• Korean Journal of Occupational Health Nursing
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• v.24 no.2
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• pp.67-75
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• 2015

Purpose: The objective of the present study was to evaluate the effects of occupational exposure to low dose organic solvents on the prevalence of cardiovascular risk factors. Methods: Study design was retrospective cohort study subjected on 191 exposures and 118 controls working in a petrochemical manufacture company. The eight indicators related to CVD risk were followed up for five years from 2008 to 2012. The risk level was compared during the follow up years and subject's characteristics, and the change of risk level were analyzed with repeated measures ANOVA and multiple logistic regression analysis. Results: At the start year 2008, the rate over cutoff value (ROCV) of BS (p<.001) and mean systolic BP (p=.017) were higher in organic solvent exposure group and the others showed no difference. And by the subject's characteristics, odds ratio of the ROCV of BS were higher in organic solvent exposure group and work shift group as 2.51 and 3.07. Comparing the results in 2012 to those of 2008, cardiovascular disease risk in organic solvent exposure group was about 1.5 times higher than that of in the control group. Conclusion: Gradual increase in the CVD risk was identified in organic solvent exposure group. However, the risk might be influenced by shift work and bad behaviors rather than organic solvent exposure.

• Journal of Welding and Joining
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• v.7 no.4
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• pp.56-67
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• 1989

In this study, the possibility of evaluating the peculiar fracture strength of weldment in high strength steels was investigated by means of a small punch(SP) test. In order to obtain the ductile-brittle transition temperature(DBTT) of SP energy by which the fracture strength of weldment in structural steels such as SS41 and SM53B steels had been evaluated in our preceding publication, the effects of notches and loading rates on SP energy were discussed. It was found that the correspondence of SP energy to critical COD at test temperature -196.deg. C showed a linear relation with some deviation. The empirical correlation with scatter band, Esp/(Esp)p = 1.67[.delta./(.delta./sub c//(.delta./sub c/)/sub p/]-0.55, was developed between the SP energy ratio and critical COD ratio of each weld structure compared with parent material at test temperature -196.deg. C. In addition, there did not appear to be a significant effect of test materials and specimen size etc. on the correlation.

• Korean Journal of Microbiology
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• v.40 no.1
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• pp.12-16
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• 2004

Acid proteinase has been discovered in Aspergillus niger (acid protease A) and Cryphonectria parasitica (acid proteinase EapC) and it plays major roles in cheese formation from milk. In this study, a partial gene encoding acid proteinase in Penicillium oxalicum HCLF-34 was cloned by using PCR with degenerate primers corresponding to highly conserved regions of the acid proteinase. The partial acid proteinase gene in P. oxalicum HCLF-34 contains an open reading frame of 438 base pairs and encodes an acid proteinase protein of 146 amino aicds. The predicted amino acid sequences showed 71 % homology with acid protease A and 67% homology with EapC.

• Food Science and Biotechnology
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• v.27 no.6
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• pp.1781-1789
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• 2018

In this study, whey proteins were fermented with 34 lactic acid bacteria for 48 h at $37^{\circ}C$ and their ability to inhibit angiotensin 1-converting enzyme (ACE) activity were compared. All the lactic acid bacteria displayed varying proteolytic abilities in whey. Their fermentates also displayed varying abilities to inhibit ACE in vitro. Seven fermentates showed strong ACE inhibitory abilities between $84.70{\pm}0.67$ and $52.40{\pm}2.1%$ with $IC_{50}$ values between $19.78{\pm}1.73$ and $2.13{\pm}0.7mg/ml$. Pediococcus acidilactici SDL1414 showed the strongest ACE inhibitory activity of $84.7{\pm}0.67%$ ($IC_{50}=19.78{\pm}1.73{\mu}g/ml$). Mass spectrometry revealed that more than half (57.7%) of the low molecular weight peptides (< 7 kDa) in the P. acidilactici SDL1414 fermented samples were ACE inhibitory peptides. Our results show that P. acidilactici SDL1414 could be used as a starter culture in the dairy industry to develop antihypertensive functional foods for hypertension management.

• Development and Reproduction
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• v.25 no.1
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• pp.67-72
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• 2021

This study investigated the IGF-1 signal in specific tissues using Pacific oysters artificially matured via water temperature elevation. Pacific oysters were subjected to water temperature elevation from March to June, and 20 were randomly sampled each month. The condition index (CI) and tissue weight rate (TWR) were examined by measuring shell length, shell height, shell width, and soft tissue weight. The IGF-1 signal in tissues (adductor muscle, digestive glands, gills, labial palps, mantle edges, and gonads) was analyzed by sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blotting. From April to June, the TWR of females and males increased from 19.1±2.9 to 21.0±3.6 and 18.2±2.0 to 19.2±2.5, respectively, while the CI remained the same. The IGF-1 signal in each tissue differed. IGF-1 was expressed in the adductor muscle, while tyrosine was expressed in all tissues. The phosphor (p)-ERK and p-AKT activities were high in the adductor muscle, mantle edge, and gonads. IGF-1 signaling affected the growth and maturity of the Pacific oysters examined.

• Journal of Korean Dental Hygiene Science
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• v.4 no.2
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• pp.67-75
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• 2021

Background: Workers' oral health problems result in work disruption, including absenteeism or early leave, which reduces work efficiency. This study was conducted to investigate the subjective oral health status and oral problems of workers,and to identify the factors disrupting workflow due to oral problems. Methods: A self-report questionnaire was administered to 300 industrial workers in a metropolitan area. A total of 284 individuals were finally analyzed, after excluding the data of 16 workers who had missing responses among the recovered questionnaires. Results: Subjective oral health status was average in 44.4%, healthy in 32.0%, and unhealthy in 16.9% of the study population. Subjective oral health problems were the highest in the order of food impaction(28.9%), cavity(26.8%), tooth sensitivity (22.9%), and calculus(21.1%). However, sudden and unexplained tooth pain (12.0%), gum swelling and tooth mobility (10.2%), and wisdom tooth pain (4.9%) were relatively low. The average monthly income (p<.05) and subjective oral health status (p<.01) were statistically significant factors interrupting workflow. Conclusion: To minimize workers' oral health problems and work disruption due to oral diseases, it is necessary to promote workers' oral health and oral disease prevention programs within the workplace.

• Journal of Korean Neurosurgical Society
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• v.65 no.3
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• pp.469-478
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• 2022

Objective : Cranial base chordomas are rare, but their treatment is challenging. Tumor recurrence is still common despite improvements in microsurgical techniques and postoperative radiotherapy. We retrospectively analyzed the course of treatment, overall survival, and recurrence/progression of chordomas over the past 10 years. Methods : We retrospectively reviewed 50 patients who underwent surgery at Tianjin Huanhu Hospital between 2010 and 2020 and were pathologically diagnosed with chordomas. Tumor resection was performed within the maximum safe range in all patients; the extent of resection was evaluated by imaging; and the incidence of complications, recurrence or progression, and overall survival were assessed. Results : Fifty patients were divided into the low-risk group (LRG) and high-risk group (HRG) based on the cranial chordoma grading system (CCGS). The Karnofsky Performance Scale scores and gross total resection rate of the LRG were significantly higher than those of the HRG (p<0.05). The incidence of complications and mortality in the LRG were lower than those of HRG. The analysis of cumulative survival and cumulative recurrence free survival/progression free survival (RFS/PFS) showed no statistical differences in the extent of resection for survival, recurrence, or progression. Univariate and multivariate analyses showed that Ki-67 was significantly associated with tumor recurrence and was an independent hazard factor (p=0.02). Conclusion : The CCGS can help neurosurgeons anticipate surgical outcomes. Pathological results are important in evaluating the possibility of tumor recurrence, and postoperative radiotherapy improves overall survival and RFS/PFS.

• Journal of the Korean Society of Physical Medicine
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• v.18 no.4
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• pp.67-75
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• 2023

PURPOSE: This study aimed to identify the clinical factors that contribute to age-related loss of skeletal muscle mass (ALSMM) among young Korean male adults. METHODS: This was a cross-sectional study involving 955 men aged between 20-29 years. They underwent screening to assess the ALSMM. The study examined a variety of factors, including age, height, weight, body mass index (BMI), waist circumference (WC), skeletal muscle mass index (SMI), lifestyle-related habits such as smoking and drinking status, systolic and diastolic blood pressure (SBP/DBP), fasting blood glucose (FBG) levels, as well as the serum triglyceride and total cholesterol (TC) levels. RESULTS: The variables that displayed significant associations with ALSMM were height, weight, BMI, WC, SMI, FBG, TC, DBP, and alcohol consumption (p < .05). Serum triglyceride levels, SBP, and smoking status did not exhibit statistical significance (p > .05). CONCLUSION: The study identified the contributing factors associated with the ALSMM in community-dwelling young adult males. These findings would enrich the current body of literature on ALSMM and provide potential risk factors associated with its development in young Korean males.

• International Journal of Industrial Entomology and Biomaterials
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• v.48 no.2
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• pp.67-77
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• 2024

This study aims to assess the efficacies of exogenous enzymes, derived from invertebrate gut-associated microbes, as feed additives, in reducing volatile organic compound (VOC) emissions using an in vitro pig intestine continuous fermentation system. An in vitro continuous fermentation model was used to simulate a comparable bionic digestion system by co-reacting feed, enzymatic additives (arazyme, mannanase, and xylanase, derived from the gut bacteria of Nephila clavata, Eisenia fetida, and Moechotypa diphysis, respectively), and gastrointestinal microbes, followed by an analysis of their correlations. A significant correlation was observed between exogenous enzyme supplementation and reduced VOC emissions in the fecal phase of continuous fermentation (p < 0.05). The concentration of VOCs decreased by 3.75 and 2.75 ppm in the treatment group following arazyme and multi-enzyme supplementation, respectively, compared to that in the control group (7.83 ppm). In addition, supplementation with arazyme and multiple enzymes significantly affected the microbial composition of each fermentation phase (p < 0.05). In particular, Lactiplantibacillus pentosus and Pediococcus pentosaceus, which changed in abundance according to arazyme or multi-enzyme supplementation, exhibited a positive relationship with VOC emissions. These results suggest that exogenous enzymes derived from invertebrate gut-associated bacteria can be efficiently applied as feed additives, leading to a reduction in VOC emissions.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.21 no.2
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• pp.353-365
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• 1991

The author analyzed and compared tomographs with lateral oblique transcranial radiographs of 60 temporomandibular joints from 30 asymptomatic young adults. The results were as follows: 1. The mean height & width of condylar head were 6.82±1.99㎜, 11.98±1.28㎜ in tomographs and 5.41±0.79㎜, 10.67±1.28㎜ in transcranial radiographs. The mean height of articular fossa was 10.19±1.60㎜ in tomographs and 8.44±1.65㎜ in transcranial radiographs. 2. The mean width of articular fossa was 20.71 ±2.98㎜ in tomographs and 17.47±2.58㎜ in transcranial radiographs. There were significant differences in both the height and the width of articular fossa between two radiographic techniques (P<0.01). 3. In centric occlusion, the superior joint spaces were 4.28±1.09㎜, 4.18±1.28㎜, the anterior joint spaces were 2.84±1.02㎜, 2.53±0.72㎜, the posterior joint spaces were 3.11±1.19㎜, 2.66±0.89㎜ in tomographs and transcranial radiographs respectively. There were significant differences in right posterior joint spaces (P<0.05), and posterior joint spaces (P<0.05) between two radiographic techniques. 4. The condylar position in articular fossa was displaced posteroinferiorly (-0.35±4.40㎜ posteriorly, -1.55±1.24㎜ inferiorly) in tomographs and anteroinferiorly (0.45±3.77㎜ anteriorly, -1.29±1.26㎜ inferiorly) in transcranial radiographs with 1 inch opening. In maximum opening, it was displaced anteroinferiorly (5.39±3.63㎜ anteriorly, -1.22±1.67㎜ inferiorly) in tomographs and anteroinferiorly (6.35±4.00㎜ anteriorly, -0.55 ±1.98㎜ inferiorly) in transcranial radiographs. There was significant difference in superoinferior positions of both condyles with maximum opening between two radiographic techniques (P<0.05).