• Childhood Kidney Diseases
• /
• 제3권1호
• /
• pp.57-63
• /
• 1999

목 적 : 신질환의 조기 진단을 위한 집단뇨검사 방법으로 단백뇨와 혈뇨검사를 동시에 시행하여 그 결과를 분석함으로써 집단뇨검사에서 잠혈검사 추가가 가지는 진단적 의의를 알아 보고자 하였다. 방법 및 대상 : 1차 선별검사는 전국 33개교 26,508명의 고등학교 1년생(16세군)을 대상으로 하였고 정밀검사는 서울시 1개교 875명의 고등학교 1년생(16세군)을 대상으로 실시하였다. 방법은 1997년 8월부터 12월까지 4개월간 한국 건강관리 협회와 공동으로 학교에서 무작위로 채취된 소변을 Combur-10 $N^{(R)}$ M (Boehringer Mannheim, Germany)검사지로 단백뇨, 혈뇨, 농뇨, 아질산염 등을 검사하였다. 양성자의 기준은 단백뇨, 혈뇨, 농뇨가 $1^{+}$ 이상인 경우와 아질산염에 양성반응이 나오는 경우로 정하였다. 실제 신질환의 감별을 위한 정밀검사는 1차 집단뇨검사 양성자를 대상으로 본원에서 실시하였다. 결 과 : 1) 1차 집단검사 결과에서 단백뇨 유병율은 $0.73\%$, 혈뇨 유병율은 $2.69\%$, 농뇨 유병율은 $0.23\%$ 그리고 아질산염 유병율은 $0.03\%$로 조사 되었다. 2)서울지역 1개교(875명)선별 정밀검사 결과: 1차검사 단백뇨 양성자 8명($0.91\%$)중 1명은 기립성 단백뇨, 나머지 7명은 일시적 단백뇨로 확인되었다. 1차검사 혈뇨 양성자는 41명($4.86\%$)이었고 이중 재검이 가능했던 33명중 6명만이 지속적인 혈뇨 양성자였고, 다시 시행한 정밀검사에서 한명만이 무증상 단독 혈뇨증으로 확인되었으며 나머지 5명은 정상이었다. 1차 소변검사 이상자 52명에 대한 혈액검사 및 초음파검사는 모두 정상이었다. 1차검사에서 혈뇨 양성자 33명중 1명(약$3\%$)만이 신질환이 의심되는 경우였고 나머지 32명($91\%$)은 정상이었다. 결 론 : 1) 혈뇨검사는 위양성이 높기 때문에 ($97\%$) 집단뇨검사에 포함시킬 경우 불필요한 시간과 경비의 낭비가 있을수 있다고 생각된다. 2) 집단뇨검사는 검사 기관에 따라 얻어지는 결과의 차이가 심하기 때문에 단일 기관으로 통합 관리해야 할 것이다. 3) 요로감염증의 선별검사에서 농뇨와 아질산염 검사는 양성율이 낮으므로 그 효용성에 대한 연구는 좀더 필요하다고 생각된다.

• 혜화의학회지
• /
• 제18권2호
• /
• pp.81-88
• /
• 2009

Background : Almost people know hypertension's treatment is taking western medicine. But korean herbal medicine(KHM) also have an effect of turning down blood pressure. Objectives : This study aims to review the influence of KHM on hypertension in korean internal medicine's studies systematically. Additionally, we tried to estimate the change of data of hypertension and let people know a possibility of herbal treatment on hypertension. Methods : Systematic studies searches were performed on one database of korean internal medicine to November 2009. Screening and selection of the studies and extraction of data were performed by one author. Results : Twelve studies were included. All studies were performed retrospectively. Almost studies's object were hypertensive rats. Two studies's object were rabbits and only one study's object was hopitalized patients. Blood pressure and pulse was changed significantly after taking KHM in almost studies, and rest of items, aldosterone, catecholamine, electro, angiotensin converting enzyme inhibitory effect, renin activity were changed significantly after taking KHM. Conclusions : KHM might have an effect of lowering blood pressure, but almost studies's object were animals, so it is necessary to investigate an effect of KHM for people.

• 대한한방내과학회지
• /
• 제21권2호
• /
• pp.291-297
• /
• 2000

Objective : In order to find antiviral compounds against Herpes simplex virus type I(HSV-1) and II(HSV-2) from herb medicines, a convenient virus-induced cytopathic effect(CPE) inhibition assay was introduced. Methods : Fourteen purchased herbal medicines, and their toxicity of infected cell and anti-viral activities were evaluated. Among them, the major part of herbal medicines showed cell stability compared with the contrast. Results : Cytotoxic concentration (CC) of the $H_2O$ extracts of Hyongbangpaedoksan against HSV-1 and HSV-2 was 181.12. This is high level cytotoxic concentration compared with the contrast. Therefore, we assumed that the high level cytotoxic concentration of herbal medicine play a major role in improvement of antiviral activity at the first infective cell. But antiviral effect was unable to figure out for selective index(Sl)=CC50/EC50. The other herbal medicines were unable to showed potent anti-HSV activity. Conclusions : The antiviral activation using herbs in this thesis have unlimited objects, to select research object will help to show the direction of antiviral drug development that have less side effect and more excellent efficiency.

• 대한한방종양학회지
• /
• 제4권1호
• /
• pp.199-209
• /
• 1998

In order to find antiviral effect against Human immunodeficiency virus(HIV), Herpes simplex virus type I(HSV-1) and II(HSV-2) from herb medicines, publicated 29 paters on anti-viral effect of herbal medicines and a convenient virus-induced cytopathic effect (CEP) inhibition assay was introduced. The major virus on experiment are HIV, Hepatitis B virus and HSV-1,2. Those of other studies showed inhibition of infected virus DNA replication and screening test of herbal medicines. More than 15 extractions were prepared by pure water boiling from herbal medicines, and their toxicity of infected cell and anti-viral activities were evaluated. Among them, the major part of herbal medicines showed cell stability compared with the contrast. Cytotoxic concentration (CC) of the $H_2O$ extracts of Padoo against HIV was <4.0, Hyungbangpaedoksan against HIV was 9.3, Whangyonhaedoktang against HIV-1 and HSV-2 was 15.3. These are high level cytotoxic concentration compared with the contrast. But antiviral effect was unable to figure out for selective $index(SI)=CC_{50}/EC_{50}$. The other herbal medicines were unable to showed potent anti-HIV and anti-HSV activity. The antiviral activation using herbs in this thesis have unlimited objects, to select research object will help to show the direction of antiviral drug development that have less side effect and more excellent efficiency.

• 정보처리학회논문지:컴퓨터 및 통신 시스템
• /
• 제12권2호
• /
• pp.85-92
• /
• 2023

코로나바이러스감염증-19와 같은 호흡기 감염병은 주로 밀집/밀폐/밀접 공간인 실내에서 일어난다. 호흡기 감염병 이상징후의 존재 여부는 발열, 기침, 재채기 및 호흡곤란 등의 초기 증상을 통해 판단되고 있으며, 이러한 초기 증상에 대한 상시 모니터링이 요구된다. 열화상 온도 스크리닝 시스템은 개인의 피부 온도 상승의 징후가 있는지 초기에 선별하는 빠르고 쉬운 비접촉 스크리닝 방법을 제공하지만, 측정 타겟, 주변 온도 등의 측정 환경과 피 측정대상과의 측정 거리에 따른 오차로 인해 정확한 온도측정이 어렵다. 그리고 국제표준 IEC 80601-2-59 에서는 내안각(Inner Canthus) 인접한 영역에 대한 안면 열화상 촬영을 권고하고 있다. 본 논문에서는 가시광 카메라 모듈과 열화상 카메라 모듈에 대해서 이미지 일치화 보정을 수행하였으며, 흑체(Blackbody)를 이용해 측정 환경에 대한 열화상 카메라 모듈 온도를 보정하였다. 표준에서 권고하는 측정 타겟을 인식하기 위해 딥러닝 기반 객체 인식 알고리즘과 내안각 인식 모델을 개발하였으며, 100명의 실험자군에 대한 데이터셋을 적용하여 인식 모델 정확도를 도출하였다. 또한 라이다 모듈을 이용한 객체 거리 측정과 선형회귀 보정 모듈을 통해 측정 거리에 따른 오차를 보정하였다. 제안한 모델의 성능 측정을 위해 모터 스테이지, 열화상 온도 스크리닝 시스템, 흑체로 구성된 실험환경을 구축하였으며, 1m에서 3.5m 사이 가변 거리에 따른 온도측정 결과 0.28℃ 이내의 오차 정확도를 확인하였다.

• 대한임상검사과학회지
• /
• 제41권1호
• /
• pp.42-46
• /
• 2009

Unlike most bacteria, Treponema pallidum subspecies cannot be readily isolated or sustained in cell culture for numerous generations. In korea, two non treponemal tests are currently considered as standard; the VDRL slide test and RPR card test. These tests are based on an antigen composed of an alcoholic solution containing measured amount of cardiolipin, cholesterol, and sufficient purified lecithin to produce reactivity. The nontreponemal reagin tests measure immunoglobulin M (IgM) and IgG to lipoidal material released from damaged host cells as well as to lipoprotein-like material and possibly by cardiolipin released from the treponemes. The object of the evaluation was to evaluate the performance of the Mediace RPR kit on the automated biochemistry analyzer system as a method for screen method of syphilis as well as to identify BFP possibility. For evaluation of routine screening test, a total 2,380 specimens tested by Mediace RPR from 28th Oct, 2007 to 22th Feb, 2008. For evaluation of BFP possiblility, we measured samples which have potential BFP reaction in Syphilis test such as ANA (anti-nuclear antibody) positive (135 samples), CRP (C-reactive protein) positive (100 samples), RF (Rheumatoid factor) positive (26 samples), and other potential BFP cases (17 samples) including total 278 samples. These samples were tested quantitative test Mediace RPR with Hitachi 7600 P module. For comparison with current manual test, VDRL slide test were performed. Of these 2380 specimens, 2350 were negative, 30 were positive, and one were positive with TPHA. Both methods agreed for 2356 (98.9%) samples. Of the 30 samples showed positive results over 1.0 R.U, 6 samples showed positive results with VDRL test. Of these 6 samples, 1 samples showed positive with TPHA test. The combination of the Automated Biochemistry analyzer and VDRL test for retest can be increase efficiency of syphilis screening test.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권9호
• /
• pp.4521-4524
• /
• 2012

Object: In the present study, we compared the positive cytodiagnostic test rates with discrepancies using self-collection devices for cervical cancer screening. We made this survey to examine whether or not our self-smear preparation method using the Kato self-collection device contributed to an improved rate of detecting atypical cells compared with existing recommended preparation methods. Methods: Specimens were collected at 14 facilities handling self-collection methods, and samples were collected by a physician in 2 facilities. The chisquared test was performed using the SPSS ver. 20 statistical software to determine the relationships between the positive cytodiagnostic rate, specimen preparation methods, and self-collection devices. Results: Collecting cells using the Kato self-collection device and preparing liquid-based specimens, we obtained a significantly higher rate of positive cytodiagnosis and our results were equal to those obtained with the direct method. Conclusions: Taking into consideration increased needs for screening using the self-collection method in future, with even more improved test accuracy, a screening test that is acceptable to society needs to be established.

• 수산경영론집
• /
• 제34권1호
• /
• pp.185-211
• /
• 2003

Initially, the system of outside director of cooperative has the object of consulting an external specialist. Recently, it takes a serious view of monitoring about securing clean management on the operating crisis. Nevertheless, in the field of NFFC(National Federation of Fisheries Cooperatives), it is difficult that the system of outside director of cooperative attains that is initial object. And in the field of FC(Fisheries Cooperative), it isn't in force about the outside director of cooperative. Therefore, it is important to make a following system improvement. (1) The ratio of outside directors among the member of board of directors has to be increased. (2) Outside director's term of office has to be amended from lyears to 2years and the current method of selection should be reformed to be a strict one with high standard of requirement and substantial screening for membership. (3) Outside directors' wage system must be actualized by adopting incentive system' etc. A measure of appointing an executive in a similar business line or organizations to ours as an outside director must be considered. FC have to introduce the system of outside director. (4) A recognition of proper management of outside directors and putting in practice is essential.

• Biomolecules & Therapeutics
• /
• 제27권4호
• /
• pp.349-356
• /
• 2019

Behavioral analysis in mice provided important contributions in helping understand and treat numerous neurobehavioral and neuropsychiatric disorders. The behavioral performance of animals and humans is widely different among individuals but the neurobehavioral mechanism of the innate difference is seldom investigated. Many neurologic conditions share comorbid symptoms that may have common pathophysiology and therapeutic strategy. The forced swim test (FST) has been commonly used to evaluate the "antidepressant" properties of drugs yet the individual difference analysis of this test was left scantly investigated along with the possible connection among other behavioral domains. This study conducted an FST-screening in outbred CD-1 male mice and segregated them into three groups: high performers (HP) or the active swimmers, middle performers (MP), and low performers (LP) or floaters. After which, a series of behavioral experiments were performed to measure their behavioral responses in the open field, elevated plus maze, Y maze, three-chamber social assay, novel object recognition, delay discounting task, and cliff avoidance reaction. The behavioral tests battery revealed that the three groups displayed seemingly correlated differences in locomotor activity and novel object recognition but not in other behaviors. This study suggests that the HP group in FST has higher locomotor activity and novelty-seeking tendencies compared to the other groups. These results may have important implications in creating behavior database in animal models that could be used for predicting interconnections of various behavioral domains, which eventually helps to understand the neurobiological mechanism controlling the behaviors in individual subjects.

• 한국컴퓨터정보학회논문지
• /
• 제28권4호
• /
• pp.105-112
• /
• 2023

농산물 선별 시스템은 작물의 형태를 보전하기 위하여 비파괴적인 선별이 주로 사용된다. 이러한 비파괴 선별 기술로는 가시광선, 근적외선, 엑스선, 감마선 등의 광학적 특성을 이용하고 있으며 본 논문에서는 엑스선을 이용한 선별을 이용한다. 엑스선 영상은 엑스선의 밀도에 따라 그레이 영상으로 생성되어 육안으로 시료의 결함을 감지하기가 어렵다. 미세한 결함을 발견하기 위해서는 영상을 확대하거나 픽셀의 범위를 수정하여 적정한 픽셀의 영역만을 표시하여 결함을 탐지해야 한다. 이런 작업은 비효율적이다. 따라서 본 논문은 엑스선의 광역적인 밀도와 지역적인 밀도에 대한 상대적인 밀도를 측정하여 색상화된 결함을 표시하는 새로운 방법을 제안한다. 하나의 픽셀에 대한 상대적인 밀도는 주위 픽셀과의 상대적인 차이를 나타내며, 이런 픽셀을 정상과 결함으로 나타내는 엑스선 영상의 색상화 방법도 제안한다. 실험에서는 육안으로 볼 수 없는 농작물의 병해충 또는 새싹 부분을 특정 색으로 색상화 하여 농산물 선별 시스템에 활용할 수 있게 하였다. 제안된 방법은 엑스선을 이용한 선별 시스템에 적용되어 농산물 선별 시스템뿐만 아니라 가공식품, 부품 제조와 같은 제조 공정에서 사용되어 불량품을 선별하는 방법에 적극적으로 이용될 수 있을 것이다.