• Journal of Korean Ophthalmic Optics Society
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• v.15 no.4
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• pp.381-388
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• 2010

Purpose: This study was to compare the contrast sensitivity evaluated the visual ability at near wearing functional lenses for pre-presbyopes altered their single vision lenses to functional progressive addition lenses with low addition for 2 months. Methods: Healthy 32 subjects aged 24.03${\pm}$1.87 (male 23, female 9) who were recruited from university students wore functional progressive addition lenses(EYE-T, Chemilens Co., Korea, ADD 0.75D) for 2 months. Corrected visual acuity at distance and near and contrast sensitivity at near were tested right after wearing functional progressive addition lenses to compare wearing single vision lenses. And we had second test after 2 months later. Results: Comparing between test and retest, contrast sensitivity at near wearing functional progressive addition lenses was improved more than wearing single vision lenses at all spatial frequency of right, left and both eyes. Conclusions: There was considered that contrast sensitivity test is useful to evaluate the visual ability as well as quality of near work and can be applied variously.

• Journal of Korean Ophthalmic Optics Society
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• v.13 no.1
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• pp.125-129
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• 2008

Purpose: To research the study of abnormal refraction eye on women population of university students in South - East Korea. Methods: Between March 2007 and October 2007, the refraction test of eye glasses wearer was evaluated on women population (367 students, aged 19~22 years) of university in living on Kyung-Nam and Pusan province. Data was analysed with T-test. Results: On the abnormal refraction status, Compound Myopic Astigmatism was 76.72%, simple myopia was 10.90%, mixed astigmatism was 6.27%, respectively. On the prevalence of myopic power, low was 59.57%, moderate was 24.93%, high was 15.49%, respectively. On the myopic equivalent power, the right eye had more increase to compare to left eye. but these was not a statically significant correlation (p<0.5) between the right and left eyes. On the anisometropia of spherical equivalents and cylinder power, most subjects was under 1.0 diopter. On the other hand, the type of astigmatic axis was with-the rule (70.79%), against -the rule (18.41%), and oblique (10.80%). Conclusions: This study identify that the refraction status of abnormal refraction eye on women population in university students in South-East Korea have been more increased prevalence the myopia and astigmatism.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.9 no.2
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• pp.66-78
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• 1999

The purpose of this study was to investigate the toxic effects of iso-butylalcohol on Sprague-Dawley (SD) rats which were treated 0, 333, 1,000 and 3,000 ppm for 6 hours a day, 5 days a week for 13 weeks by inhalation. Iso-butylalcohol did not induce any abnormal change in the viewpoint of clinical signs, feed consumption, ophthalmic test, urinalysis, hematology and blood biochemistry during and at the termination of the inhalation toxicity test. We did not find any abnormal findings in the gross and microscopic observations due to the inhalation of iso-butylalcohol. There was no alteration in relative organ weight owing to the inhalation of the iso-butylalcohol. In conclusion, concentration was 3,000 ppm in rats under the inhalation of 6 hours a day, 5 days a week for 13 week. Iso-butylalcohol did not show any change in the clinical signs, feed consumption, ophthalmic test, urinalysis, hematology and blood biochemistry, together with no alteration in the gross and pathological findings.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.2
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• pp.195-200
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• 2015

Purpose: This study was performed in order to figure out the influence of illumination on visual function. Methods: 40 adults (male 21, female 19) of average age $23.93{\pm}1.59$ years were participated in this study. The test chart surface illumination was adjusted to 5, 50, 200, 500 and 800 lx, and then amplitude of accommodation, near point of convergence, far and near distance phoria, far and near distance fusional vergence, relative accommodation, and accommodation lag were measured at each illumination condition. Results: As illumination intensity of test chart was reduced, amplitude of accommodation was significantly decreased (p<0.05), accommodation lag was also decreased, near point of convergence was receded, and horizontal phoria showed a tendency of esodeviation. In the case of negative fusional vergence, with reduction of illumination intensity, the break point and the recovery point were decreased but in the case of positive fusional vergence, the break point was increased. The negative and positive relative accommodation were significantly decreased (p<0.05) with reduction of illumination intensity. Conclusions: In clinical practice, visual functional test should be performed under condition of adequate illumination level through patient's living environment and job.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.1
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• pp.47-52
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• 2012

Purpose: This study was to evaluate visual fatigue with passing of watching 3D TV in short term and with experience of watching 3DTV in long term. Methods: 98 adult subjects aged $33.5{\pm}5.5$ years (22 to 51 years; 12 females and 86 males) agreed to participate in this study. Subjects were asked to watch 52 inch LED 2D and 3D television (Shutter glasses method) at 2.7 meters for 65minutes with wearing their habitual glasses or contact lenses. For evaluating visual fatigue, subjects were verbally responded to 11 questions : eye straining, eye paining, dry eye, sore eye, watery eye, photophobia, blur vision, diplopia, eye fatigue, headache, and dizziness with scale 0 to 3 at each measurement while watching 3D and 2D TV. Results: The mean scores of visual fatigue were $2.08{\pm}2.14$, $3.19{\pm}3.02$, $3.40{\pm}3.37$, $3.53{\pm}3.07 $for after 5 minutes, 25 minutes, 45 minutes, and 65 minutes respectively for 3D TV, and $0.40{\pm}1.03$, $0.22{\pm}0.70$, $0.22{\pm}0.58$, and $0.17{\pm}0.52$ after 25, 45, and 65 minutes respectively for 2D TV. Visual fatigue for watching 3D TV was significantly higher than for watching 2D TV at all measurements sessions (paired t-test, p < 0.001). The visual fatigue significantly increased during watching 3D TV for 65 minutes (p < 0.001, RM-ANOVA). The visual fatigue during watching 3D TV was significantly increased until 25 minutes (paired t-test, p < 0.001), stable after that. For correlation between visual fatigue and 3D watching experience, the more 3D watching experiences were significantly the less visual fatigues in photophobia, blur vision, diplopic and dizzy symptoms (ANOVA, all F(1, 96) = 4.500, all p < 0.05), but there was not significantly different in the other symptoms (ANOVA, F (1, 96) = 2.123, p = 0.148). Conclusions: Visual fatigue for watching 3D TV was higher than for watching 2D TV, increase by 25 minutes. It was different by symptoms for correlation between visual fatigue and 3D watching experience.

• Journal of Korean Ophthalmic Optics Society
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• v.12 no.4
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• pp.55-69
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• 2007

The purpose of this study was to perform a clinical test using ez NANOsence II RGP contact lenses for the effects of visual acuity and cornea on subjects with abnormal refraction status. One hundred twenty one adults (twenty nine males, ninety two females, range = 17 to 43, mean = 22.86) were recorded. The subject's history including, the symptoms from previous lens wear, were studied. The subjects were observed, both pre and post lens wear, for any symptoms and signs of change of the eye. The Visual acuity and the binocular status were tested at the far distance using the contact lens. The refraction test was performed on the naked eye using the objective method (Topcon KR-8100, Japan). The Stereopsis test was performed at the near distance after contact lens wear by the Titmus fly (Stereo Optical Co., U.S.A) and TNO (TECH, The netherlands). The contrast sensitivity diagnosis was performed at 1m distance after contact lens wear by the contrast sensitivity chart (pelli-Robertson, USA). The corneal topography was analyzed on the naked eye after lens wear by ORB scan (Bausch Lomb, U.S.A.). The ultra structure of surface on the contact lens was observed using SEM (JMS-5800, Japan). The chemical component's of the contact lens was analyzed by EDS program. The results of this study were as follows: 1. The longer of contact lens wear period, The subjects have acquired the most improved visual function. 2. Subjects had experienced few side effects wearing the contact lenses. 3. The lenses were easy to use by the subjects. 4. The longer of contact lens wear period, the power of cornea had more decrease. but the base curve of cornea had more increase and corneal astigmatism was decrease (p<0.01). Also, the thickness of corneal center was few decrease. 5. Longer periods of using the contact lens showed stereopsis and contrast sensitivity at more normal values. 6 The corneal topographical after lens wear showed most subjects with similar morphology for different wear periods. 7. The surface ultrastructure of the new and used contact lens was the similar fine shape. 8. The chemical component's of in the new and used contact appeared to have similar results. In conclusion, this study showed that the surface ultrastructure and chemical component's of the new and used contact lens are similar. In addition, the subjects had improved the quality of vision and few experienced any side effects during long periods of contact lens wear. Also they have decrease of corneal astigmatism during the long period of lens wear. Our test has showed that the chemical composition and fine structure of contact lens have related to the visual function on contact lens wearer. In this paper, we suggested that ez NANOsence II RGP contact lenses had a moderate effect for correcting vision of abnormal refraction eye.

• Korean Journal of Veterinary Research
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• v.53 no.2
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• pp.133-136
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• 2013

To report multiple congenital ocular defects in a Bedlington terrier dog aged 2.5 months with blindness. Routine ophthalmic examinations were performed for the clinical signs. Menace responses and cotton ball test were absent in both eyes (OU), but pupillary light reflexes were normal in OU. Slit lamp biomicroscopy reveled corneal dystrophy, posterior subcapsular cataract, microphthalmia in OU and lenticular coloboma in the right eye. In indirect ophthalmoscopy and ultrasonography, retinal detachment and posterior lenticonus were shown in OU. It is the first report of lenticular coloboma and posterior lenticonus in a Bedlington terrier dog.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.3
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• pp.331-337
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• 2014

Purpose: This is a comparative experimental study on the amount of phoria by the removal time of binocular fusion. In this study, three tests were used for phoria test like Howell test, Thorington test and developed 3D polarizing test. Methods: In this study, it was considered the removal time of binocular fusion for measuring phoria. The three methods were used for measuring quantity of phoria: Howell test, Thorington test and developed 3D Polarizing test. The measurements progressed quickly to avoid eye-strain. So we designed the test charts for marking 3D display modules and the apparatus inserted lenses, like Maddox lens and prism, which are compatible with three phoria tests. The phoria at the moment separation was measured when the binocular fusion was broken through the apparatus and the that at the stable separation was measured when activity of the separated two images like indicated box and figure on horizontal axis stopped. Results: There were statistically significant difference between quantity of phoria at moment separation and that at stable separation. Amount of phoria at moment separation was relatively larger than amount of that at stable separation. In result in exophoria, the quantity of phoria at moment separation was higher than that at stable separation, and in phoria measured by developed 3D polarizing test, it shows the similar results at two condition. Conclusions: For exophoria, the amount of phoria at moment separation of binocular fusion was relatively larger than that at stable separation. The amount of difference between phoria values at moment separation and that at stable separation was alike among three phoria tests. Usually in working, there is no distinction between moment separation and stable separation. But there were definitely the difference between two ways to separate binocular fusion. Therefore, it is need for writing on prescription test name for measuring phoria and condition of separation of binocular fusion.

• Journal of Biomedical Engineering Research
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• v.40 no.5
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• pp.143-150
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• 2019

To evaluate the toxicity of ophthalmic drug, the Draize test and Bovine Corneal Opacity and Permeability (BCOP) test commonly used. In Draize test, experimental animals were under stress and pain due to long-term exposure of drug. In addition, regarding physiological functions, animal model is not perfectly reflected a human eye condition. Although some models such as $EpiOcular^{TM}$, HCE model, LabCyte Cornea-Model, and MCTT $HCE^{TM}$ were already presented advanced cornea ex-vivo model to replace animal test. In this sense, cornea tissue structure mimicked ex-vivo toxicity model was fabricated in this study. The corneal epithelial cells (CECs) and keratocytes (CKs) isolated from rabbit eyeball were seeded on non-patterned silk film (n-pSF) and patterned silk film (pSF) at $32,500cells/cm^2$ and $6,500cells/cm^2$. Sequentially, n-pSF and pSF were stacked to mimic a multi-layered stroma structure. The thickness of films was about $15.63{\mu}m$ and the distance of patterns was about $3{\mu}m$. H&E stain was performed to confirm the cell proliferation on silk film. F-actin of CKs was also stained with Phalloidin to observe the cytoskeletal alignment along with patterns of the pSF. In the results, CECs and CKs were shown the good cell attachment on the n-pSF and pSFs. Proliferated cells expressed the specific phenotype of cornea epithelium and stroma. In conclusion, we successfully established the ex-vivo cornea toxicity model to replace the eye irritation tests. In further study, we will set up the human ex-vivo cornea toxicity model and then will evaluate the drug screening efficacy.

• Journal of Korean Ophthalmic Optics Society
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• v.9 no.2
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• pp.333-343
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• 2004

Impression cytology refers to application of cellulose acetate filter material to the ocular surface to remove the superficial layers of the conjunctival epithelium. The technique is non-invasive, is easy to perform, causes minimal discomfort to the patient, and can be used to follow changes in the conjunctival ocular surface over time. With this method, the morphology of the conjunctival ocular surface can be studied and the degree of squmaous metaplasia assessed. This study was performed to evaluate the conjunctival surface by impression cytology in dry eye patients. A total of 70 students with no contact lens wearing history were recruited. Subjects were required to fill in a McMonnies dry eye symptom questionnaire. The non-invasive tear thinning time(TIT) test of each subject was measured, followed by Schirmer tear test(STI), tear film break-up time(TBUT) tests and Rose-bengal staining were performed as a baseline. Conjunctival epithelial cells from the inferior bulbar conjunctiva were harvested by the impression cytology technique. The specimens collected were labelled and stained with PAS(Periodic Acid Schift)-haematoxylin. The goblet cells and conjunctival epithelial cells were observed under a light microscope of 400x magnification. The specimens were classified according to the Nelson Grading scale which was based on the degree of squamous metaplasia such as changes of goblet cells density, size/form, N:C(nucleus : cytoplasm) ratio. Dry eye patients were observed morphological changes of the epithelial cells, different nuclear alterations, decrease of the goblet cells density. The degree of cytological changes was related to severity of dry eye conditions. When the epithelial cell morphology was graded according to the system described by Nelson, specimens from the control group revealed 91.43% of the eyes to be grade 0 and 8.57% to be grade 1, whereas of the dry eye patients, 20% were grade 0, 42.86% grade 1, 34.29% grade 2 and 2,86% grade 3. Impression cytology represents a non- or minimally invasive biopsy of the ocular surface epithelium with no side effects or contraindications. It has demonstrated to be a useful diagnostic aid for a wide variety of processes involving the ocular surface. This technique is a safe, simple method and may help increase understanding of various ocular surface alterations in dry eye patients.