• Korean Journal of Clinical Laboratory Science
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• v.38 no.3
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• pp.203-207
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• 2006

The purpose of this study was to develop discriminant analysis models for predicting cervical normal/dysplasia case diagnoses using cytometric features derived from the digital image analysis of cell monolayers. The database consisted of 19 cases diagnosed either as normal (n=5), moderate dysplasia (n=7), severe dysplasia (n=7) on monolayer preparations. We studied the nuclear and cytoplasmic characteristics of cells in the normal, moderate dysplasia and severe dysplasia on cervical samples. The morphometric parameters selected for the analysis were nuclear/cytoplasmic ratio and the nuclear variations measured by image analysis on normal and precancerous lesions of cervical smears; several shape factors; area; perimeter; maximal, minimal and equivalent circle diameters. The results showed that the dysplasia samples exhibited changes in both cellular and nuclear form and size but lacked substantial differences in the tumor grades. The coefficient of nuclear variation is as follows to normal cell $21.8{\pm}3.2%$, moderate dysplasia $33.5{\pm}6.1%$, severe dysplasia $27.7{\pm}5.8$ of cervical smears.

• Journal of applied mathematics & informatics
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• v.26 no.1_2
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• pp.355-364
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• 2008

Under pathological stress stimuli, dynamics of a biological system can be changed by alteration of several components such as functional proteins, ultimately leading to disease state. These dynamics in disease state can be modeled using differential equations in which kinetic or system parameters can be obtained from experimental data. One of the most effective ways to restore a particular disease state of biology system (i.e., cell, organ and organism) into the normal state makes optimization of the altered components usually represented by system parameters in the differential equations. There has been no such approach as far as we know. Here we show this approach with a cardiac hypertrophy model in which we obtain the existence of the optimal parameters and construct an optimal system which can be used to find the optimal parameters.

• Journal of applied mathematics & informatics
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• v.26 no.3_4
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• pp.811-818
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• 2008

Biological systems with both protein-protein and protein-gene interactions can be modeled by differential equations for concentrations of the proteins with time-delay terms because of the time needed for DNA transcription to mRNA and translation of mRNA to protein. Values of some parameters in the mathematical model can not be measured owing to the difficulty of experiments. Also values of some parameters obtained in a normal stress condition can be changed under pathological stress stimuli. Thus it is important to find the effective way of determining parameters values. One approach is to use optimization algorithms. Here we construct an optimal system used to find optimal parameters in the equations with nonnegative time delays and apply this optimization result to the Nuclear factor-${\kappa}B$ pathway.

• Clinical and Experimental Reproductive Medicine
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• v.28 no.4
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• pp.295-300
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• 2001

Objective : To assess the effects of progesterone and acetyl-L-carnitine used after treated with Isolate�� gradient before semen cryopreservation-thawing on sperm parameters and membrane integrity. Material and Methods : From April 2001 to July 2001, ten normal male partner of couples who were visited in vitro fertilization (IVF) clinics. the semens were treated with $Isolate^{(R)}$ gradient before cryopreservation, spermatozoa was incubated with progesterone (1, 5 and $10{\mu}M$), acetyl-L-carnitine (2.5, 5 and $10{\mu}M$), or both (progesterone, $1{\mu}M$; and acetyl-L-carnitine, $5{\mu}M$) for 30 min. Results: There were no differences in sperm parameters and vital stain among isolate only treated group, progesterone (1, 5 and $10{\mu}M$), acetyl-L-carnitine (2.5, 5 and $10{\mu}M$) and both (progesterone, $1{\mu}M$; and acetyl-L-carnitine, $5{\mu}M$). But, in high concentration of acetyl-L-carnitine ($10{\mu}M$) treated group, sperm parameters and vital stain were decreased. The statistical method was used ANOVA (Kruskal-Wallis test) and p value was <0.01. Conclusions : Neither progesterone nor acetyl-L-carnitine show to be protective effect on the cryodamage assessed by sperm parameters and vital stain (eosin-Y stain) in normal sperm. High concentration of acetyl-L-carnitine ($10{\mu}M$), however, was harmful effect on cryoprevention.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.54 no.11
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• pp.680-688
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• 2005

The electrical current generated by heart creates not only electric potential but also a magnetic field. We have observed electrophysiological phenomena of the heart by measuring components of magnetocardiogram(MCG) using 61 channel superconducting quantum interference device(SQUD) system. We have analyzed the possibility and characteristics of MCG parameters for diagnosis of ischemic heart disease. A technique for automatic analysis of MCG signals in time domain was developed. The methods for detecting the position, the interval, the amplitude ratio, and the direction of single current dipole were examined in the MCG wave. The position and interval parameters were obtained by calculating the gradients of a envelope curve which could be formed by the difference between the maximum and minimum envelope of multi-channel MCG signals. We show some differences of the frequency contour map between the normal MCG and the abnormal (ischemic heart disease) MCG. The direction of single current dipole can be defined by rotating the magnetic field according to Biot-Savart's law at each point of MCG signals. In this study, we have examined the direction of single current dipole from searching for the centroids of positive and negative magnetic fields. The amplitude ratio parameters for measuring 57 deviation consisted of A$_{T}$/A$_{R}$ and other ratios. and We developed a new analysis method, which is based on the frequency contour map of electromagnetic field. Using theses parameters, we founded significant differences between normal subjects and ischemic patients in some parameters.

• Journal of The Korean Society of Agricultural Engineers
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• v.60 no.1
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• pp.11-20
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• 2018

This study is to calibrate the SWAT (Soil and Water Assessment Tool) water quality of SS (Suspended Solid), T-P (Total Phosphorus), and T-N (Total Nitrogen) by focusing on 2014~2015 drought periods and identify the important parameters. For Gongdo watershed ($366.5km^2$), the SWAT was calibrated for 2 cases of 2002~2006 normal year focusing calibration and 2014~2015 drought focusing calibration respectively. The parameters of N_UPDIS (Nitrogen uptake distribution parameter) and CMN (Rate factor for humus mineralization of active organic nutrients) played important roles for T-N calibration during drought periods. The SWAT SS, T-N, and T-P average $R^2$ (Coefficient of determination) results by focusing on 2014~2015 drought periods calibration showed 0.71, 0.65 and 0.62 while 2002~2006 normal year focusing calibration showed 0.63, 0.58 and 0.50 respectively. Also SWAT SS, T-N, and T-P model efficiency NSE (Nash-Sutcliffe efficiency) results by focusing on drought period (2014~2015) calibrated showed 0.76, 0.77, 0.87 respectively. Even though the SS, T-P parameters were unchanged during the calibration, the SS and T-P results were improved by the hydrological parameters (SCS-CN, SOL_K, SLSOIL) during the drought periods. The SWAT water quality calibration needs to be considered for the movement of SS and nutrients transport especially focusing on the drought characteristics.

• Physical Therapy Rehabilitation Science
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• v.9 no.1
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• pp.10-17
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• 2020

Objective: Hallux valgus (HV) is a common musculoskeletal deformity that is accompanied with pain and continues to decrease one's quality of life and ability to perform daily life activities by affecting gait and static stability. Therefore, this study aimed to investigate the effect of the angle of HV (HVA) and to compare the one-legged stance and gait parameters in young adults with less HV and severe HV. Design: Cross-sectional study. Methods: Forty young adults were divided into two groups, where HVA ≥15° (n=20) was defined as HV, and HVA <15° (n=20) was defined as normal. For balance ability, the center of pressure (COP) path, velocity, length of axis of the COP path, deviation of the x-axis and y-axis, and percentage of foot pressure were measured, and gait, the foot rotation angle, step length, percentage of each phase of the gait cycle, time change from the heel to forefoot, and maximum pressure of the forefoot and midfoot were measured. Results: Significant differences were found in sway length and time change from heel to forefoot during walking between the normal and HV groups (p<0.05). Most parameters were not associated with the HVA, but parameters such as length of axis and time to change from heel to forefoot were significantly associated with the HVA (p<0.05). Conclusions: These results suggest that most one-legged stance and gait parameters were not significantly affected by the HVA in young adults; therefore, future studies are needed in order to address other dynamic parameters and other methods of gait analysis for detecting clinically meaningful conditions.

• The Korean Journal of Applied Statistics
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• v.24 no.6
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• pp.1161-1168
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• 2011

The approximation for the distribution functions of nonparametric test statistics is a significant step in statistical inference. A rank sum test for dispersions proposed by Ansari and Bradley (1960), which is widely used to distinguish the variation between two populations, has been considered as one of the most popular nonparametric statistics. In this paper, the statistical tables for the distribution of the nonparametric Ansari-Bradley statistic is produced by use of polynomially adjusted normal approximation as a semi parametric density approximation technique. Polynomial adjustment can significantly improve approximation precision from normal approximation. The normal-polynomial density approximation for Ansari-Bradley statistic under finite sample sizes is utilized to provide the statistical table for various combination of its sample sizes. In order to find the optimal degree of polynomial adjustment of the proposed technique, the sum of squared probability mass function(PMF) difference between the exact distribution and its approximant is measured. It was observed that the approximation utilizing only two more moments of Ansari-Bradley statistic (in addition to the first two moments for normal approximation provide) more accurate approximations for various combinations of parameters. For instance, four degree polynomially adjusted normal approximant is about 117 times more accurate than normal approximation with respect to the sum of the squared PMF difference.

• The Journal of Korean Physical Therapy
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• v.10 no.1
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• pp.127-138
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• 1998

This study was carried out tn invstigate and compare biomechanical characteristics during free speed gait in hemiplegic patients after stroke who took therapeutic exercise by analyzing kinematic and kinetic data in the sagital plane and electromyographic data. Six patients($41\~69$ years old) and age-matched six volunteers in good health(51-61 years old) wire studied. The patients were sorted into two groups, depending on their self-speed of walking : fast speed group(3 patients) and slow speed group(3 patients). The results were as fellows. : 1. In spatio-temparal parameters, affected and unaffected side of fast group showed symetry but blew group showed asymetry of single limb support, opposite foot contact and stance phase (p<0.05). Compared with normal group, patient group showed slower velocity, shoter stride length and longer double limb support (p<0.05). 2. In the pelvic anterior tilt, patient group showed lower valued than normal group. It. In the ground reaction force-vertical force, fast group showed similar double peak gragh compared with normal group, butvslow group showed lower values without double peak (p<0.05).

• Phonetics and Speech Sciences
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• v.8 no.4
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• pp.89-95
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• 2016

The purpose of this work is to analyze and synthesize the pseudo-periodicity of voice using a source model. A speech signal has periodic characteristics; however, it is not completely periodic. While periodicity contributes significantly to the production of prosody, emotional status, etc., pseudo-periodicity contributes to the distinctions between normal and abnormal status, the naturalness of normal speech, etc. Measurement of pseudo-periodicity is typically performed through parameters such as jitter and shimmer. For studying the pseudo-periodic nature of voice in a controlled environment, through collected natural voice, we can only observe the distributions of the parameters, which are limited by the size of collected data. If we can generate voice samples in a controlled manner, experiments that are more diverse can be conducted. In this study, the probability distributions of vowel pitch variation are obtained from the speech signal. Based on the probability distribution of vocal folds, pulses with a designated jitter value are synthesized. Then, the target and re-analyzed jitter values are compared to check the validity of the method. It was found that the jitter synthesis method is useful for normal voice synthesis.