• 대한전자공학회논문지SD
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• 제47권8호
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• pp.29-35
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• 2010

본 논문에서는 내장된 자체 테스트 기법 (BIST, Built-In Self Test)을 적용 할 때 저전력 테스트가 가능한 패턴 생성기를 제안하였다. 테스트 시 WSA (Weighted Switching Activity)가 많이 발생하는 노드인 heavy nodes의 선택 알고리듬을 제안하였으며, heavy nodes에 천이를 발생시키는 입력부 곧 heavy inputs을 찾는 알고리듬을 나타내었다. 고장 검출율을 높이는 최적의 heavy nodes의 수를 결정하고 선택된 입력부에 변형된 LFSR의 출력을 인가하여 테스트 시 발생하는 천이를 줄였다. 제안하는 패턴 생성기는 몇 개의 AND 게이트와 OR 게이트를 LFSR에 추가하여 적은 하드웨어 오버헤드로 간단히 구현된다. ISCAS 벤치 회로에 적용한 실험을 통해 제시하는 방법이 기존의 기법에 비해 평균 소비 전력을 감소시키면서 고장 검출율을 상승시키는 것을 검증하였다.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2009년도 추계학술대회
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• pp.517-520
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• 2009

헬스케어 분야에 무선센서네트워크를 적용하기 위해서 저비용, 저전력, 초소형 사이즈인 이동성 센서노드들에 의한 헬스케어 응용시스템에 대한 연구가 활발히 진행되어지고 있다. 특히, 헬스케어 센서노드는 환자가 쉽게 착용해서 환자의 건강상태를 모니터링을 하는데 주된 목적으로 하고 있으나, 센서노드 특성상 통신할 수 있는 전송범위를 극복하기 위해 멀티 홉 기반으로 문제를 해결해 왔지만 센서노드가 이동시 멀티 홉 형성에 다소 많은 시간적인 지연이 요구된다. 이런 문제로 인해 본 연구에서는 주변센서노드와 이동형 헬스케어 센서노드에 신속한 라우팅 변화를 위한 질의 기법을 구현했다. 무선 센서네트워크 노드의 라우팅 프로토콜이 노드의 이동성이나 패킷 전송 등을 처리하기 위해서 노드들 사이에 신속한 링크 연결에 대한 효율적인 컨트롤이 가능하기 위해서 비컨(Beacon) 메시지를 헬스케어 센서노드를 휴대한 환자의 활동 상태에 따라 비컨 메시지의 주기적인 질의를 부여하무로써 주변 센서노드와 헬스케어 센서노드 사이의 네트워크 형성이 신속하게 형성할 수가 있다.

• 동의생리병리학회지
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• 제18권5호
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• pp.1337-1342
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• 2004

The purpose of this research was to investigate the immunoregulatory effect and the leukemia cell apoptosis of EtOH extract of OGAPI(OGP). The proliferation of cultured splenocytes, thymocytes and mesenteric lymph node cells were enhanced by the addition of OGP. Splenic and thymic T lymphocytes, especially TH and Tc cells were significantly increased in OGP-administered mice. OGP markedly increased the production of γ-interferon in mice serum and accelerated the phagocytic activity in peritoneal macrophages. OGP treatment enhanced the apoptosis of L1210 mouse leukemia and Jurkat, Molt4 human leukemia cells, and increased the expression of apoptosis-related ICE, c-myc, p53 gene in Jurkat cell. These results suggest that OGP have an immunoregulatory action and anti-cancer activity.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제21권2호
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• pp.139-148
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• 1999

Oral cancer is a common neoplasm in humans and etiologic mechanism is not well known, so treatment and evaluation of oral cancer is difficult problem. Traditional TNM classification between prognosis of tumors and classification of histopathologic differentiation has problem like lack of objectivity through operators. In molecular biology, cancer is developed by alteration of activation of oncogene and/or inactivation of tumor suppressor gene. The p53 gene, one of the tumor suppresor genes, is believed to play an important role through mutation and overexpression in the progression of human cancers. The p53 mutation is most frequent genetic disorder in humans. The Cyclin D1 has tumor suppresion activity by regulation of cell cycle. The Cyclin D1 regulate activity of Rb tumor suppresor gene by stimulation of CDK4 The purpose of this study was to observe the expression of p53 protein and Cyclin D1 in oral squamous cell carcinoma, and to get expectation of the malignancy and prognosis of oral squamous cell carcinoma. Using the 15 cases of squamous cell carcinoma and the microscopic H&E and immunohistochemical stain. We divided it into 3 groups according to the stain extent, clinical stage and histologic differentiation. The results were as follows1.In the features of immunohistochemical stain of 15 cases of squamous cell carcinoma, positive reaction of p53 was identified in 8 cases (53.3%) and positive reaction of cyclin D1 was identified in 3 cases (20%). Both positive reaction of p53 protein and Cyclin D1 was show in only one case. 2.8 of p53 positive cases were linked in 87.5% of the end stage tumor, 62.5% of neck node involvement, 87.5% of poorly and moderately histopathplogic differentiation. 3. All 3 of Cyclin D1 positive cases were linked in the end stage tumor, neck node involvement, poorly and moderately histopathologic differentiation. From above results, expression of p53 protein was identified in 53.3% of 15 cases and these results mean oral squamous cell carcinoma was drived by mutation of p53 protein. Especially, highly positive reaction of p53 protein and Cyclin D1 was identified in cases that involvement of neck lymph node and the end stage tumors and it means that the evaluation of p53 protein and Cyclin D1 was useful for evaluation of malignant tumor as specific tumor marker.

• The Korean Journal of Physiology
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• 제20권1호
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• pp.17-29
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• 1986

갑상선 호르몬의 표적기관(target organ) 중의 하나인 심장이 hyperthyroid상태에서 심박동수의 증가, 부정맥 그리고 세포 수들에서 sodium, potassium pump기능이 항진되는 것으로 보고되고 있다. 증진된 Pump기능과 더불어 positive chronotropic effect는 심장의 향도잡이로 알려진 동방결절 과 심방근에 어떤 변화에 의하여 발현되는지 알아보기 위하여 $3{\sim}6$개월령의 토끼 (체중 약 1.5kg내외)에 3,3',5-l-triiodothyronine$(T_3)$을 투여하며 실험적으로 hyperthyroid상태를 유도한 다음 심장세포 내에 유리미세전극을 삽입하여 기록한 결과 다음과 같은 성적을 얻었다. 1) 심박동수는 투여 전(Day 1) $169.0{\pm}28.0\;beat/min(Day\;7)$에서 $264.2{\pm}18.9\;beat/min(Day\;7)$으로 156% 가량 증가되었고 체중은 투여전 체중의 $68.2{\pm}2.0%$로 현저한 감소를 보였다. 2) $T_3$투여군에서 활동전압기간은 $148.0{\pm}29.1\;msec$에서 $107.0{\pm}13.6\;msec$로 감소하여 심박동증가를 반영하였으나 그 외의 활동전압 Parameter에서 대조군과 유의한 차를 관찰할 수 없었다. 3) 세포막에 대한 Potassium ion투과성의 영향을 알아보기 위하여 10, 15, $20mM-K^+\;Tyrode$용액을 사용한 결과 SA node에서 $15mM\;K^+$에서 활동전압 발사가 대조군에 비해 현저하게 감소하였고, 4) Ta 투여군에서 심방근의 안정막전압 탈분극 정도는 15mM(P<0.05), $20mM-K^+Tyrode$용액(P<0.05)에서 대조군보다 유의성있게 낮았다. 5) Sodium, potassium pump기능은 대조군에 비해 동방결절$(13.4{\pm}1.1\;vs.\;19.5{\pm}7.1mV,\;p<0.1)$과 심방근$(15.1{\pm}5.5\;vs.\;25.8{\pm}10.0mV,\;p<0.025)$에서 모두 높은 값을 얻었다. 6) $T_3$에 의한 calcium ion의 영향을 알아보기 위하여 $Ca^{++}\;channel\;blocker$로 $MnCl_2$를 사용한 결과 $T_3$ 투여군의 동방결절은 정상대조군의 것보다 낮은 농도의 $MnCl_2$ 용액에서 흥분성의 감소를 보였다.

• Journal of Life Science
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• 제9권1호
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• pp.58-63
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• 1999

Highly metastatic mouse T-lymphoma CS21 cells can grow in vitro when cocultured with CA12 lymph node stromal cells, but they undergo apoptotic cell death when separated from CA12 stromal cells. It has been found that cysteine and interleukin-7(IL-7) as antiapoptotic soluble factors that produced by CA12 stromal cells. In this study, we report that an ICE family protease is activated in CS21 cells when separated from CA12 stromal cells and cultured alone. Enzyme purification using an avidin affinity column revealed that the involved cysteine protease possessed caspase3-like death protease activity. In addition, when IL-7 was added to CS21 cell culture, the protease activity could not be detected during partial purification of the enzyme. Taken together, these results strongly suggest that the caspase3-like protease activation is suppressed by IL-7 as an antiapoptotic factor that leads to abrogation of apoptosis execution.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제7권9호
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• pp.2101-2119
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• 2013

The spectrum allocation is an attractive issue for mobile cognitive radio (CR) network. However, the time-varying characteristic of the spectrum allocation is not fully investigated. Thus, this paper originally deduces the probabilities of spectrum availability and interference constrain in theory under the mobile environment. Then, we propose a prediction mechanism of the time-varying available spectrum lists and the dynamic interference topologies. By considering the node mobility and primary users' (PUs') activity, the mechanism is capable of overcoming the static shortcomings of traditional model. Based on the mechanism, two prediction-based spectrum allocation algorithms, prediction greedy algorithm (PGA) and prediction fairness algorithm (PFA), are presented to enhance the spectrum utilization and improve the fairness. Moreover, new utility functions are redefined to measure the effectiveness of different schemes in the mobile CR network. Simulation results show that PGA gets more average effective spectrums than the traditional schemes, when the mean idle time of PUs is high. And PFA could achieve good system fairness performance, especially when the speeds of cognitive nodes are high.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제15권4호
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• pp.260-264
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• 2009

센서네트워크 시스템을 응용한 u-Healthcare 시스템 기술에 대한 많은 연구가 진행되고 있다. 이를 사람이 아닌 동물에 적용시켜 애완동물의 상태를 웹을 통하여 관리할 수 있는 uPetCare(Ubiquitous Pet-Care System)을 설계 및 구현하였다. uPetCare System의 주된 기능으로는 1) 센서를 통한 데이터의 수집, 2) 멀티-홉 통신 3) 싱크 노드에서의 데이터 압축(compression) 및 정리(aggregation), 4) 웹 서버에서의 데이터 저장, 5) AJAX 기술을 통한 실시간 정보 확인 6) 상황 인지 시스템을 통한 펫 관리 시스템을 포함한다.

• Natural Product Sciences
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• 제27권4호
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• pp.300-306
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• 2021

Chronic ultraviolet (UV) radiation causes photoaging, which represents skin damage, disrupts skin barrier function, and promotes wrinkle formation. We investigated that the polysaccharide extract of an edible basidiomycetous white jelly mushroom, Tremella fuciformis, (TF-Glucan^®) exhibited statistically photoprotective activity by inhibiting matrix metalloproteases (MMPs) and increasing collagen synthesis, and an anti-inflammatory activity by inhibiting nitric oxide and pro-inflammatory cytokines at the concentrations of less than 1000 ㎍/ml, which is not cytotoxic (p < 0.05). Additionally, TF-Glucan^® increased the expression of involucrin and filaggrin to prevent the disruption of UVB-induced barrier function (p < 0.05). TF-Glucan^® was assessed as a safe material by the human primary skin irritation (1, 3, 5%), human repeated insult patch test (no sensitization at 5%), 3T3 NRU phototoxicity assay (no phototoxicity, PIF < 2, MPE < 0.1), eye irritation test test by BCOP (no category, IVIS ≤ 3) and local lymph node assay (negative at 10, 25, 50%) for identifying potential skin sensitizing. These results suggest that TF-Glucan^® may be useful as an anti-photoaging ingredient for developing cosmeceuticals.

• 대한수의학회지
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• 제37권2호
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• pp.375-381
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• 1997

The purpose of the production of monoclonal antibodies aganist the Canine distemper virus(CDV) were perfect diagnosis and a new approach to treat canine distemper because the diagnosis and treatment of canine distemper were difficult. Canine distemper virus(CDV) was purified using saturated ammonium sulfate, and injected into hind footpads of BALB/c mouse. 12-15 days later, popliteal lymph node(PN) cells were harvested and fused with SP2/O myeloma cells. Characteristics of monoclonal antibodies were analysed. 1. 9 hybridomas produce the specific antibody against CDV. 2. 6 monoclonal antibodies are against intranuclear and cytoplasmic component of CDV, and 3 monoclonal antibodies are against cytoplasmic inclusions. 3. All monoclonal antibodies did not react with other 5 different viruses (CAV-I, CAV-II, CCV, CPV and CPIV) and react with another CDV-FXNO strain. 4. 3 monoclonal antibodies have neutralizing activity against CDV. 5. Antigenic difference was observed between CDV by IFA.