• Journal of Nutrition and Health
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• 제56권6호
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• pp.602-614
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• 2023

본 연구는 근생성 및 근위축 완화효능을 가진 유효소재 발굴의 필요성에 의해 polygalacin D가 근원세포 분화 및 미토콘드리아에 미치는 영향과 항암제 유도 근위축에 대한 완화효과를 각각 세포 및 동물실험을 통해 확인하고자 하였다. 그 결과, polygalacin D는 다핵을 지닌 근관세포의 수와 분화 종결인자인 MHC isoforms의 발현량을 증가시켰고 근육 내 단백질 분해 인자인 MuRF1, Smad2/3의 발현량은 유의적으로 감소시켰다. 또한 미토콘드리아 생합성 조절인자인 Pgc1α의 발현은 증가시키고 미토콘드리아 분열인자인 Drp1과 Fis1의 발현은 감소시켰다. 한편 zebrafish 동물모델을 통해 항암제 유도 근위축에 대한 개선효과를 확인한 결과, polygalacin D는 항암제에 의해 유도된 근위축과 미토콘드리아 손상을 완화시켰다. 이상의 결과들은 polygalacin D가 미토콘드리아 기능 증진을 매개로 근원세포 분화 촉진 및 근육 단백질 분해 저하 효과를 지닐 뿐만 아니라, 미토콘드리아 손상을 개선하여 항암제로 유도된 근위축에 대한 완화 효과를 나타냄을 시사한다. 따라서 본 연구를 통해 polygalacin D가 근생성 및 근위축 예방과 치료를 위한 잠재적인 유효소재로서의 가능성을 제시하였다.

• The Journal of Korean Physical Therapy
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• 제28권5호
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• pp.297-302
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• 2016

Purpose: This study was conducted to evaluate the effects of bridge exercise on the structural characteristics of trunk muscles in patients with lumbar pain by applying the exercise on either a stable or an unstable surface. Methods: Thirty subjects participated in the experiment and were randomly divided into an unstable bridge exercise group (UBEG) and a stable bridge exercise group (SBEG). The exercise program for each group was conducted three times a week over a six-week period. The structural characteristics of trunk muscles were measured by obtaining images using an ultrasound imaging device. Results: The thicknesses of the external oblique (EO), internal oblique (IO), and transverse abdominis (TrA) and the fiber angle of the erector spinae (ES) in the UBEG and the SBEG showed statistically significant increases in all items measured after the experiment. A comparison of groups conducted after the experiment to determine the effects of the exercise on each group showed no significant differences between groups for any of the measured items. Conclusion: A comprehensive review of the study results showed statistically significant increases in the thicknesses of the EO, IO, and TrA and the fiber angle of ES in both the UBEG and the SBEG. While the comparison of the groups with respect to the effects of the exercise revealed no significant differences, there were relatively larger effects in the UBEG than in the SBEG.

• 한국축산식품학회지
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• 제35권1호
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• pp.101-107
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• 2015

The aim of this study was to investigate the effects of various marination processes on the quality characteristics of chicken breast prepared with chicken feet gelatin and wheat fiber. The chicken feet gelatin was swollen with hydrochloric solution (0.1 N HCl, pH $1.31{\pm}0.02$) and dehydrated by freeze-drying. The composition (w/w) of the marinade was water (10%), soy sauce (12%), phosphate (0.3%), wheat fiber (1.5%), and chicken feet gelatin (1.5%). Three samples of chicken breast were manufactured with Tumbler (only tumbler), Tenderizer (tenderizer and tumbler), and Injector (injector and tumbler). The water content of the Injector sample was significantly higher than those of the Tumbler and Tenderizer samples (p<0.05). During heating, the lightness of all chicken breasts increased and the redness decreased. The tumbling and cooking yield of the Injector sample were significantly higher than those of the Tumbler and Tenderizer samples (p<0.05). The shear force of the Tenderizer sample was significantly lower than that of the Tumbler and Injector samples (p<0.05). No significant differences, except for color, were observed in the sensory analysis of the samples. Thus, the proper selection of mechanical processing is important to improve the quality characteristics of marinated chicken breast, considering the types of final products.

• Physical Therapy Rehabilitation Science
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• 제9권4호
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• pp.275-280
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• 2020

Objective: Compression wear is an external aid which promotes performance and recovery, diminishes muscular microtrauma, reduces muscle fiber recruitment, improves neuromechanics, enhances coordinative activities, and reduces the perceived exertion. The purpose of this study was to investigate the relationship between athletic taping and compression wear on dynamic postural balance in healthy young men. The hypothesis was that the athletic taping and compression wear would affect dynamic postural balance, with athletic taping having a different effect on dynamic postural balance in healthy young adults. Design: Cross-sectional study. Methods: Thirty-seven healthy young men participated in this study. To examine the association between athletic taping and compression wear, 3 clinical measurement tools, including 5 times sit-to-stand (5xSTS), one-leg standing (OLS) test, and Y-balance test (YBT) in 5 different conditions, namely (1) non-supporting, and support with (2) athletic taping, (3) regular compression wear, (4) silicon compression wear, and (5) double-fiber compression wear were used. Results: The distance of the Y-balance test (YBT) on both the dominant and non-dominant sides showed a statistically difference among the 5 supporting conditions (p<0.05). The distance measured via the YBT in the non-support condition was significantly different than that in the other four supporting conditions (p<0.05). However, 5xSTS and OLS were not significantly different in these supporting conditions. Conclusions: The results of this study suggest that athletic taping, silicon compression wear, and double-fiber compression wear were more effective for dynamic balance than non-supporting and regular compression wear.

• 통합자연과학논문집
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• 제10권2호
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• pp.74-77
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• 2017

Bradykinin receptor B2 (B2R) is a GPCR protein which binds with the inflammatory mediator hormone bradkynin. Kallidin, a decapeptide, also signals through this receptor. B2R is crucial in the cross-talk between renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS) and in many processes including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Thus the structural study of the receptor becomes important. We have predicted the peptide structures of Bradykinin and Kallidin from their amino acid sequences and the structures were docked with the receptor structure. The results obtained from protein-protein docking could be helpful in studying the B2R structural features and in the pathophysiology in various diseases related to it.

• 제어로봇시스템학회논문지
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• 제11권11호
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• pp.936-942
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• 2005

Recently the exoskeletal power assistive equipment which is a kind of wearable robot has been widely developed to help the human body motion. For the elderly people and patients, however, some limits exist due to the weight and volume of the equipments. As a feasible solution, a tendon-driven exoskeletal power assistive device fur the lower body, and caster walker are proposed in this research. Since the caster walker carries the heavy items, the weight and volume of the wearable exoskeleton are minimized. The key control is used to generate the joint torque required to assist motions such as sitting, standing and walking. Experiments were performed for several motions and the EMG sensors were used to measure the magnitude of assistance. When the motion of sitting down and standing up was compared with and without wearing the proposed device, the $25\%$ assistance was acquired.

• 통합자연과학논문집
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• 제9권4호
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• pp.234-240
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• 2016

Bradykinin receptor B2, a GPCR protein, binds with the inflammatory mediator hormone bradkynin. It plays an important role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). Also, it is involved in many processes including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Hence, studuying the structural features of the receptor becomes important. But the unavailability of the three dimensional structure of the protein makes the analysis difficult. Hence we have performed the homology modelling of Bradykinin receptor B2 with 5 different templates. 25 different homology models were constructed. Two best models were selected based on the model validation. The developed models could be helpful in analysing the structural features of Bradykinin receptor B2 and in pathophysiology of various disorders related to them.

• 한국수산과학회지
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• 제36권5호
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• pp.463-468
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• 2003

This study observed change of survival rate, activity and foot structure of the equilateral venus (Gomphina veneriformis) exposed to cadmium. Survival rate and activity of the clam exposed to cadmium was reduced with increase of exposure duration and concentration. Change of survival rate and activity was observed in the early exposure time (7 days) in the condition of above 1 77 mg/L and 0.88 mg/L, respectively. Activity reduction of the clam exposed to cadmium seems to be caused by epidermal layer deformation, muscle fiber fragmentation and muscular layer collapse of the foot.

• The Journal of Korean Physical Therapy
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• 제14권3호
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• pp.345-354
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• 2002

A Study of Clinical Application of the Connective Tissue Massage General massage is termed kneading and rubbing. It will bring the effect of blood volume and cardiovascular reaction. Connective tissue massage is a diagnostic and treatment method. But the general massage has not diagnostic aspect. Connective tissue massage techniques are stimulating and stretching the LCT, mast cell, collagenous fiber, fascia, skin, muscle and nerve tissue. Diagnostic aspects of connective tissue massage are visible investigation, manual investigation, and stroking on the reflex zone. CTM do stroking with 3, 4th finger tips on the whole body for the treatment.

• 한국농공학회:학술대회논문집
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• 한국농공학회 2005년도 학술발표논문집
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• pp.649-654
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• 2005

This study proposes a particular approach to assess information about NDVI(Normalized Difference Vegetation Index) and LAI(Leaf Area Index) from the spectroradiometer and NOAA/AVHRR satellite data. AVHRR data were collected in twelves months over a one year period in 2004. We calculated 10-day composite NDVI using daily composite AVHRR surface reflectance products(1km spatial resolution). The 10-day composite NDVI have a great effect on the plant growth conditions. Considerably, NDVI was increased by developing muscle fiber tissue from April to May. Then the NDVI increased until the August and then decreased until February. The highest month was at August and the lower month was at December. The difference NDVI analysis using December and another months data was conducted, the results were provided information on the variation of vegetation coverage. The result suggest that a relationship established between the LAI and NDVI in 2004.