• Journal of the Korean Applied Science and Technology
• /
• v.26 no.2
• /
• pp.124-131
• /
• 2009

We have produced, characterized and compared different colloidal vehicles based on nanoemulsions. We also have investigated morphology and droplet distribution by means of electron microscope and photon correlation spectroscopy. Nanoemulsion systems characterized by different method on formulations have been obtained. Hydration power has been studied by means of a corneometer, measuring the skin electrical capacitance before and after the application of various type of skin lotions. It has been demonstrated that nanoemulsion with oil or fatty alcohol displayed a pronounced hydration power with respect to the solubilization system. In order to compare the smoothness of the skin after using skin lotion, we have measured the friction force. The skin lotions produced by nanoemulsion technique show improved smoothness of an atopic skin.

• Proceedings of the SCSK Conference
• /
• 2003.09b
• /
• pp.307-307
• /
• 2003

Strategies to make finished products more stable and efficacious can take advantage of formulation technologies- ingredients and techniques - to improve their delivery into the skin by both enhanced penetration and delayed release. Nanometer range particles and emulsion droplets can be formed with a selection of either silicone copolyol or conventional organic surfactants and dispersion shear rates sufficient to generate stable submicron droplets. By incorporating these into systems with biomimetic liquid crystalline gel networks in either simple or multiple phase emulsions the skin delivery can be enhanced as shown in tape stripping experiments. Such systems can stabilize labile actives, such as Vitamin C and retinol, and aid delivery. Laboratories in U.S and Europe investigated actives including green tea polyphenols, salicylic acid and methyl and benzyl nicotinate.

• Polymer Science and Technology
• /
• v.23 no.2
• /
• pp.174-184
• /
• 2012

• Food Science and Industry
• /
• v.41 no.1
• /
• pp.33-45
• /
• 2008

• Journal of Dairy Science and Biotechnology
• /
• v.36 no.4
• /
• pp.187-195
• /
• 2018

Nano-delivery systems, such as nanoparticles, nanoemulsions, and nanoliposomes, are carriers that have been used to enhance the chemical as well as physical stability and bioavailability of bioactive compound. Food-grade nano-delivery system can be produced with edible biopolymers including proteins and carbohydrates. In addition to the low-toxicity, biocompatibility, and biodegradability of these biopolymers, their functional characteristics, such as their ability to bind hydrophobic bioactive compounds and form a gel, make them potential and ideal candidates for the fortification of bioactive compounds in functional dairy foods. This review focuses on different types of nano-delivery systems and edible biopolymers as delivery materials. In addition, the applications of food-grade nano-delivery systems to dairy foods are also described.

• Biomolecules & Therapeutics
• /
• v.31 no.1
• /
• pp.16-26
• /
• 2023

Diabetes is an untreatable metabolic disorder characterized by alteration in blood sugar homeostasis, with submucosal insulin therapy being the primary treatment option. This route of drug administration is attributed to low patient comfort due to the risk of pain, distress, and local inflammation/infections. Nanoparticles have indeed been suggested as insulin carriers to allow the drug to be administered via less invasive routes other than injection, such as orally or nasally. The organic-based nanoparticles can be derived from various organic materials (for instance, polysaccharides, lipids, and so on) and thus are prevalently used to enhance the physical and chemical consistency of loaded bioactive compounds (drug) and thus their bioavailability. This review presents various forms of organic nanoparticles (for example, chitosan, dextron, gums, nanoemulsion, alginate, and so on) for enhanced hypoglycemic drug delivery relative to traditional therapies.

• Journal of Microbiology and Biotechnology
• /
• v.26 no.1
• /
• pp.72-79
• /
• 2016

The fungal morphologies and pellet sizes were controlled in acetophenone reduction by Rhizopus oryzae. The acetophenone conversion and (S)-phenylethanol enantiomeric excesses (e.e.) reached the peak after 72 h of incubation when using pellets with 0.54 mm diameter, which showed an excellent performance compared with suspended mycelia, clumps, and pellets with 0.65 or 0.75 mm diameter. Furthermore, nano-sized acetophenone was used as a substrate to improve the performances of biotransformation work. The results showed that the conversion of nanometric acetophenone and (S)-phenylethanol e.e. reached the maximum (both >99%) after 32 h of incubation when using 0.54 mm diameter pellets, at least 24 h in advance of the control group. On the other hand, Tween 80 and 1, 2-propylene glycol showed low or no toxicity to cells. In conclusion, pellets and acetophenone nanoemulsions synergistically result in superior performances of acetophenone reduction.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.42 no.4
• /
• pp.387-392
• /
• 2016

In this work, we compared the emulsion states having the same composition of liquid paraffin/ Span 80-Tween 80/ pure water and the different mixing paths and temperatures. Routes reaching the final composition in three component phase diagram were composed of three different ways. The average particle size of the emulsion prepared from the different mixing routes showed a significant difference and decreased as the mixing temperature was increased. However, the mixing route affected more in the size of the emulsions than mixing temperature.

• Prospectives of Industrial Chemistry
• /
• v.20 no.6
• /
• pp.2-12
• /
• 2017

최근 피부산업은 미용적인 관점뿐만 아니라 피부질환치료에 대한 관심까지 폭넓게 성장하고 있어 피부의 건강을 개선하고 치료할 수 있는 새로운 신기술 개발이 다각적으로 이루어지고 있다. 특히 기술의 고도화와 체계화를 통한 피부과학기술의 진보가 화학, 화학공학, 재료공학을 기반으로 하는 전통학문분야와 조직공학, 바이오나노공학, 감성공학 등을 기반으로 하는 신학문분야가 융복합되어 이루어지고 있다. 따라서, 본 고에서는 피부산업에서 전략적인 응용이 가능한 피부 나노바이오 콜로이드의 연구개발에 대한 최근 현황을 소개하고자 한다.

• Journal of Powder Materials
• /
• v.30 no.6
• /
• pp.493-501
• /
• 2023

This study aimed to develop a solid self-nanoemulsifying drug delivery system (solid-SNEDDS) to enhance the formulation of ketoconazole (KTZ), a BCS Class II drug with poor solubility. Ketoconazole, which is insoluble above pH 3, requires solubilization for effective delivery. This SNEDDS comprises oil, surfactant, and co-surfactant, which spontaneously emulsify in the gastrointestinal tract environment to form nanoemulsions with droplet sizes less than 100 nm. The optimal SNE-vehicle composition of oleic acid, TPGS, and PEG 400 at a 10:80:10 weight ratio was determined based on the smallest droplet size achieved. This composition was used to prepare liquid SNEDDS containing ketoconazole. The droplet size and polydispersity index (PDI) of the resulting liquid SNEDDS were analyzed. Subsequently, solid-SNEDDS was fabricated using a spray-drying method with solidifying carriers such as silicon dioxide, crospovidone, and magnesium alumetasilicate. The physicochemical properties of the solid-SNEDDS were characterized by scanning electron microscopy and powder X-ray diffraction, and its solubility, droplet size, and PDI were evaluated. In particular, the solid-SNEDDS containing ketoconazole and crospovidone in a 2:1 weight ratio exhibited significantly enhanced solubility, highlighting its potential for improved medication adherence and dissolution rates.