• 한국염색가공학회지
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• 제34권4호
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• pp.284-301
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• 2022

The limitations of food production caused by global warming, consumption of soil fertility, and land shortage have demanded the development of alternative foods. Their market has been increasing, and in particular, there is an urgent need for an alternative meat. Among them, the non-slaughtered cell-cultured meat that can be manufactured in the laboratory, that is, cultured meat, is in the spotlight, which can solve the problem of meat consumption while including the advantages of meat. It is classified into minced cultured meat and structured one with a structure similar to that of real meat. The latter is currently facing limitations related scaffolds, cells, and the multiplicative problems, and many attempts are being made to solve them. The complex problem is related to secure texture and taste as well as structural similarity to actual meat. To solve the problems, it is necessary to lay emphasis on cells, there are fat cells and vascular cells, and the most fundamental cells, muscle cells. These are the main cells that control the texture and nutrients of meat, and unlike other cells, they grow in the form of fibers. A myofibril (also known as a muscle fibril) is a basic rod-like organelle of a muscle cell, which is a quantitatively major component of meat, and one of the tissues that maintain the appearance of the body and bones. In this review article, we focused on the growth of muscle cells into long, tubular cells known as muscle fibers using the fabricated fibrous scaffold, and reviewed not only research results for muscle tissue engineering but also various results in the related fields for the last five years.

• Korean Chemical Engineering Research
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• 제62권2호
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• pp.153-162
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• 2024

발사 전 발사장 주변 해상 위험구역 안전확보는 필수 조건이다. 해상안전이 확보되지 못한 경우 발사는 중지 또는 연기되는 상황에 직면하게 된다. 하지만, 수상 레저 활동 인구 증가 등으로 해상 공공안전 확보에 어려움이 발생하고 있다. 통제해역 내 선박 진입, 수상 레저 장비의 무단출입과 소개 명령 불응이 해당 된다. 본 논문에서는 발사체 개발 및 발사장 운영 전문가 등 22명을 대상으로 델파이/ 계층분석법을 활용하여 해상 공공안전 위협요인을 10개 항목으로 도출하고, 해상안전 확보를 위하여 개선하여야 할 항목 5개를 도출하였다. 본 논문에서 분석한 결과 해상안전 확보를 위하여 가장 개선이 필요한 항목은 발사장 주변 위험구역 설정과 통제에 대한 관계법령 개정이나 단행법 제정 필요성이 있다. 본 논문은 전문가 의견에 대하여 중요도와 우선순위를 분석하고 일관성을 검증하여 객관적인 의견을 제시한 부분에 의미가 있다고 사료 된다.

• 대한약침학회지
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• 제3권1호
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• pp.101-118
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• 2000

Introduction : In spite of the use of Bee Venom aqua-acupuncture in the clinics, the scientific evaluation on effects is not enough. Bee Venom aqua-acupuncture is used according to the stimulation of acupuncture point and the chemical effects of Bee Venom. The aims of this study is to investigate the analgegic effects of the Bee Venom aqua-acupuncture, through the change of writhing reflex Materials and Methods : Pain animal model was used acetic acid method. The changes of writhing reflex of the mice which were derived pain by injecting acetic acid into the abdomen, after stimulating Bee Venom aqua-acupuncture on Chungwan($CV_{12}$) and non acupuncture point on the backside were measured. Results : 1. It showed that the writhing reflex were appeared on the groups which injected aceticacid only, and saline-acetic acid group(sample I), but not on the group bee venom-saline group(sample II). 2. The change of writhing reflex by Chungwan($CV_{12}$) Bee Venom aqua-acupuncture showed significant decrease in the order of Chungwan($CV_{12}$) Bee Venom aqua-acupuncture group III($2.5{\times}10^{-3}$g/kg), II($2.5{\times}10^{-4}$g/kg), and I($2.5{\times}10^{-5}$g/kg), compared with control group. There were significant decrease of number of writhing reflex in $5{\sim}10,\;10{\sim}15\;and\;15{\sim}20$ minutes intervals of Chung wan($CV_{12}$) Bee Venom aqua-acupuncture group I, and in $0{\sim}5,\;5{\sim}10,\;10{\sim}15\;and\;15{\sim}20$ minutes intervals of II and III, compared with control group. 3. The change of writhing reflex by non acupuncture point Bee Venom aqua-acupuncture showed significant decrease in the $0{\sim}5\;and\;5{\sim}10$ minutes intervals and the total number of writhing reflex in $2.5{\times}10^{-4}$g/kg group, compared with control group 4. The effects of writhing reflex of Chungwan($CV_{12}$) Bee Venom aqua-acupuncture group showed significant decrease, compared with non acupuncture point Bee Venom aqua-acupuncture group. Conclusion : This study shows that the Bee Venom aqua-acupuncture on Chungwan($CV_{12}$) decreases the numbers of writhing reflex. As the analgegic effects of Bee Venom aqua-acupuncture is recognized. Bee Venom aqua-acupuncture treatment is expected for pain modulation. In order to use it in many ways, more researches are needed for the dose and stability of Bee Venom aqua-acupuncture.

• 동의생리병리학회지
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• 제19권1호
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• pp.114-118
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• 2005

The purpose of this study was to investigate the possibility of Inonotus obliquus as an functional resource. To assess the effects of Inonotus obliquus in culturing method by using unpolished rice in 15non-insulin dependent diabetes mellitus persons, we examined changes of hematological and chemical variables, DM indices content in serum during the Inonotus obliquus supplementation. GOT, GPT concentrations were significantly decreased. But TIBC content was significantly increased. Fasting glucose level during Inonotus obliquus supplementation was decreased respectively. These results show that modest dose of Inonotus obliquus in culturing method by using unpolished rice supplementation can decrease fasting blood glucose level without any changes in health indices and nutrition status of the non-insulin dependent diabetes mellitus person. These results indicated that Inonotus obliquus in culturing method by using unpolished rice diet is effective therapeutic regimen for the control of metabolic derangements in diabetes mellitus. Also, the results imply that Inonotus obliquus in culturing method by using unpolished rice can be used as possible functional food materials. However, large amounts of Inonotus obliquus in culturing method by using unpolished rice showed be used cautiously application.

• Journal of Microbiology and Biotechnology
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• 제24권6호
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• pp.795-802
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• 2014

The aim of this study was to determine the effects of temperature and supplementation with skim milk powder (SMP) on the microbial and proteolytic properties during the storage of cottage cheese. Cottage cheese was manufactured using skim milk with 2% SMP and without SMP as the control, and then stored at $5^{\circ}C$ or $12^{\circ}C$ during 28 days. The chemical composition of the cottage cheese and the survival of the cheese microbiota containing starter lactic acid bacteria (SLAB) and non-starter culture lactic acid bacteria (NSLAB) were evaluated. In addition, changes in the concentration of lactose and lactic acid were analyzed, and proteolysis was evaluated through the measurement of acid soluble nitrogen (ASN) and non-protein nitrogen (NPN), as well as electrophoresis profile analysis. The counts of SLAB and NSLAB increased through the addition of SMP and with a higher storage temperature ($12^{\circ}C$), which coincided with the results of the lactose decrease and lactic acid production. Collaborating with these microbial changes, of the end of storage for 28 days, the level of ASN in samples at $12^{\circ}C$ was higher than those at $5^{\circ}C$. The NPN content was also progressively increased in all samples stored at $12^{\circ}C$. Taken together, the rate of SLAB and NSLAB proliferation during storage at $12^{\circ}C$ was higher than at $5^{\circ}C$, and consequently it led to increased proteolysis in the cottage cheese during storage. However, it was relatively less affected by SMP fortification. These findings indicated that the storage temperature is the important factor for the quality of commercial cottage cheese.

• 한국결정성장학회:학술대회논문집
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• 한국결정성장학회 1996년도 The 9th KACG Technical Annual Meeting and the 3rd Korea-Japan EMGS (Electronic Materials Growth Symposium)
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• pp.5-18
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• 1996

The solid state cesium ion source os alumino-silicate based zeolite which contains cerium. The material is an ionic conductor. Cesiums are stably stored in the material and one can extract the cesiums by applying electric field across the electrolyte. Cesium ion bombardment has the unique property of producing high negative ion yield. This ion source is used as the primary source for the production of a negative ion without any gas discharge or the need for a carrier gas. The deposition of materials as an ionic species in the energy range of 1.0 to 300eV is recently recognized as a very promising new thin film technique. This energetic non-thermal equilibrium deposition process produces films by “Kinetic Bonding / Energetic Condensation" mechansim not governed by the common place thermo-mechanical reaction. Under these highly non-equilibrium conditions meta-stable materials are realized and the negative ion is considered to be an optimum paeticle or tool for the purpose. This process differs fundamentally from the conventional ion beam assisted deposition (IBAD) technique such that the ion beam energy transfer to the deposition process is directly coupled the process. Since cesium ion beam sputter deposition process is forming materials with high kinetic energy of metal ion beams, the process provider following unique advantages:(1) to synthesize non thermal-equilibrium materials, (2) to form materials at lower processing temperature than used for conventional chemical of physical vapor deposition, (3) to deposit very uniform, dense, and good adhesive films (4) to make higher doposition rate, (5) to control the ion flux and ion energy independently. Solid state cesium ion beam sputter deposition system has been developed. This source is capable of producing variety of metal ion beams such as C, Si, W, Ta, Mo, Al, Au, Ag, Cr etc. Using this deposition system, several researches have been performed. (1) To produce superior quality amorphous diamond films (2) to produce carbon nitirde hard coatings(Carbon nitride is a new material whose hardness is comparable to the diamond and also has a very high thermal stability.) (3) to produce cesiated amorphous diamond thin film coated Si surface exhibiting negative electron affinity characteristics. In this presentation, the principles of solid state cesium ion beam sputter deposition and several applications of negative metal ion source will be introduced.

• Applied Biological Chemistry
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• 제37권5호
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• pp.349-355
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• 1994

비파괴 측정법의 하나인 근적외 분광분석법을 응용하여 국내산 황색종 잎담배의 품질에 관련된 주요성분인 수분, 니코틴, 전질소, 환원당 및 색깔 등을 신속, 정확하게 동시에 측정하기 위한 가능성을 조사하였다. 근적외 영역의 광학데이타와 기존 습식분석법에 의한 잎담배의 수분, 니코틴, 전질소, 환원당 및 L, a, b 측정치 간에 중회귀 분석을 행한 결과, 검정용 시료에 대한 측정오차(SEP)가 각각 0.28%, 0.25%, 0.07%, 1.25, 0.44 및 1.07이며, 시료의 전처리없이 30초 이내에 동시에 측정 가능함을 알 수 있었다. 아울러 잎담배 수매, 원료가공 및 제품담배 제조현장에 활용하기 위한 보급형 근적외 분광분석기의 개발 가능성도 검토하였다.

• Tuberculosis and Respiratory Diseases
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• 제84권3호
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• pp.200-208
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• 2021

Background: Hypersensitivity pneumonitis (HP) is an increasingly recognized form of diffuse parenchymal lung disease. Krebs von den Lungen-6 (KL-6) is now classified as a human MUC1 mucin protein, and regenerating type II pneumocytes are the primary cellular source of KL-6/MUC1 in the affected lungs of patients with interstitial lung diseases (ILD). Serum KL-6/MUC1 levels have been demonstrated to be useful for the evaluation of various ILD. To determine the role of circulating KL-6 in evaluating the disease activity and management of HP. Methods: An observational cross-sectional study was conducted on 51 patients with HP and 20 healthy controls. Serum KL-6 levels were measured in both groups. Patients were further assessed based on chest high-resolution computed tomography (HRCT), pulmonary function test, 6-minute walk test, echocardiography, bronchioalveolar lavage, and/or transbronchial biopsy. Patients were divided into the fibrotic and non-fibrotic groups according to the HRCT findings. Results: The median serum KL-6 levels were significantly higher in HP patients as compared to the control group. The median serum KL-6 levels were found to be higher in the non-fibrotic HP group (1,900 IU/mL) as compared to the fibrotic group (1,200 IU/mL). There was a significant inverse correlation between serum KL-6 serum level and the dose of steroids as well as the duration of steroid therapy. Conclusion: The presence of higher KL-6 levels in the non-fibrotic HP group implies its enhanced production by regenerating pneumocytes in response to alveolar injury. The significant association between serum KL-6 levels and the dose and the duration of steroid therapy emphasizes the significant role of steroids in the stabilization of the disease.

• 생물환경조절학회지
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• 제16권2호
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• pp.89-95
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• 2007

겨울철 난방연료가 많이 소모되는 대규모 연동형 온실의 보온성을 향상시키기 위해 터널용 보온자재로 많이 사용되는 다겹보온커튼을 이용하여 기존의 부직포, 알루미늄스크린 등과 보온성을 상대적으로 비교하였다. 또한 다겹보온자재는 보온성이 높으나 두께가 두꺼워 전동모터를 이용한 자동개폐장치를 구성하기 어려운 단점이 있으므로 연동형 온실에 적용할 수 있는 고장이 적고 작동이 원활한 커튼 개폐장치를 개발하여 작물재배 및 난방연료 절감효과를 검토하였다. 다겹보온자재와 부직포, 알루미늄스크린 등의 보온커튼용 자재의 열 관류량을 측정하여 상대적인 보온효과를 비교한 결과 부직포에 비해 알루미늄스크린의 열관류량이 적었고, 알루미늄 및 화학솜의 3겹보온자재와 다겹보온자재는 알루미늄스크린에 비해 열관류량이 각각 23.3%, 43.0% 적게 나타나 다겹보온자재의 보온성이 우수한 것으로 판단되었다. 다겹보온자재는 여러 겹으로 누빈 조합형 보온자재이므로 두께가 두껍고 화학솜, 폴리폼 등 연신되기 쉬운 자재를 이용하므로 장기간 사용시 커튼 개폐장치의 예인선이나 보온자재가 처지게 될 우려가 있으므로 예인식과 권취식 개폐방법을 동시에 적용하여 보온커튼 개페장치를 구성하였다. 시험용 온실 에 다겹보온커튼과 부직포커튼을 설치하고 풋고추를 재배한 결과 다겹보온커튼 설치 온실에서 풋고추의 생육이 유리하였고 초기수량도 27% 정도 증수되었으며, 경유온풍기의 난방연료 소모량은 46%정도 절감되었다.

• 한국잠사곤충학회지
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• 제25권2호
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• pp.37-43
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• 1984

누에병 중에 피해가 막대한 전염성 연화병을 방제하기 위하여 바이러스 증식을 특이적으로 억제하는 guanidine 유도체중에서 그 억제효과가 큰 guanidine hydrochloride(GH)를 도입하여 전염성 연화병 바이러스의 증식억제효과에 관하여 조사하였다. 1. 누에에 대한 GH의 약해시험 결과에서는 GH농도 0.01% 수준 이하에서는 약해가 전혀 없었다. 2. FV 감염잠 혼입에 따른 피해조사에서는 화용비율은 무처리(대조) 89.2% (100)에 대하여 1% 감염잠혼입구 70.7%(79), 5% 감염잠 혼입구 38.4%(43)이었으며 1만두수견양은 대조구 21.3kg(100)에 대하여 1% 혼입구 16.7kg(77), 5% 혼입구 8.8kg(41)으로서 전자와 같은 경향으로 나타났다. 3. FV에 대한 GH의 발병억제효과는 GH 0.01% 농도에서 대조구에 비하여 약 10배의 억제효과가 있었다. 4. GH의 투여회수와 발병억제효과에서는 FV접종후 계속 투여하는 것이 가장 효과적이었다. 5. FV 접종후 GH투여시간에 대한 발병억제 효과는 접종과 동시에 투여는 것이 가장 효과적이었다. 6. FV의 GH에 의한 시험관내 불활화조사에서는 GH가 시험관내에서 FV를 불활화시키는 작용이 인정되지 않았다.