• Journal of Energy Engineering
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• v.21 no.2
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• pp.119-123
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• 2012

Although LNG storage tanks are very delicate with chloride attack owing to its operating inshore location, specific integrity management system for chloride attack has not been studied so far. As the design warranty life time, about 25 years, has come, to prevent paying huge amount of construction cost and required resources for new alternative storage tanks and manage the life time of operating storage tanks, the basic data of chloride attack is necessary. This study intended to build up basic data for following detailed study to develop technologies for life time management of LNG storage tanks, NT Build 492 method in North Europe was used to test chloride diffusion coefficient for the newly-constructing concrete outer tank. Results of these tests lead us to the conclusion that 90 days diffusion coefficients show 46% of 28 days' due to a large quantity of fly ash mixing and much similar to estimation from concrete process table. It seems resonable to conclude that 90 days specimens are recommended estimating the chloride diffusion coefficient for LNG storage tanks to enhance the reliabilities.

• Journal of Veterinary Clinics
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• v.27 no.3
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• pp.289-294
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• 2010

Mandarin fish (SSOGARI: Korean name) has emerged as new aquaculture and aquarium fish among Korean native fish species. Unfortunately, this fish could not exempt from infectious agent invasion. As an epidemiological survey, high mortality of mandarin fish (Siniperca scherzeri) observed from a fish farm in Gyeongnam province of South Korea. The major macroscopic sign of the diseased fish was severe multifocal dermal ulceration. Histological observation revealed inflammation, necrosis and colonization of bacteria in various tissues. Seven bacterial isolates from the diseased fish were identified as Aeromonas salmonicida subsp. salmonicida (typical A. salmonicida) using API 20E and 20NE system. However, the polymerase chain reaction (PCR) assay using two different primers (AP and MIY) revealed that the bacterial strains were not typical A. salmonicida, but atypical A. salmonicida. This study demonstrates that PCR assay is a reliable method for the confirmation of atypical A. salmonicida in mandarin fish as compared to biochemical tests. Furthermore, this is the first account of extensive dermatitis in mandarin fish due to atypical A. salmonicida infection, which has high potential in aquaculture and aquarium fish among native fish species.

• Journal of Preventive Medicine and Public Health
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• v.37 no.4
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• pp.381-389
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• 2004

Objective : To compare the efficacy between SKI306X and Diclofenac by using generalized estimating equations (GEE) methodology in the analysis of correlated bivariate binary outcome data in Osteoarthritis (OA) diseases. Methods : A randomized, double-blind, active comparator-controlled, non-inferiority clinical trial was conducted at 5 institutions in Korea with the random assignment of 248 patients aged 35 to 75 years old with OA of the knee and clinical evidence of OA. Patients were enrolled in this study if they had at least moderate pain in the affected knee joint and a score larger than 35mm as assessed by VAS (Visual Analog Scale). The main exposure variable was treatment (SKI 306X vs. Diclofenac) and other covariates were age, sex, BMI, baseline VAS, center, operation history (Yes/No), NSAIDS (Y/N), acupuncture (Y/N), herbal medicine (Y/N), past history of musculoskeletal disease (Y/N), and previous therapy related with OA (Y/N). The main study outcome was the change of VAS pain scores from baseline to the 2nd and 4th weeks after treatment. Pain scores were obtained as baseline, 2nd and 4th weeks after treatment. We applied GEE approach with empirical covariance matrix and independent(or exchangeable) working correlation matrix to evaluate the relation of several risk factors to the change of VAS pain scores with correlated binary bivariate outcomes. Results : While baseline VAS, age, and acupuncture variables had protective effects for reducing the OA pain, its treatment (Joins/Diclofenac) was not statistically significant through GEE methodology (ITT:aOR=1.37, 95% CI=(0.8200, 2.26), PP:aOR=1.47, 95% CI=(0.73, 2.95)). The goodness-of-fit statistic for GEE (6.55, p=0.68) was computed to assess the adequacy of the fitted final model. Conclusions : Both ANCOVA and GEE methods yielded non statistical significance in the evaluation of non-inferiority of the efficacy between SKI306X and Diclofenac. While VAS outcome for each visit was applied in GEE, only VAS outcome for the fourth visit was applied in ANCOVA. So the GEE methodology is more accurate for the analysis of correlated outcomes.

• Textile Coloration and Finishing
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• v.26 no.1
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• pp.45-52
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• 2014

Red pine (Pinus densiflora) is widely used traditional medicine, pharmacological and nutritional values from which the phytochemical compounds are derived. The present study was aimed to examine the antibacterial effects in the absence and presence of a immature red pine cone extract against 13 microorganisms. The components in the aqueous extract from immature red pine cone were identified by GC-MS. About 1.4% of total polyphenolic compound was measured in aqueous extract collected from immature red pine cone. Also, the high concentration of ${\beta}$-phellenandrene, ${\alpha}$-pinene, limonene, bornyl acetate and aldehyde was detected in total ion chromatograms. Of total 13 microorganisms, 4 microorganisms including Pseudomonas aeruginosa, Vibrio cholera, Listeria monocytogenes, Klebsiella pneumonia were effectively killed by aqueous extract of immature red pine cone. The highest anti-bacterial effect was detected in P. aeruginosa, followed by V. cholera, L. monocytogenes and K. pneumonia. In case of P. aeruginosa, the largest diameter of inhibition zone was maintained to 1/2 solution treated cells and slightly decreased at 1/4 and 1/8 solution treated cells. Also, in test used V. cholera and L. monocytogenes, the inhibition zone was strongly formed in only 1 and 1/2 solution treated cells, while K. pneumonia showed the very small diameter of inhibition zone in all concentrations. Therefore, these results suggested that the aqueous extracts of immature red pine cone should be considered as a new and potentially important anti-bacterial substrate to effectively prevent the microbial infection and penetration.

• Journal of the Korean Geotechnical Society
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• v.27 no.12
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• pp.17-25
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• 2011

A fabric of soil media may change due to certain factors such as dissolution of soluble particles, desiccation, and cementation. The fabric changes affect the mechanical behavior of soils. The purpose of this study is to investigate the effects of geo-material dissolution on shear strength. Experiments and numerical simulations are carried out by using a conventional direct shear and the discrete element method. The dissolution specimens are prepared with different volumetric salt fraction in sand soils. The dissolution of the specimens is implemented by saturating the salt-sand mixtures at different confining stresses in the experimental study or reducing the sizes of soluble particles in the numerical simulations. Experimental results show that the angle of shearing resistance decreases with the increase in the soluble particle content and the shearing behavior changes from dilative to contractive behavior. The numerical simulations exhibit that macro-behavior matches well with the experimental results. From the microscopic point of view, the particle dissolution produces a new fabric with the increase of local void, the reduction of contact number, the increase of shear contact forces, and the anisotropy of contact force chains compared with the initial fabric. The shearing behavior of the mixture after the particle dissolution is attributed to the above micro-behavior changes. This study demonstrates that the reduction of shearing resistance of geo-material dissolution should be considered during the design and construction of the foundation and earth-structures.

• Journal of Food Hygiene and Safety
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• v.33 no.5
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• pp.399-403
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• 2018

In this study, safety investigations on harmful microorganisms and mycotoxins were conducted on honeybee drone pupae as a new food material, which is rich in nutrients and capable of being mass produced in apiaries. The honeybee drone pupae produced in apiaries were collected from three different regions in Korea and frozen immediately. Subsequently, the samples were subjected to freeze-drying. According to the Korean Food Code test method, coliforms, Salmonella species, Staphylococcus aureus, and enterohemorrhagic Escherichia coli were not detected in 280 honeybee drone pupas. In addition, mycotoxins, aflatoxin $B_1$, ochratoxin A, deoxynivalenol, and zearalenone were not detected. Therefore, it is proposed that the honeybee drone pupae collected from the beehives and immediately frozen as safe from harmful microorganisms and mycotoxins and can be used as a food material.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.11B
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• pp.1715-1724
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• 2010

This paper analyzes the limitations and provides alternative options for Korean Military LISI model, which is based on interoperability assessment model, LISI(Level of Information System Interoperability), developed for US defense information systems and reformed to suit the Korean Military environment by ADD. Korean Military's LIST model is applied to all systems(information system, weapon systems, non-weapon systems)' interoperability assessment defined in acquisition regulations by Joint Interoperability Test Center, a subordinate unit of Defense Command and Control Forces and the only assessment agency of defense interoperability. LISI was basically developed as an assessment model for information system's interoperability, but due to it's shortfall in assessing complex systems including information systems, weapon and non-weapon systems required from New environment SOSI(System of Systems Interoperability) has recently been researched and developed. On the other hand, it is inevitable that Korean Military's LISI model face fundamental limitations as an interoperability assessment tool for Defense Information System as well as for weapon and non-weapon systems, since it was benchmarked and reformed from the US LISI model. In order to overcome such limitations, MND and associated agencies are providing improvement methods through studies. This paper will provide LISI capability model's assessment criteria on Application(P), Infrastructure(I), Data(D), restraints of on comparison assessment process of unit systems evaluated and politic alternatives to overcome the restraints.

• Journal of the Korean Society for Railway
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• v.16 no.6
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• pp.473-481
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• 2013

The purpose of this research is to evaluate the improvements in the strength and injection range of loose ground after injecting $CaCO_3$(created by microorganism reaction). For this purpose, three cases of single-layer (Sand, SP, SW) specimens were made in a 150mm D ${\times}$ 200mm H space and two cases of multi-layer specimens (SW/SP, SP/SW) were made in a 150mm D ${\times}$ 300mm H space. The specimens were made with a relative density of 30% of soft ground and an injection was given over a time of one day. The uniaxial compression strength was measured with a cone penetrometer and the injection range was observed by checking the bulb formation around the injection nozzle. Also, the compositions of the specimens were assessed through XRD analyses. Based on the test results, a compressive strength of 500kPa and 15cm thick cementation were noted due to the cementation of the soil. This implies that there are significant effects of the pore condition and size on bio-grouting technology.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.36 no.4
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• pp.253-258
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• 2010

Until now, evaluating the efficacy of brightening mainly depends on total reflective light measurement. For example, SHV (Saturation, Hue, Value), $L^*$ $a^*$ $b^*$ (CIELAB color space system) color space system was used and lightness and saturation changes were chosen as major parameters for evaluating brightening effect. However, those parameters were calculated from total reflective light on the skin and it is hard to evaluate perceptive efficacy such as luminescence, and glossy. In this research, we applied new method for estimating change of luminescence of skin by using 'Lumiscan' which uses polarized light for detecting surface and inside reflective light independently. We also tested 15 different parameters for finding correlations between luminescence and those parameters. As a results, our 2 different brightening products showed 5 ~ 9 % increase of luminescence at 4 and 8 weeks. And we also found that skin roughness (-28 %), melanin index (-17 %), redness (-7 %), hydration (15 %), and lightness (6 %) were related to luminescence of skin.

• Journal of Pharmaceutical Investigation
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• v.29 no.4
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• pp.355-360
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• 1999

Triflusal is a new antithrombotic agent which inhibits both platelet cyclooxygenase and c-AMP phosphodiesterase activity. The purpose of the present study was to evaluate the bioequivalence of two triflusal capsules, $Disgren^{TM}$ (Myung-In Pharmaceutical Co., Ltd.) and $Tigriri^{TM}$ (Hana Pharmaceutical Co., Ltd.) according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, $22.94{\pm}1.83$ in age and $63.7l{\pm}10.43$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one capsule containing 300 mg of triflusal was orally administered, blood was taken at predetermined time intervals and the concentrations of triflusal in serum were determined using HPLC method with UV detector. Pharmacokinetic parameters such as $AUC_t$ $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_t$ $C_{max}$ and $T_{max}$ between two capsules were -0.30%, 0.81 % and -3.03%, respectively when calculated against the $Disgren_{TM}$ capsule. The powers $(1-{\beta})$ for $AUC_t$ $C_{max}$ and $T_{max}$ were 98.29%,84.73% and 81.02%, respectively. Minimum detectable differences $({\Delta})$ at ${\alpha}=0.1$ and $1-{\beta}=0.8$ were all less than 20% (e.g., 12.91%, 18.46% and 19.65% for $AUC_t$ $C_{max}$ and $T_{max}$ respectively). The 90% confid,ence intervals were all within ${\pm}20%$(e.g., $-8.97{\sim}8.37$, $-11.58{\sim}13.22$ and $-16.23{\sim}10.17$ for $AUC_t$ $C_{max}$ and $T_{max}$, respectively). All of the above parameters ($1-{\beta}, {\Delta}$ and 90% confidence intervals) met the criteria of KFDA for bioequivalence, indicating that $Tigriri^{TM}$ capsule is bioequivalent to $Disgren^{TM}$ capsule.