• Communications of the Korean Mathematical Society
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• v.32 no.1
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• pp.29-38
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• 2017

The main objective of this paper is to establish certain unified integral formula involving the product of the generalized Mittag-Leffler type function $E^{({\gamma}_j),(l_j)}_{({\rho}_j),{\lambda}}[z_1,{\ldots},z_r]$ and the Srivastava's polynomials $S^m_n[x]$. We also show how the main result here is general by demonstrating some interesting special cases.

• IMMUNE NETWORK
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• v.3 no.1
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• pp.61-68
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• 2003

Background: Fibroblast functions both as a structural element and as a vital immunoregulatory cell. Fibroblasts regulate inflammation through governing of chemokine expression. In order to elucidate the mechanisms by which the expressions of chemokines were regulated, the co-stimulatory effects of Th1 and proinflammatory cytokines were compared using nasal mucosal fibroblasts. Methods: Human nasal mucosa was obtained from surgery for septal deviation and the growth of fibroblasts was established. Fibroblasts from 4th to 6th passage were stimulated with various combinations of cytokines. To inhibit selected signaling pathways, fibroblasts were pretreated with cyclosporin A, wortmannin, staurosporine, and dexamethasone prior to the stimulation with cytokines. The supernatants were collected and chemokines were detected with a sandwich enzyme-linked immunosorbent assay. Results: $TNF-{\alpha}/IFN-{\gamma}$-induced production of RANTES was inhibited by all inhibitors used. MCP-1 was produced constitutively and $TNF-{\alpha}$-induced or $TNF-{\alpha}/IFN-{\gamma}$-induced production of MCP-1 was not inhibited by cyclosporin A or wortmannin, but by stauroporine or dexamethasone. All inhibitors used in this experiment inhibited $TNF-{\alpha}/IFN-{\gamma}$-induced or $IL-1{\beta}/IFN-{\gamma}$-induced production of MCP-2 in nasal mucosal fibroblasts. Although staurosporine or dexamethasone showed strong inhibitory effects, cyclosporin A or wortmannin did not inhibit the production of MCP-3 by $IL-1{\beta}/IFN-{\gamma}$ treatment. Conclusion: Chemokines were strongly induced by stimulation of cytokines in combination and showed different pattern of inhibition by the inhibitors. Therefore, it was assumed that cytokines acted on multiple pathways or on unknown pathways which converged to gene-specific transcription factors.

• Communications of the Korean Mathematical Society
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• v.28 no.2
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• pp.297-301
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• 2013

When certain general single or multiple hypergeometric functions were introduced, their reduction formulas have naturally been investigated. Here, in this paper, we aim at presenting a very interesting reduction formula for the Srivastava's triple hypergeometric function $F^{(3)}[x,y,z]$ by applying the so-called Beta integral method to the Henrici's triple product formula for hypergeometric series.

• BMB Reports
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• v.34 no.5
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• pp.484-488
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• 2001

STATs are proteins with a dual function: signal transducers in the cytoplasm and transcriptional activators in the nucleus. Among the six known major STATs (STAT1-6), STAT3 has been implicated in the widest range of signaling pathways that regulate cell growth and differentiation. As a part of our on-going investigation on the pleiotropic functions of STAT proteins, we examined the role of STAT3 as a molecular adaptor that links diverse cell growth signaling pathways. We observed that STAT3 can be specifically activated by multiple cytokines, such as IL-3, in transformed fibroblasts and IL-4 or IFN-$\gamma$ in primary immune cells, respectively. The selective activation of STAT3 in H-ras-transformed NIH3T3 cells is associated with an increased expression of phosphoserioe STAT3 in these cells, compared to the parental cells. Notably phosphoresine-STAT3 interacts with oncogenic ras, shown by immunoprecipitation and Western blots. The results suggest the role of STAT3 in rasinduced cellular transformation as a molecular adaptor linking the Jak/STAT and Ras/MAPK pathways. In primary immune cells, IL-4 and IFN-$\gamma$ each induced (in addition to the characteristic STAT6 and STAT1 homodimers) the formation of STAT3-containing complexes that bind to GAS probes, which correspond to the $Fe{\varepsilon}$ Rll and $Fe{\gamma}$ RI promoter sequences, respectively. Since IL-4 and IFN-$\gamma$ are known to counter-regulate the expression of these genes, the ability of STAT3 to form heterodimeric complexes with STAT6 or STAT1 implies its role in the fine-tuned control of genes that are regulated by IL-4 and IFN-$\gamma$.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.26 no.11
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• pp.966-977
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• 2015

This paper presents a novel modified coaxial cavity resonator and its application to bandpass filters with compact size and improved quality factor(Q-factor). The proposed resonator is made up of ${\Gamma}-shape$ or curved four inner conductive posts within a single cavity, which provides quadruplet to realize bandpass filter. No metallic walls inside the cavity are required, and thus the utilization efficiency of the cavity space is improved. As a result, the unloaded Q can be approximately 15 % higher in comparison to the conventional coaxial resonator, or more than 35 % volume saving can be achieved while maintaining the similar Q-factor value with the conventional designs. In addition, due to the multiple cross-coupling occurring within the cavity, including the source-to-load coupling, four flexible transmission zeros can be created to realize different filtering functions. Simulations as well as experimental results of four- and eight-pole filters are presented to validate this attractive design concept. Good agreement between measured and computed results is obtained.

• Biomolecules & Therapeutics
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• v.23 no.5
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• pp.421-427
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• 2015

Imperatorin has been known to exert many biological functions including anti-inflammatory activity. In this study, we investigated the inhibitory effects of imperatorin on the production of inflammatory mediators in mouse bone marrow-derived mast cells (BMMC). Imperatorin inhibited degranulation and the generation of eicosanoids (leukotriene $C_4$ ($LTC_4$) and prostaglandin $D_2$ ($PGD_2$) in IgE/antigen (Ag)-stimulated BMMC. To elucidate the molecular mechanism involved in this process, we investigated the effect of imperatorin on intracellular signaling in BMMC. Biochemical analyses of the IgE/Ag-mediated signaling pathway demonstrated that imperatorin dramatically attenuated degranulation and the production of 5-lipoxygenase-dependent $LTC_4$ and cyclooxygenase-2-dependent $PGD_2$ through the inhibition of intracellular calcium influx/phospholipase $C{\gamma}1$, cytosolic phospholipase $A_2$/mitogen-activated protein kinases and/or nuclear factor-${\kappa}B$ pathways in BMMC. These results suggest that the effects of imperatorin on inhibition of degranulation and eicosanoid generation through the suppression of multiple steps of IgE/Ag-mediated signaling pathways would be beneficial for the prevention of allergic inflammation.

• Korean Journal of Occupational Health Nursing
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• v.22 no.4
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• pp.324-333
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• 2013

Purpose: This study was conducted to compare the changes in the levels of liver enzymes after providing health education to workers. Methods: Among 909 electronics-manufacturing workers, 96 (10.6%) workers had abnormal liver functions. Of these, male workers were randomly assigned into either the health education experimental group (48 [52.2%]) or the control group (44 [47.8%]). Depending on the level of participation in the health education, workers in the experimental group were classified into the participation (32 [34.8%]) and non-participation groups (16 [17.4%]). Changes in the levels of liver enzymes were compared among three groups. Results: The changes in the levels of gamma-glutamyltransferase (r-GTP) in the participation, non-participation, and control groups were $-25.3{\pm}54.5$ IU/L, $-4.4{\pm}24.1$ IU/L, and $-5.3{\pm}38.8$ IU/L, respectively (p=.036). Aspartate transaminase, alanine transaminase, waist circumference, body mass index, daily alcohol consumption, weekly exercise, and changes in smoking habits in the 3 groups did not differ significantly. In the multiple linear regression analysis, the variable of education participation revealed a significant regression coefficient of -25.10 when the change in r-GTP levels was the dependent variable. Conclusion: A brief health education targeted towards the management of liver disease among workers improved r-GTP levels.

• CELLMED
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• v.8 no.2
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• pp.6.1-6.7
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• 2018

Myristica fragrans Houtt is commonly known as "nutmeg", it produces two spices: mace and nutmeg. Mace and nutmeg are strongly aromatic in nature and known as jowzabuwa and javetri/bisbasah respectively in the Unani system of medicine. M. fragrans was used as early as 700 BCE by Indian, however, ancient Greeks and Romans were not aware of it. Later Arab traders introduce M. fragrans into Europe followed by Portuguese and Dutch merchants. Mace is very useful medicine in the Unani system of medicine because of its therapeutic uses in salasal al-bawl (urinary incontinence), amrad-i-qalb (cardiac diseases), amrad-i-dimagh (central nervous system), zo'fe bah (sexual debility), amrad al-rahim (uterine diseases), and su-i-hazim (indigestion). The most important constituents of mace essential oil are ${\alpha}-pinene$, sabinene, myrcene, limonene, 1,8-cineole, terpinen-4-ol, myristicin, ${\gamma}-terpinene$, and safrole. The seed and mace extract of nutmeg contain quite high tannins, flavonoids, and terpenoids. Mace has pharmacological functions such as antibacterial and antifungal, anti-inflammatory, analgesic, antidiarrhea, antioxidant, chemoprotective, neuropharmacologic, and antidiabetic properties. To explore the correlation between the traditional uses and the same proven by recent researches, a comprehensive review is highlighted in this paper. Further, pharmacological activities which are not reported in classical texts are also discussed.

• The Journal of Pediatrics of Korean Medicine
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• v.21 no.2
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• pp.1-12
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• 2007

Objectives : Allergic children have known to have multiple behavior problems. Among them, attentional ability disorder is one of the most common problems. This study is to examine relationship between learning ability and allergic rhinitis by analyzing EEG status of children. Methods : We analyzed cognitive functions of two different children groups; 21 children with allergic rhinitis and 19 normal children with CANS 3000(Central & Autonomic Nervous System, LAXTHA Inc., Korea), cognitive functions assessment program by EEG. Results : 1. According to mean active EEG rhythm of Theta, Alpha, SMR, M-beta, there were no significant difference between allergic rhinitis and the normal group. 2. According to mean active EEG rhythm of right H-beta, Gamma wave allergic rhinitis group's value was significantly higher than that of the normal group. 3. According to mean cognitive strength, response, concentration, left / right brain activity and learning ability score, there were no significant difference between allergic rhinitis and the normal group. 4. According to mean workload score, allergic rhinitis group's value was significantly higher than that of the normal group. Conclusions : It is likely that allergic rhinitis group, which showed relatively high frequency EEG rhythm, is more fragile to stress and less active on mental processing. Along side with physical examination, psychological assessment should also be conjugated on treating children with allergic rhinitis.

• Economic and Environmental Geology
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• v.36 no.3
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• pp.243-255
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• 2003

The mathematical models for GIS-based spatial data integration have been developed for geological applications such as mineral potential mapping or landslide susceptibility analysis. Among various models, the effectiveness of fuzzy logic based integration of multiple sets of geological data is investigated and discussed. Unlike a traditional target-driven fuzzy integration approach, we propose a data-driven approach that is derived from statistical relationships between the integration target and related spatial geological data. The proposed approach consists of four analytical steps; data representation, fuzzy combination, defuzzification and validation. For data representation, the fuzzy membership functions based on the likelihood ratio functions are proposed. To integrate them, the fuzzy inference network is designed that can combine a variety of different fuzzy operators. Defuzzification is carried out to effectively visualize the relative possibility levels from the integrated results. Finally, a validation approach based on the spatial partitioning of integration targets is proposed to quantitatively compare various fuzzy integration maps and obtain a meaningful interpretation with respect to future events. The effectiveness and some suggestions of the schemes proposed here are illustrated by describing a case study for landslide susceptibility analysis. The case study demonstrates that the proposed schemes can effectively identify areas that are susceptible to landslides and ${\gamma}$ operator shows the better prediction power than the results using max and min operators from the validation procedure.