• Title/Summary/Keyword: nature exploration

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Data Mining for High Dimensional Data in Drug Discovery and Development

  • Lee, Kwan R.;Park, Daniel C.;Lin, Xiwu;Eslava, Sergio
    • Genomics & Informatics
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    • v.1 no.2
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    • pp.65-74
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    • 2003
  • Data mining differs primarily from traditional data analysis on an important dimension, namely the scale of the data. That is the reason why not only statistical but also computer science principles are needed to extract information from large data sets. In this paper we briefly review data mining, its characteristics, typical data mining algorithms, and potential and ongoing applications of data mining at biopharmaceutical industries. The distinguishing characteristics of data mining lie in its understandability, scalability, its problem driven nature, and its analysis of retrospective or observational data in contrast to experimentally designed data. At a high level one can identify three types of problems for which data mining is useful: description, prediction and search. Brief review of data mining algorithms include decision trees and rules, nonlinear classification methods, memory-based methods, model-based clustering, and graphical dependency models. Application areas covered are discovery compound libraries, clinical trial and disease management data, genomics and proteomics, structural databases for candidate drug compounds, and other applications of pharmaceutical relevance.

Faint Quasar Candidates at z~5 in the ELAIS-N1 field

  • Shin, Suhyun;Im, Myungshin;Kim, Yongjung;Hyun, Minhee;Jeon, Yiseul;Kim, Minjin;Kim, Dohyeong;Kim, Jae-Woo;Taak, Yoon Chan;Yoon, Yongmin;Choi, Changsu;Hong, Jueun;Jun, Hyunsung David;Karouzos, Marios;Kim, Duho;Kim, Ji Hoon;Lee, Seong-Kook;Pak, Soojong;Park, Won-Kee
    • The Bulletin of The Korean Astronomical Society
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    • v.42 no.2
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    • pp.74.2-74.2
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    • 2017
  • Faint quasars are important to test the possibility that quasars are the main contributor to the cosmic reionization. However, it has been difficult to find faint quasars due to the lack of deep, wide-field imaging data. In this poster, we present our efforts to find faint quasars in the ELAIS-N1 field through the deep data (iAB ~ 25) obtained by the Subaru Hyper Suprime-Cam (HSC) Strategic Program survey. To select reliable quasar candidate, we also use the near-infrared (NIR) data of the Infrared Medium-deep Survey (IMS) and the UKIRT Infrared Deep Sky Survey (UKIDSS) - Deep Extragalactic Survey (DXS). Using multiple-band color cuts, we select high redshift quasar candidates. To confirm them as high redshift quasars, candidates are observed by the SED camera for QUasars in EArly uNiverse (SQUEAN) instrument in several medium band filters that can sample the redshifted Lyman break efficiency. The quasar sample will be used to study the growth of BH and stellar mass, the relation between the quasar activity and the host galaxy, and their contribution to the cosmic re-ionization.

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Are Quasars Growing Fast in the Early Universe?: The Lowest Eddington Ratio Quasar at z~6

  • Kim, Yongjung;Im, Myungshin;Jeon, Yiseul;Kim, Minjin;Hyun, Minhee;Kim, Dohyeong;Kim, Jae-Woo;Taak, Yoon Chan;Yoon, Yongmin;Choi, Changsu;Hong, Jueun;Jun, Hyunsung David;Karouzos, Marios;Kim, Duho;Kim, Ji Hoon;Lee, Seong-Kook;Pak, Soojong;Park, Won-Kee
    • The Bulletin of The Korean Astronomical Society
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    • v.42 no.2
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    • pp.44.3-45
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    • 2017
  • To date, luminous quasars at z ~ 6 have been found to be in maximal accretion with the Eddington ratios, ${\lambda}Edd$ ~ 1, suggesting enhanced nuclear activities in the early universe. However, this may not be the whole picture of supermassive black hole (SMBH) growth since previous studies have not reached on faint quasars that are more likely to harbor SMBHs with low ${\lambda}Edd$. To understand the accretion activities in quasars at high redshift, we obtained the deep near-infrared (NIR) spectrum of a quasar, IMS J2204+0112, one of the few faintest quasars that have been identified at z ~ 6. From the NIR spectrum, we find that IMS J2204+0112 harbors a SMBH with about a billion solar mass, with ${\log}({\lambda}Edd)=-0.91$. This is the lowest accretion rate found so far for quasars at z ~ 6, but a common value among quasars at z ~ 2. The inclusion of this object in the ${\lambda}Edd$ analysis gives the intrinsic ${\lambda}Edd$ distribution of z ~ 6 quasars, which is lower than previous results that are based on bright quasars, but it is still higher than ${\lambda}Edd$ of z ~ 2 quasars. Although the number statistics needs to be improved in future, the low peak ${\lambda}Edd$ value is consistent with the SMBH growth from a massive black hole seed (~ 105 Msun) or from a stellar mass black hole through short-duration super-Eddington accretion events (${\lambda}Edd$ > 10).

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A Comparison on the Representation of the Celestial of the Ninth Heaven in The Canonical Scripture versus The Scripture of the Jade Pivot (《典經》 與 《玉樞寶經》 中 九天應元雷聲普化天尊之形象比較)

  • Ho, Jinchyuan;Chen, Meihua;Tsai, Peifen
    • Journal of the Daesoon Academy of Sciences
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    • v.34
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    • pp.1-26
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    • 2020
  • In Taiwanese Daoism, the Celestial Worthy of the Ninth Heaven, Responder, Thunderbolt-bearer, and Transformer of the Universe (九天應元雷聲普化天尊) is the highest deity in the Thunder Ministry. In the the Korean new religion, Daesoon Jinrihoe (大巡真理會), he is the Supreme God. However, since the Celestial Worthy of the Ninth Heaven, Responder, Thunderbolt-bearer, and Transformer of the Universe has the same name in these two traditions, it naturally leads people to wonder whether or not they can be considered the same deity. Or failing that, it could still be asked, to what extent are these two deities related? Or it could further be asked what meaning does the Celestial Worthy of the Ninth Heaven, Responder, Thunderbolt-bearer, and Transformer of the Universe have in these two religions? Anyhow, all such questions depend on first establishing a greater degree of basic clarity. Religious scripture can serve as a cornerstone in gaining such basic clarity. Scripture almost invariably contains information regarding the divine nature, divine authority, and sacrosanctity of deities reflective of what is understood by the devotees of those religions. Clues on the precise nature of these key attributes of deity-depiction can be drawn out of scriptural accounts, and as such, the research presented in this paper will begin by comparing two relevant scriptures. The representative scriptures highlighted in this paper will be The Canonical Scripture (典經) of Daesoon Jinrihoe and The Scripture of the Jade Pivot (玉樞寶經) of Zhengyi (Orthodox Unity, 正一) Daoism. These scriptures will serve as the basis for exploration and analysis of the divine attributes of the Celestial Worthy of the Ninth Heaven, Responder, Thunderbolt-bearer, and Transformer of the Universe in terms of his divine nature, divine authority, and sacrosanctity. By comparing these two scriptural accounts of his divine attributes, the similarities and differences that arise can be properly explored. This paper endeavors to clarify the ultimate purpose of 'the Celestial Worthy of the Ninth Heaven, Responder, Thunderbolt-bearer, and Transformer of the Universe.' In this paper, the first step will be an exploration of scriptural analysis. The contents of this paper is roughly divided into four sections. The first section is an exploration of the general contents of the two scriptures, including their origin, contents, and value. The second section focuses on the three main divine attributes of the Celestial Worthy of the Ninth Heaven, Responder, Thunderbolt-bearer, and Transformer of the Universe: his divine nature, divine authority, and sacrosanctity. The third section will compare the depictions of the deity in the two scriptural accounts in terms of those three attributes. Lastly, the deity's evolutionary history in both religions is shown and compared and final remarks are made on the contemporary value of the Celestial Worthy of the Ninth Heaven, Responder, Thunderbolt-bearer, and Transformer of the Universe.

OVERVIEW OF NORTH ECLIPTIC POLE DEEP MULTI-WAVELENGTH SURVEY (NEP-DEEP)

  • Matsuhara, H.;Wada, T.;Oi, N.;Takagi, T.;Nakagawa, T.;Murata, K.;Goto, T.;Oyabu, S.;Takeuchi, T.T.;Malek, K.;Solarz, A.;Ohyama, Y.;Miyaji, T.;Krumpe, M.;Lee, H.M.;Im, M.;Serjeant, S.;Pearson, C.P.;White, G.J.;Malkan, M.A.;Hanami, H.;Ishigaki, T.;Burgarella, D.;Buat, V.;Pollo, A.
    • Publications of The Korean Astronomical Society
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    • v.32 no.1
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    • pp.213-217
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    • 2017
  • The recent updates of the North Ecliptic Pole deep ($0.5deg^2$, NEP-Deep) multi-wavelength survey covering from X-ray to radio-wave is presented. The NEP-Deep provides us with several thousands of $15{\mu}m$ or $18{\mu}m$ selected galaxies, which is the largest sample ever made at these wavelengths. A continuous filter coverage in the mid-infrared wavelength (7, 9, 11, 15, 18, and 24 µm) is unique and vital to diagnose the contributions from starbursts and AGNs in the galaxies out to z=2. The new goal of the project is to resolve the nature of the cosmic star formation history at the violent epoch (e.g. z=1-2), and to find a clue to understand its decline from z=1 to present universe by utilizing the unique power of the multiwavelength survey. The progress in this context is briefly mentioned.

Survey of Faint Quasar candidates at 4.7 ≤ z ≤ 5.2

  • Shin, Suhyun;Im, Myungshin;Kim, Yongjung;Hyun, Minhee;Park, Woojin;Ji, Tae-geun;Jeon, Yiseul;Kim, Minjin;Kim, Dohyeong;Kim, Jae-Woo;Taak, Yoon Chan;Yoon, Yongmin;Choi, Changsu;Hong, Jueun;Jun, Hyunsung David;Karouzos, Marios;Kim, Duho;Kim, Ji Hoon;Lee, Seong-Kook;Pak, Soojong;Park, Won-Kee
    • The Bulletin of The Korean Astronomical Society
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    • v.43 no.1
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    • pp.59.4-60
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    • 2018
  • To investigate the impact of the high-redshift quasars on cosmic reionization, the faint end slope of the quasars luminosity function has to be determined precisely. More quasars with low luminosity are needed to constrain the contribution to reionization in the early universe. However, finding these quasars has been regarded as tough process owing to the improper shallow depth of imaging data. In recent days, the release data of Subaru Hyper Suprime-Cam (HSC) Strategic Program survey which provide the deep images reaching ~ 25 mag facilitates searching the faint quasars candidates. To find faint quasar candidates in ELAIS-N1 field, along with the HSC data, two near-infrared (NIR) data sets also be used : The Infrared Medium-deep Survey (IMS) and The UKIRT Infrared Deep Sky Survey (UKIDSS) - Deep Extragalactic Survey (DXS). Quasar candidates selected from the multi-band color cut were observed by the SED camera for QUasars in EArly uNiverse (SQUEAN) instrument. To trace the redshifted Lyman break efficiently, appropriate medium bands comparable to targeted redshift range are chosen. The most reliable quasar candidates are finally determined through SED fitting. Using this less luminous quasars candidates, we can speculate the relation between the quasar growth and the host galaxy unbiasedly and estimate the contribution to the cosmic reionization.

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Global Trends of In-Situ Resource Utilization (우주 현지자원활용 글로벌 동향 )

  • Dong Young Rew
    • Journal of Space Technology and Applications
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    • v.3 no.3
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    • pp.199-212
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    • 2023
  • In contrast to the short-term nature of lunar missions in the past, lunar missions in new space era aim to extend the presence on the lunar surface and to use this capability for the Mars exploration. In order to realize extended human presence on the Moon, production and use of consumables and fuels required for the habitation and transportation using in-situ resources is an important prerequisite. The Global Exploration Roadmap presented by the International Space Exploration Coordination Group (ISECG), which reflects the space exploration plans of participating countries, shows the phases of progress from lunar surface exploration to Mars exploration and relates in-situ resource utilization (ISRU) capabilities to each phase. Based on the ISRU Gap Assessment Report from the ISECG, ISRU technology is categorized into in-situ propellant and consumable production, in-situ construction, in-space manufacturing, and related areas such as storage and utilization of products, power systems required for resource utilization. Among the lunar resources, leading countries have prioritized the utilization of ice water existing in the permanent shadow region near the lunar poles and the extraction of oxygen from the regolith, and are preparing to investigate the distribution of resources and ice water near the lunar south pole through unmanned landing missions. Resource utilization technologies such as producing hydrogen and oxygen from water by hydroelectrolysis and extracting oxygen from the lunar regolith are being developed and tested in relevant lunar surface analogue environments. It is also observed that each government emphasizes the use and development of the private sector capabilities for sustainable lunar surface exploration by purchasing lunar landing services and providing opportunities to participate in resource exploration and material extraction.

Exploration on the Development and Characteristics of Composites Painting in the Contemporary Art Ecology

  • Wang Jing Jing
    • International Journal of Advanced Culture Technology
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    • v.11 no.1
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    • pp.232-240
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    • 2023
  • The ecological expression of art in modern society takes the harmonious developmental relationship between man and nature as an element and combines it with the various manifestations of painting as an expression of ecological artistic development. The necessary relationship for the harmonious development of nature is accurately articulated, and the ecological changes in people are expressed in integrated materials that inspire human reflection. In the pursuit of material pleasures, mankind is neglectful and indifferent to the environment. The development of composite painting in art and ecology is a process that more reveres the harmony between man and nature as well as satisfying the creative value of the work. After systematic evaluation and research, people have engaged in various structural forms of composite art painting development in the long history of art development, focusing on the integration of environmental and ecological culture. In the process of nature education going through development, the comprehensive practical development of nature education is enhanced and efforts are made to feel new ecological art ideas and new ways of valuing environmental protection. In this paper, an observational study of eco-art will be carried out, starting from the theory of hierarchical division and analyzing the contradictory relationship between man and nature. Recognize nature, understand it and feel it through eco-art painting. The analysis of the contradictory relationship between man and nature is combined with the identification of various types of information that give value to the environmental protection public, and the combination of ecological painting and nature art to achieve an upgrade of the environmental protection idea of the value of painting. In the development of artistic ecological comprehensive painting, it is necessary to put forward technical requirements and standards that meet the development of modern industry according to the characteristics and methods of ecological painting. The author of this paper discusses the necessity and social value of artistic ecological painting creation from the artist's point of view, expounds the practical achievements of ecological painting from the perspective of the history and present situation of the development of ecological aesthetics at home and abroad, and gives the concept and creative method of contemporary art comprehensive material painting in combination with his own actual situation.

A survey of leisure participation and leisure exploration of community dwelling stroke patients (지역사회 거주 뇌졸중 환자의 여가 참여 및 여가 탐색 조사)

  • Jeong, Eun-Hwa
    • Journal of Industrial Convergence
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    • v.18 no.4
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    • pp.41-49
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    • 2020
  • The purpose of this study was to provide basic information on leisure participation and leisure exploration of community-dwelling stroke patients through a multi-dimensional leisure participation evaluation tool. The subjects in this study were 35 people living with stroke in the community. As a result of study, the most involved leisure activities were in order of watching TV, communicating, and exercise alone. Most of the satisfaction level of leisure participation was 7-10 points, but exercise alone was 5.2 points due to the purpose of health management. Leisure exploration was the most frequent exercise alone and sports, and interest was 8-10 points. The most important obstacles for leisure participation were physical problems depending on the nature of the stroke disease. Through the results of this study, it is necessary to activate a stroke patient's discharge plan and activate a community stroke patient's leisure intervention program so that they can participate in leisure activities of their choice through voluntary leisure exploration.

Clinical Experience of Foreign Body Granuloma in the Apex of Orbit (안와첨부 이물 육아종의 치험례)

  • Paik, Hye Won;Choi, Jong Woo;Chong, Hyun Kwon;Lee, Paik Kwon;Ahn, Sang Tae
    • Archives of Plastic Surgery
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    • v.32 no.1
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    • pp.131-134
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    • 2005
  • It is often difficult to identify and localize intraorbital foreign bodies despite of modern high-resolution imaging investigation. Especially, posteriorly located foreign bodies have increased risks of morbidity that surgical approach is often complicated. No matter how trivial it seems, retained foreign body, particularly organic in nature, may give rise to severe orbital and cerebral complications. High clinical suspicion, proper diagnostic studies, timely referral to a skilled orbital surgeon are mandatory. We report a case of intraorbital wooden foreign body that required two separate exploration for removal. Initial exploration failed to identify and locate the foreign body completely. After the operation, fistula formation and purulent discharge were developed and the imaging investigation results were equivocal, complicating the management. A second exploration yielded multiple intraorbital wooden foreign body in the apex of orbit. The patient fully recovered without complication. The evaluations and the details of management strategy are discussed.