• Journal of Technology Innovation
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• v.20 no.2
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• pp.135-159
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• 2012

To the analysis and discussion whether to conceptualization between the basis and LCM(Life cycle management) of patentability decisions and evergreening through research on patent application strategies and litigation cases. The Stakeholders have said that the LCM and evergreening strategies are an innovative effort to develop new pharmaceuticals, while others say that it is an effort to block generic pharmaceuticals from entering the market and permanently dominate the market by generic pharmaceuticals manufacturers or health economic perspectives. To achieve the goal of research, to discuss for conceptualization LCM and Evergreening strategies through patent application strategies for 14 pharmaceuticals for APIs and case studies for litigations. As a results, the LCM is getting patent rights for the results of research at the initial R&D stage and as such this shall be regarded as part of an effort for technology innovation. However, Evergreening is granting patent rights for the results by making high permission barrier to prevent the market entry of generic pharmaceuticals in the late development period during the pharmaceuticals development process or after their launch. This may lead to the problem of getting weak in health economic aspects and consumer welfare aspects by lowering the market accessibility of cheap generic pharmaceuticals.

• Journal of the Semiconductor & Display Technology
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• v.15 no.4
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• pp.51-60
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• 2016

Consumers who use mobile applications for their skin care are increasing due to increasing interest in skin care and smart phone use. A survey was conducted to select popular skin care mobile applications to be installed in the smart phone targeting 1,000 men and women in South Korea who are interested in their skin care. Questioned items included skin care awareness and recognition, skin care type, and the intention of using skin health care mobile services. The respondents thought the best skin as 'Flawless skin (52.3%)'. Also, 'Skin trouble' and 'Skin aging' were their major concerns. 47.1% of the respondents used mobile skin care applications, and 56.6% intended to try new mobile skin care services. The results on interesting field of skin care showed significant difference depending on gender, marital status, and annual average household income. Moreover, the results on effort made for skin care showed significant difference depending on age, gender, and marital status. They wanted the functions such as 'Review on cosmetic products by brand (23.8%)', 'Self skincare method (16.8%)', 'Continuous monitoring service (16.2%)', 'Information on cosmetic products (13.4%)'. The result of this study would be reliable as basic material for skincare mobile service area. Further studies could be focused on developing application in accordance with needs and how it should be applied.

• The Journal of Korean Society for Radiation Therapy
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• v.10 no.1
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• pp.69-77
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• 1998

When a high energy photon beam is used to treat lesions located in the upper respiratory air passages or in maxillary sinus, the beams often must traverse an air cavity before it reaches the lesion. Because of this traversal of air, it is not clear that the surface layers of the lesion forming the air-tumor tissue interface will be in a state of near electronic equilibrium; if they are not, underdosing of these layers could result. Although dose corrections at large distances beyond an air cavity are accountable by attenuation differences, perturbations at air-tissue interfaces are complex to measure or calculate. This problem has been investigated for 4MV and 10MV X-ray beams which are becoming widely available for radiotherapy with linear accelerator. Markus chamber was used for measurement with variouse air cavity geometries in X-ray beams. Underdosing effects occur at both the distal and proximal air cavity interface. The magnitude depended on geometry, energy, field sizes and distance from the air-tissue interfaces. As the cavity thickness increased, the central axis dose at the distal interface decreased. Increasing field size remedied the underdosing, as did the introduction of lateral walls. Fellowing a $20{\times}2{\times}2\;cm^3$\;air\;cavity,\;4{\times}4\;cm\;field\;there\;was\;an\;11.5\%\;and\;13\%\;underdose\;at\;the\;distal\;interface,\;while\;a\;20{\times}20{\times}2\;cm^3\;air\;cavity\;yielded\;a\;24\%\;and\;29\%$ loss for the 4MV and 10MV beams, respectively. The losses were slightly larger for the 10MV beams. The measurements reported here can be used to guide the development of new calculation models under non-equilibrium conditions. This situation is of clinical concern when lesions such as larynx and maxillary carcinoma beyond air cavities are irradiated.

• Journal of radiological science and technology
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• v.28 no.2
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• pp.129-135
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• 2005

IT communication industries of current society are developed in enormous growth, our country leading the world in the number of super high speed internet equipments in use. In the pride oneself on communication network of those, mobile terminal technology and wireless phone production hold a high rank. Data communication and networking may be the fastest growing technologies in our culture today. In this way, IT fields conjugated in the daily quick, the fact that department of radiological science didn't discharged one's duties on current IT education. The curriculum of radiological technologists that play an important part between skill and occupation's education as major and personality didn't performed one's part most effectively on current IT environments and digital radiological equipments interface. Therefore, in this paper current curriculum of radiological science are catched hold of trend and problems on digital radiology environments, on fact the present state of problems, for radiological engineering and HIS manager, new curriculum course are suggested a reform measure of culture and major education curriculum introduction.

• Annals of Laboratory Medicine
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• v.38 no.6
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• pp.585-590
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• 2018

Background: Although testing to detect weak D antigens using the antihuman globulin reagent is not required for D- patients in many countries, it is routinely performed in Korea. However, weak D testing can be omitted in D- patients with a C-E- phenotype as this indicates complete deletion of the RHD gene, except in rare cases. We designed a new algorithm for weak D testing, which consisted of RhCE phenotyping followed by weak D testing in C+ or E+ samples, and compared it with the current algorithm with respect to time and cost-effectiveness. Methods: In this retrospective study, 74,889 test results from January to July 2017 in a tertiary hospital in Korea were analyzed. Agreement between the current and proposed algorithms was evaluated, and total number of tests, time required for testing, and test costs were compared. With both algorithms, RHD genotyping was conducted for samples that were C+ or E+ and negative for weak D testing. Results: The algorithms showed perfect agreement (agreement=100%; ${\kappa}=1.00$). By applying the proposed algorithm, 29.56% (115/389 tests/yr) of tests could be omitted, time required for testing could be reduced by 36% (8,672/24,084 min/yr), and the test cost could be reduced by 16.53% (536.11/3,241.08 USD/yr). Conclusions: Our algorithm omitting weak D testing in D- patients with C-E- phenotype may be a cost-effective testing strategy in Korea.

• International Journal of Advanced Culture Technology
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• v.9 no.3
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• pp.131-141
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• 2021

The present study is following a series of research investigations on design resources coming from collected data referring to users' awareness and preferences. The aim of this research is to test the Healthcare Environmental Color Index as a basis for practitioners in the field of healthcare design. An array of color samples selected from previous research, have been presented to the respondents via an online survey, in order to identify the preferences of the two groups on the relation between environmental color and health. As a result of the first experiment and through the comparison of processed data, the maximum percentage of respondents from each group is validating the relation between environmental color and health. For the second experiment we intend to highlight the patterns of color preferences for each group, and thus to test the color samples healing function. The compared data also showed a higher awareness of Koreans than Romanians on the potential of color applied to healing environment. Last but not least in the third experiment we show the top five color samples preferred by each group. It is significant that the comparison of the results validated once more some of our previous findings related to the healthcare environment, such as: the general preference for the green hue (associated to fatigue relax according to color psychology) and the blue hue (sedation release effect) but also the yellow hue - associated to bright energy. Three out of the top five preferred color samples have been identical to both groups while the other two samples have shown characteristic variations. These results show that similarities are strong and can be used in a glocal design strategy as an accessible tool for any practitioner. Based on the Healthcare Environmental Color Index and users' preferences analysis, a new design culture for healthcare can be established and developed.

• Nuclear Engineering and Technology
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• v.51 no.3
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• pp.843-852
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• 2019

In the present study, we established a comprehensive dataset of dose coefficients (DCs) of the new meshtype ICRP reference computational phantoms (MRCPs) for idealized external exposures of photons and electrons with the Geant4 code. Subsequently, the DCs for the nine organs/tissues, calculated for their thin radiosensitive target regions, were compared with the values calculated by averaging the absorbed doses over the entire organ/tissue regions to observe the influence of the thin sensitive regions on dose calculations. The result showed that the influences for both photons and electrons were generally insignificant for the majority of organs/tissues, but very large for the skin and eye lens, especially for electrons. Furthermore, the large influence for the skin eventually affected the effective dose calculations for electrons. The DCs of the MRCPs also were compared with the current ICRP-116 values produced with the current ICRP-110 reference phantoms. The result showed that the DCs for the majority of organs/ tissues and effective dose were generally similar to the ICRP-116 values for photons, except for very low energies; however, for electrons, significant differences from the ICRP-116 values were found in the DCs, particularly for superficial organs/tissues and skeletal tissues, and also for effective dose.

• Journal of Environmental Health Sciences
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• v.45 no.2
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• pp.173-185
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• 2019

Objectives: The objectives of this study are to evaluate the accuracy and precision of exposure model ECETOC TRA v.3.1 by comparing model predictions with repeated exposure measurements in Korean workplaces and to investigate the applicability of ECETOC TRA to Korean workplace exposure assessment in K-REACH. Methods: Measured values and work conditions for 14 kinds of chemicals collected from exposure field surveys conducted at 10 companies in Korea were utilized for this study. All possible process categories (PROCs) considered to be relevant to each work process classification were selected and applied to ECETOC TRA as major determining parameters. In order to quantify the accuracy of the model, the lack of agreement (bias, relative bias, precision) was calculated and the risk ratios for each exposure situation between estimated and measured were also compared. Results: The estimated values varied between five and 25 times according to the PROCs for all exposure situations (ESs) based on tasks/chemicals. The results showed that most of the estimated values were below the measured values, and just 13 of 53 tasks were above the measured values. The overall bias and precision were $-2.91{\pm}1.62$ with ECETOC TRA, and we found that ECETOC TRA showed a low level of conservatism when applied to Korean workplaces, similar to previous studies. Conclusions: This study demonstrates that the existed PROC codes have limitations in fully covering various ESs in Korea. In order to improve the applicability of ECETOC TRA in K-REACH, the addition of new PROCs for Korean industries are necessary.

• The Journal of the Convergence on Culture Technology
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• v.7 no.1
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• pp.327-335
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• 2021

We aimed to find new space types and characteristics for creating gardens in the city through the type of idle space in the city, present guidelines that can be used in creating gardens in the future, and establish basic data for expanding green infrastructure. As a result, we found that the idle space in the city was classified into four types, and it was determined that differentiation should be given to the creation of each type. The achievements of this study can be a potential source of urban ecosystem services that can provide community benefits and opportunities for urban regeneration through the redevelopment of the community and support the health and well-being of local residents. In addition, urban idle space can be a valuable resource as a green infrastructure that can be used to support the health of urban ecosystems and improve the quality of life of urban residents.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2022.10a
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• pp.389-391
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• 2022

Efforts by the Ministry of Environment and local governments in Korea are continuing to manage the aging of water supply and sewage buried underground. With the support of the Korea Institute of Environmental Industry and Technology's water and sewage innovation technology development project, it is conducting a project to predict and exchange accidents due to aging, and to apply smart functions to new buried pipes. As one of these studies, this paper proposes the design of a dashboard concept model for digital twin-based smart pipe health monitoring, one of the key features of the entire study. Since remote control and monitoring are one of the main functions, distributed transmission and reception agents are deployed to visualize monitoring situations in real time and to increase user affinity by deploying intuitive UI. To validate the design of this proposed special digital twin based smart pipe state monitoring, we construct the conceptual model level and measure the agent effectiveness to validate its excellence.