• Asian Pacific Journal of Cancer Prevention
• /
• 제17권7호
• /
• pp.3619-3622
• /
• 2016

Background: Triple negative breast cancers (TNBCs) are high grade aggressive tumors generally with a poor prognosis, not responding to hormonal and anti Her2 Neu therapy. Expression of the antiapoptotic B cell lymphoma 2 gene (Bcl-2) is associated with low grade, slowly proliferating hormone receptor positive tumors with improved survival. Anti Bcl2 agents can be used as alternative targeted therapy in triple negative cancers. Materials and Methods: The objective of this study was to determine the immunohistochemical expression of Bcl2 in triple negative breast cancers and any correlation with clinicopathological variables in Northern Pakistan. Results: All 52 patients were females, aged between 28 and 80 years(average $48.0{\pm}12.1$). 28 cases (53.8%) were positive for Bcl2, this being associated with low grade invasive ductal carcinomas, lymph node metastasis and lymphovascular invasion. Conclusions: Bcl-2 may be an important prognostic factor and its expression might be used for targeted therapy using Anti Bcl2 drugs.

• 감성과학
• /
• 제23권4호
• /
• pp.3-20
• /
• 2020

본 연구의 목적은 노화에 따라 나타나는 시공간 주의배분능력과 정서지각 편향성의 변화에 대해 탐구하는 것이다. 본 연구에서는 시공간 주의배분능력을 측정하기 위해 useful field of view (UFOV) 과제와 정서지각 편향성을 측정하기 위해 정서지각과제(emotional perception task)를 사용하였다. 본 연구에는 노인 집단의 23명과 청년 집단의 25명의 총 48명의 실험참가자가 참여하였다. 실험 결과, UFOV 과제에서는 노인 집단이 청년 집단에 비해 느린 반응속도와 낮은 정답률을 보여 노인 집단이 청년 집단보다 저하된 시공간 주의배분능력을 가지고 있다는 것을 나타냈다. 또한, 정서지각과제에서는 노인 집단이 청년 집단에 비해 긍정적 정서지각 편향성과 부정적 정서지각 편향성 모두 크게 나타났다. 상관분석 결과에서는 정서지각과제의 정답률에 대한 부정적 정서지각 편향성이 UFOV 과제의 시야각 30° 조건의 반응속도와 유의미한 정적 상관관계가 나타났다(r=.289). 또한, 정서지각과제의 정답률에 대한 긍정적 정서지각 편향성은 UFOV 과제의 모든 시야각 조건들의 정답률과 유의미한 정적 상관관계가 나타났으며(r=.305, r=.322, r=.299), 반응속도와 유의미한 부적 상관관계가 나타났다(r=-.345, r=-.295, r=-.308). 이러한 결과는 노화가 저하된 시공간 주의배분능력 그리고 긍정적 정서지각 편향성과 부정적 정서지각 편향성의 증가와 관련있다는 것을 의미하고, 노화에 따라 나타나는 긍정적 및 부정적 정서지각 편향성은 저하된 시공간 주의배분능력과 관련성이 있는 것으로 여겨진다.

• 대한수의학회지
• /
• 제58권1호
• /
• pp.9-16
• /
• 2018

A preliminary study into the protective mechanisms of adaptive immunity against porcine reproductive and respiratory syndrome virus (PRRSV) in piglets (n = 9) born to a gilt challenged intranasally with a type-2 PRRSV. Immune parameters (neutralizing antibodies, $CD3^+CD4^+$, $CD3^+CD8^+$, $CD3^+CD4^+CD8^+$ T-lymphocytes, and PRRSV-specific interferon $(IFN)-{\gamma}$ secreting T-lymphocytes) were compared with infection parameters (macro- and microscopic lung lesion, and PRRSV-infected porcine alveolar macrophages ($CD172{\alpha}^+PRRSV-N^+\;PAM$) as well as with plasma and lymphoid tissue viral loads. Percentages of three T-lymphocyte phenotypes in 14-days post-birth (dpb) peripheral blood mononuclear cell (PBMC) had significant negative correlations with percentages of $CD172{\alpha}^+PRRSV-N^+\;PAM$ (p < 0.05) as well as with macroscopic lung lesion (p < 0.01). Plasma and tissue viral loads had significant (p < 0.05) negative correlations with $CD3^+CD4^+CD8^+$ T-lymphocyte percentage in PBMC. Frequencies of $CD3^+CD8^+$ and $CD3^+CD4^+$ T-lymphocytes in 14-dpb PBMC had significant negative correlations with of lymph node (p = 0.04) and lung (p = 0.002) viral loads. $IFN-{\gamma}$-secreting T-lymphocytes frequency had a significant negative correlation with gross lung lesion severity (p = 0.002). However, neutralizing antibody titers had no significant negative correlation (p > 0.1) with infection parameters. The results indicate that T-lymphocytes contribute to controlling PRRSV replication in young piglets born after in-utero infection.

• 한국빅데이터학회지
• /
• 제3권2호
• /
• pp.101-112
• /
• 2018

본 연구는 기계학습의 하나인 신경망 분석과 음이항 회귀분석을 활용하여 경찰신고건수를 예측하고자 2016년 6월부터 2017년 5월까지 충남지방경찰청에 접수된 112신고 데이터를 이용하여 예측모델을 개발하였다. 모델을 개발하기 위해 경찰신고건수에 영향을 줄 수 있는 시간, 휴일, 휴일 전날, 계절, 기온, 강수량, 풍속, 관할면적, 인구, 외국인 수, 단독주택비율, 기타주택비율 변수 등을 활용하였다. 변수의 종류에 따라 몇몇은 경찰신고건수와 양의 상관관계 또는 음의 상관관계가 확인되었다. 사용된 두 개의 방법론을 비교한바, 신경망분석의 예측 결과는 예측 값과 실제 값의 상관계수 0.7702, RMSE 2.557이고, 음이항 회귀분석은 상관계수 0.7158, RMSE 2.831으로 나타났다. 신경망분석은 해석가능성은 낮지만, 음이항 회귀분석에 비해 예측력이 뛰어나다는 것이 확인되었다. 향후 경찰관서에서 본 연구의 예측모델을 기초로 하여 최적의 경찰력 배치를 할 수 있을 것으로 기대된다.

• 한국감성과학회:학술대회논문집
• /
• 한국감성과학회 2003년도 춘계학술대회 논문집
• /
• pp.120-122
• /
• 2003

In this study, an experiment was conducted in order to investigate the feasibility and effectiveness of and on-line subjective assessment (OLSA) system. The present study compared Galvanic Skin Response (GSR) with the OLSA by presenting 28 subjects in their 20s with pictures arousing either positive or negative sensibility. According to the correlation coefficients, changes in subjective sensibility caused by the positive visual stimulus were related more closely to GSR, from the positive visual stimulus, and changes in subjective sensibility caused by the negative visual stimulus were related more closely to GSR from the negative visual stimulus. In conclusion, the most remarkable characteristic of the present system is that it not only assesses the average sensibility when stimuli are presented, but also shows the changing strength of sensibility over time.

• 대한가정학회지
• /
• 제45권4호
• /
• pp.87-96
• /
• 2007

The purpose of this study was to investigate the relationship between the father's emotional expressiveness and verbal controls, and his children's social competency depending on gender. Subjects were 156 five-year-old children and their fathers in 4 private kindergarten in Gyeongi province. The data obtained were analyzed by frequencies, percentiles, means, standard deviations, Cronbach's alpha, t-test, and Pearson's correlations. The major findings of this study were as follows: 1) A significant difference was found between the children's gender in terms of children's external behavioral problems in social competency. 2) There was a negative correlation between the fathers' negative emotional expressiveness and their male children's social competency. 3) There was a negative correlation between the fathers' imperative control under verbal controls and their male children's social competency.

• 한국간호교육학회지
• /
• 제14권2호
• /
• pp.216-223
• /
• 2008

Purpose: The purpose of this study was to discover attitudes toward organ donation in brain dead donors and nursing ethical values of staff nurses. Method: The subjects were 196 nurses with direct patient care in a university hospital. Data collection was carried out for one month in September, 2008 using structured questionnaire. The data were analyzed using frequency, percentage, mean and standards deviation, ANOVA and Pearson's Correlation with SPSS program. Result: The mean score of a positive attitude toward organ donation in brain dead donors was 3.59 points, and a negative attitude score was 3.02 points. The mean score of nursing ethical value was 3.05 points. The age and the length of career had a reverse correlation with a negative attitude toward organ donation. Nursing ethical values had a positive correlation with a negative attitude toward organ donation. Conclusion: It is necessary to increase understanding and recognition of brain death organs donation in the nurses who participate in direct patient care so as to help facilitate organ donation.

• 대한간호학회지
• /
• 제38권1호
• /
• pp.55-63
• /
• 2008

Purpose: The purpose of this study was to examine the relationship between eating disorders and parent-adolescent communication in middle school students. Method: There were 267 adolescents taken as participants from two middle schools in rural areas. Data were collected from June to July 2005, using the Eating Disorder Inventory-2 questionnaire (23 items) and Parent-Adolescent Communication Inventory (10 items for open family communication, 10 items for problem in family communication). The SPSS Win version 12.0 was used for descriptive analysis, t-test, and partial correlation coefficient. Result: The mean score on the eating disorder was 2.74 (range: 1-6). Meanwhile, the mean scores on the parent-adolescent communication was 3.37 (range: 1-5). There were significant differences in eating disorders according to gender, age, negative perception of the participant's body weight, family's perception of obesity, diet experiences, and BMI. Eating disorders showed a significant negative correlation with parent-adolescent communication. Conclusion: In this study, there was a significant negative correlation between eating disorders and parent-adolescent communication. In order to prevent an eating disorder, education and training to enhance communication skills should be provided to adolescents and their parents as well.

• 한국근적외분광분석학회:학술대회논문집
• /
• 한국근적외분광분석학회 2001년도 NIR-2001
• /
• pp.1515-1515
• /
• 2001

Retrogradation of starch is one of important quality indexes for food based on starch such as rice. Therefore, in this research, possibility of near infrared spectroscopy to determine the degree of the retrogradation was examined. The degree of the retrogradation was indicated as the degree of geratinization analyzed by BAP(-amylase-pullulanase) method. 20 samples which have a wide range of the degree of the retrogradation were prepared and the NIR spectra of the samples were measured in reflectance mode with the NIR Systems 6500. In the correlation plots calculated from the 2nd derivative values of the MSC treated spectra and the degree of the geratinization, the major negative peaks of 1544 nm and 2258 nm, and the major positive peaks of 1460 nm, 1602 nm, 1766 nm and 2136 nm could be observed, indicating that NIR absorption at the positive peak wavelengths became strong while the absorption at the negative peak wavelengths became weak as the degree of the retrogradation increased. Because there is negative correlation between the degree of the retrogradation and the degree of the geratinization. As a result of MLR using the 2nd derivative values of the MSC treated spectra and the degree of the geratinization, good calibration equation which include 2258 nm as the first wavelength and 1764 nm as the second one could be obtained, indicating that NIR spectroscopy has a possibility to detect the retrogradation of starch. In order to find the assignment of the bands observed in the correlation plots, further study may be needed.

• 한국보육지원학회지
• /
• 제14권3호
• /
• pp.59-76
• /
• 2018

Objective: The purpose of this study was to examine the relationships among teachers' resilience, difficulty in emotional regulation, and teaching strategies for behavior problems of children. Methods: A total of 200 day care and kindergarten teachers were surveyed. The collected data were analyzed by Pearson's correlation and multiple regression. Results: First, teachers' resilience, difficulty in emotional regulation and teaching strategies for children with behavior problems were significantly related. Teachers' resilience showed a positive correlation with teachers' positive prevention and reaction strategies but showed a negative correlation with teachers' negative reaction strategies. Among the teachers' difficulty in emotional regulation, the factor of difficulty for impulsive control and lack of attention showed negative correlations with teachers' prevention and positive reaction strategies. Second, teachers' resilience and difficulty in emotional regulation significantly explained the teaching strategies for children with behavior problems. Teachers' resilience was found to be the most important variable explaining teaching strategies for children with behavior problems. Conclusion/Implications: This study revealed that teachers' resilience and difficulties in emotional regulation were important psychological and emotional characteristics for teachers when teaching children with behavior problems.