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http://dx.doi.org/10.13160/ricns.2016.9.4.234

Theoretical Structure Prediction of Bradykinin Receptor B2 Using Comparative Modeling  

Nagarajan, Santhosh Kumar (Department of Bioinformatics, School of Bioengineering, SRM University)
Madhavan, Thirumurthy (Department of Bioinformatics, School of Bioengineering, SRM University)
Publication Information
Journal of Integrative Natural Science / v.9, no.4, 2016 , pp. 234-240 More about this Journal
Abstract
Bradykinin receptor B2, a GPCR protein, binds with the inflammatory mediator hormone bradkynin. It plays an important role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). Also, it is involved in many processes including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Hence, studuying the structural features of the receptor becomes important. But the unavailability of the three dimensional structure of the protein makes the analysis difficult. Hence we have performed the homology modelling of Bradykinin receptor B2 with 5 different templates. 25 different homology models were constructed. Two best models were selected based on the model validation. The developed models could be helpful in analysing the structural features of Bradykinin receptor B2 and in pathophysiology of various disorders related to them.
Keywords
Bradykinin Receptor B2; GPCR; GPR54; Bradkynin; Homology Modelling;
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