• 대한화학회지
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• 제67권1호
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• pp.19-27
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• 2023

동물실험에 의존하는 전통적인 위해성평가 방법의 한계가 명확하게 드러나면서, 동물실험이 아닌 최첨단 기술을 활용한 화학물질 위해성평가 방법론들이 연구되고 있다. 이는 곧 신규접근법(New Approach Methodologies, NAMs)이라는 개념으로 구체화되었으며 차세대 위해성평가(Next generation risk assessment, NGRA) 프레임워크로 구현되었다. 하지만 신규접근법 데이터는 신뢰도 문제로 인해 극히 제한적으로 화학물질의 규제 의사결정과정에 활용되고있다. 이에 규제 공동협력기관 APCRA 이니셔티브는 화학물질 위해성평가에 신규접근법 데이터의 활용을 증진시키기 위해 여러 사례연구를 수행하였으며, 이를 바탕으로 차세대 위해성평가의 전망에 대해 논의한 바 있다. 따라서 본 총설에는 APCRA 이니셔티브가 수행한 사례연구 두 편을 중심으로 신규접근법을 활용한 차세대 위해성평가의 개념과 전망을 제시하였다.

• Industrial Engineering and Management Systems
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• 제13권4호
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• pp.369-382
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• 2014

This paper introduces a new multi-product multi-period multi-objective aggregate production planning problem. The proposed problem is modeled using multi-objective mixed-integer mathematical programming. Three objective functions, including minimizing total cost, maximizing customer services level, and maximizing the quality of end-product, are considered, simultaneously. Several constraints such as quantity of production, available time, work force levels, inventory levels, backordering levels, machine capacity, warehouse space and available budget are also considered. Some parameters of the proposed model are assumed to be qualitative and modeled using fuzzy sets. Then, a fuzzy goal programming approach is proposed to solve the model. The proposed approach is applied on a real-world industrial case study of a color and resin production company called Teiph-Saipa. The approach is coded using LINGO software. The efficacy and applicability of the proposed approach are illustrated in the case study. The results of proposed approach are compared with those of the existing experimental methods used in the company. The relative dominance of the proposed approach is revealed in comparison with the experimental method. Finally, a data dictionary, including the way of gathering data for running the model, is proposed in order to facilitate the re-implementation of the model for future development and case studies.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회/대한산업공학회 2003년도 춘계공동학술대회
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• pp.474-479
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• 2003

This paper addresses the problem of B-spline surface interpolation to serial contours, where the number of points varies from contour to contour. A traditional lofting approach creates a set of B-spline curves via B-spline curve interpolation to each contour, makes them compatible via degree elevation and knot insertion, and performs B-spline surface lofting to get a B-spline surface interpolating them. The approach tends to result in an astonishing number of control points in the resulting B-spline surface. This situation arises mainly from the inevitable process of progressively merging different knot vectors to make the B-spline curves compatible. This paper presents a new approach for avoiding this troublesome situation. The approach includes a novel process of getting a set of compatible B-spline curves from the given contours. The process is based on the universal parameterization [1,2] allowing the knots to be selected freely but leading to a more stable linear system for B-spline curve interpolation. Since the number of control points in each compatible B-spline curve is equal to the highest number of contour points, the proposed approach can realize efficient data reduction and provide a compact representation of a B-spline surface while keeping the desired surface shape. Some experimental results demonstrate its usefulness and quality.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제50권2호
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• pp.110-115
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• 2024

A 22-year-old male patient presented to the clinic with severe pain in the preauricular area with an inability to completely occlude the jaw. Facial computed tomography and magnetic resonance imaging revealed a well-defined lesion that was tentatively diagnosed as a benign tumor or cystic mass. Surgical approach of a lesion in the condyle is delicate and problematic as many vulnerable anatomical structures are present. There are several methods for surgery in this area. Typically, an extraoral approach is dangerous because of potential injuries to nerves and arteries. The intraoral approach also presents difficulties due to the lack of visibility and accessibility. On occasion, coronoidectomy may be performed. The goal here was to determine an easier and safer new surgical approach to the condyle. We reached the anterior part of the pterygoid plate in the same method as in Le Fort I surgery. From this point, through the external pterygoid muscle, approaching the anterior aspect of the condyle is relatively easy and safe, with minimal damage to the surrounding tissues. Pus was drained at the site, and the lesion was diagnosed as an abscess. Pain and inability to close the mouth resolved without recurrence.

• Journal of Mechanical Science and Technology
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• 제20권5호
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• pp.658-667
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• 2006

Fractional derivative models, which are used to describe the viscoelastic behavior of material, have received considerable attention. Thus it is necessary to put forward the analysis solutions of dynamic systems containing a fractional derivative. Although previously reported such kind of fractional calculus-based constitutive models, it only handles the particularity of rational number in part, has great limitation by reason of only handling with particular rational number field. Simultaneously, the former study has great unreliability by reason of using the complementary error function which can't ensure uniform real number. In this paper, a new approach is proposed for an analytical scheme for dynamic system of a spring-mass-damper system of single-degree of freedom under general forcing conditions, whose damping is described by a fractional derivative of the order $0<{\alpha}<1$ which can be both irrational number and rational number. The new approach combines the fractional Green's function and Laplace transform of fractional derivative. Analytical examples of dynamic system under general forcing conditions obtained by means of this approach verify the feasibility very well with much higher reliability and universality.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2006년도 International Symposium on GPS/GNSS Vol.1
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• pp.491-494
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• 2006

Kalman filtering (KF) is hard to be applied to the SINS (Strap-down Inertial Navigation System)/RDSS (Radio Determination Satellite Service) integrated navigation system directly because the time delay of RDSS positioning in active mode is random. BP (Back-Propagation) Neuron computing as a powerful technology of Artificial Neural Network (ANN), is appropriate to solve nonlinear problems such as the random time delay of RDSS without prior knowledge about the mathematical process involved. The new algorithm betakes a BP neural network (BPNN) and velocity feedback to aid KF in order to overcome the time delay of RDSS positioning. Once the BP neural network was trained and converged, the new approach will work well for SINS/RDSS integrated navigation. Dynamic vehicle experiments were performed to evaluate the performance of the system. The experiment results demonstrate that the horizontal positioning accuracy of the new approach is 40.62 m (1 ${\sigma}$), which is better than velocity-feedback-based KF. The experimental results also show that the horizontal positioning error of the navigation system is almost linear to the positioning interval of RDSS within 5 minutes. The approach and its anti-jamming analysis will be helpful to the applications of SINS/RDSS integrated systems.

• Computers and Concrete
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• 제23권1호
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• pp.69-80
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• 2019

Modeling approach for mesoscopic model of concrete depicting mass transportation and physicochemical reaction is important since there is growing demand for accuracy and computational efficiency of numerical simulation. Mesoscopic numerical simulation considering binder, aggregate and Interfacial Transition Zone (ITZ) generally produces huge number of DOFs, which is inapplicable for full structure. In this paper, a three-dimensional multiscale approach describing three-phase structure of concrete was discussed numerically. An effective approach generating random aggregate in polygon based on checking centroid distance was introduced. Moreover, ITZ elements were built by parallel expanding the surface of aggregates on inner side. By combining mesoscopic model including full-graded aggregate and macroscopic model, cases related to diffusivity and thickness of ITZ, volume fraction and grade of aggregate were studied regarding the consideration of multiscale compensation. Results clearly showed that larger analysis model in multiscale model expanded the diffusion space of chloride ion and decreased chloride content in front of rebar. Finally, this paper addressed some worth-noting conclusions about the chloride distribution and rebar corrosion regarding the configuration of, rebar diameter, concrete cover and exposure period.

• International Journal of Computer Science & Network Security
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• 제23권5호
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• pp.163-171
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• 2023

The intelligent transportation system has made a huge leap in the level of human services, which has had a positive impact on the quality of life of users. On the other hand, these services are becoming a new source of risk due to the use of data collected from vehicles, on which intelligent systems rely to create automatic contextual adaptation. Most of the popular privacy protection methods, such as Dummy and obfuscation, cannot be used with many services because of their impact on the accuracy of the service provided itself, they depend on changing the number of vehicles or their physical locations. This research presents a new approach based on the shuffling Nicknames of vehicles. It fully maintains the quality of the service and prevents tracking users permanently, penetrating their privacy, revealing their whereabouts, or discovering additional details about the nature of their behavior and movements. Our approach is based on creating a central Nicknames Pool in the cloud as well as distributed subpools in fog nodes to avoid intelligent delays and overloading of the central architecture. Finally, we will prove by simulation and discussion by examples the superiority of the proposed approach and its ability to adapt to new services and provide an effective level of protection. In the comparison, we will rely on the wellknown privacy criteria: Entropy, Ubiquity, and Performance.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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• pp.114-117
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• 1998

Chinese traditional drugs have a long history to be used in clinics to treat various diseases and are confirmed to be effective approach through thousands of years of medical practice. Therefore, as a common understanding, the drug development from traditional Chinese medicines could be considered as a “shortcut” way with less blindness and more saving of time and money since development of new Chinese drugs has a different approach from that of western new drugs. Firstly, Chinese new drug development can be simplified as “from men to animal” process rather than “from animal to men” in western medicines. Hence the successful rate would be higher. Secondly, the original drugs or prescriptions from which the new drugs are planned to develop have been known what symptoms they are indicated for. Therefore, the developing procedure is actually a refine process with much less blindness than that of western drugs.

• International Journal of Reliability and Applications
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• 제2권2호
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• pp.81-97
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• 2001

Lifetesting problems have been the subject of investigations for over three decades. Most suggested approaches are markedly different from those used in the related but wider goodness of fit problems. In the current investigation, it is demonstrated that a goodness of fit approach is possible in many lifetesting problems and that It results in simpler procedures that are asymptotically equivalent or better than standard ones. They may also have superior finite sample behavior. Several perennial classes are addressed here. The class of increasing failure rate (IFR) and the class of new better than used (NBU) are addressed first. In addition, we provide testing for a newer and practical class of new better than used in convex ordering (NBUC) due to Cao and Wang (1991). Other classes can be developed similarly and this point is illustrated with the classes of new better than used in expectation (NBUE) and harmonic new better than used in expectation (HNBUE).