• Toxicological Research
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• v.33 no.2
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• pp.79-96
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• 2017

A variety of xenobiotic chemicals, such as polycyclic aromatic hydrocarbons (PAHs), aryl- and heterocyclic amines and tobacco related nitrosamines, are ubiquitous environmental carcinogens and are required to be activated to chemically reactive metabolites by xenobiotic-metabolizing enzymes, including cytochrome P450 (P450 or CYP), in order to initiate cell transformation. Of various human P450 enzymes determined to date, CYP1A1, 1A2, 1B1, 2A13, 2A6, 2E1, and 3A4 are reported to play critical roles in the bioactivation of these carcinogenic chemicals. In vivo studies have shown that disruption of Cyp1b1 and Cyp2a5 genes in mice resulted in suppression of tumor formation caused by 7,12-dimethylbenz[a]anthracene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, respectively. In addition, specific inhibitors for CYP1 and 2A enzymes are able to suppress tumor formation caused by several carcinogens in experimental animals in vivo, when these inhibitors are applied before or just after the administration of carcinogens. In this review, we describe recent progress, including our own studies done during past decade, on the nature of inhibitors of human CYP1 and CYP2A enzymes that have been shown to activate carcinogenic PAHs and tobacco-related nitrosamines, respectively, in humans. The inhibitors considered here include a variety of carcinogenic and/or non-carcinogenic PAHs and acethylenic PAHs, many flavonoid derivatives, derivatives of naphthalene, phenanthrene, biphenyl, and pyrene and chemopreventive organoselenium compounds, such as benzyl selenocyanate and benzyl selenocyanate; o-XSC, 1,2-, 1,3-, and 1,4-phenylenebis(methylene)selenocyanate.

• Proceedings of the Korean Vacuum Society Conference
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• 2012.02a
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• pp.479-479
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• 2012

유기발광소자는 낮은 구동전압, 저전력, 높은 명암비, 빠른 응답속도, 넓은 시야각 및 높은 박막의 특성을 가지고 있어서 차세대 평판 패널디스플레이 기술로 각광받고 있다. 하지만 청색 유기발광소자는 적색과 녹색 유기발광소자에 비해 낮은 신뢰성, 발광효율 및 색 순도의 문제점을 가지고 있어, 이를 개선하기 위한 연구가 다양하게 연구되고 있다. 청색 유기발광소자의 경우 발광층 내부로 주입되는 정공과 전자의 균형을 조절하기 위해 p-i-n 구조를 사용하거나 이리듐-유기물 합성물과 같은 인광물질의 적용하여 발광효율을 높이는 청색 유기발광소자에 대한 연구가 진행되고 있다. 하지만 정공 보조층과 청색 형광층의 도핑구조의 청색 유기발광소자에 대한 발광효율 증가 메커니즘에 관한 연구는 비교적 많이 이루어지지 않았다. 본 연구에서는 열 증착 방법을 이용하여 정공 보조층과 청색 형광층으로 구성된 이중 발광층을 사용한 청색유기발광소자의 발광효율 증가 메커니즘에 대해 연구하였다. 10%의 2,9-dimethyl-4,7-diphenyl-1,10-phenanthorlene (BCP)로 도핑된 2-methyl-9,10-bis(naphthalene-2-yl)anthracene (MADN)층을 발광층으로 사용한 유기발광소자, 5% MADN으로 도핑된 1, 3-bis(carbazol-9-yl)benzene (mCP) 층을 발광층으로 사용한 소자 및 10% BCP로 도핑 된 MADN 층과 5% MADN로 도핑 된 mCP층을 혼합하여 발광층으로 사용한 소자의 전류밀도-전압-발광 특성을 비교하여 청색 유기발광소자의 발광효율 증가 메커니즘을 분석하였다. 이중 발광층을 가지는 소자는 두 단일 발광층 중심부의 경계면에서 축적된 정공에 의해 발생한 쿨롱 인력으로 더 많은 전자들을 끌어들이게 되어 엑시톤 형성 및 빛 방출이 증가하였다. 이 실험의 결과는 MADN 형광물질을 가진 청색 유기발광소자의 발광효율 증가 메커니즘에 대한 이해를 높이는데 도움을 줄 수 있다.

• Applied Chemistry for Engineering
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• v.8 no.6
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• pp.967-972
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• 1997

Recovery of aromatics in extract phase which was obtained by batch equilibrium extraction between light cycle oil(LCO) and dimethylsulfoxide(DMSO) solution as solvent was investigated by re-extraction. To select the most suitable re-extraction solvent for recovery of aromatics in extract phase, distribution equilibrium was measured between extract phase and solvents. The solvents used were benzene(B), toluene(T), m-Xylene(mX), n-hexane(Hx) and n-hexane(Hx) and n-Octane(Ot). From the distribution coefficients and yields of aromatics, Hx seemed to be the most suitable. Furthermore, effects of operation parameters for re-extraction of aromatics in the extract phase were studied by batch equilibrium re-extracion with Hx as solvent. Yields of aromatics were found to increase with increasing solvent/feed (extract phase) mass ratio(S/F), while distribution coefficients of aromatics were fixed irrespective of S/F used. Operating temperature did not affect distribution coefficients and yields of aromatics. Distibution coefficients and yields of naphthalene group(carbon numer : 10~12) increased with increasing cabon number. Mass transfer rates of aromatics were also measured with a batch stirred vessel.

• 유체기계공업학회:학술대회논문집
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• 2004.12a
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• pp.289-296
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• 2004

The present study has been performed to investigate the influences of rectangular fins on heat transfer in an impingement/effusion cooling system with crossflow. To simulate the impingement/effusion cooling system with initial crossflow, two perforated plates are placed in parallel and staggered arrangements with a gap distance of 2 times of the hole diameter. The crossflow passes between the plates, and various rectangular fins are installed on the plates. Reynolds number based on the hole diameter is fixed to 10,000 and the flow rate of crossflow is changed from 0.5 to 1.5 times of that of the impinging jet. A naphthalene sublimation method is used to obtain the heat/mass transfer coefficients on the effusion plate. Also to analyze the flow characteristics, a numerical calculation is performed. When rectangular fins are installed, the flow and heat transfer pattern is changed greatly from case without fins. In the injection hole region, the jet impinges on effusion plate without deflection and wall jet spreads symmetrically. In the effusion region, the crossflow accelerates due to the decrease of cross-sectional area in the channel. Local heat/mass transfer coefficients are enhanced significantly compared to case without fins. As the blowing ratio increases, the effect of fins against the crossflow becomes more significant and then the higher average heat/mass transfer coefficients are obtained than the case without fins.

• Bulletin of the Korean Chemical Society
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• v.35 no.10
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• pp.3041-3046
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• 2014

Blue emitting materials, 9,10-bis-biphenyl-4-yl-anthracene (AC-P), 9,10-bis-[1,1';4',1"]terphenyl-4-yl-anthracene (AC-DP), and 9,10-bis[3",5"-deiphenyltriphenyl-4'-yl]anthracene (AC-TP) were synthesized through boration and Suzuki aryl-aryl coupling reaction. EL performance of blue light-emitters was optimized and improved by varying the chemical structures of the side groups. In the thin film state, the three materials exhibit $PL_{max}$ values in the range of 442-456 nm. EL device with the synthesized compounds in the following configuration was fabricated: ITO/4,4',4"-tris(N-(2-naphthyl)-N-phenylamino)triphenylamine (2-TNATA) 60nm/N,N'-bis (naphthalene-1-yl)-N,N'-bis(phenyl)benzidine (NPB) 15nm/synthesized blue emitting materials (30nm)/1,3,5-tri(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl (TPBi) 20nm/LiF 1nm/Al 200nm. The current efficiency and C.I.E. value of AC-TP were 3.87 cd/A and (0.15, 0.12). A bulky and non-planar side group helps to prevent ${\pi}-{\pi}^*$ stacking interaction, which should lead to the formation of more reliable amorphous film. This is expected to have a positive effect on the high efficiency of the operating OLED device.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.29 no.3 s.234
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• pp.356-367
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• 2005

The spray characteristics of DISI injector have a great role in gasoline engine efficiency and emission. Thus, many researchers have studied to investigate the spray characteristics of swirl and slit injectors that are used in a DISI engine. In this study, we tried to provide spray parameters, which affect on the spray characteristics such as injection pressure, ambient pressure and ambient temperature. In addition, we calculated $t_{b}\;and\;t_{c}$ to investigate the break up mechanism of test injectors and obtained $C_{v}$ to evaluate the spray characteristics. As the ambient pressure increases in case of slit injector, $C_{v}$ decreases. The laser-induced exciplex fluorescence (LIEF) technique, which is based on spectrally resolved two-color fluorescent emissions, has applied to measure the liquid and vapor phases for on evaporating spray simultaneously. The TMPD/naphthalene proposed by Melton is used as a dophant to detect exciplex signal. The temporal and spatial distribution of liquid and vapor phases during the mixture formation process was measured by this technique. In the LIEF technique, the vapor phase is detected by the monomer fluorescence while the liquid phase is tracked by the exciplex fluorescence. From this experiment, we found that the spray area of the vapor phase is increased with elapsed time after injection and the area of liquid is decreased when the ambient pressure is 0.1MPa. However, the area tends to increase until the end of injection when the ambient pressure is 1.0MPa.

• Korean Journal of Microbiology
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• v.39 no.3
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• pp.123-127
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• 2003

Sphingomonas chungbukensis DJ77 is able to metabolize phenanthrene as the sole carbon and energy source. The plasmid pUPX5 includes phnS gene encoding 2-hydroxychromene-2-carboxylate (HCCA) isomerase, which is needed for phenanthrene and naphthanene degradation. We determined the nucleotide sequence of DNA fragment of 3271 bp which included the phnS gene. The fragment included an open reading frame of 594 bp which has ATG initiation codon and TAA termination codon and GGAA ribosomal binding site. The predicted amino acid sequence of the enzyme consists of 198 amino acids. The deduced amino acid sequence of the phnS enzyme exhibited 94％ identity with that of the corresponding enzyme in Sphingomonas aromaticivorans F199. The phnS gene is located downstream and in the same operon as phnQ and phnR, encoding a 2,3-dihydroxybiphenyl 1,2-dioxygenase and a ferredoxin component of biphenyl dioxygenase, respectively.

• Journal of Microbiology and Biotechnology
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• v.22 no.3
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• pp.283-291
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• 2012

Bioremediation efforts often rely on the application of surfactants to enhance hydrocarbon bioavailability. However, synthetic surfactants can sometimes be toxic to degrading microorganisms, thus reducing the clearance rate of the pollutant. Therefore, surfactant-resistant bacteria can be an important tool for bioremediation efforts of hydrophobic pollutants, circumventing the toxicity of synthetic surfactants that often delay microbial bioremediation of these contaminants. In this study, we screened a natural surfactant-rich compartment, the estuarine surface microlayer (SML), for cultivable surfactant-resistant bacteria using selective cultures of sodium dodecyl sulfate (SDS) and cetyl trimethylammonium bromide (CTAB). Resistance to surfactants was evaluated by colony counts in solid media amended with critical micelle concentrations (CMC) of either surfactants, in comparison with non-amended controls. Selective cultures for surfactant-resistant bacteria were prepared in mineral medium also containing CMC concentrations of either CTAB or SDS. The surfactantresistant isolates obtained were tested by PCR for the Pseudomonas genus marker gacA gene and for the naphthalene-dioxygenase-encoding gene ndo. Isolates were also screened for biosurfactant production by the atomized oil assay. A high proportion of culturable bacterioneuston was tolerant to CMC concentrations of SDS or CTAB. The gacA-targeted PCR revealed that 64% of the isolates were Pseudomonads. Biosurfactant production in solid medium was detected in 9.4% of tested isolates, all affiliated with genus Pseudomonas. This study shows that the SML is a potential source of surfactant-resistant and biosurfactant-producing bacteria in which Pseudomonads emerge as a relevant group.

• Environmental Analysis Health and Toxicology
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• v.20 no.1
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• pp.57-65
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• 2005

Effects of five polycyclic aromatic hydrocarbon (PAHs) constituents (naphthalene, fluorine, fluoranthene, benzo(a)pyrene, pyrene) on fertilization and early development of sea urchin egg, sperm and fertilized egg were investigated. The eggs, sperm and fertilized eggs were exposed to several concentrations of PAHs (1, 10, 100, 1000 and 10000㎍/L). The rate of fertilization and hatching decreased when the eggs and sperm were exposed to aqueous solution of PAHs. Also, Exposure of fertilized eggs with each PAHs did decrease survival and hatching rate. Concentration-dependent toxic effects on the rate of fertilization, hatching, survival and abnormality in A. crassispina were observed following exposure to PAHs (1, 10, 100, 1000 and 10000㎍/L). These data show that PAHs exposure decreased in fertilization success of sea urchin egg and sperm and producted abnormal embryo. It is plausible to suggest that PAHs had the potential to significantly reduce coastal recruitment of sea urchin.

• The KSFM Journal of Fluid Machinery
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• v.16 no.6
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• pp.19-25
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• 2013

The effect of tip gap height on heat/mass transfer characteristics on the floor of cavity squealer tip has been investigated in a turbine cascade for power generation by employing the naphthalene sublimation technique. The squealer rim height is chosen to be an optimal one of $h_{st}/c$ = 5.51% for the tip gap height-to-chord ratios of h/c = 1.0, 2.0, 3.0 and 4.0%. The results show that heat transfer on the cavity floor is strongly dependent upon the behavior of the cavity flow falling down onto the floor. For lower h/c, the floor heat transfer is influenced by the tip leakage flow falling down along the inner face of the suction-side squealer, whereas the floor heat transfer for higher h/c is augmented mainly due to the impingement of leakage flow on the floor near the leading edge. Compared to the plane tip surface heat transfer, the cavity floor heat transfer is less influenced by h/c. For h/c = 1.0%, the average thermal load is as low as a half of the plane tip surface one, and the difference in the thermal load between the two cases tends to decrease with increasing h/c.