• Journal of Korean Medicine for Obesity Research
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• v.18 no.1
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• pp.27-35
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• 2018

Objectives: The aim of this study is to investigate the effects of Daecheongryoung-tang (DCR) therapy on body weight, serum total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglyceride, free fatty acid, total lipid, phospholipid level and complete blood cell count of obese rats. Methods: 34 rats are divided into 4 groups, the rats in the normal group are 7 and the rats in the other group are 9 per group; Normal group (general fat diet and no medication), Control group (high-fat diet and no medication), DCR_L group (high-fat diet and DCR 250 mg medication) and DCR_H group (high-fat diet and DCR 500 mg medication). DCR is administrated for 6 weeks. Results: There is significant statistical difference between Control group and DCR-H group for the body weight, the total cholesterol, LDL cholesterol, triglyceride, free fatty acid level. Also, there is significant statistical difference among Control group, DCR_L group and DCR_H group for body weight, triglyceride, free fatty acid and phospholipid level. Conclusions: These results suggest that medication of DCR_L and DCR_H is effective for the treatment of obesity.

• Nutrition Research and Practice
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• v.5 no.6
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• pp.503-510
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• 2011

The aim of this study was to investigate whether a water extract of L. cladonioides (LC) has an anti-obesity effect in 3T3-L1 cells and obese mice. Treatment of differentiated 3T3-L1 adipocytes with LC caused a significant increase in glycerol release and reduced the protein expression of the adipogenic transcription factors, $PPAR{\gamma}$ and C/$EBP{\alpha}$. In an animal model, obese mice were artificially induced by a high fat diet for 10 weeks. Experimental groups were treated with LC (100 mg/kg/day) by gavage for the next 10 weeks. At the end of experiment, the body weight of the LC group mice was reduced by 14.2% compared to the high fat diet (HFD) group. The treatment also decreased liver (31.0%), epididymal (18.0%) and retroperitoneal (19.3%) adipose tissue, and kidney (6.7%) weights, respectively, compared with those of the HFD group. LC prevented diet-induced increases in the serum level of TC (22.6%), TG (11.6%), and glucose (35.0%), respectively, compared with the HFD group. However, the HDL-C level was higher in the LC group (26.1%) than the HFD group. The results of this study thus suggest that LC suppressed lipid accumulation and expression of adipogenic transcription factors, and increased the amount of glycerol release. LC also indicated an anti-obese and anti-hyperlipidemic effect.

• The Korean Journal of Community Living Science
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• v.27 no.1
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• pp.147-159
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• 2016

The purpose of this study was to evaluate the dietary quality of Korean females according to BMI, using the Korea National Health and Examination Survey data (KNHANES V-1). The study incorporated an individual-based, one-on-one interview with a cohort of 3,552 Korean females, including underweight, obese, and normal subjects, based on BMI calculation from 8,958 samples throughout the country. In this study, BMI between 18.5 and 25 was considered as normal, < 18.5 as underweight, and ${\geq}25$ as obese. We classified the subjects into three groups: the underweight group (n = 206), normal group (n = 2,353) and obese group (n = 993). The result of analysis of nutrient intake was a percentage of Korean RNI. Overall, calcium intake tended to be lower for groups with lower BMI. The result of dietary quality are as follows: For NAR analysis, all groups showed a less than 1.0 for all nutrient levels. In particular, with respect to calcium, all groups showed to have a lower NAR score than that of other nutrients; this was also the case for the Vitamin A. The average NAR score was 0.76 in the underweight group, 0.83 in the normal group, and 0.78 in the obese group. The results suggest the necessity of obesity-related nutritional education programs in Korea, particularly for Korean women.

• Journal of the Korean Dietetic Association
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• v.19 no.2
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• pp.103-111
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• 2013

In this study, we examined chewing frequency, eating rates, and food consumption volume according to the body mass index of male and female college students. Twenty-five male college students were divided into a normal weight male group (<23 body mass index, n=14) and an obese male group (${\geq}23$ body mass index, n=11). Twenty-five female college students were divided into a normal weight female group (<23 body mass index, n=21) and an obese female group (${\geq}23$ body mass index, n=4). Subjects were provided with abundant fried rice and allowed to consume it at their own pace. Chewing frequency, total mealtime, rate of eating, consumption volume, calorie intake, and the amount of one bite were measured. There were no significant differences in chewing frequency, total mealtime, rate of eating, consumption volume, calorie intake, and the amount of one bite between the normal and obese male groups. There were also no significant differences in chewing frequency, consumption volume, calorie intake, and the amount of one bite between the normal and obese female groups. However, the obese female group had a significantly shorter mealtime and significantly higher eating rate compared with the normal group. Thus, our study suggests that females who eat a meal for a longer time may reduce their food intake, consequently inducing body weight loss.

• Journal of the Korea Convergence Society
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• v.9 no.10
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• pp.449-456
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• 2018

The purpose of this study was to identify the effects of bicycling exercise by analyzing the changes of inflammation-related factors and growth hormone with obese middle-aged women for 8 weeks to identify the effects of bicycle exercise. In this study, 15 middle aged obese women were divided into exercise group and control group. Changes in inflammation-related factors and growth hormone were analyzed as a measurement variable were analyzed by employing two-way ANOVA with repeated measures. This study finds that $TNF-{\alpha}$ and IL-6 were significantly decreased in the exercise group and increased in the control group. Growth hormone was increased in the exercise group but not in the control group. The results of this study suggest that bicycling exercise is an exercise program to prevent cardiovascular and chronic diseases of obese middle-aged women.

• Journal of Korean Academy of Nursing
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• v.35 no.5
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• pp.858-867
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• 2005

Purpose: This study was done to determine the effects of walking exercise training(WET) on metabolic syndrome risk factors and body composition in obese middle school girls. Method: A non-equivalent pretest-posttest experimental design was used. Twenty seven subjects participated in this study from one women's middle school in Busan. The participants were purposely allocated to an experimental group (n=14) and a control group (n=13). The experimental group participated in 30-60 minutes of WET with 55 to $75\%$ of a maximal heart rate six days a week for 12 weeks. Results: The prevalence of individual risk factors on metabolic syndrome were improved in the experimental group after the intervention. The high waist circumference(WC), high triglyceride(TG), low high density lipoprotein cholesterol(HDL-C), high blood pressure(BP) and high fasting glucose(FG) were 21.4, 21.4, 14.3, 28.6 and $7.2\%$, respectively. There were significant differences in WC (F=22.24, p<.001), TG (F=5.34, p=0.30), body weight(F=21.99, p<.001), fat mass(F=19.17, p<.001), and $\%$ body fat(F=17.93, p<.001) between the experimental and control group after the intervention. However, there were no significant differences in HDL-C, FG and BP between the experimental and control group after the intervention. Conclusion: These results indicate that WET is effective in decreasing risk factors of the metabolic syndrome and body composition components in obese middle school girls. These findings suggest that WET can be useful as a nursing intervention in the prevention of obesity-related disorders in obese adolescents.

• The Journal of Pediatrics of Korean Medicine
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• v.32 no.2
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• pp.1-10
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• 2018

Objectives This study investigated the effects of Hataedock treatment with Douchi on induction of allergic rhinitis in obese induced NC/Nga mice. Methods NC/Nga mice were divided into control group (Ctrl), allergic rhinitis induced obese mice group (ARE), and allergic rhinitis induced obese mice group with Douchi Hataedock treatment (FGT). The 3-week-old mice of the FGT group were given one 10 mg/kg dose of Douchi Hataedock extract and sensitized with allergic antigens at weeks 4, 5, and 6. After 1 week of final sensitization, allergic rhinitis was induced primarily in mice nasal cavities for five days. After one week of the completion with the first induction, the second induction was introduced by the same method. After 1 week, few samples of the nasal mucosal tissues of each group were prepared. The factor of Th2 differentiation and inflammation control such that IL-4, STAT6, CD40, $Fc{\varepsilon}RI$, substance P, MMP-9, $NF-{\kappa}B$ p65, p-IkB, iNOS and COX-2 were observed by immunohistochemistry. Also, the difference in nasal mucosal injury was observed by histochemical method (PAS staining). Results The FGT group showed that reduced IL-4 production, STAT6 expression and CD40 expression by regulating excessive Th2 differentiation. Also, production of substance P and MMP-9 and activity of $Fc{\varepsilon}RI$ in mast cells were decreased. Inhibition of $NF-{\kappa}B$ p65 activity was induced by inhibition of p-IkB, and the production of inflammatory enzymes iNOS and COX-2 were decreased. In addition, the damage of intramural respiratory epithelium was low and excessive mucin secretion in goblet cells was low. Conclusions This study confirmed the possibility of controlling the allergic rhinitis in obese children who are expected to have an overactive inflammation.

• Toxicological Research
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• v.34 no.1
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• pp.41-48
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• 2018

The efficacy of highly active antiretroviral therapy (HAART) has led to an increase demand for therapeutic use, thereby necessitating investigation into drug toxicity. This study was designed to investigate the in vivo effects of HAART on sperm parameters and testicular oxidative stress in lean and obese rats. Wistar rats (males, n = 40, weighing 180~200 g) were assigned randomly into 4 groups and treated accordingly for 16 weeks as follows: Control (C): lean group fed with standard rat chow; Diet induced obesity (DIO): obese animals fed a high caloric diet; C + ART: lean animals treated with HAART; DIO + ART: obese animals treated with HAART. An antiretroviral drug combination of Tenofovir, Emtricitabine and Efavirenz at a dose of 17, 26 and 50 mg/kg/day was administered for the latter 6 weeks via jelly cube feeding. At the end of the experimental period, sperm analysis was performed on sperm collected from the caudal epididymis, while the testis was homogenized for antioxidant enzyme and lipid peroxidation assays. Results showed that HAART significantly decreased sperm motility (p < 0.05) in both lean and obese animals, and viability (p < 0.05) in the DIO group. Testicular glutathione, catalase and superoxide dismutase were significantly decreased (p < 0.05), while Thiobarbituric acid reactive substances (TBARS) levels were significantly increased (p < 0.05) when the DIO+ART group was compared to Control group. Thus, the decreased sperm qualities associated with HAART might be as a result of increased testicular oxidative stress prominent in obese animals.

• Journal of the Korean Society of Clothing and Textiles
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• v.17 no.3
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• pp.448-458
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• 1993

The purpose of this study was to study real body size and ideal body shape by consoidering the degree of satisfaction at body part and understanding body size by the degree of leanness/obesity. The subjects in this study were 201 female college students aged from 18 to 26. Boby measurements and survey were taken from May to June, 1991 and 1992. Data were analyzed by correlation analysis, regression analysis, cluster analysis, ANOVA, discriminant analysis and crosstabulation analysis. The results were as follows ; 1. The subjects tended to be satisfied with long and slim limbs, slim trunk, and prefered to be tall in height and light in weight. Also the consciousness about thickness was keener than that about length of the body. 2. The subjects were conscious that lower body was more obese than and upper body. Also, the consciousness of whole body had higher correlation with that of upper body than lower body. 3. The subjects were classified into 4 clusters each consisting 23, 87. 68, 23 by cluster analysis of 21 variables after a transformation of measurements to eliminate body size factor. This classification was considered to express how lean or how obese a human body appears. 4. According to the degree of leanness/obesity from lean tendency group I to obese tendency group IV, characteristics of the body shape were changed as follows ; height lower, limbs shorter, trunk and limbs thicker and weight heavier. 5. The subjects of lean tendency group I were more satisfied with their body than those of obese tendency group IV. 6. The subjects, although they were not judged to be obese by somatometric measurements, felt themselves obese. Also, they hoped to be slimmer at lower body than upper body.

• Journal of Community Nutrition
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• v.8 no.2
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• pp.63-68
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• 2006

This research analyzed the hematological index and health related habits such as alcohol drinking, smoking and exercise, by classifying 539 middle-aged men (age: 40 - 59) into a normal weight group, an overweight group and an obese group, according to BMI (body mass index). As a result, 33.6% (n = 181) of subjects had a BMI of 23 or less and 30.2% (n = 163) were overweight and 36.2% (n = 195) were obese (BMI > 25). The average systolic/diastolic blood pressures of total subjects were 130.96mmHg and 80.38mmHg, respectively. And the average pressure of normal subjects was 126.85/77.57mmHg, which was significantly lower than in overweight and obese subjects. Diastolic blood pressure shows significant differences among the three groups. The overall average cholesterol level of normal subjects was 193.81mg/dl, which was significantly lower than those in overweight subjects. Those in obese subjects were significantly higher than in overweight subjects. The GOT (glutamic oxaloacetic transaminase), GPT (glutamic pyrutic transaminase), ${\gamma}$-GTP (gamma-glutamyl transpeptidase) levels of obese subjects were significantly higher than in the overweight subjects. Frequency of alcohol drinking showed no significant difference among the groups. The smoking ratio in the obese group was higher than in the normal and overweight groups. The ratio of smokers was 53.1 %, and the alcohol drinking ratio was 81.0% of the total subjects. The frequency of drinking showed significant correlations with systolic blood pressure (p < 0.05) and diastolic blood pressures (p < 0.01) and ${\gamma}$-GTP (p < 0.01). The duration of smoking showed a negative correlation (p < 0.01) with diastolic blood pressure, total cholesterol and ${\gamma}$-GTP. On the other hand, exercising frequency showed negative correlations with blood glucose, ${\gamma}$-GTP and GPT(p < 0.01). These hematological indices were correlated with health related habits such as alcohol drinking, smoking and lack of exercise, and to be the cause of chronic diseases. Therefore, proper nutritional education is needed to establish advisable health related habits to maintain proper body weight. (J Community Nutrition 8(2): 63-68, 2006)