• Proceedings of the Technology Innovation Conference
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• 2006.02a
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• pp.187-204
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• 2006

According to increasing dependancy of national competitiveness on her level of science and technology, the Korean Government devote herself to expansion of technological capability in nation-wide. As a result, the numbers and sizes of national R&D programs, one of public technology policies, are abruptly increased. Recently, the government closely examines the introduction of performance-based budgeting regime as well as the accountability issue in public sector. In the fulfillment of accountability, it has considerable importance that the government executes measurement and strategic management of their performances of all the national R&D programs, how they are properly executed in conformity with respective missions and characteristics. It needs a tool for clearly measuring the programs' performances. In this study, the Balanced Scorecard (BSC) is suggested as an alternative. However, the logics of ordinary BSC cannot be directly applied to the program unit. This study reviews the basic concept and principles of BSC and discusses the necessary conditions for proper application of BSC into national R&D programs.

• Journal of Korea Technology Innovation Society
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• v.19 no.4
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• pp.687-710
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• 2016

This study aims to empirically estimate distributed lag effects of expenditure by type of R&D on scientific publication in the national R&D program. To analyze the lag structure between them, we used a dataset comprised of panel data from 104 technologies categorized by 6T (IT, BT, NT, ST, ET, CT) from 2007 to 2014, and employed multiple regression analysis based on the polynomial distributed lag model. This is because it is highly likely to emerge multicollinearity, if a distributed lag model without special restrictions is applied to multiple regression analysis. The main results are as follows. In the case of basic research, its lag effects are relatively evenly distributed during four years. On the other hand, the applied research and experimental development have distributed lag effects for three years and two years respectively. Therefore, when it comes to analyzing performance of scientific publication, it is necessary to be performed with characteristics of the time lag by type of R&D.

• Journal of the Korea Safety Management & Science
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• v.18 no.3
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• pp.109-116
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• 2016

The purpose of this study is to explore the research and development(R&D) programs for effectively response of population aging. We analyzed of aging-related R&D support status by National Science and Technology Information Services(NTIS) and reviewed of foreign aging-related R&D programs. It was found that the overall lack of support systems, the R&D support status for Korea's aging society is very low performance and the difference appears in the annual support status, etc. It is very important to enhance the effectiveness of R&D programs in order to effectively prepare for aging society. I suggested support measures of the R&D for aging society by survey research. The result of this study will help in planning of the R&D for aging society and contribute to increasing of welfare for the aged.

• Journal of Digital Convergence
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• v.14 no.8
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• pp.47-56
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• 2016

This study is on the actual analysis of R&D investment effect through DEA in terms of efficiency resulted from forestry sector climate change response R&D project. Namely, it is clarifying the mechanism of the scientific, technological, social performance result and output, depending on research development cost, employment size as same input. Also, it is in-depth analysis on which performance operates more efficiently in any detailed business. With the study result, we seek political implications to enhance investment effect and core element to consider R&D business project in the future.

• Journal of Technology Innovation
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• v.5 no.2
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• pp.126-154
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• 1997

This paper addresses a methodology for monitoring the first phase('92-94') progress and its implication fo Highly Advanced National R&D Projects (HAN or G7 project) in Korea. The authors suggest a three-stage life cycle model for the management of national R&D program; planning stage, implementing & monitoring stage, and evaluating & harvesting stage. The interim evaluation, the main focuses of this paper, is one of the key issues for the effective management of national R&D program at the implementing & monitoring stage. The conceptual framework of the interim evaluation was developed both through reviewing related literature and considering the characteristics of the HAN program. A stepwise procedure of interim evaluation was introduced: 'initial screen' and 'detailed examination'. At initial screen all 11 projects were reviewed in terms of both their relevance and performance in order to decide whether further detailed scrutiny is needed or not. If there exist critical problems on the relevance or on the intermediate progress of each project, it is to be under further detailed examination. Evaluation was initiated by the G7 Planning and Evaluation Committee, which was established for advising, directing, and monitoring the HAN Projects, with the help of large number of experts from industries, universities, and research institutes. The monitoring results were reported to the related ministries and project coordinating agencies, and reflected in the second phase.

• Journal of Technology Innovation
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• v.19 no.1
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• pp.177-201
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• 2011

This study is trying to estimate the effect of survey of prior art on the technological performance of national R&D program, with the purpose to enhance understanding on the relationship between utilization of patent information and R&D activities. Patent and Technology Trend Research, one of the survey of prior art which gives the information about existing technology and patent trend to the project team has been carried out since 2005. In this paper, effects which Patent and Technology Trend Research has on the technological performance of national R&D projects are estimated by using multiple regression model considering input factors, characteristics of an agent and supplier of money. The result is that Patent and Technology Trend Research has positive and significant effect on the grant and application of domestic and foreign patent. This result can give an hint that the utilization of patent information make the R&D process efficient and effective.

• Journal of Korea Technology Innovation Society
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• v.13 no.3
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• pp.459-470
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• 2010

The aim of this study were to investigate the process of national R&D project planning by using the industry quantitative analysis(especially supply-chain enterprise ananlysis). In the selection process of funding project, the role and significance of the industry analysis can be identified as the effective guideline of using this methodology. Across the study, the following is noted : the factors of R&D effectiveness and R&D necessity are found reliable and valid. On the other hand, the emptiness of supply chain and the positive effect of foreign trade balance did not influence the selection of project. The information gained from this study will help us to define better expectations and industry analysis employing to the National R&D Project Planning.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2006.11b
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• pp.239-252
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• 2006

The government had invested national resources in nano technology actively since 2000 to promote the R&D of nano technology. In addition, the government reorganized the science and technology administration system recently enacting new laws related with science and technology to promote the efficient policy of science and technology. At this point, we need to understand the status of national R&D expenditures for the efficient priority setting and budget coordination of national R&D expenditures by the concerned variables such as program objectives, sector of performance, character of work and technology fields and suggests the policy implications.

• Journal of Applied Biological Chemistry
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• v.49 no.1
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• pp.21-23
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• 2006

As part of a program to discover bioactive natural products from marine organisms, two new enantiomers, ent-3,6-Epidioxy-4,6,8,10-tetraethyltetradeca-7,11-dienoic acid and ent-[3,5-Diethyl-5-(2-ethyl-hex-3-enyl)-5H-furan-2-ylidene]-acetic acid methyl ether, were isolated from a sponge Plakortis sp. These compounds showed strong in vitro antiproliferative effects on promastigotes of Leishmania mexicania, flagellate protozoan that causes leishmaniasis. Structures were assumed by interpretation of NMR spectroscopic data and optical rotation. Both compounds exhibited significant antileishmanial activities in vitro with $IC_{50}$ of 1.0-23.0 ${\mu}g/ml$.

• The Korean Journal of Nuclear Medicine
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• v.38 no.4
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• pp.294-299
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• 2004

Purpose: Both human NIS and mutant $D_2R$ transgenes are proposed as reporting system in transplanted cell tracking. Using hepatoma cell lines, we constructed a dual reporter system containing human sodium-iodide symporter (hNIS) and dopamine 2 receptor ($D_2R$) and compared its characteristics. Materials and Methods: The recombinant plasmid ($pIRES-hNIS/D_2R$) was constructed with IRES (internal ribosome entry site) under control of the CMV promoter $pIRES-hNIS/D_2R$ was transfected to human hepatoma SK-Hep1 cell line with lipofectamine. HEP-ND ($SK-Hep1-hNIS/D_2R$) cells stably expressing hNIS and $D_2R$ was established by selection with G418 for two weeks. RT-PCR was performed to investigate the expression of both hNIS and $D_2R$ genes. The expressions of hNIS and $D_2R$ were measured by $^{125}I$ uptake assays and receptor binding assays. Specific binding of $D_2R$ to $[^3H]spiperone$ was verified by Scatchard plot with (+) butaclamol as a specific inhibitor. $K_d\;and\;B_{max}$ values were estimated. The correlation between hNIS and $D_2R$ expression was compared by using each clone. Results: Similar quantities of hNIS and $D_2R$ genes were expressed on HEP-ND as RT-PCR assays. HEP-ND cells showed 30 to 40 fold higher radioiodine uptakes than those of parental SK-Hep1 cells. $^{125}I$ uptake in HEP-ND cells was completely inhibited by $KClO_4$, a NIS inhibitor Specific binding to HEP-ND cells was saturable and the $K_d\;and\;B_{max}$ values for HEP-ND cells were 2.92 nM, 745.25 fmol/mg protein and 2.91nM, 1323 fmole/mg protein in two clones, respectively. The radioiodine uptake by hNIS activity and $D_2R$ binding was highly correlated. Conclusion: We developed a dual positron and gamma imaging reporter system of hNIS and $D_2R$ in a stably transfected cell line. We expect that $D_2R$ and hNIS genes can complement mutually as a nuclear reporting system or that $D_2R$ can be used as reporter gene when hNIS gene were used as a treatment gene.