• Journal of Microbiology
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• 제43권1호
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• pp.11-16
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• 2005

Matrix metalloproteinase (MMP)-9 plays an important role in the pathogenesis of bronchial asthma. Neovastat, having significant antitumor and antimetastatic properties, is classified as a naturally occurring multifunctional antiangiogenic agent. We evaluated the therapeutic effect of Neovastat on airway inflammation in a mouse model of asthma. BALB/c mice were immunized subcutaneously with ovalbumin (OVA) on days 0, 7, 14, and 21 and challenged with inhaled OVA on days 26, 29, and 31. Neovastat was administrated by gavage (5 mg/kg body weight) three times with 12 h intervals, beginning 30 min before OVA inhalation. On day 32, mice were challenged with inhaled methacholine, and enhanced pause (Penh) was measured as an index of airway hyperresponsiveness. The severity of airway inflammation was determined by differential cell count of bronchoalveolar lavage (BAL) fluid. The MMP-9 concentration in BAL fluid samples was measured by ELISA, and MMP-9 activity was measured by zymography. The untreated asthma group showed an increased inflammatory cell count in BAL fluid and Penh value compared with the normal control group. Mice treated with Neovastat had significantly reduced Penh values and inflammatory cell counts in BAL fluid compared with untreated asthmatic mice. Furthermore, mice treated with Neovastat showed significantly reduced MMP-9 concentrations and activity in BAL fluid. These results demonstrate that Neovastat might have new therapeutic potential for airway asthmatic inflammation.

• Healthcare Informatics Research
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• 제24권4호
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• pp.387-393
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• 2018

Objectives: This paper describes an experience of implementing seamless service trials online and offline by adopting Internet of Things (IoT) technology based on near-field communication (NFC) tags and Bluetooth low-energy (BLE) beacons. The services were provided for both patients and health professionals. Methods: The pilot services were implemented to enhance healthcare service quality, improve patient safety, and provide an effective business process to health professionals in a tertiary hospital in Seoul, Korea. The services to enhance healthcare service quality include healing tours, cancer information/education, psychological assessments, indoor navigation, and exercise volume checking. The services to improve patient safety are monitoring of high-risk inpatients and delivery of real-time health information in emergency situations. In addition, the services to provide an effective business process to health professionals include surveys and web services for patient management. Results: Considering the sustainability of the pilot services, we decided to pause navigation and patient monitoring services until the interference problem could be completely resolved because beacon signal interference significantly influences the quality of services. On the other hand, we had to continue to provide new wearable beacons to high-risk patients because of hygiene issues, so the cost increased over time and was much higher than expected. Conclusions: To make the smart connected hospital services sustainable, technical feasibility (e.g., beacon signal interference), economic feasibility (e.g., continuous provision of new necklace beacons), and organizational commitment and support (e.g., renewal of new alternative medical devices and infrastructure) are required.

• 말소리와 음성과학
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• 제8권3호
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• pp.61-66
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• 2016

The purpose of this study is to examine the speaking rate(overall speaking rate and articulatory rate) of Parkinson's disease patients with palilalia(PDP). Palilalia is traditionally characterized by not only compulsive repetitions of words and phrases, but also by increased rate of speech based on auditory perception. Since Souques(1908) first characterized palilalia as fast speech rate from the perspective of auditory perception, few studies have evaluated PDP speech using acoustic methods. To compare the speech rate between PDP and normal subjects, we included five PDP and eight control subjects(age over 55), as well as the date acquired under reading tasks(standardized Korean paragraph). The difference in median of the overall speaking rate was not statically significant between the PDP group(median 5.25, IQR 1.30) and normal group(median 4.76, IQR 0.71). The PDP, however, had a significantly higher syllables per second on the articulatory rate(median 6.60, IQR 1.04) than normal subjects(median 5.60, IQR 0.52). Results indicated no differences in pause over 250msec and disfluency duration between the two groups. To provide useful insight into PDP speech, multiple levels of analysis should be employed.

• 보건교육건강증진학회지
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• 제25권4호
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• pp.83-92
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• 2008

Objectives: This study was to develop and evaluate a web-based multimedia content for the education of hospice volunteers. Methods: The multimedia content was developed based on Baik's teaching and learning structure plan model. The developed program was evaluated by 24 hospice volunteer university students. Results: On main page, there were 4 menu bars that consisted of a lecture guide, cyber lecture, pause and quiz. In the operation of the web based multimedia content, HTML, Java Script, Photoshop and multimedia technology were utilized. There were significant differences in the test scores, before and after using this web-based learning program. After using a web-based learning program, scores of students were much higher. Conclusion: The developed web based program is based on systematic structure and it can provide hospice volunteers with the educational flexibilities and will be help for them to perform the more efficient hospice care.

• 정보처리학회논문지B
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• 제16B권2호
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• pp.141-150
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• 2009

본 논문에서는 사람의 노랫소리를 자동으로 채보할 수 있는 시스템을 제안한다. 먼저 입력된 음성으로부터 추출된 피치 정보를 안정화된 역확산 방정식(Stabilized Inverse Diffusion Equation : SIDE)을 이용하여 음절 단위로 분할한다. 이를 바탕으로 유전자 알고리즘에 기반한 클러스터링을 통해 음길이 인식을 수행하였다. 또한 시창자의 음 높이에 강인한 음정 인식을 위하여 상대 음정이라는 개념을 도입하였다. 그리고 휴지기 정보를 이용한 마디 추출 알고리즘을 적용하여 보다 정확한 노래의 채보를 가능하게 하였다. 제안된 시스템을 통하여 동요 16곡을 채보한 결과 마디 인식률은 91.5%였으며, DMOS 방법으로 측정한 악곡 전체 유사도는 3.82로써 시스템 성능의 유효성을 확인할 수 있었다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2005년도 제36회 하계학술대회 논문집 C
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• pp.2140-2142
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• 2005

This paper presents the experimental results on the preliminary breakdown characteristics under a highly non-uniform electric field in $SF_6/CO_2$ gas mixtures. The impulse preliminary breakdown developments are investigated by the measurements of corona current and light emission images. As a result, the preliminary breakdown development mechanisms for both positive and negative polarities are same. The first streamer corona is initiated at the tip of needle electrode, and the leaders develop with a stepwise propagation and bridge the test gap. The pause time of leader pulses in the positive polarity is significantly shorter than that in the negative polarity. Also, the time interval between the first streamer corona onset and breakdown in the negative polarity was much longer than that in the positive polarity The discharge channel paths in the positive polarity were zigzag. On the other hands, the leader channel in the negative polarity was thicker than that in the positive polarity.

• 대한음성학회:학술대회논문집
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• 대한음성학회 1996년도 10월 학술대회지
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• pp.43-52
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• 1996

This paper deals with the nature and function of intensification in Korean in a wider scope of intensification which was not paid proper attention including intensification in the initial position as well as middle position. Unobserved new areas of intensification in the initial position are paid more attention like sound split of polysemy e.g. (s'eda), (kyongk'i) by means of intensification and north Korean application of intensification on (wonsu) and intensification of borrowed English. The recent phenomenon of ‘gwua’ intensification is experimented on two groups of people, young students and old people beyond 65 years old by means of sociolinguistic analysis. The result shows that its intensification is a form of student violent power and a mark of extreme solidarity among activist students. Thirty three university students(male 16, female 17) are asked to explained to write the meanings(feelings or when to use, etc.) of the words which have normal form and intensified forms. The results show intensification attaches the meaning of ‘emphasis,’ to bring the extremely polarized emotion: samll to the smallest, exact to the perfect exactness, bad to the worst feeling. Four words are being split to express different meaning with the word intensified. In conclusion, the nature of so called saisiot(t) e.g. intensification is voiceless tensed pause and its functions are the polarization of the original meaning of the word, sound split of polysemy and attachment of social values by intensification.

• 의료법학
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• 제13권2호
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• pp.285-308
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• 2012

The Korean supreme court said that Mrs Kim who was in a persistent vegetative state had a right to die if she had a presumed will or assumption of dying against Severance hospital in 2009. Presumed would be vague and can not be subjective to conjecture though, the court had a developed trial on the case. I recommend the higher valued notion such as the 'right to decide on the life extension' is more logical than assumptive will. To achieve this recommendation, I will search right to life, right to decision, human dignity and find the good relationship between them. In conclusion, I will announce that if PVS patients without advanced directives aren't able to express their will and no one could not assume their right to die in spite of meaningless life extension. So only the due and strict procedure about the extinction of meaningless PVS patients will allow them to sacrifice themselves or remove life extension ventilators. Also active euthanasia would be possible under the strict procedure of making advanced directives and the act of helping active euthanasia additionally, the crime of abetting suicide would not be executed in the legal scope.

• 한국통신학회논문지
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• 제28권10B호
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• pp.876-890
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• 2003

This paper proposes a protocol for the reliableand QoS-aware multicast transport, which is called the Enhanced Communications Transport Protocol (ECTP). The ECTP has so far been developed and standardized in ITU-T SG17 and ISO/IEC JTC 1/SC 6. Differently from the conventional reliable multicast, as shownin the IETF RMT WG, the ECTP additionally provides several distinct features such as tight control of multicast session, tree-based error control, and QoS management. For the tight control of multicast connections, the sender is at the heart of one-to-many group communications, and it is responsible for overall connection management such as connection creation/termination, pause/resumption, and the join and leave operations. for tree-based reliability control, ECTP configures a hierarchical tree during connection creation. Error control is performed within each local group defined by a control tree, which was partly designed like the IETF TRACK approach. Each parent retransmits lost data in response to retransmission requests from its children. For QoS management, ECTP supports QoS negotiation for resource reservation, and it also provides QoS monitoring and maintenance operations. ECTP has been implemented and tested on Linux machine, along with Application Programming Interfaces based on Berkeley sockets. For basic testing of the ECTP functionality, we give some preliminary experimental results for performance comparison of ECTP and TCP unicast transports. In conclusion, we describe the status of ECTP experimentations over APAN/KOREN testbed networks

• 대한한의학회지
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• 제17권2호
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• pp.48-57
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• 1996

This study is to review the oriental medical literatures about Chungye and endocrinologic literatures about menstration, pregnancy, menopause and male-sex cycle. The conclusions obtained are as follows; First, according to Naegyung, Chungye exists in both male and female, it makes human fertile. It comes with starting menstration and is exhausted with menopause. Second, it was said that the name of Chungye originated in Chun of Chunjinjiki(energy of genuine cosmos) and Gye of Imgyejisu(water of Imgye). Third, some authors advocated that Chungye is menstration. But it was criticized by other authors and it is not accepted at the present time. Forth, there was an assertion that Chungye is Eumjung. The assertion has been developed as the hypothesis that Chungye may be a endocrinologic substance relavant to menstration and pregnancy. Fifth, there was an interpretation that Chungye is FSH. But this interpretation might be unreasonable if it is based on the results observed by endocrinologic researches. According to the current endocrinologic researches, Chungye may be GnRH, when Chungye is the necessary endocrinologic substance to menstration and pregnancy, exists in male and female and is exhausted with menopause.