• Title/Summary/Keyword: non-smokers

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Effects of Erythromycin and New Macrolides on the Serum Theophylline Level and Clearance (혈중 Theophylline 농도 및 청소율에 대한 Erythromycin과 New Macrolides 항생제의 영향)

  • Lee, Heung-Bum;Lee, Yong-Chul;Rhee, Yang-Keun
    • Tuberculosis and Respiratory Diseases
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    • v.45 no.3
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    • pp.546-552
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    • 1998
  • Background: Up to 90% of a theophylline dose is biotransformed, by interaction with one or more the variants of the cytochrome P-450 drug metabolism system. Macrolides affect the elimination of theophylline by influencing on the microsomal enzyme systems. We evaluate the effect of erythromycin and new macrolides on the serum theophylline level and clearance. Method : Subjects consisted of moderate asthmatic patients with normal renal and hepatic functions. All subjects were non-smokers and treated with oral theophylline 400 mg per day. We randomly assigned 53 patients into four groups. Each group was treated with one macrolides, the first group erythromycin(n:19, 500 mg bid), second roxithromycin (n:14. 150 mg bid), third clarithromycin (n:10, 250 mg bid) and fourth azithromycin(n:10, 250 mg bid). We measured the serum theophylline level and clearance at three intervals, at pretreatment, after the first and fourth week after receiving the following macrolides, erythromycin, roxithromycin and clarithromycin. When azithromycin was administered, the serum theophylline level was measured at pretreatment and after one week of treatment They were measured by a computerized program of Bayesian method. Results : When compared with control, erythromycin and roxithromycin-treated groups had a significantly elevated serum theophylline level and decreased clearance. However, there were no significant changes of the serum theophylline level and clearance in clarithromycin and azithromycin-treated groups. Conclusion : These results suggest that theophylline dose may need to be readjusted and have periodic drug monitoring when erythromycin or roxithromycin is administered concurrently.

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The Case-Control Study on the Risk Factors of Stroke in Korean Adults (중풍 발생 위험인자에 대한 환자-대조군 연구)

  • Kang, Kyung-Won;Kang, Byung-Gab;Cga, Min-Ho;Go, Mi-Mi;Park, Sae-Wook;Bang, Oak-Sun;Cho, Ki-Ho;Kim, Yoon-Sik;Choi, Sun-Mi
    • Korean Journal of Oriental Medicine
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    • v.13 no.2 s.20
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    • pp.65-69
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    • 2007
  • Background and Purpose : The purpose of this case-control study was to show the relationship between risk factors(past medical history, BMI, WHR, smoking, drinking), warning signs(dyscinesia, sightless, dysarthria, sensory disorder, numbness, blephalospasm, facial spasm, tension) and the incidence of stroke in korean adults. Methods : 455 stroke patients were enrolled as the case group and 180 non-stroke patients as control group from Oct. 2005 to Feb. 2006. Patients were hospitalized within 2 weeks after the onset of stroke. Obesity were defined as $BMI{\geq}25kg/m2$, $WHR{\geq}0.9$ in male and $WHR{\geq}0.8$ in female. Risk factors and warning signs were obtained from personal interview. The analysis of the data was done by chi-square test. Fisher's exact test and test-sample t-test. Results : The percentage of current smokers(or current drinkers) of case group is higher significantly than that of control group. The past medical history of risk factors were found to be transient ischemic attack(p=0.0698), facial palsy(p=0.4061), hypertension(p<0.0001), hyperlipidemia(p=0.1484), DM(p<0.0001), ischemic heart disease(p=0.0093), migraine(p=0.0014) and hypochondria(p=0.2370). $WHR{\geq}0.9$ in male had a 6.696 (3.711-12.082) odds ratio, $WHR{\geq}0.8$ in female had a 1.567 (0.659-3.726) odds ratio. $BMI{\geq}25kg/m2$ had a 2.017(1.263-3.222). The dyscinesia and sensory disorder of warning signs were found to be statistical difference between case and control group. Conclusions : According to the above results, it was found that smoking, drinking, BMI, WHR, hypertension, DM, ischemic heart disease, migraine affected to the incidence of stroke.

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Repeatability and Appropriate Predicted Value of Portable Spirometry on Korean Adults (휴대용 폐기능 검사기의 재현성과 기대치에 관한 연구)

  • Choi, Jun-Yong;Jung, Hee-Jae;Lee, Kun-Young;Jeong, Seung-Yeon;Hwang, Joon-Ho;Rhee, Hyung-Koo;Jung, Sung-Ki
    • The Journal of Internal Korean Medicine
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    • v.26 no.3
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    • pp.587-595
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    • 2005
  • Objectives : The object of this study was to evaluate repeatability of portable spirometry and to determine an appropriate equation for predicted value. Materials and Methods : The subjects were 76 men and 45 women recruited from among Kyunghee University oriental medical students. Portable spirometry was performed via the procedure recommended in ATS guidelines. Repeatability of spirometry was checked against ATS repeatability standards and NHLEP QC grade. Percentage of predicted value of non-smokers was calculated through a Caucasian population-based regression equation(by Morris et al.) and Korean population based regression equation(by Kim et al.). These were compared. Result : 91.7% of subjects matched repeatability standards of ATS and 95% of subjects got interpretable NHLEP QC grades of A, B, and C. Mean percentage of predicted value by Morris et al. were as follows: Mean of FVC% was 90.86, FEV1% was 96.66, FEV1/FVC% was 107.48. Mean percentage of predicted value by Kim et al. were as follows. Mean FVC% was 92.38, FEV1% was 89.77, FEV1/FVC% was 96.95. Conclusions : Results of this study show that more than 90% of subjects meet repeatability criteria. This supports a role for the portable spirometer as a primary oriental medical office tool. Further, results are a verify that they Korean population-based predicted value equation is a more appropriate standard than the Caucasian population-based one, but a still more accurate standard is needed for the Korean adult population.

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The Relationship between Health-related Quality of Life and Yangseng Level among Blue-Collar Workers (일부(一部) 생산직(生産職) 근로자(勤勞者)들의 건강관련(健康關聯) 삶의 질(質)과 양생수준(養生水準)과의 관계(關係))

  • Bae, Jae-Ryong;Jeong, Myong-Soo;Lee, Ki-Nam
    • Journal of Society of Preventive Korean Medicine
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    • v.12 no.1
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    • pp.1-17
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    • 2008
  • Objective : This research was done to discover whether or not workers' health related quality of life(HRQOL) depends on their own Yangseng(養生) level, which is also known as one's care of one's health, and also if their HRQOL is affected by the level, to what extent. The subjects of the study were blue-collar workers of a workplace. Method : Blue-collar workers of a workplace were asked to fill out their pre-organized questionaires given to them by their company as a process of health examination. The questionaires carried questions regarding their levels of Yangseng and their HRQOL. For the purpose of the research, a total of 961 data were selected from the questionaires filled out by the blue-collar workers and then analyzed. Result : Each workers's level of Yangseng becomes high or low by one or all of general characteristics. With regard to Yangseng level according to health-related lifestyle were found to have a relatively higher level of Yangseng. With reference to HRQOL according to general characteristics, those in the 20s were found to have a physical summary scale(PCS), but no significant difference was found in the other scales. As regards the quality of life(QOL) according to health-related lifestyle, those who exercise regularly were found to have a relatively higher PCS, while no smokers, those who do not drink alcoholic, and those who sleep at least seven hours a day were found to have a relatively higher mental summary scale(MCS). As to the relation between the level of Yangseng and HRQOL, the level of Yangseng was found to have an interrelation with PCS and MCS in terms of its degree. Statistics also show that each area of Yangseng level has a significant impact on the two qualities-PCS and MCS. Conclusion : One who has a higher level of Yangseng was found to be the one who enjoys a higher HRQOL. Specially, the three kinds of habits that are good for good health -non-smoking, no drinking and seeping seven hours a day- were found to be able to improve the QOL. In this respect, those who want to stay healthy are recommended to cultivate a healthier habit of living.

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Well-Being Levels and Well-Being Behavior, and Its Related Factors Among Women in Daegu City (대구지역 거주 여성들의 웰빙 수준 및 웰빙 행동에 관련된 요인)

  • Yoo, Su-Jung;Cho, Sung-Hyoun;HwangBo, Gak
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.7
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    • pp.3065-3073
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    • 2012
  • The purpose of this study was to examine the characteristics of well-being behavior of women living in Daegu and analyze their well-being levels according to their socio-demographic variables, thereby determining the effects of each variable on well-being behavior. A survey of 320 women was conducted and T-test, ANOVA was conducted for the well-being levels and well-being behavior based on socio-demographic variables. Multiple regression analysis was analyze the factors affecting well-being behavior. The major findings of this study were as follows. A higher level of education led to a higher level of well-being. Moreover, educational or counseling workers, those with higher monthly incomes, those with higher expenses spent on self-management, those who considered their physical condition good, and those who drank once or twice a week showed higher levels of well-being. According to the analysis of the variables influencing well-being behavior, those with an older age, a higher level of education, and higher expenses for self-management and non-smokers revealed higher degrees of involvement in well-being behavior. We need to maintain women's identity by establishing values of and beliefs in well-being and inspiring them with healthy consciousness of well-being so that we can encourage them to participate in sound well-being behavior.

Clinico-pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India

  • Malik, Prabhat Singh;Sharma, Mehar Chand;Mohanti, Bidhu Kalyan;Shukla, N.K.;Deo, S.V.S.;Mohan, Anant;Kumar, Guresh;Raina, Vinod
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.1
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    • pp.489-494
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    • 2013
  • Background: Lung cancer is one of the commonest and most lethal cancers throughout the world. The epidemiological and pathological profile varies among different ethnicities and geographical regions. At present adenocarcinoma is the commonest histological subtype of non-small cell lung cancer (NSCLC) in most of the Western and Asian countries. However, in India squamous cell carcinoma has been reported as the commonest histological type in most of the series. The aim of the study was to analyze the current clinico-pathological profile and survival of lung cancer at our centre. Materials and Methods: We analyzed 434 pathologically confirmed lung cancer cases registered at our centre over a period of three years. They were evaluated for their clinical and pathological profiles, treatment received and outcome. The available histology slides were reviewed by an independent reviewer. Results: Median age was 55 years with a male:female ratio of 4.6:1. Some 68% of patients were smokers. There were 85.3% NSCLC and 14.7% SCLC cases. Among NSCLCs, adenocarcinoma was the commonest histological subtype after the pathology review. Among NSCLC, 56.8% cases were of stage IV while among SCLC 71.8% cases had extensive stage disease. Some 29% of patients did not receive any anticancer treatment. The median overall and progression free survivals of the patients who received treatment were 12.8 and 7.8 months for NSCLC and 9.1 and 6.8 months for SCLC. Conclusions: This analysis suggests that adenocarcinoma may now be the commonest histological subtype also in India, provided a careful pathological review is done. Most of the patients present at advanced stage and outcome remains poor.

Lifestyle Practice among Malaysian University Students

  • Al-Naggar, Redhwan Ahmed;Bobryshev, Yuri V.;Mohd Noor, Nor Aini Binti
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.3
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    • pp.1895-1903
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    • 2013
  • Background: It is well established that a healthy lifestyle is of benefit in the prevention of diseases such as cancer and promotion of well-being. Therefore, the objective of this study was to determine lifestyle practice and associated factors among university students in Malaysia. Materials and Methods: A cross sectional study was conducted over six months from November 2011 until May 2012 among the students from the Management and Science University. This study was approved by its ethical committee, the students being explained the objective and invited to participate. A consent form was signed by all study participants. Questionnaire was distributed randomly to the students of the five faculties through their lecturers in different faculty. For univariate analysis t-test and ANOVA test were performed. Multiple linear regression used for multivariate analysis using SPSS 13.0. Results: A total number of 1100 students participated with a mean age of $22.1{\pm}2.21$ (SD) years. The majority were 22 years or younger (56.3%), female (54%), Malay (61.5%), single (92.3%), with family monthly income ${\geq}5000$ Ringgit Malaysia (41.2%). Regarding lifestyle, about were 31.6% smokers, 75.6% never drank alcohol and 53.7% never exercised. Multivariate analysis showed that age, sex, race, parent marital status, participant marital status, type of faculty, living status, smoking status, exercise, residency, brushing teeth, fiber intake and avoid fatty food significantly influenced the practice of drinking alcohol among university students (p=0.006, p=0.042, p<0.001, p=0.003, p=0.002, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p=0.003, p<0.001; respectively). It similarly showed that sex, race, parent marital status, participant marital status, monthly family income, exercise, residency, brushing teeth and fiber intake significantly influenced the practice of sun protection (p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p=0.017, p<0.001, p<0.001, p<0.001; respectively) and that age, sex, parent marital status, participant marital status, type of faculty, living status, exercise, taking non-prescribed medication, brushing the teeth, coffee consumption and fiber intake were significantly influenced the practice of fruits consumption (p=0.008, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p=0.002, p<0.001, P<0.001; respectively). Conclusions: This study showed a poor practice of healthy lifestyle among university students. Therefore universities should emphasize a healthy lifestyle in all faculties as a required subject. Socio-demographic characteristics significantly influenced practice and thus should be considered when planning preventive measures among university students. Frequent campaigns and educational seminars are to be encouraged.

Determinants of Smoking Initiation and Susceptibility to Future Smoking among School-Going Adolescents in Lagos State, Nigeria

  • Odukoya, Oluwakemi Ololade;Odeyemi, Kofoworola Abimbola;Oyeyemi, Abisoye Sunday;Upadhyay, Ravi Prakash
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.3
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    • pp.1747-1753
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    • 2013
  • Background: It is projected that low and middle-income countries will bear a major burden of tobacco related morbidity and mortality, yet, only limited information is available on the determinants of smoking initiation among youth in Africa. This study aimed to assess the determinants of smoking initiation and susceptibility to future smoking among a population of high school school students in Lagos, Nigeria. Materials and Methods: Baseline data from an intervention study designed to assess the effect of an anti-smoking awareness program on the knowledge, attitudes and practices of adolescents was analyzed. The survey was carried out in six randomly selected public and private secondary schools in local government areas in Lagos state, Nigeria. A total of 973 students completed self-administered questionnaires on smoking initiation, health related knowledge and attitudes towards smoking, susceptibility to future smoking and other factors associated with smoking. Results: Of the respondents, 9.7% had initiated smoking tobacco products with the predominant form being cigarettes (7.3%). Males (OR: 2.77, 95%CI: 1.65-4.66) and those with more pro-smoking attitudes (OR: 1.44, 95%CI: 1.34-1.54) were more likely to have initiated smoking. Those with parents and friends who are smokers were 3.47 (95%CI: 1.50-8.05) and 2.26 (95%CI: 1.27-4.01) times more likely to have initiated smoking. Non-smoking students, in privately owned schools (OR: 5.08), with friends who smoke (5.09), with lower knowledge (OR: 0.87) and more pro-smoking attitudes (OR 1.13) were more susceptible to future smoking. In addition, respondents who had been sent to purchase cigarettes by an older adult (OR: 3.68) were also more susceptible to future smoking. Conclusions: Being male and having parents who smoke are predictors of smoking initiation among these students. Consistent with findings in other countries, peers not only influence smoking initiation but also influence smoking susceptibility among youth in this African setting. Prevention programs designed to reduce tobacco use among in-school youth should take these factors into consideration. In line with the recommendations of article 16 of the WHO FCTC, efforts to enforce the ban on the sales of cigarettes to minors should be also emphasised.

Cases of Green Tobacco Sickness: Occupational Nicotine Poisoning in Tobacco Harvesters in Korea (담배 재배 농부에서 발생한 담배잎농부병(green tobacco sickness) 증례)

  • Lim, Hyun-Sul;Lee, Kwan
    • Journal of agricultural medicine and community health
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    • v.26 no.2
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    • pp.7-14
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    • 2001
  • Cases of green tobacco sickness were described. During the cutting of tobacco plants throughout harvest, four cases of green tobacco sickness occurred in August 2001, Korea. The range of age was 42-55 years. The most frequent symptoms included dizziness, weakness, nausea, vomiting, abdominal cramps, headache, and difficulty breathing. All affected individuals worked in fields of wet tobacco, where their clothes became wet from moisture on the plants or sweating. They were all healthy, except one with hypertension. They are all non-smokers. They recovered after fluid and antiemetic administrations within two days. Most of doctors misdiagnosed their symptoms as a pesticide poisoning or heat injury. Green tobacco sickness is a condition that has long been known as an occupational health risk among tobacco harvesters. Nicotine poisoning by dermal absorption is reported to be the cause of green tobacco sickness. In Korea, there are many tobacco harvesters, and most of them may be sticken with green tobacco sickness. But, no case of green tobacco sickness has been reported. We report cases of green tobacco sickness occurred to the tobacco harvesters with a review of articles.

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Effects of life style on psychosomatic a subjective a symptoms of the dental technology students (일 대학 치기공과 재학생의 생활습관이 심신 자각증상에 미치는 영향)

  • Kwon, Soon-Suk;Lee, Hye-Eun
    • Journal of Technologic Dentistry
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    • v.38 no.1
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    • pp.37-49
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    • 2016
  • Purpose: This research is performed through the analysis of the dental technology students' life-style factors of their daily lives that have a close relation with health, and the self-reported symptoms which are related to psychosomatic diseases, for the production of basic data for the change of life-styles and the development of educational programmes. Methods: This research has been performed through questionnaires from the beginning of October of 2014 till the end of November through the Dental Technology students of G-do, chosen by random sampling method after informed consent, where out of the 270 papers, 258 results were used for the analysis. Results: Firstly, the results of the research was as follows: Non-smokers accounted for 61.2%, student who did not do regular physical activities accounted for 50.4%, students who had sleeping hours of 6 to 7 hours accounted for 35.7%, students who eat snacks accounted for 63.2%, students who eat breakfast once to twice a week accounted for 30.6%, students who had an average number of drinks of once to twice a week accounted for 39.9%, and students with BMI of '$18.5^{\circ}{{\neq}}22.9$' accounted for 56.2%, being the highest. Secondly, in gender, smoking (p<.001), regular physical activity (p<.001), BMI (p<.001), eat snacks (p<.05), average number of drinks (p<.05), and of the health check-up, eat breakfast (p<.05), of the year level, eat snack (p<.01), BMI (p<.01), hours of sleep (p<.05), of major satisfaction, regular physical activity (p<.01), and BMI (p<.05), and there was a significant statistical difference, but there were no significant statistical difference in religion. Thirdly, of the bodily self-reported symptoms of the correlation analysis within the life-style variables and the self-reported symptoms, multiple subjective symptoms (I), respiratory (A), eye and skin (B), and digestive organs (C) were the highest in the correlation analysis with regular physical activity (p<.01), and of mental health, impulsiveness (H), mental instability (J), and depression (K) showed highest results in correlation analysis with regular physical activity (p<.01, p<.05), lie scale (L) and irregular and life (G) with eat breakfast (p<.01), and aggressiveness (F) with BMI (p<.01), showed highest results in correlation analysis. Fourthly of the Dental technology students' bodily self-reported symptoms, life-style factors which had a statistically significant effect appeared to be regular physical activity (p<.001) and BMI (p<.05), and of the mental self-reported symptoms, causes that did not have statistically significant effect appeared to be regular physical activity (p<.05) and eat breakfast (p<.05). Conclusion: This research concludes that in order to develop correct life-style habits for health promotion and reduce self-reported symptoms related to the Dental Technology students' diseases, education for the recognition of the necessity of self health promotion must be conducted, and a education programme scheme for the Dental technology curriculum for practicing the correct life-style habits in daily life is required.