Role of Krebs von den Lungen-6 (KL-6) in Assessing Hypersensitivity Pneumonitis |
Mostafa, Amira Ismail
(Department of Chest Diseases, Faculty of Medicine, Cairo University)
Salem, Ayman Elsayed (Department of Chest Diseases, Faculty of Medicine, Cairo University) Ahmed, Heba Allah Moussa (Department of Chest Diseases, Faculty of Medicine, Cairo University) Bayoumi, Aml Ibrahim (Department of Chest Diseases, Faculty of Medicine, Cairo University) Halim, Radwa M. Abdel (Department of Chemical Pathology, Faculty of Medicine, Cairo University) Samie, Rasha M. Abdel (Department of Internal Medicine, Faculty of Medicine, Cairo University) |
1 | Comes A, Wong AW, Fisher JH, Morisset J, Johannson KA, Fell CD, et al. Association of body mass index and change in weight with mortality in patients with fibrotic interstitial lung disease. Am J Respir Critical Care Med 2020;201:A1096. |
2 | Kobayashi J, Tsukagoshi M, Hagiwara S, Kitamura S, Hirota N, Saito K. Hypersensitivity pneumonitis monitored with serum KL-6, a marker of interstitial pneumonia. Nihon Kyobu Shikkan Gakkai Zasshi 1996;34:837-42. |
3 | Inoue Y, Barker E, Daniloff E, Kohno N, Hiwada K, Newman LS. Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. Am J Respir Crit Care Med 1997; 156:109-15. DOI |
4 | American Thoracic Society; European Respiratory Society. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 2002;165:277-304. DOI |
5 | Ohtani Y, Inase N, Miyake S, Yoshizawa Y, Saiki S. Fatal outcome in chronic bird fancier's lung. Am J Med 2002;112:588-90. DOI |
6 | Selman M, Pardo A, King TE Jr. Hypersensitivity pneumonitis: insights in diagnosis and pathobiology. Am J Respir Crit Care Med 2012;186:314-24. DOI |
7 | Inase N, Ohtani Y, Sumi Y, Umino T, Usui Y, Miyake S, et al. A clinical study of hypersensitivity pneumonitis presumably caused by feather duvets. Ann Allergy Asthma Immunol 2006;96:98-104. DOI |
8 | Akashi T, Takemura T, Ando N, Eishi Y, Kitagawa M, Takizawa T, et al. Histopathologic analysis of sixteen autopsy cases of chronic hypersensitivity pneumonitis and comparison with idiopathic pulmonary fibrosis/usual interstitial pneumonia. Am J Clin Pathol 2009;131:405-15. DOI |
9 | Churg A, Muller NL, Flint J, Wright JL. Chronic hypersensitivity pneumonitis. Am J Surg Pathol 2006;30:201-8. DOI |
10 | Okamoto T, Fujii M, Furusawa H, Tsuchiya K, Miyazaki Y, Inase N. The usefulness of KL-6 and SP-D for the diagnosis and management of chronic hypersensitivity pneumonitis. Respir Med 2015;109:1576-81. DOI |
11 | Vasakova M, Morell F, Walsh S, Leslie K, Raghu G. Hypersensitivity pneumonitis: perspectives in diagnosis and management. Am J Respir Crit Care Med 2017;196:680-9. DOI |
12 | Ohnishi H, Miyamoto S, Kawase S, Kubota T, Yokoyama A. Seasonal variation of serum KL-6 concentrations is greater in patients with hypersensitivity pneumonitis. BMC Pulm Med 2014;14:129. DOI |
13 | Ohtani Y, Saiki S, Kitaichi M, Usui Y, Inase N, Costabel U, et al. Chronic bird fancier's lung: histopathological and clinical correlation: an application of the 2002 ATS/ERS consensus classification of the idiopathic interstitial pneumonias. Thorax 2005;60:665-71. DOI |
14 | McCormack FX, King TE Jr, Bucher BL, Nielsen L, Mason RJ. Surfactant protein A predicts survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1995;152:751-9. DOI |
15 | Hayakawa H, Shirai M, Sato A, Yoshizawa Y, Todate A, Imokawa S, et al. Clinicopathological features of chronic hypersensitivity pneumonitis. Respirology 2002;7:359-64. DOI |
16 | Kinnula VL, Ishikawa N, Bergmann U, Ohlmeier S. Proteomic approaches for studying human parenchymal lung diseases. Expert Rev Proteomics 2009;6:619-29. DOI |
17 | Low RB, Giancola MS, King TE Jr, Chapitis J, Vacek P, Davis GS. Serum and bronchoalveolar lavage of N-terminal type III procollagen peptides in idiopathic pulmonary fibrosis. Am Rev Respir Dis 1992;146:701-6. DOI |
18 | Takemura T, Akashi T, Kamiya H, Ikushima S, Ando T, Oritsu M, et al. Pathological differentiation of chronic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis/usual interstitial pneumonia. Histopathology 2012;61:1026-35. DOI |
19 | Yokoyama A, Kohno N, Hirasawa Y, Kondo K, Abe M, Inoue Y, et al. Evaluation of soluble IL-6 receptor concentration in serum and epithelial lining fluid from patients with interstitial lung diseases. Clin Exp Immunol 1995;100:325-9. DOI |
20 | British Thoracic Society Standards of Care Committee. The diagnosis, assessment and treatment of diffuse parenchymal lung disease in adults. Introduction. Thorax 1999;54 Suppl 1:S1-14. |
21 | Johannson KA, Elicker BM, Vittinghoff E, Assayag D, de Boer K, Golden JA, et al. A diagnostic model for chronic hypersensitivity pneumonitis. Thorax 2016;71:951-4. DOI |
22 | Standardization of spirometry, 1994 update. American Thoracic Society. Am J Respir Crit Care Med 1995;152:1107-36. DOI |
23 | Chan YH. Biostatistics 102: quantitative data: parametric and non-parametric tests. Singapore Med J 2003;44:391-6. |
24 | Hanak V, Golbin JM, Hartman TE, Ryu JH. High-resolution CT findings of parenchymal fibrosis correlate with prognosis in hypersensitivity pneumonitis. Chest 2008;134:133-8. DOI |
25 | Pugashetti J, Graham J, Boctor N, Mendez C, Foster E, Juarez M, et al. Weight loss as a predictor of mortality in patients with interstitial lung disease. Eur Respir J 2018;52:1801289. DOI |
26 | Adegunsoye A, Oldham JM, Demchuk C, Montner S, Vij R, Strek ME. Predictors of survival in coexistent hypersensitivity pneumonitis with autoimmune features. Respir Med 2016;114:53-60. DOI |
27 | Silva CI, Muller NL, Lynch DA, Curran-Everett D, Brown KK, Lee KS, et al. Chronic hypersensitivity pneumonitis: differentiation from idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia by using thin-section CT. Radiology 2008;246:288-97. DOI |
28 | Trahan S, Hanak V, Ryu JH, Myers JL. Role of surgical lung biopsy in separating chronic hypersensitivity pneumonia from usual interstitial pneumonia/idiopathic pulmonary fibrosis: analysis of 31 biopsies from 15 patients. Chest 2008;134:126-32. DOI |
29 | Jack CI, Jackson MJ, Johnston ID, Hind CR. Serum indicators of free radical activity in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1996;153:1918-23. DOI |
30 | Okamoto T, Tsutsui T, Suhara K, Furusawa H, Miyazaki Y, Inase N. Seasonal variation of serum KL-6 and SP-D levels in bird-related hypersensitivity pneumonitis. Sarcoidosis Vasc Diffuse Lung Dis 2015;31:364-7. |
31 | Glazer CS, Rose CS, Lynch DA. Clinical and radiologic manifestations of hypersensitivity pneumonitis. J Thorac Imaging 2002;17:261-72. DOI |
32 | Izbicki G, Shitrit D, Yarmolovsky A, Bendayan D, Miller G, Fink G, et al. Is routine chest radiography after transbronchial biopsy necessary?: a prospective study of 350 cases. Chest 2006;129:1561-4. DOI |
33 | Chan YH. Biostatistics 103: qualitative data: tests of independence. Singapore Med J 2003;44:498-503. |
34 | Chan YH. Biostatistics 104: correlational analysis. Singapore Med J 2003;44:614-9. |
35 | Abd El-Kareem D, Akl YM, Nakhla GA, Elhindawi AA, Eltorky MA. Clinico-pathologic presentation of hypersensitivity pneumonitis in Egyptian patients: a multidisciplinary study. Multidiscip Respir Med 2017;12:10. DOI |
36 | Akl Y, Soliman YM, El-Korashy RI, El-Hennawi YH. Demographic study of hypersensitivity pneumonitis in Egypt: a single center experience. Am J Respir Crit Care Med 2017;195:A1566. |
37 | Fletcher CM. The clinical diagnosis of pulmonary emphysema; an experimental study. Proc R Soc Med 1952;45:577-84. |
38 | Alakhras M, Decker PA, Nadrous HF, Collazo-Clavell M, Ryu JH. Body mass index and mortality in patients with idiopathic pulmonary fibrosis. Chest 2007;131:1448-53. DOI |
39 | Patel RA, Sellami D, Gotway MB, Golden JA, Webb WR. Hypersensitivity pneumonitis: patterns on high-resolution CT. J Comput Assist Tomogr 2000;24:965-70. DOI |
40 | Kondoh Y, Taniguchi H, Katsuta T, Kataoka K, Kimura T, Nishiyama O, et al. Risk factors of acute exacerbation of idiopathic pulmonary fibrosis. Sarcoidosis Vasc Diffuse Lung Dis 2010;27:103-10. |
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