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Studies on Phenotype of Reproduction and Production of Human Growth Hormone(hGH) with Transgenic Rats II. Different Reproductive Phenotypes Determined by hGH Levels in hGH Transgenic Rats (Human 성장호르몬을 도입한 Transgenic Rats의 작출과 번식표현형에 관한 연구 II. 형질전환된 Rats의 hGH수준이 번식표현형에 미치는 영향)

  • 장규태;김성현;성환후;주학진;박미령;윤창현
    • Korean Journal of Animal Reproduction
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    • v.22 no.2
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    • pp.137-143
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    • 1998
  • The effects of continuous GH(hGH) secretion on the female reproduction was studies in adults female transgenic rats expressing the hGH gene with a mouse whey acid protein (mWAP) promotor. Two line of transgenic female rats carrying the mWAP/hGH gene were established and used in the study. One was characterized by relatively high levels of serum hGH (high line), and the other had relatively low levels (low line). 1. High line female rats had recurring, Pseudopregancy-like estrous cycles accompanied by increased serum progesterone level for 2 weeks after ovulation, and they were fertile. 2. In the rats, luteinization occurred spontaneously without cervical stimulation, probably due to high levels of serum hGH, which has prolactin (PRL)-like activity in the rat. 3. Low line female rats had recurring, regular 4-days estrous PRL surge following cervical stimulation were not, detected and PRL secretion was not induced by a dopamine antagonist. 4. The ovarian tissue in this line had a much higher number of corpora lutea and grew much heavier than in normal littermates, suggesting impairment of PRL induced structural luteolized. Su, pp.ession of PRL secretion in the low line rats was, at least in part, due to a marked decrease in the number of lactotrophs in the pituitary. The present study shows that the serum hGH level plays a crucial role in regulating luteal function in female transgenic rats expressing the hGH gene.

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An approximate procedure for throughput of 3-stage flow line considering quality inspection (품질을 고려한 3-stage flow line의 수율 근사계산)

  • Lee, Jong-Seung;Ji, Yong-Hoon
    • Journal of Industrial Technology
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    • v.16
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    • pp.207-216
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    • 1996
  • This paper develops an algorithm for throughput of a 3-stage flow line with job inspection stations, limited buffer capacity, and exponential processing times. Each stage consists of a single workstation, and an infinite number of jobs always waits in front of the first workstation. Blocking may occur when a processed job is waiting at one workstation for another workstation to become available. Numerical example results provide insights into the problems related to quality inspection and measure of performance of flow lines.

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A Study on the Squeal Noise for Domestic EMU (국내 전동차 스퀼소음에 관한 연구)

  • 문경호;김재철;유원희;서정원
    • Proceedings of the KSR Conference
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    • 2002.10a
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    • pp.66-71
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    • 2002
  • Squeal noise is generated by railway vehicles transversing tight curves. This squeal has always been noticed as one of the most disturbing noise sources of railway systems. At present we cannot predicted squeal noise that is influenced by a large number of dependent parameters. In this study, we performed structural analysis to find out the frequency of the wheel and also measured squeal noise at Seoul subway line 1, line 2, line 4 for domestic EMU(Electrical Multiple Unit).

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Establishment and Identification of a Debao Pony Ear Marginal Tissue Fibroblast Cell Line

  • Zhou, X.M.;Ma, Y.H.;Guan, W.J.;Zhao, D.M.
    • Asian-Australasian Journal of Animal Sciences
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    • v.17 no.10
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    • pp.1338-1343
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    • 2004
  • The Debao pony ear marginal tissue fibroblast cell line (NDPEM 2/2) was uccessfully established using either primary explant technique or collagenase technique. The characterizations of the cell line were identified as following: the cells were adherent and of density limitation; population doubling time (PDT) of cells made with the two techniques were 35.9 h and 48 h, respectively; chromosome analysis showed that the frequency of cell chromosome number to be 2n=64 was 91.3%-92.8%. Confirmed by isoenzyme analysis, this cell line had no cross- contamination. Tests for microbial contamination from bacteria, fungi, virus or mycoplasma were negative. This newly established cell line meets all the standard quality controls of ATCC. It will provide a precious genetic resource for the conservation of the Debao pony breed, as well as effective experimental material for genetic studies on Debao ponies.

The Arrangement of Stocker for Optimization Number and Utilization (Stocker 수와 가동률의 최적화를 위한 Stocker 배치 방법)

  • 안종호
    • Proceedings of the Korea Society for Simulation Conference
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    • 1999.10a
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    • pp.30-34
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    • 1999
  • 반도체 산업의 시장은 매년 증가하고 있으며 생산환경, 설비 등의 변화로 인하여 매년 많은 수의 기존 FAB Line이 변화되고 새로이 건설되고 있다. 그 동안 반도체 산업의 성장은 주로 설계기술, 설비기술, Chip Size의 소형화 등의 기술적인 개발에 의존하고 있었으나 반도체 기술의 확산, 시장 경쟁력의 격화 등으로 생산성 향상에 의한 원가절감이 성장의 근본요인이 되고 있다. 즉 FAB Line의 시스템적인 관리통제의 기술이 반도체 산업의 성패를 좌우하는 시대로 접어든 것이다. FAB Line은 크게 Bay와 Stocker, 각 Lot (또는 Batch) 들을 운반하는 Inter-System으로 구성된다. 이러한 Line은 대체 특성, 분기 현상, 돌발 상황 등의 특수한 경우가 많아 Analytic 모델로 접근하기에는 사실상 불가능하다. 특히 Stocker와 Bay 간의 이동은 더욱 그렇다. 따라서 적절한 설계과정을 거친 Simulation적 접근이 합리적이다. 본 논문에서는 FAB Line에서 Stocker 배치의 다양한 실험을 수행하였다. 그 결과 Line에서 최적의 Stocker 수와 가동률을 알아내었다. 반도체 생산라인에서는 제품별 또는 같은 제품이라도 Version이 다른 경우 FAB 공정가운데 약 10% 내외만이 바뀌는 점을 감안하면 본 논문의 결과는 쉽게 생산현장에 적용될 수 있을 것이며, 이것은 비단 반도체 공정뿐 아니라 제조업에서도 적용되리라 예상한다.

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Application of Bucket Brigades in Assembly Cells for Self Work Balancing (자율적인 밸런싱을 실현하는 Bucket Brigade 기반의 조립셀 운영방식)

  • Koo, Pyung-Hoi
    • IE interfaces
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    • v.22 no.2
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    • pp.144-152
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    • 2009
  • Assembly line has been recognized as an efficient production system in mass production. However, the recent production environment characterized as mass customization urges production managers to transform a long assembly line to a number of short assembly cells. To maximize the utilization of resources in an assembly cell, it is important to have the line balanced. This paper presents a bucket brigade-based assembly cell. Bucket brigade is a way of coordinating workers who progressively perform a set of assembly operations on a flow line. Each worker follows a simple rule: perform assembly operations on a product until the next worker downstream takes it over; then go back to the previous worker upstream to take over a new assembly job. In this way, the line balances itself. The bucket brigade assembly cell is analyzed and compared with traditional assembly lines and general assembly cells. The paper also discusses some prerequisite requirements and limitations when the bucket brigade assembly cells are employed.

Calculation Method of Dedicated Transmission Line's Meteological Data to Forecast Renewable Energy (신재생에너지 예측을 위한 송전선로의 계량 데이터 계산 방법)

  • Ja-hyun, Baek;Hyeonjin, Kim;Soonho, Choi;Sangho, Park
    • KEPCO Journal on Electric Power and Energy
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    • v.8 no.2
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    • pp.55-59
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    • 2022
  • This paper introduce Renewable Energy forecasting technology, which is a part of renewable management system. Then, calculation method of dedicated transmission line's meteorological data to forecast renewable energy is suggested. As the case of dedicated transmission line, there is only power output data combined the number of renewable plants' output that acquired from circuit breakers. So it is need to calculate meteorological data for dedicated transmission line that matched combined power output data. this paper suggests two calculation method. First method is select the plant has the largest capacity, and use it's meteorological data as line meteorological data. Second method is average with weight that given according to plants' capacity. In case study, suggested methods are applied to real data. Then use calculated data to Renewable forecasting and analyze the forecasting results.

Heritabilities, Genotypic and Phenotypic Correlations, and Selection Indices in Aromatic Tobacco Varieties(Nicotiana tabacum L. (향끽미종 잎담배 유전에 관한 연구)

  • 김준철;황주광
    • Journal of the Korean Society of Tobacco Science
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    • v.3 no.1
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    • pp.49-57
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    • 1981
  • To obtain genetic information for breeding aromatic tobacco, broad sense heritabilities, phenotypic, and genotypic correlations were obtained for the following characters : days to frowert, plant height, number of leaves, leaf shape and nicotine. Six pure line varieties and the first and second generations of 5 crosses among them were employed in this study. The heritabilities for number of leaves and nicotine were very high in pure line varieties. However, the heritabilities for days to flower and yield were low in six varieties as well as in F2. Genotypic correlations had higher values than phenotypic did. Heritabilities calculated from segregating generations were lower than those from pure varieties, regardless of crosses involved. Positive phenotypic correlations between yield and plant height were observed in all crosses. Same phenomenon was observed with correlations between days to flower and number of leaves. The genotypic and phenotypic variances and covariances entering into the computation of correlations were used to construct the seletion indices for yield. The use and limitation of selection index was also discussed.

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Analysis on the free surface flow induced by a pair of source-sink in Stokes flow (스톡스 유동장 내의 한 쌍의 소오스-싱크에 의한 자유표면 유동해석)

  • Jeong, Jae-Tack;Park, Jong-Sun
    • 한국전산유체공학회:학술대회논문집
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    • 2008.03b
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    • pp.304-307
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    • 2008
  • Two-dimensional Stokes flow due to the line source and line sink of same strength in semi-infinite flow region with free surface is analysed using complex variable theory and conformal mapping. Surface tension effects are included while gravity is neglected. From the results of analysis, flow pattern and free surface shape are obtained and velocity distribution on the free surface is determined with 2 independent parameters Ca (capillary number) and h (non-dimensionalized distance between source and sink). When the location of the sink is above the source, velocity on the free surface converges and a cusp occurs on the free surface for the value of Ca above some critical capillary number.

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