• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제16권1호
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• pp.106-116
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• 2005

연구목적 : 초기 청소년 ADHD 고위험군을 과잉행동-충동성을 동반하지 않는 부주의성 유형(ADHD-I)과 과잉행동-충동성을 동반한 유형(ADHD-HI/C)으로 분류한 후, 이들 간에 기질 및 기질 적합성과 문제행동에서의 차이점을 비교하고자 하였다. 방법 : 서울 모 남자 중학교 1, 2학년생과 그 부모를 대상으로 연구를 실시하였다. ADHD 고위험군을 선정하기 위해 ADHD 행동증상을 평정하는 세 척도 '((1)' 한국어판 ADHD 평가척도, (2) 부모용 단축형 코너스 평가척도, (3) 청소년용 단축형 코너스-웰스 자가평정척도)를 사용하여 2개 척도 이상에서 상위 $20\%$에 해당하는 경우를 고위험군으로 선정하였고, 이 중 ADHD평정척도의 부주의성 차원과 과잉행동/충동성 차원을 활용하여 각각 상위 $20\%$의 조합으로 하위유형을 분류하였다. 최종 연구대상은 ADHD-I 고위험군이 25명, ADHD-HI/C 고위험군이 70명, 정상군이 70명 이었다. 기질 및 기질 적합도를 측정하기 위해 학생들에게는 '개정판 기질차원척도' (DOTS-R)를, 부모에게는 '개정판 기질차원척도 : 맥락' (DOTS-R : Ethnotheory)을 사용하였으며, 문제행동 특성을 평가하기 위해 '한국판 청소년 문제행동 자가평정 척도' (K-YSR)를 이용하였다. 결과 : 기질 면에서는 ADHD-HI/C 고위험군이 다른 집단에 비해 '일반적인 활동수준' (general activity)이 두드러지게 높았다. 부모의 기대 맥락에서는 '일반적인 활동수준'에서 ADHD-HI/C 고위험군이 다른 두 집단에 비해 높아 자녀의 활동성에 대한 기대가 컸으며, '새로운 자극에 대한 융통/경직성' (flexibility/rigidity) 및 '기분' (mood) 면에서 세 집단 간에 차이가 유의미했는데 특히 자녀의 긍정적 기분을 기대하는 수준에서 ADHD-I 고위험군의 부모와 ADHD-HI/C 고위험군의 부모간에 유의한 차이가 있었다. 기질 적합도에서는 '기분'과 관련하여 세 집단 간에 차이가 유의미했는데, 특히 ADHD 고위험군의 두 하위유형은 정상군보다 '기분'과 관련된 적합도과 낮아 정서적인 차원에서 부모-자녀 간 부적합성이 ADHD의 행동증상과 관련되어 있음을 시사하였다. 문제행동 영역에서는 ADHD-HI/C 고위험군이 내면화 및 외현화 문제 모두에서 뚜렷하게 문제행동이 많은 것으로 나타났으며, ADHD 하위유형별로 비교할 때 외현화 문제에서는 ADHD-HI/C 고위험군이 ADHD-I 고위험군에 비해 유의하게 심각했지만 내면화 문제에서는 두 유형 간에 심각도의 차이가 유의하지 않았다. 결론 : 초기 청소년 ADHD 고위험군의 기질 및 기질 적합성 특성이 하위유형에 따라 차이가 있는 것으로 나타났으며, 이는 청소년 ADHD 행동증상 및 하위유형의 발현이 기질 뿐 아니라 환경과의 상호작용과 중요한 관련이 있음을 시사하였다. 또한 청소년 ADHD 행동증상과 하위유형은 기질 특성에서는 활동성 차원이, 기질 적합성 특성에서는 기분 차원이 연관이 있었다. 문제행동 특성에서는 하위유형별로 서로 다른 양상을 보였다.

• 근관절건강학회지
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• 제1권1호
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• pp.97-115
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• 1994

The purpose of this study was to examine the reliability and validity of the observed behaviors of subjects who suffered from low back pain with spinal diseases, Thirty two low back pain patients admitted on the neurosurgical unit in an army hospital were compared with 30 normal controls belonged to an army unit, by means of matching the age, hight and weight. Observed pain behaviors were developed by the researcher on the bases of literature and patient observation. This tool consists of 18 behaviors seperated into two major groups : mutually exclusive and concomittent behaviors. The mutually exclusive behaviors included coding cathegories for 6. body motions assumed by the subjects during the observation session. These 6 standardized motions consisted of sitting from standing first, and serially tying down, reclining, sitting again, and then standing, 6 steps walking. Concomittent behaviors consisted of 12 observable patterns that can be observed systematically from the face, grimacing, bracing, rubbing, walking with arms fixed, support with hands on sitting or standing, guarded movement, limping, unbalaced weightbearing, stopped movement from tying position to sitting, sighing and graoning. Subjects were videotrecorded as they performed a 6-standardized sequence of motions, simultanously researcher measured the time spent performing each motion and step length. Patients were asked torate their subjective pain score on the 10 mm graphic rating scale ranging from 'no pain' to 'sever pain'. For scoring of the pain behaviors, two trained nursing officiers independently and simutanously viewwd each videorecording and checked subject 'pain behaviors at the observational item checklist. The result of the study are summarized as follows : 1. Reability of the observational tool was a=.845. 2. Spearman's rho and percentage agreement were p=.97 and 81.7 persent respectively, that indicate adequate interrater reability of this tool. 3. The sensitivity rate of the tool was .875 while specificity rate .866 for differentiating patient from the normal. 4. When difference in the objective pain indices between patient group and control were compared, there was significant difference of all indices, such as pain behavior(t=7.71, p=.0001). spent time performing motion(t=14.2, p=.0001), step length (t=-10.72, p=.0001). 5. There were differences in the objective indices the subjective pain subgroups (low, medium, high). Differences in the mean score of objective pain behavior (F=6.376. p=.005) and spent time for moyion(F=4.631, p=.018). But there were no significant differences in the step length among the subgroups(F=.667, p=.521). 6. Highly correlated pain behavior items wiyh subjective pain score were 'stopped movement from lying position to sitting', 'limping', 'support with hands on sitting or standing', 'bracing', 'guarding' and 'walking with arms fixed'. In summary, although some of rho behavior items such as sighing and groaning in this study could not be observed because of videotaped datd, the reliability and validity of the over all observation method were satifactory. Thus, the results of the present study demonstrate rye potetional utility of the tool in assessing objective pain complementing self-reported pain in low back pain patients.

• BMB Reports
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• 제56권10호
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• pp.563-568
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• 2023

DNA methylation regulates gene expression and contributes to tumorigenesis in the early stages of cancer. In colorectal cancer (CRC), CpG island methylator phenotype (CIMP) is recognized as a distinct subset that is associated with specific molecular and clinical features. In this study, we investigated the genome-wide DNA methylation patterns among patients with CRC. The methylation data of 1 unmatched normal, 142 adjacent normal, and 294 tumor samples were analyzed. We identified 40,003 differentially methylated positions with 6,933 (79.8%) hypermethylated and 16,145 (51.6%) hypomethylated probes in the genic region. Hypermethylated probes were predominantly found in promoter-like regions, CpG islands, and N shore sites; hypomethylated probes were enriched in open-sea regions. CRC tumors were categorized into three CIMP subgroups, with 90 (30.6%) in the CIMP-high (CIMP-H), 115 (39.1%) in the CIMP-low (CIMP-L), and 89 (30.3%) in the non-CIMP group. The CIMP-H group was associated with microsatellite instability-high tumors, hypermethylation of MLH1, older age, and right-sided tumors. Our results showed that genome-wide methylation analyses classified patients with CRC into three subgroups according to CIMP levels, with clinical and molecular features consistent with previous data.

• Journal of Community Nutrition
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• 제1권1호
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• pp.10-15
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• 1999

This study was undertaken with 542 fifth-grade elementary school children to investigate the characteristics in lifestyle, eating habits, food preferences of overweight and obese children in the Pocheon area of Korea. Anthropometry was conducted to determine obesity, and data was obtained on lifestyle, eating habits and food preferences by using questionnaires. The prevalence rate of obesity was 19.5% for boys and 8.5% for girls, and 14.3% of boys and 14.4% of girls were overweight. No significant differences was found in the body size and education years of parents, family income and the empolymental status of mother. Boys did not show any significant difference between subgroups in lifestyle, eating habits and food preferences. Obese girls watched TV longer and liked physical education less than normal and overweight groups, suggesting that an inactive lifestyle can be related to girls' obesity in this study. Overweight girls answered that they had significantly lower preferences for empty-calorie foods such as candies/caramels and cookies as well as high-fat foods such as samgyupsal(pork belly) than normal weight girls, implicating the fear of obesity for overweight girls, although more studies should be done including an assessment of actual intake of these foods. The preferences of obese girls for these foods were not higher than those of normal-weight girls, suggesting that the preference for certain foods may not be the characteristic of obese girls in this study. A special program for nutritional education with a different focus should be developed to combat the problems of each subgroup depending on gender and obesity status to improve the physical fitness of the children in this area.

• 생물정신의학
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• 제24권4호
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• pp.212-218
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• 2017

Objectives We aimed to examine whether mindfulness skills are mediating the improvements of depressive symptoms in patients with mood disorders who practiced Mindfulness-Based Cognitive Therapy (MBCT). Methods A total of 19 patients with mood disorder were included in this study. The participants were divided into two subgroups: a normal to mild depression group and a moderate depression group. The participants completed questionnaires to assess depressive symptoms, anxiety, quality of life, suicidal idea, and mindfulness skills which were measured by the Five Facets of Mindfulness Questionnaire (FFMQ) before and after MBCT course. Results The moderate depression group showed improvements through MBCT in depressive symptoms and suicidal idea, but not in anxiety and quality of life. The normal to mild depression group showed no significant change through MBCT. The improvement of depressive symptoms in the moderate depression group was predictable by improvements of the five facets of mindfulness, especially by 'observe' and 'non-react' components. Conclusions This study showed that currently depressive patients with moderate severity but not with normal to mild severity benefit from MBCT in reducing depressive symptoms and suicidal idea. The improvement of depressive symptoms was mediated by improved mindfulness skills through MBCT.

• 한국식품영양학회지
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• 제27권4호
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• pp.570-580
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• 2014

The purpose of this study was to investigate the effect of calcium (Ca) and vitamin D (vit. D) levels on metabolism of various minerals such as Ca, P, Mg, Fe, Zn, Cu, and Cr. The comparison was made on the rats that were placed on diet containing powdered skim milk with different Ca and vit. D levels for 5 weeks. A total of 42 5-week-old Sprague-Dawley rats were divided into 7 groups as follows: Control group consisted of normal Ca and normal vit. D (0.5% Ca, 1,000 IU vit. D); Experimental groups were divided into low (0.25%) and high (1.0%) calcium levels; and vit. D group was divided into low (10 IU), normal (1,000 IU), and high (5,000 IU) subgroups. The weight gain and food efficiency ratios of the rats were not significantly different with increasing dietary Ca levels. The absorption rates of 7 minerals (Ca, P, Mg, Fe, Zn, Cu, and Cr) were significantly decreased with increasing dietary Ca levels. Also, fecal excretion of P significantly increased with increasing dietary vit. D levels (p<0.05), and urine excretion of Fe was significantly increased with increasing dietary vit. D levels (p<0.001). The result indicated that higher Ca intake affected on bioavailability of other minerals, due to interactions among minerals in the process of intestinal absorption. However, vitamin D intake had no effect on bioavailability of several minerals. Therefore, it could be suggested that adequate Ca intake is important for balance of the minerals.

• 치과방사선
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• 제28권1호
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• pp.205-213
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• 1998

This study was designed to reveal the correlationship between the internal derangement state of TMJ and clinical characteristics including pain and mandibular dysfunction. One hundred and twenty five subjects with TMJ signs and symptoms were chosen for two years. The level of pain and madibular dysfunction were evaluated by Visual Analog Scale(VAS) and Craniomandibular Index(CMI). The diagnostic categories of TMJ internal derangement were determined by arthrography and they included normal disc position, anterior disc displacement with reduction(ADDR), rotational disc displacement with reduction (RDDR), anterior disc displacement without reduction(ADDNR), and rotational disc displacement without reduction(RDDNR). Also disc perforation was used as a criteria to divide the diagnostic subgroups. The obtained results were as follows; 1. The patient distribution of each group was 5 in normal disc position(4％), 40 in ADDR(32％), 30 in RDDR(24％), 34 in ADDNR(27％), and 16 in RDDNR(13％). 2. Perforation was observed in 8％ of ADDR, 10％ of RDDR, 32％ of ADDNR, and 19％ of RDDNR. 3. CMI of non-reduction group was higher than that of reduction or normal group(p<0.05), but V AS showed no significant difference.4. CMI of perforation group was higher than that of non-perforation group in reduction group (p<0.05). 5. There were no significant differences of CMI and VAS between anterior disc displacement group and rotational disc displacement group in both reduction and non-reduction group. 6. CMI of RDDNR group was higher than that of RDDR group(p<0.05). 7. There were no significant difference of CMI and VAS between bilateral involvement group and unilateral involvement group(p<0.05).

• 대한지역사회영양학회지
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• 제9권3호
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• pp.292-302
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• 2004

The nutritional status of middle-aged overweight and control normal subjects were evaluated for the purpose of providing the background information of the degenerative disease control. A survey was conducted with 293 healthy subjects (121 males and 172 females) between the ages 40-64. The average BMI (body mass index) of male subjects was 24.5 $\pm2.75$, and that of females was 23.5 $\pm2.87$. The average values of WHR (waist-hip ratio) were 0.88 $\pm0.04$, for males and 0.82 $\pm0.07$, for females. The normal BMI group (BMI 18.5-22.9) comprised 28.9% of males and 47.1% of females. The percentage of overweight subjects (BMI 23-24.9) was 26.4% of males and 30.8% of females. The obese group (BMI ＞ 25) was 44.6% of males ana 22.1% of females, showing the greater rate of obese state among male subjects. The average energy intakes were 76.6 $\pm14.9$% for males and 77.8 $\pm12.6$, % for females, protein intakes were 108.0 $\pm24.6$% for males and 111.2 $\pm22.7$, % for females of the RDA levels. The average intakes of other nutrients were above the 75% of RDA levels except calcium. The average nutrient intakes of the three subgroups according to their BMI values were not different for both males and females. There were weak correlations between obesity and blood biochemical indices. There were positive correlations between BMI or WHR and hemoglobin, hematocrit, fasting glucose, total cholesterol, triglyceride, AST or ALT. There were negative correlations between BMI or WHR and HDL-cholesterol. These results suggest that the obesity rate of middle-aged is an influential factor of chronic disease. The middle-aged subjects of this study with higher educational and socioeconomic background tend to have desirable nutrition knowledge and attitude, but the application of their knowledge or attitude was relatively poor.

• The Korean Journal of Physiology
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• 제5권1호
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• pp.23-42
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• 1971

1. 인삼주정추출물이 흰쥐의 부신, 간, 비장 및 췌장의 핵산 함유량에 어떤 영향을 미치며, 인삼 투여를 받고 있는 동물이 스트레스(ACTH의 투여로 대신)를 받을 경우에 이들 장기 핵산 함유량에 어떠한 변동이 오는지를 알기 위하여 90마리의 흰쥐($150{\sim}200gm$) 수컷을 인삼군과 식염수군 및 정상군으로 나누고 이것을 각각 다시 둘로 쪼개어 인삼군, 인삼-ACTH군, 식염수군, 식염수-ACTH군, 정상군 및 정상-ACTH군의 여섯 작은 무리로 나누어 다음과 같은 실험을 하였다. 인삼군과 인삼-ACTH군에서는 몸무게 100gm에 대하여 인삼주정추출액(생리적 식염수 1ml속에 4mg의 인삼주정추출물이 포함된 용액)을 0.5ml의 비율로 매일 등뒤 피하에 5일동안 주사하였으며, 식염수군과 식염수-ACTH군에는 생리적 식염수를 몸무게 100gm에 대하여 0.5ml의 비율로 인삼군과 동일한 방법으로 주사하였다. 실험시작 제 5일째에 정상군과 식염수군 및 인삼군은 각각 전처치 없이 또는 인삼 혹은 식염수 주사후 2시간 만에 도살하고, 정상-ACTH군, 인삼-ACTH군 및 식염수-ACTH군은 각각 직접 또는 인삼이나 식염수를 투여한 다음 1시간 만에 ACTH를 주사하고, 그 시각부터 1시간후에 도살하여 부신, 간, 비장 및 췌장 조직의 핵산 함유량을 측정하였다. 이들 측정치를 지표로하여 인삼이 장기 핵산에 미치는 영향을 관찰한바 다음과 같은 결과를 얻었다. 1) 부신조직 RNA, DNA 및 RNA/DNA는 인삼군의 값이 정상군 및 식염수군의 그것보다 현저하게 많다. 인삼군의 값에 대한 인삼-ACTH군 값의 감소율은 정상군 및 식염수군에 대한 정상-ACTH군 및 식염수-ACTH군의 그것보다 현저하게 크다. 2) 간 조직의 RNA, DNA 및 RNA/DNA는 인삼군의 값이 정상군 및 식염수군의 값보다 현저하게 감소되었다. 인삼군 값에 대한 인삼-ACTH군 값의 감소율은 정상군 및 식염수군에 대한 정상-ACTH군 및 식염수-ACTH군의 그것 보다 적다. 3) 비장 조직의 RNA와 RNA/DNA는 인삼군의 값이 정상군의 그것 보다 현저하게 증가되며, 식염수군 보다는 감소된다. 인삼군의 DNA는 정상군에서 보다 감소되며, 식염수군의 그것 보다 증가된다. 인삼군 값에 대한 인삼-ACTH군 값의 감소율은 정상군에 대한 정상-ACTH군의 그것 보다 크며, 식염수군에 대한 식염수-ACTH군의 그것 보다는 작다. 4) 췌장 조직의 RNA와 DNA는 인삼군의 값이 정상군 및 식염수군의 그것 보다 현저하게 감소된다. 인삼군의 RNA/DNA는 정상군 및 식염수군의 그것 보다 증가된다. 인삼군에 대한 인삼-ACTH군의 RNA와 RNA/DNA 감소율은 정상군에 대한 정상-ACTH군의 그것 보다 적으나 식염수군에 대한 실염수-ACTH군의 그것 보다는 현저하게 크다. 인삼-ACTH군의 DNA는 인삼군의 그것 보다 증가되었으나, 정상-ACTH군 및 식염수-ACTH군의 DNA는 정상군 및 식염수군의 그것보다 감소되었다. 이상의 실험성적만으로 명확한 해석을 내리기는 어려우나 인삼은 장기의 RNA, DNA 및 RNA/DNA 비율에 현저한 영향을 미치는 것으로 보인다. 대체로 인삼은 부신의 RNA와 DNA 함유량 및 RNA/DNA 비율을 모두 증가시키나 다른 장기에서는 이들 값을 감소시키는 경향이 있다. 한편 인삼의 투여를 받은 동물에서는 ACTH투여후 조기에 부신 조직의 RNA, DNA 및 RNA/DNA의 감소율이 커지며, 간, 비장 및 췌장 조직의 RNA, DNA 및 RNA/DNA의 감소율은 적어지는 경향이 있다. 2. 인삼 및 ACTH의 투여에 의하여 부신, 췌장, 간 및 비장의 DNA와 RNA 함유량이 변동하는 모습을 화학적 방법으로 추적하여 얻은 전편의 성적을 형태학적 및 조직화학적 방법으로 입증할 목적으로 몸 무게 18~20gm의 마우스 수컷 40마리와 몸 무게 150~200gm의 흰쥐 수컷 20마리를 사용하여 각각 식염수군, 인삼군, 식염수-ACTH군 및 인삼-ACTH군의 4무리로 나누고 그중 마우스에서는 $^{3}H$-thymidine을 이용한 자기방사법을 써서 부신, 췌장, 비장 및 간등 4조직의 DNA 합성능을 비교 관찰하고, 흰쥐에서는 methylgreen pyronine 염색을 이용한 조직화학적 방법을 써서 위의 4조직의 RNA 함유량을 측정한 바 다음과 같은 결과를 얻었다. 1. 인삼 투여는 마우스의 부신피질과 비장 및 간의 표지 세포수를 식염수의 투여만을 받은 대조동물의 그것에 비하여 유의하게 증가시키나, 췌장에서 만은 오히려 표지 세포 수효를 감소시킨다. 그리고 인삼을 투여받은 흰쥐의 부신을 비롯하여 췌장, 비장 및 간 조직은 모두 methylgreen pyronine에 의하여 식염수군에서 보다 짙게 염색된다. 2. 식염수-ACTH군 및 인삼-ACTH군의 표지 세포수는 부신피질, 췌장, 비장 및 간 조직에서 모두 식염수군 및 인삼군에 비하여 감소되고, methylgreen pyronine으로 염색 할 경우에도 이들 조직은 식염수군 및 인삼군에 비하여 모두 묽게 염색된다. 3. 그러나 인삼-ACTH군의 표지 세포수는 부신피질, 비장, 췌장 및 간 조직에서 모두 식염수-ACTH군의 그것에 비하여 덜 감소되며, pyronine 염색에서도 4조직은 모두 식염수-ACTH군에서 보다 짙게 염색된다. 그러므로 인삼은 핵산 함유량에 현저한 영향을 미쳐 대체로 핵산의 생성을 촉진시키며, ACTH투여로 인하여 야기되는 조직 핵산 함유량의 감소를 어느 정도 억제한다.

• Korean Journal of Mathematics
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• 제19권2호
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• pp.181-189
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• 2011

Let G be a group and X be a nonempty set and H be a subgroup of G. For a given ${\phi}_G\;:\;G{\times}X{\rightarrow}X$, a group action of G on X, we define ${\phi}_H\;:\;H{\times}X{\rightarrow}X$, a subgroup action of H on X, by ${\phi}_H(h,x)={\phi}_G(h,x)$ for all $(h,x){\in}H{\times}X$. In this paper, by considering a subgroup action of H on X, we have some results as follows: (1) If H,K are two normal subgroups of G such that $H{\subseteq}K{\subseteq}G$, then for any $x{\in}X$ ($orb_{{\phi}_G}(x)\;:\;orb_{{\phi}_H}(x)$) = ($orb_{{\phi}_G}(x)\;:\;orb_{{\phi}_K}(x)$) = ($orb_{{\phi}_K}(x)\;:\;orb_{{\phi}_H}(x)$); additionally, in case of $K{\cap}stab_{{\phi}_G}(x)$ = {1}, if ($orb_{{\phi}_G}(x)\;:\;orb_{{\phi}H}(x)$) and ($orb_{{\phi}_K}(x)\;:\;orb_{{\phi}_H}(x)$) are both finite, then ($orb_{{\phi}_G}(x)\;:\;orb_{{\phi}_H}(x)$) is finite; (2) If H is a cyclic subgroup of G and $stab_{{\phi}_H}(x){\neq}$ {1} for some $x{\in}X$, then $orb_{{\phi}_H}(x)$ is finite.