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Intravenous patient-controlled analgesia hydromorphone combined with pregabalin for the treatment of postherpetic neuralgia: a multicenter, randomized controlled study

  • Huang, Ying;Xu, Chenjie;Zeng, Tao;Li, Zhongming;Xia, Yanzhi;Tao, Gaojian;Zhu, Tong;Lu, Lijuan;Li, Jing;Huang, Taiyuan;Huai, Hongbo;Ning, Benxiang;Ma, Chao;Wang, Xinxing;Chang, Yuhua;Mao, Peng;Lin, Jian
    • The Korean Journal of Pain
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    • v.34 no.2
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    • pp.210-216
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    • 2021
  • Background: Postherpetic neuralgia (PHN) is the most common complication of acute herpes zoster. The treatment of PHN remains a challenge for clinical pain management. Despite the effectiveness of anticonvulsants, antidepressants, and lidocaine patches in reducing PHN, many patients still face intractable pain disorders. In this randomized controlled study, we evaluated whether hydromorphone through intravenous patient-controlled analgesia (IV PCA) was effective in relieving PHN. Methods: Patients with PHN were randomly divided into two groups, one group received oral pregabalin with IV normal saline, another group received oral pregabalin with additional IV PCA hydromorphone for two weeks. Efficacy was evaluated at 1, 4, and 12 weeks after the end of the treatments. Results: Two hundred and one patients were followed up for 12 weeks. After treatment, numerical rating scale (NRS) score of patients in the hydromorphone group was significantly lower than that of the control group, and the difference of NRS scores between the two groups was statistically significant at 4 and 12 weeks after treatment. The frequency of breakthrough pain in the hydromorphone group was significantly lower than that in the control group 1 and 4 weeks after treatment. After treatment, the quality of sleep in the hydromorphone group was significantly improved compared with the control group. The most common adverse reactions in the hydromorphone group were dizziness and nausea, with no significant respiratory depression. Conclusions: IV PCA hydromorphone combined with oral pregabalin provides superior pain relief in patients with PHN, which is worthy of clinical application and promotion.

The Relationship of Anxiety, Risk Perception, Literacy, and Compliance of Preventive Behaviors during COVID-19 Pandemic in Nursing Students (간호대학생의 코로나19에 대한 불안, 위험인식, 정보이해력 및 감염예방행위 수행간의 관계)

  • Park, Jin-Hee;Kim, Ji-Hye;Lee, Hyun-Ju;Kang, Purum
    • Journal of the Korean Applied Science and Technology
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    • v.38 no.1
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    • pp.48-59
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    • 2021
  • This study aimed to explore anxiety, risk perception, information literacy, and performance level of infection prevention practices against coronavirus disease (COVID-19) among nursing students during the pandemic. A descriptive online survey was conducted, targeting a total of 224 nursing students from June 8, 2020 to 14, 2020. The collected data were analyzed using descriptive statistics, t-test, analysis of variance, and correlation analysis using SPSS 26.0. The nursing students' level of anxiety was 6.86 out of 10, which was normal. Their information literacy level and performance level of infection prevention practices were 3.50 out of 4 and 4.44 out of 5, respectively, and these scores were considered high. The higher the level of anxiety, risk perception, and information literacy, the higher the level of infection prevention practices. The level of anxiety with respect to infection and risk perception may increase when new types of infectious diseases such as COVID-19 break out. Therefore, it is necessary to promote the accurate understanding of the infectious diseases by providing sufficient information. Accurate understanding of new infectious diseases can reduce the risk of transmission as it encourages people to thoroughly perform infection prevention practices.

The Factors of Self-esteem, Anger Expression on the SNS Addiction Tendency among High School Students (고등학생의 자아존중감과 분노표현이 SNS중독경향성에 미치는 영향 요인)

  • Kim, Ji-Hyeon;Kim, Hyang-Soo;Kim, Gun-Hee;Kim, Min-Ju;Kim, Yoon-Sun;Kim, Jung-Won;Nam, Kyung-Min
    • Journal of the Korean Applied Science and Technology
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    • v.38 no.1
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    • pp.157-167
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    • 2021
  • This study is a descriptive research study to find out the relationship between degree of Self-Esteem, Anger-Out, Anger-In, Anger-Control and SNS Addiction Tendency of high school students, and the factors that influence SNS addiction tendency. For a total of 10 days from May 18 to 28, 2020, a total of 100 people were collected using online questionnaires to those who were attending high schools in S and G regions and using SNS. As a result of the study, SNS addiction tendency and self-esteem(r=.385, p<.001), anger-control(r=-.354, p<.001) showed a normal inverse correlation, and an anger-out (r=.321, p=.001), anger-in (r=308, p=.002) showed a common net correlation. Factors affecting SNS addiction tendencies were self-esteem(β=-.297, p=.001), gender(β=.266, p=.003), and anger-out(β=.247, p=.007), with 27.7% explanatory power in the regression model(F=12.279, p<.001). Therefore, it is necessary to develop programs to increase high school students' self-esteem and lower their anger-out in order to reduce SNS addiction tendencies, especially for female high school students in gender.

The Relationship between Health and Mind-Body State According to Five Colors Preference (오색(五色)선호도에따른 건강과 심신상태의 관련성 연구)

  • Ahn, Ji-Hye
    • Journal of Naturopathy
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    • v.9 no.1
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    • pp.1-12
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    • 2020
  • Purposes: The purpose of this study was to investigate the relationship between five viscera, environmental and seasonal changes, and their preference for five colors. Methods: The survey performed using the Chinese medicine constitution and the five cardinal colors (Red, Blue, Yellow, White, Black) paper. Results: The blood types distributions were A, O, B, AB, and others in order. The proportion of smokers(75.6%) and non-drinkers(25.6%). Their color preferences were highest in blue and the lowest in black, but not significant. The proportion of the viscera was stomach(45.3%), liver-lung, intestine, and heart, and the tastes were spicy(48.8%), sweet, sour, salty, and bitter in order. Blue was the highest in all. kidneys(8.3%) preferred red and bitter yellow. The change in mind(35.7%) was highest, followed by scary thoughts and their color preferences varied. The most preferred place was 'cold place,' and 'dry place' was low. The most preferred seasons were 'autumn (38.6%), and the lowest was rainy. And their colors preference were blue. The respondents(89.9%) were normal, 5.7% hypertension and 4.4% hypotension. Healthy people preferred blue (91.8%) and hypertensives yellow with not significant. The diabetics preferred blue and red(p<.04). Conclusions: In the questionnaire survey on the health and physical abnormalities of Seoul citizens, various distributions found in each category, and most of them preferred blue. The results indicated that the questionnaire and the five- colored preference were a little interrelated. However, the results are to be primary data for research in this field.

The Effects of Pre-service Early Childhood Teacher's Sense of Humor and Emotional Intelligence on Teacher Efficacy (예비유아교사의 유머감각과 정서지능이 교사효능감에 미치는 영향)

  • Kim, Ji-Yoon
    • Journal of Korea Entertainment Industry Association
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    • v.15 no.6
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    • pp.141-151
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    • 2021
  • The purpose of this study was to investigate the pre-service early childhood teacher's sense of humor, emotional intelligence on their teacher efficacy. The subjects of this study were 253 pre-service early childhood teachers in Seoul and Gyeonggi province. The statistical analysis of this study was analyzed using the SPSS V. 22.0 program. The result of the study is summarized as follows. First, in terms of the result for general trends in sense of humor, emotional intelligence, and teacher efficacy were found to be above normal. Second, the result of the current study reveals that the sense of humor, emotional intelligence, and teacher efficacy was correlated. Also, there was a statistically significant positive correlation between the sense of humor, emotional intelligence, and teacher efficacy. Third, it was found that the 'creation of humor', 'humor preference' of sub-factor in the sense of humor, and 'to perceive other people's emotion' of sub-factor in emotional intelligence affected the early childhood pre-service teacher's teacher efficacy. Therefore, it is necessary to promote both sense of humor and emotional intelligence in order to enhance the teacher efficacy in pre-service early childhood teachers.

Gingival pigmentation treatment using Er;YSGG laser (Er;YSGG 레이저를 이용한 치은 색소침착 제거 증례보고)

  • Kim, Hyunjong
    • Journal of the Korean Academy of Esthetic Dentistry
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    • v.30 no.2
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    • pp.53-58
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    • 2021
  • The attractiveness of the gingiva is determined by its color, shape, and the shape and location of the boundary between the teeth and the gingival tissue. The standards beauty, balance, and health of the gingiva are all different, but the general public would agree that a coral pink gingiva is more beautiful than black or brown gingiva. Hence, one would be able to smile more confidently in public if he or she receives a gingival pigmentation removal surgery that changes the color of black or brown gums to a beautiful pink color with relative simplicity. The color of one's gingiva varies from pale pink to deep bluish purple, depending on many health components. The most prominent among these include the vascular supply, epithelial thickness, the degree of keratinization, and the presence of pigment in the epithelium. Melanin, carotene, reduced hemoglobulin, and oxyhemoglobulin are the main pigments contributing to the normal color of the oral mucosa. The health of one's gingival tissue are essential for an attractive smile. Excessive melanin deposits in the basal and early basal layers of the epithelium stored in the form of melanosomes frequently cause pigmentation. Although there are many different procedures to remove this pigmentation, the it was removed using the Er;YSGG laser. It is my wish that, through this case study, many people

DoS/DDoS attacks Detection Algorithm and System using Packet Counting (패킷 카운팅을 이용한 DoS/DDoS 공격 탐지 알고리즘 및 이를 이용한 시스템)

  • Kim, Tae-Won;Jung, Jae-Il;Lee, Joo-Young
    • Journal of the Korea Society for Simulation
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    • v.19 no.4
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    • pp.151-159
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    • 2010
  • Currently, by using the Internet, We can do varius things such as Web surfing, email, on-line shopping, stock trading on your home or office. However, as being out of the concept of security from the beginning, it is the big social issues that malicious user intrudes into the system through the network, on purpose to steal personal information or to paralyze system. In addition, network intrusion by ordinary people using network attack tools is bringing about big worries, so that the need for effective and powerful intrusion detection system becomes very important issue in our Internet environment. However, it is very difficult to prevent this attack perfectly. In this paper we proposed the algorithm for the detection of DoS attacks, and developed attack detection tools. Through learning in a normal state on Step 1, we calculate thresholds, the number of packets that are coming to each port, the median and the average utilization of each port on Step 2. And we propose values to determine how to attack detection on Step 3. By programing proposed attack detection algorithm and by testing the results, we can see that the difference between the median of packet mounts for unit interval and the average utilization of each port number is effective in detecting attacks. Also, without the need to look into the network data, we can easily be implemented by only using the number of packets to detect attacks.

Differences in the cardiovascular change in normal and obese according to treadmill exercise (트레드밀 운동에 따른 정상인과 비만인의 심혈관계 변화 차이)

  • Kyung-jin Lee;Young-jun Kim;Sung-hwan Ji;Jeongwoo Jeon;Jiheon Hong;Jaeho Yu;Jinseop Kim;Seong-Gil Kim;Dongyeop Lee
    • Journal of Advanced Technology Convergence
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    • v.2 no.2
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    • pp.39-47
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    • 2023
  • The purpose of this study is to examine the difference in cardiovascular changes between obese people and the general public using a treadmill. This study was conducted by recruiting 32 adult males who had no experience in hospital visits or treatment due to cardiovascular disease. The subjects were divided into an obese group and a general group based on BMI 25 and performed treadmill exercise for 12 minutes. SBP, DBP, HR, MAP, and PP before and after the treadmill were measured to see the difference in cardiovascular system changes. Data analysis was evaluated using an independent t-test. In the case of SBP, MAP, and PP, there were significant differences between groups (P<0.05). For DBP and HR, no significant difference was found between the two groups (P>0.05). The subjects of this study consisted only of healthy adult males in their 20s, and there is a limitation in that it was performed in a short time.

A Study on A Tablet-PC Based Application Design For Self-examination of Dementia (치매 자가 진단을 위한 태블릿 PC용 어플리케이션 설계 연구)

  • Ryu, Neung Hwa;Park, Seung Ho
    • Design Convergence Study
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    • v.13 no.2
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    • pp.143-164
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    • 2014
  • In this study, we suggest a tablet-PC based application as an instrument for self-examination of dementia and aim to evaluate its usability for the practical use. The tool for the self-diagnosis of dementia is testing a person's sentence comprehension, which is investigated by the accuracy of a sentence-picture matching task, and the result of the test can differentiate individuals with dementia of Alzheimer's type from normal aging population. According to its use for diagnosis of dementia, we developed a new version of sentence-picture matching task by a cooperative study with NABLE(Neurogenic communication And Brain Lab at Ewha) and applied to the application as a main function. Targeting the New Silver who are preliminary aged people in Korea, this application can provide them with three values: 'self-', 'easy', and 'simple'. When using this application, users can gain these values by an instruction manual with the recorded guide voice, easy-to-use functions and the simplified menu structure of it. After prototyping, we conducted the usability test and it was proved as a result that the New Silver users can easily operate the application by themselves.

A Study on the Depression Relief Effect of Visual Psychological Stabilization Image Using EEG Analysis (뇌파 분석을 이용한 시각 심리 안정 영상의 우울감 완화 효과에 대한 연구)

  • Gurim Kang;Sooyeon Lim
    • The Journal of the Convergence on Culture Technology
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    • v.9 no.5
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    • pp.563-568
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    • 2023
  • The government's strengthening of the standards for mentally ill patients and expanding the scope of examinations to the entire nation reflects the changing times. According to the OECD's announcement (2021), the incidence of depression and anxiety has more than doubled since the prolonged COVID-19 pandemic in countries around the world, with Korea's prevalence ranking first. However, only 12.1% of those who have been diagnosed with mental disorders received counseling and treatment from experts. The difference between depression and simple depression is significant depending on whether it is medically treated or temporary, but it can be seen that the continuation of depression is depression. In order to reduce this depression, Kandinsky's work was visualized and created. In a study conducted by changing the playback speed of the produced Kandinsky image, beta and gamma values, which showed the largest deviation when compared to depressive patients and normal people, increased significantly when viewed at 90fps, which was most effective in relieving depression. Artistic creations are bound to be accepted differently depending on the individual's perspective, but it is hoped that research that can improve the phenomenon of individuals suffering from depression by integrating artificial intelligence and traditional mental health approaches will be further developed and widely used for treatment.