lines, with significant elevation as compared to normal bladder tissues (p<0.0001). Higher DcR3 expression was related to the status of invasion, lymph node metastasis and recurrence. Furthermore, DcR3 expression was negatively correlated with caspase-3 and positively associated with Bcl-2, VEGF, Ki-67 labeling index (LI), PCNA LI and P53 (all p<0.0001), respectively. Conclusions: DcR3 may play a crucial role as an oncogene in tumorigenesis, deterioration and progress of BUC via influencing related pathways of apoptosis, proliferation and angiogenesis. The detection of DcR3 protein in the formalinfixed and paraffin-embedded samples could assist to predict in prognosis of BUC patients.

• 한국직업건강간호학회지
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• 제27권1호
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• pp.67-75
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• 2018

Purpose: The purpose of this study was to identify the influence of nurses' emotional intelligence and communication within the organization on teamwork in Armed Forces hospitals. Methods: This study employed a cross-sectional design with a convenience sample of 195 nurses from five Armed Forces hospitals in Korea. Data were collected through a self-administered questionnaire from August 7 to 23, 2017 and analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient, and multiple regression. The SPSS/WIN 21.0 program was used for all analyses. Results: The degree of teamwork was $5.03{\pm}0.73$, with scores ranging from 1 to 7. Emotional intelligence and communication within the organization were positively correlated with teamwork. Specifically, communication within the organization (${\beta}=.60$, p<.001), the intensive care unit (${\beta}=.21$, p=.001), and the medical general ward (${\beta}=.17$, p=.010) were identified as factors influencing teamwork. This model explained 51% of the variance in teamwork, and it was statistically significant (F=35.09, p<.001). Conclusion: These results imply the need to develop an approach including communication within the organization to improve teamwork among nurses in Armed Forces hospitals.

• 한국세라믹학회지
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• 제41권4호
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• pp.289-296
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• 2004

양론조성에 근접하는 (Ca/P=1.62-1.67, molar ratio) 휘스커 및 짧은 막대형상의 수산화아파타이트 (Ca$_{10}$(PO$_4$)$_{6}$(OH)$_2$를 $\alpha$-Ca$_3$(PO$_4$)$_2$($\alpha$-TCP) 수용액 (pH 11)의 가수분해와 수열반응으로 각각 합성하였다. 생성된 HAp의 입자형상은 합성방법에, 미세구조의 발달은 반응조건에 주로 의존하였다 가수분해의 경우 반응시간의 경과와 더불어 휘스커 입자들의 상호 교차와 장축방향에서의 응집이 일어났다 반면에, 수열처리에 있어서는 반응과정 중 임계크기(길이 0.75$mu extrm{m}$, 지름 0.3$\mu\textrm{m}$) 이상으로의 입성장은 일어나지 않았으며 과다한 반응시간(20$0^{\circ}C$, $\geq$3시간)은 입자들의 심한 응집을 유발하였다.

• 디지털융복합연구
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• 제16권2호
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• pp.261-267
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• 2018

본 연구는 치과종사자들의 코칭리더십이 직무 만족도, 동기부여적 자아개념, 삶의 질에 미치는 영향을 조사하기 위해 대구,경북지역 205명의 치과위생사(간호조무사)를 조사하였다. 코칭리더십의 전체 평균은 5점 척도에서 2.67, 개발코칭 2.61, 관계코칭 2.61로 나타났다. '나의 상사는 나의 발전을 위한 연수교육 기회를 적극적으로 제공해 준다'가 2.50으로 가장 낮았다. 일반적 특징에 따른 코칭리더십은 20-25세, 경력 1-5년, 미혼, 수입 2000만원 이하, 직속상관은 여성, 직속상관 나이 20-30세, 직속상사 직위는 팀장, 선임치과위생사가 높았다(p<.05). 코칭리더십에 대한 직무만족도, 동기부여적 자아개념, 삶의 질이 양의 상관관계를 나타냈다(p<.05). 따라서 올바른 코칭리더십은 직무만족도를 높이고 개인의 발전을 높이기 위한 동기부여적 자아개념을 향상시켜 삶의 질도 높인다.

• 한국산업보건학회지
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• 제8권1호
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• pp.67-75
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• 1998

The objectives of this study were both to evaluate the level and correlations of hazardous agents and to suggest measures to control industrial hygiene problems caused by using water-soluble metalworking f1uids(MWF). Geometric mean of formaldehyde(0.039 ppm) was higher than criteria of NIOSH(0.016ppm). Formaldehyde, originally existed in the biocide, is released and used to kill microbes in soluble MWF. Microbe concentrations were above $10^4No./mL$ in 14 MWF tanks among 20 tanks surveyed. Nitrosamines that is formed by reaction of nitrosating group and amines was detected to $18.4-47.1{\mu}g/m^3$. Formaldehyde concentration was low when microbes were abundant(r=-0.67, p=0.011), and high when open tank area was wide(r=0.75. p=0.012). The significant relationship between pH and microbes(r=-0.76. p=0.003) was also observed. The predominant bacteria species in MWF were Pseudomonas spp., Bacillus spp., Comamonas testosteroni, Acinetobacter haemolyticus, Bordertella bronchiseptica in order. Therefore, hazardous agents emitted by using water-soluble MWF seems to be correlated microbial growth. In order to minimize worker's exposure to several hazardous agents by an water-soluble MWF and to increase productivity, microbial growth must be controlled to the lowest level as possible. Administrative control as well as engineering control must comprehensively be applied to control microbe's growth in water-soluble MWF.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5537-5540
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• 2015

Purpose: To research the association between pre-treatment elevated platelet count and clinicopathologic characteristics in breast cancer (BC), as well as explore the relationship between pre-treatment elevated platelet count and HER2 status and prognosis of BC patients. Materials and Methods: A retrospective cohort of BC patients who were newly diagnosed or treated by surgery only and had pathological detection results and platelet values in the Department of Oncology, the First Affiliated Hospital of Liaoning Medical College were enrolled from 1/1/2008 until 31/12/2009, and followed up until 31/12/2014. Age, thrombocyte parameters before chemotherapy and/or radiotherapy, immunohistochemical (IHM) indexes, and regional lymph node (LN) involvement and progression-free survival (PFS) were recorded. Results: A total of 447 eligible subjects were included in this research. As we analyzed, for HER2, positive and negative, the incidence rates of elevated platelet count were 25.8% and 14.7% (P<0.05). In the Cox proportional hazards model both variables were independent risk factors for BC (for HER2, OR, 0.592, 95% confidence interval, CI, 0.355 to 0.985, P=0.044;f or PLT, OR, 0.998, 95% CI, 0.996 to 1.000, P=0.042). For ER, PR, Ki67 and LN involvement, the differences were not statistically significant (P>0.05). Conclusions: In this research, pre-treatment elevated level of platelet count demostrated a significantrelationship with HER2 amplification/overexpression, and both variables significantly influenced the prognosis of BC. However, elevated platelet count did not exhibit any association with ER, PR, Ki67 and LN involvement.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6059-6064
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• 2014

Background: Colorectal cancer is the second most frequent cancer in Malaysia. Nevertheless, there is little information on treatment and outcomes nationally. We aimed to determine the demographic, clinical and treatment characteristics of colorectal cancer patients treated at the University Malaya Medical Centre (UMMC) as part of a larger project on survival and quality of life outcomes. Materials and Methods: Medical records of 1,212 patients undergoing treatment in UMMC between January 2001 and December 2010 were reviewed. A retrospective-prospective cohort study design was used. Research tools included the National Cancer Patient Registration form. Statistical analysis included means, standard deviations (SD), proportions, chi square, t-test/ANOVA. P-value significance was set at 0.05. Results: The male: female ratio was 1.2:1. The mean age was 62.1 (SD12.4) years. Patients were predominantly Chinese (67%), then Malays (18%), Indians (13%) and others (2%). Malays were younger than Chinese and Indians (mean age 57 versus 62 versus 62 years, p<0.001). More females (56%) had colon cancers compared to males (44%) (p=0.022). Malays (57%) had more rectal cancer compared to Chinese (45%) and Indians (49%) (p=0.004). Dukes' stage data weres available in 67%, with Dukes' C and D accounting for 64%. Stage was not affected by age, gender, ethnicity or tumor site. Treatment modalities included surgery alone (40%), surgery and chemo/radiotherapy 32%, chemo and radiotherapy (8%) and others (20%). Conclusions: Significant ethnic differences in age and site distribution, if verified in population-based settings, would support implementation of preventive measures targeting those with the greatest need, at the right age.

• 대한한방소아과학회지
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• 제34권3호
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• pp.67-75
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• 2020

Objectives This study is conducted to evaluate Th2 skewed condition control through skin fat barrier formation from the treatment using Coptidis Rhizoma and Glycyrrhiza uralensis extract. Methods The 6-week-old NC/Nga mice were divided into 4 groups: Control group (Ctrl), lipid barrier eliminate treatment group (LBET), Coptidis Rhizoma and Glycyrrhiza uralensis feeding treatment after lipid barrier elimination group (CGFT), dexamethasone feeding treatment after lipid barrier elimination group (DxFT). After 3 days, differences in skin condition, improvement of skin fat barrier, and control of Th2 skewed condition of each group were observed. Results Pathologic skin damage and tissue changes were less in the CGFT group than in the LBET and DxFT groups, and Transepidermal water loss (TEWL) and pH were also significantly decreased (p < 0.05). The filaggrin intensity and positive response also increased significantly in the CGFT group (p < 0.05). Kallikrein-related peptidase (KLK) 7, Protease activated receptor (PAR)-2, Thymic stromal lymphopoietin (TSLP), Interleukin (IL)-4, and the products of the Th2 differentiation process also showed a significant decrease compared to the LBET and DxFT groups (all p < 0.05). Conclusions The Coptidis Rhizoma and Glycyrrhiza uralensis extract causes skin barrier recovery and function recovery through the formation of skin fat barrier. This leads to the conclusion that Coptidis Rhizoma and Glycyrrhiza uralensis extract can control Th2 differentiation through the formation of skin fat barrier.

• Journal of Animal Science and Technology
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• 제47권2호
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• pp.221-232
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• 2005

This study was carried out to investigate the effect of replacing fish meal or soybean meal with feather meal or bromelain treated feather meal in broiler diets on the performances and nutrient utilization. Two hundred and twenty-five broilers were randomly allotted to five dietary treatrnents((1) control, basal diet; (2) PFM 50, 50 % of the fish meal replaced with bromelain treated feather meal; (3) PFM 100, 100% of the fish meal replaced with bromelain treated feather meal; (4) PSM 20, 20 % of the soybean meal replaced with bromelain treated feather meal; and (5) PSM 40, 40% of the soybean meal replaced with bromelain treated feather meal) in a 5-week feeding trial. In the overall period, body weight gain of the PFM 50(1,807 g), PSM 20(1,816 g) and PSM 40(1,823 g) were the highest and that of the PFM 100 was 1,744 g. The body weight gain of the control(1,698 g) was the lowest(p < 0.05) among treatments. Feed conversion was significantly(p< 0.05) improved when bromelain treated feather meal replaced 20% of the fish meal in the basal diet. Digestibilities of dry matter, ether extract, organic matter and phosphorus were not different among the treatments. Digestibility of crude protein of PFM 50(65.87 %), PSM 20(67.18 %) and PSM 40(67.56%) were the highest, and that of the control(54.49%) was the lowest(p < 0.05) among treatments. Arrunonia and hydrogen sulfide gases from the feces were significantly(p < 0.05) decreased in chicks fed the PFM 50, PSM 20 and GFM 40 diets, when observed after 3 weeks of feeding trials. Feed costs of the control and PFM 50 were 604 and 629 won, respectively but that of PSM 50 was 820 won. Therefore, replacement of fish meal with bromelain treated feather meal in the diets for chicks could be useful for economic production.

• 한국콘텐츠학회논문지
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• 제15권3호
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• pp.229-240
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• 2015

본 연구는 일반인과 간호사의 죽음 인식과 안락사에 대한 태도를 비교하고 상관관계를 확인하기 위한 서술적 조사연구이다. 자료수집은 2010년 3월 5일부터 5월 30일까지 구조화된 설문지를 사용하였고 연구 대상자는 간호사 192명과 일반인 255명으로 총 447명이었다. 수집된 자료는 SAS Program 12.0을 사용하여 실수, 백분율, 평균, t-test로 ANOVA, Duncan test 및 Pearson's correlation coefficient 분석하였다. 연구결과는 간호사의 죽음에 대한 인식 점수는 평균 2.67점으로 일반인 2.62점보다 높은 점수를 보였으며 통계적으로 유의한 차이가 있었다(p= .030). 안락사에 대한 태도 점수도 간호사가 2.67점, 일반인이 2.63점으로 간호사가 더 높았으며 유의한 차이가 있었다(p= .009). 죽음 인식과 안락사에 대한 태도 간 상관관계는 일반인(r= .465, p= .001). 과 간호사 (r= .294, p= .001). 모두 정적인 유의한 관계가 있는 것으로 나타났다. 즉 두 집단 모두 죽음에 대한 인식 정도가 높을수록 안락사에 대하여 수용적인 태도를 보였다. 본 연구의 결과를 통하여 우리 사회의 죽음 인식의 수준을 높이고 안락사에 대한 이해를 돕는 방안이 다각도로 마련될 필요가 있으며 이를 위하여 의료인 뿐 아니라 일반인을 위한 교육프로그램 개발과 교육을 확대해 나갈 것을 제언한다.