• Molecules and Cells
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• v.37 no.1
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• pp.81-87
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• 2014

Chronic pressure-overload cardiac hypertrophy is associated with an increased risk of morbidity/mortality, largely due to maladaptive remodeling and dilatation that progresses to dilated cardiomyopathy. Alternative splicing is an important biological mechanism that generates proteomic complexity and diversity. The recent development of next-generation RNA sequencing has improved our understanding of the qualitative signatures associated with alternative splicing in various biological conditions. However, the role of alternative splicing in cardiac hypertrophy is yet unknown. The present study employed RNA-Seq and a bioinformatic approach to detect the RNA splicing regulatory elements involved in alternative splicing during pressure-overload cardiac hypertrophy. We found GC-rich exonic motifs that regulate intron retention in 5' UTRs and AT-rich exonic motifs that are involved in exclusion of the AT-rich elements that cause mRNA instability in 3' UTRs. We also identified motifs in the intronic regions involved in exon exclusion and inclusion, which predicted splicing factors that bind to these motifs. We found, through Western blotting, that the expression levels of three splicing factors, ESRP1, PTB and SF2/ASF, were significantly altered during cardiac hypertrophy. Collectively, the present results suggest that chronic pressure-overload hypertrophy is closely associated with distinct alternative splicing due to altered expression of splicing factors.

• BLOOD RESEARCH
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• v.53 no.4
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• pp.314-319
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• 2018

Background Iron overload is a risk factor affecting all patients with thalassemia intermedia (TI). We aimed to determine whether there is a relationship of serum ferritin (SF) and alanine aminotransferase (ALT) with liver iron concentration (LIC) determined by R2 magnetic resonance imaging (R2-MRI), to estimate the most relevant degree of iron overload and best time to chelate in patients with TI. Methods In this cross-sectional study, 119 patients with TI (mean age years) were randomly selected and compared with 120 patients who had a diagnosis of thalassemia major (TM). Correlations of LIC, as determined by R2-MRI, with SF and ALT levels, were assessed in all participants. A P-value <0.05 was considered statistically significant. Results SF and LIC levels were lower in patients with TI than in those with TM; only ferritin values were significant. We found a statistically significant relationship between SF and LIC, with cut-off estimates of SF in patients with TI who had splenectomy and those who entered puberty spontaneously (916 and 940 ng/mL, respectively) with LIC >5 mg Fe/g dry weight (P<0.0001). A significant relationship was also found for patients with TI who had elevated ALT level (63.5 U/L), of 3.15 times the upper normal laboratory limit, using a cut-off for LIC ${\geq}5mg\;Fe/g\;dry\;weight$. Conclusion We determined the cut-off values for ALT and SF indicating the best time to start iron chelation therapy in patients with TI, and found significant correlations among iron overload, SF, and ALT.

• Journal of the Society of Naval Architects of Korea
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• v.58 no.3
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• pp.158-166
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• 2021

In this paper, a numerical analysis technique using a body force model is investigated to estimate the available net thrust of multi-pod-driven ice-breaking vessels under bollard pull and overload conditions. To employ the body force model in present flow simulations, drag and thrust components acting on the pod unit are calculated by using Propeller Open Water (POW) test data. The available net thrusts according to the direction of operation are evaluated in both bollard pull and overload conditions under deep water. The simulation results are compared with the model test data. The available net thrusts, calculated by the present analysis for ahead operating modes at 3~6 knots which are typical speeds of the target vessel in arctic field, are agreed well with the model test results. It is also found that the present result for astern operating mode appears approximately 6 % larger than the model test result. In addition, the available net thrusts are calculated under the both operating conditions accompanied by shallow water effects, and the main cause of the difference is studied. Based on the result of the present study, it is confirmed that the body force model can be applied to the performance evaluation of multi-pod propulsion system and the main engine selection in early design stage of the vessel.

• Korean Journal of Culture and Social Issue
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• v.23 no.2
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• pp.97-129
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• 2017

The purpose of this study was to investigate the influence of techno-overload and techno-invasion on work-family conflict and the mediating role of psychological detachment from work to techno-overload and techno-invasion. In addition, this study examined the moderating role of leader-member exchange in the relationship between techno-overload, techno-invasion and psychological detachment from work. The results from 306 participants provided evidence that (1) techono-invasion was negatively related to psychological detachment from work, (2) psychological detachment from work was negatively related to work-family conflict, (3) psychological detachment from work partially mediated the relationship between techno-invasion and work-family conflict (4) leader-member exchange moderated the relationship between techno-invasion and psychological detachment from work. Based on the results, implications of these findings, limitations, and future research were dicussed in general discussion.

• Information Systems Review
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• v.25 no.3
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• pp.1-26
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• 2023

A theoretical model of information overload (Jackson and Farzaneh, 2012) with its three influential components (i.e., time, technology, and social networks) was empirically tested in the context of news consumption behavior considered as a communicative outcome. Using a national sample of South Korean adults (N = 1166), data analyses identified perceived information overload and large/diverse social networks positively associated with active and passive news consumption. Findings may imply the existence of individually varying cognitive threshold (i.e., tipping point), if crossed individuals cannot process information any further. News consumers may keep searching and receiving information to verify factuality of news even when they feel overloaded.

• The Journal of Information Systems
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• v.24 no.2
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• pp.53-72
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• 2015

Purpose The purpose of this study was to investigate the factors affecting the users' stress and using reluctant intention to use social network service(SNS). This study especially focused on stress of SNSs' user. Because SNS has led to negative effects such as invasion of privacy, addiction and social overload recently. In addition, adverse effects of SNS had caused SNSs' user to feel stress and fatigue. Design/methodology/approach This study developed hypotheses to empirically examine the factors that affect SNS users' stress and using reluctant intention. In order to verify research hypotheses, this study collected data from 362 users who currently use the SNS in Korea. Further, we used the smartPLS analysis. Findings The results of this study are as follows; First, reputation perception, unwanted relation burden, privacy concern, information overload and interaction overload had a significant positive effect on SNS users' stress. But international influence had no significant positive effect on SNS users' stress. Second, SNS users' stress had a significant positive effect on using reluctant intention. The results of this study provides theoretical foundations on the research for dark side of SNS and implies that SNS providers are in need of exerting an effort to minimize the negative aspects.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.20 no.3
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• pp.387-392
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• 2007

Overloaded Vehicles are one of biggest of hazard in durability decrease of roads and bridges. Thus, regulation was put in force about overloaded vehicles to reserve this problem. However, existing system had many problems. For these reasons, this paper presents solutions of U-intelligent overload vehicles regulation system based on manless and wireless for fixing of problems of existing system and construction of u-lTS. With this in mind, we studied about composition method of system, applications of USN, design of system controller, WCDMA/HSDPA and we verified performance of WIM Sensors in this paper.

• Aerospace Engineering and Technology
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• v.2 no.2
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• pp.11-17
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• 2003

This paper present a method of meter-out flow control for overload protection valve in full-scale airframe test. Emergency stop, which results in dump state, can be happened during full-scale airframe test by several causes. Because servo valve can't control hydraulics actuator in the dump state, pressure in cylinder chamber may rise abruptly and overload can be acted to the test article. In this paper, the procedure and technology of orifice setting are investigated to protect the test article from unexpected loads by dump. The test results show that the presented methods decrease peak loads and improve unloading characteristics of hydraulic actuators in the dump state.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.9
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• pp.4165-4187
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• 2016

As an emerging technology, cloud computing is a revolution in information technology that attracts significant attention from both public and private sectors. In this paper, we proposed a dynamic approach for live migration to obviate overloaded machines. This approach is applied on OpenStack, which rapidly grows in an open source cloud computing platform. We conducted a cost-aware dynamic live migration for virtual machines (VMs) at an appropriate time to obviate the violation of service level agreement (SLA) before it happens. We conducted a preemptive migration to offload physical machine (PM) before the overload situation depending on the predictive method. We have carried out a distributed model, a predictive method, and a dynamic threshold policy, which are efficient for the scalable environment as cloud computing. Experimental results have indicated that our model succeeded in avoiding the overload at a suitable time. The simulation results from our solution remarked the very efficient reduction of VM migrations and SLA violation, which could help cloud providers to deliver a good quality of service (QoS).

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.11
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• pp.1922-1928
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• 2008

The thermal rating of a conductor are maximum continuous current capacity and short time emergency current capacity. The overload operation for a faults have an effect on a conductor lifetime. Its time duration and overload level are limited to facility conditions of transmission lines. The short time emergency current capacity in KOREA observe the KEPCO's DESIGN RULE 1210, but its rules are not included to concept of an allowable short time duration. This papers are described to the calculation concept of short time emergency current capacity considering a time duration and an overload level. And we suggested a operation grouping and its maximum conductor temperature considering facility conditions - conductor lifetime, stability of connection points, conductor height above ground and clearance, in the operating and new T/L.