[KSCI] Korea Science Citation Index Service

Immunoregulatory Action of OGAPI 오가피의 면역조절작용

Kim Nam Seok (Department of Medicinal Biotechnology, Woosuk University)
Kwon Jin (Department of Medical Administration, Kunjang College)
Koh Ha Young (Department of Food Nutrition, Woosuk University)
Choi Dong Seong (Department of Medicinal Biotechnology, Woosuk University)
Oh Chan Ho (Department of Medicinal Biotechnology, Woosuk University)

Publication Information

Journal of Physiology & Pathology in Korean Medicine / v.18, no.5, 2004 , pp. 1337-1342 More about this Journal

Abstract

The purpose of this research was to investigate the immunoregulatory effect and the leukemia cell apoptosis of EtOH extract of OGAPI(OGP). The proliferation of cultured splenocytes, thymocytes and mesenteric lymph node cells were enhanced by the addition of OGP. Splenic and thymic T lymphocytes, especially TH and Tc cells were significantly increased in OGP-administered mice. OGP markedly increased the production of γ-interferon in mice serum and accelerated the phagocytic activity in peritoneal macrophages. OGP treatment enhanced the apoptosis of L1210 mouse leukemia and Jurkat, Molt4 human leukemia cells, and increased the expression of apoptosis-related ICE, c-myc, p53 gene in Jurkat cell. These results suggest that OGP have an immunoregulatory action and anti-cancer activity.

Keywords

Immunoregulatory; γ-interferon; Phagocytic activity; Apoptosis;

Citations & Related Records

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