• Journal of radiological science and technology
• /
• v.22 no.1
• /
• pp.5-11
• /
• 1999

This paper reviews recent major activities on instrumentation and methodology of PET. The performance of the PET instrumentation can be expressed by four physical characteristics, 1) spatial resolution, 2) coincidence resolving time, 3) energy resolution, and 4) detection efficiency. The physical and technical aspects of PET systems are briefly discussed along with these characteristics. Toward high resolution PET the recent trend has been to design multiple rings of densely packed detector arrays with scintillators. In order to satisfy the sampling requirement in reconstruction, continuous detector units has been developed. Iterative image reconstruction algorithms have received considerable attention for improvement of both the sampling requirement and image quality toward the stationary PET. Better resolving time improves the maximum true coincidence rate, which is also increased with more detectors placed in coincidence with each other. It suggests that volume PET is promising for enhancement of detection efficiency. The scattered coincidence event rate may be reduced by using detectors with better energy resolution. The use of interplane septa, however, takes over improvement of energy resolution in 2D PET. Energy resolution becomes an important factor for image quality under the condition of septa removal such as volume PET. Toward full utilization of emitting photons, 3D reconstruction incorporating oblique rays has been studied, and volume reconstruction algorithms have been developed. Practical volume PET systems impose heavy burden not only to detector sets and coincidence circuits, but also to computers in the memory requirements and the data processing. In conclusion, there have been many ingenious methods in development of PET instrumentation, which are based on unique capability of PET. They will be expected to overcome technical limitations, and to approach the fundamental limits.

• Korean Journal of Optics and Photonics
• /
• v.14 no.5
• /
• pp.504-508
• /
• 2003

We present a new point-diffraction interferometer, which has been devised for the three-dimensional profile measurement of light scattering rough surfaces. The interferometer system has multiple sources of two-point-diffraction and a CCD camera composed of an array of two-dimensional photodetectors. Each diffraction source is an independent two-point-diffraction interferometer made of a pair of single-mode optical fibers, which are housed in a ceramic ferrule to emit two spherical wave fronts by means of diffraction at their free ends. The two spherical wave fronts then interfere with each other and subsequently generate a unique fringe pattern on the test surface. A He-Ne source provides coherent light to the two fibers through a 2${\times}$l optical coupler, and one of the fibers is elongated by use of a piezoelectric tube to produce phase shifting. The xyz coordinates of the target surface are determined by fitting the measured phase data into a global model of multilateration. Measurement has been performed for the warpage inspection of chip scale packages (CSPs) that are tape-mounted on ball grid arrays (BGAs) and backside profile of a silicon wafer in the middle of integrated-circuit fabrication process. When a diagonal profile is measured across the wafer, the maximum discrepancy turns out to be 5.6 ${\mu}{\textrm}{m}$ with a standard deviation of 1.5 ${\mu}{\textrm}{m}$.

• Journal of computational fluids engineering
• /
• v.21 no.1
• /
• pp.78-85
• /
• 2016

While most AUV researches have concerned about single hydrofoil, practical AUV's are generally operated with multiple hydrofoils. Double hydrofoil study attempts to evaluate thrust and efficiency with various flapping motions, and carries out design optimization using parametric analysis. Flow patterns such as vortex shedding and wake-body interaction are carefully investigated during design variable sensitivity analysis. The purpose of this design optimization is to find out the optimal motion that yields maximum thrust and efficiency. The design optimization employes several techniques such as table of orthogonal arrays, Kriging method, ANOVA analysis and MGA. Throughout this research, it is possible to find the optimal values of heaving ratio, heaving shift and pitch shift: Heaving ratio 0.950, heaving shift $23.120^{\circ}$ and pitch shift $89.991^{\circ}$ are found to be optimal values in double hydrofoil motions. Thrust and efficiency are 16.7% and 35.1% higher than existing AUV that did not consider nonlinear dependency of motion parameters. This results may offer an effective framework that is applicable to various AUV motion analyses and designs.

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2007.04a
• /
• pp.65-73
• /
• 2007

The objective of this study is to understand how regulatory mechanisms respond to sugar status for more efficient carbon utilization and source-sink regulation in plants. So, we need to identify and characterize many components of sugar-response pathways for a better understanding of sugar responses. For this end, genes responding change of sugar status were screened using Arabidpsis cDNA arrays, and confirmed thirty-six genes to be regulated by sucrose supply in detached leaves by RNA blot analysis. Eleven of them encoding proteins for amino acid metabolism and carbohydrate metabolism were repressed by sugars. The remaining genes induced by sugar supply were for protein synthesis including ribosomal proteins and elongation factors. Among them, I focused on three hydrolase genes encoding putative $\beta$-galactosidase, $\beta$-xylosidase, and $\beta$-glucosidase that were transcriptionally induced in sugar starvation. Homology search indicated that these enzymes were involved in hydrolysis of cell wall polysaccharides. In addition to my results, recent transcriptome analysis suggested multiple genes for cell wall degradation were induced by sugar starvation. Thus, I hypothesized that enzyme for cell wall degradation were synthesized and secreted to hydrolyze cell wall polysaccharides producing carbon source under sugar-starved conditions. In fact, the enzymatic activities of these three enzymes increased in culture medium of Arabidopsis suspension cells under sugar starvation. The $\beta$-galactosidase encoded by At5g56870 was identified as a secretory protein in culture medium of suspension cells by mass spectrometry analysis. This protein was specifically detected under sugar-starved condition with a specific antibody. Induction of these genes was repressed in suspension cells grown with galactose, xylose and glucose as well as with sucrose. In planta, expression of the genes and protein accumulation were detected when photosynthesis was inhibited. Glycosyl hydrolase activity against galactan also increased during sugar starvation. Further, contents of cell wall polysaccharides especially pectin and hemicellulose were markedly decreased associating with sugar starvation in detached leaves. The amount of monosaccharide in pectin and hemicellulose in detached leaves decreased in response to sugar starvation. These results supported my idea that cell wall has one of function to supply carbon source in addition to determination of cell shape and physical support of plant bodies.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.12 no.5
• /
• pp.665-675
• /
• 2001

In this paper, the reverse link performance of a imperfect power controlled DS/CDMA cellular system that uses a base station array antenna which can effectively remove the multiple access interference is analyzed considering both beam forming algorithm and power control error in shadowing. The blocking probability of the DS/CDMA cellular system based on array parameters, $E_b/N_o$ and statistics of interference is derived, and then the system capacity corresponding to a certain blocking probability is calculated. On the assumption that the blocking probability is set 1%, the system capacity using MCGM algorithm with 12 antenna arrays is more increased maximum 32 times than that using a omni-directional antenna and about 2 times than that using MMSE algorithm, respectively.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.23 no.6
• /
• pp.761-768
• /
• 1999

This paper is studied to find the optimum condition of double-inlet Sirocco fan installed in an indoor PAC for low noise operation by the Taguchi method. The goal of this study is to obtain the best combination of each control factor which results in a desired flowrate of Sirocco fan with minimum variability. In this study, the parameter design of the Taguchi method is adopted for robust design by the dynamic characteristic analysis using orthogonal arrays and S/N ratios. The flowrate measurements are conducted by using a multiple-nozzle-type fan tester according to the orthogonal array L9($3^4$). The results of this study can be summarized as follows ; (i) The optimum condition of control factor is a set of where A is an inner to outer diameter ratio($D_1/D_2$), B is a width to outer diameter ratio($L/D_2$), C is a blade attachment angle(${\theta}$) and D is a number of blade(Z), (ii) The flowrate under the optimum condition satisfies the equation $y=0.0384{\cdot}M$ where M is a signal factor, namely number of revolution. The flowrate performance improves about 7.3% more largely as compared with the current condition, which results in about 35RPM reduction of number of revolution for the target flowrate $18.5m^3/min$, and (iii) The sensitivity analysis shows that the major factors in contribution to flowrate performance are A, B, and D ; the percentage contributions of each control factor are 44.01%(Z), 26.77%($D_1/D_2$) and 20.42%($L/D_2$).

• The Journal of the Acoustical Society of Korea
• /
• v.37 no.5
• /
• pp.300-308
• /
• 2018

The contribution analysis of various external aeroacoustic noise sources to interior noise is important, enabling to design an automobile with a low interior noise level. With a new technique, the CD (Cholesky Decomposition), it is proposed to decompose an overall interior noise spectrum into multiple spectra, each representing the contribution of a specific noise source to the interior noise. In order to validate this method, three kinds of experiments were conducted. Furthermore, it is proposed to improve the CD-based contribution analysis method to be integrated with existing exterior microphone arrays in the wind tunnel. This method was validated with an experiment with two speakers.

• Journal of Electrical Engineering and Technology
• /
• v.13 no.5
• /
• pp.2045-2049
• /
• 2018

An antenna arrays for a satellite navigation systems require more antenna elements to mitigate multiple jamming signals. In order to maintain the small array size while increasing the number of antenna elements, miniaturization technique is essential for antenna design. In this work, an electrically small circular microstrip patch antenna with a 3 dB hybrid coupler is designed as an element antenna, where the 3 dB hybrid coupler can yield the circularly polarized radiation characteristic. The miniaturized element antenna typically has too large capacitance in GPS L1 and GLONASS G1 bands, making it difficult to match with a single stand-alone non-Foster matching circuit (NFMC) in a stable state. Therefore, we propose a new matching technique, referred to as the hybrid matching method, which consists of a NFMC and a passive circuit. This passive tuning circuit manages reactance of antenna elements at an appropriate capacitance without a pole in the operating frequency range. The antenna array is fabricated, and the measured results show a reflection coefficient of less than -10 dB and an isolation of greater than 50 dB. In addition, peak gain of the proposed antenna is increased by 22.3 dB compared to the antenna without the hybrid matching network.

• Journal of Sensor Science and Technology
• /
• v.6 no.4
• /
• pp.298-306
• /
• 1997

Ultrasonic sensors are widely used in various applications due to advantages of low cost, simplicity in construction, mechanical robustness, and little environmental restriction in usage. But the main purposes of the noncontact sensors are rather narrowly confined within object detection and distance measurement. For the application of object recognition, ultrasonic sensors exhibit several shortcomings of poor directionality which results in low spatial resolution of an object, and specularity which gives frequent erroneous range readings. To resolve these problems in object recognition, an array of the sensors has been used. To improve the spatial resolution, more number of sensors are used in essence throughout the various devices of the sensor arrays. Under the disguise of a fixed number of the sensors, the array can be shifted mechanically in several steps. In this paper we propose a practical sensor resolution enhancement method using an electronic circuit accompanying the sensor array. The circuit changes the transmitter output voltage in several steps. Using the known sensor characteristics, a set of different return echo signals provide enhanced spatial resolution. The improvement is obtained without the cost of the increased number of the sensors nor extra mechanical devices.

• International Journal of Oral Biology
• /
• v.43 no.4
• /
• pp.223-230
• /
• 2018

Exosomes are Nano-sized lipid vesicles secreted from mammalian cells containing diverse cellular materials such as proteins, lipids, and nucleotides. Multiple lines of evidence indicate that in saliva, exosomes and their contents such as microRNAs (miRNAs) mediate numerous cellular responses upon delivery to recipient cells. The objective of this study was to characterize the different expression profile of exosomal miRNAs in saliva samples, periodically isolated from a single periodontitis patient. Unstimulated saliva was collected from a single patient over time periods for managing periodontitis. MicroRNAs extracted from each phase were investigated for the expression of exosomal miRNAs. Salivary exosomal miRNAs were analyzed using Affymetrix miRNA arrays and prediction of target genes and pathways for its different expression performed using DIANA-mirPath, a web-based, computational tool. Following the delivery of miRNA mimics (hsa-miR-4487, -4532, and -7108-5p) into human gingival fibroblasts, the expression of pro-inflammatory cytokines and activation of the MAPK pathway were evaluated through RT-PCR and western blotting. In each phase, 13 and 43 miRNAs were found to be differently expressed $({\mid}FC{\mid}{\geq}2)$. Among these, hsa-miR-4487 $({\mid}FC{\mid}=9.292005)$ and has-miR-4532 $({\mid}FC{\mid}=18.322697)$ were highly up-regulated in the clinically severe phase, whereas hsa-miR-7108-5p $({\mid}FC{\mid}=12.20601)$ was strongly up-regulated in the clinically mild phase. In addition, the overexpression of miRNA mimics in human gingival fibroblasts resulted in a significant induction of IL-6 mRNA expression and p38 phosphorylation. The findings of this study established alterations in salivary exosomal miRNAs which are dependent on the severity of periodontitis and may act as potential candidates for the treatment of oral inflammatory diseases.