Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Study on Inhalation Toxicity of Iso-butylalcohol Using SD Rats

Rats를 이용한 Iso-butylalcohol의 아만성 흡입독성 연구

  • Kin, Hyeon Yeong (Industrial Chemicals Research Center, Industrial Safety and Health Research Institute, Korea Industrial Safety Corporation) ;
  • Yun, Hyo In (Department of Veterinary Medicine, Chung Nam University) ;
  • Lee, Sung Bea (Industrial Chemicals Research Center, Industrial Safety and Health Research Institute, Korea Industrial Safety Corporation) ;
  • Chang, Beom Su (Department of Veterinary Medicine, Chung Nam University) ;
  • Jeong, Jae Hwang (Industrial Chemicals Research Center, Industrial Safety and Health Research Institute, Korea Industrial Safety Corporation) ;
  • Lim, Cheol Hong (Industrial Chemicals Research Center, Industrial Safety and Health Research Institute, Korea Industrial Safety Corporation) ;
  • Chung, Yong Hyun (Industrial Chemicals Research Center, Industrial Safety and Health Research Institute, Korea Industrial Safety Corporation) ;
  • Han, Jeong Hee (Industrial Chemicals Research Center, Industrial Safety and Health Research Institute, Korea Industrial Safety Corporation) ;
  • Zeon, Yoon Seok (Industrial Chemicals Research Center, Industrial Safety and Health Research Institute, Korea Industrial Safety Corporation) ;
  • Jang, Dong Hyuk (Industrial Chemicals Research Center, Industrial Safety and Health Research Institute, Korea Industrial Safety Corporation) ;
  • Ha, Chang Soo (Safety Research Center, Korea Research Institute of Chemical Technology) ;
  • Kim, Jong Chun (Safety Research Center, Korea Research Institute of Chemical Technology) ;
  • Lee, Yong Mook (Industrial Chemicals Research Center, Industrial Safety and Health Research Institute, Korea Industrial Safety Corporation)
  • 김현영 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 윤효인 (충남대학교 수의과대학) ;
  • 이성배 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 장범수 (충남대학교 수의과대학) ;
  • 정재황 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 임철홍 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 정용현 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 한정희 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 전윤석 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 장동혁 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터) ;
  • 하창수 (한국화학연구소 안전성연구센터) ;
  • 김종춘 (한국화학연구소 안전성연구센터) ;
  • 이용묵 (한국산업안전공단 산업안전보건연구원 산업화학물질연구센터)
  • Published : 1999.11.30
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Abstract

The purpose of this study was to investigate the toxic effects of iso-butylalcohol on Sprague-Dawley (SD) rats which were treated 0, 333, 1,000 and 3,000 ppm for 6 hours a day, 5 days a week for 13 weeks by inhalation. Iso-butylalcohol did not induce any abnormal change in the viewpoint of clinical signs, feed consumption, ophthalmic test, urinalysis, hematology and blood biochemistry during and at the termination of the inhalation toxicity test. We did not find any abnormal findings in the gross and microscopic observations due to the inhalation of iso-butylalcohol. There was no alteration in relative organ weight owing to the inhalation of the iso-butylalcohol. In conclusion, concentration was 3,000 ppm in rats under the inhalation of 6 hours a day, 5 days a week for 13 week. Iso-butylalcohol did not show any change in the clinical signs, feed consumption, ophthalmic test, urinalysis, hematology and blood biochemistry, together with no alteration in the gross and pathological findings.

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