• Proceedings of the Korean Society Of Semiconductor Equipment Technology
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• 2004.10a
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• pp.1-15
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• 2004

o Various microfluidic components including mixromixers and micropumps have been developed for disposable biochip applications. o Single cell capturing, positioning and nanoliter drug injection chip has been demostrated. o Multi-channel, two-dimensional micro-well array has been fabricated and cell capturing and specific reagent injection have been performed.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.47 no.12
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• pp.8-16
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• 2010

NAND multilevel cell (MLC) flash memory is widely issued because it can increase the capability of storage by storing two or more bits to a single cell. However if a number of levels in a cell increases, some physical features like cell to cell interference result cell voltage shift and it is known that a VT shift is unidirectional. To reduce errors by the effects, we can consider error correcting codes(ECC) or signal processing methods. We focus signal processing methods for the cell to cell interference voltage shift effects and propose the algorithms which reduce the effects of the voltage shift by estimating it and making level read voltages be adaptive. These new algorithms can be applied with ECC at the same time, therefore these algorithms are efficient for MLC error correcting ability. We show the bit error rate simulation results of the algorithms and compare the performance of the algorithms.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.44 no.5
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• pp.92-98
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• 2007

We propose the schemes for the dynamic channel allocation (DCA) in multi-cell OFDMA systems to avoid co-channel interference (CCI) without the additional complexity. The allocatable subcarriers areas, which is designed to avoid CCI among cells, are determined for each cell. Each cell allocates the subcarriers within the allocatable subcarriers area of the cell independently. We consider the trade off between the reduced frequency selection diversity and the amount of CCI on a subcarrier by the determination of allocatable subcarriers area. Hence, the equal allocation bound scheme for the high selectivity channel and the flexible allocation bound scheme for the low selectivity channel are proposed. Through the numerical results, it is confirmed that the proposed schemes have better performance in the aspects of the number of overlapping allocated subcarriers, the capacity and the outage probability compared to the case which does not determined the allocatable subcarriers area.

• Applied Microscopy
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• v.44 no.2
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• pp.68-73
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• 2014

With wide use of nano-materials, it is increasingly important to address their potential toxicity to mammalian cells. However, toxic effects of these materials have been mainly assessed by the cell survival assays. Considering that mitochondrial morphology and quality are highly sensitive to the condition of the cells, and the impairment of mitochondrial function greatly affect the survival of cells, here we tested the impact of multi-walled carbon nanotubes (MWNT) on the survival, mitochondrial morphology, and their membrane potential in HeLa cells. Interestingly, although MWNT did not induce cell death until 24 hours as assessed by pyknotic cell assay, mitochondrial length was elongated and the mitochondrial membrane potential was significantly reduced by exposure of HeLa cells to MWNT. These results suggest that MWNT exposure is potentially harmful to the cell, and the mechanism how MWNT alters mitochondrial quality should be further explored to assess the safety of MWNT use.

• BMB Reports
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• v.36 no.1
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• pp.43-48
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• 2003

Understanding the process of carcinogenesis will involve both the accumulation of many scientific facts derived from molecular, biochemical, cellular, physiological, whole animal experiments and epidemiological studies, as well as from conceptual understanding as to how to order and integrate those facts. From decades of cancer research, a number of the "hallmarks of cancer" have been identified, as well as their attendant concepts, including oncogenes, tumor suppressor genes, cell cycle biochemistry, hypotheses of metastasis, angiogenesis, etc. While all these "hallmarks" are well known, two important concepts, with their associated scientific observations, have been generally ignored by many in the cancer research field. The objective of the short review is to highlight the concept of the role of human adult pluri-potent stem cells as "target cells" for the carcinogenic process and the concept of the role of gap junctional intercellular communication in the multi-stage, multi-mechanism process of carcinogenesis. With these two concepts, an attempt has been made to integrate the other well-known concepts, such as the multi-stage, multi-mechanisn or the "initiation/promotion/progression" hypothesis; the stem cell theory of carcinogenesis; the oncogene/tumor suppression theory and the mutation/epigenetic theories of carcinogenesis. This new "integrative" theory tries to explain the well-known "hallmarks" of cancers, including the observation that cancer cells lack either heterologous or homologous gap junctional intercellular communication whereas normal human adult stem cells do not have expressed or functional gap junctional intercellular communication. On the other hand, their normal differentiated, non-stem cell derivatives do express connexins and express gap junctional intercellular communication during their differentiation. Examination of the roles of chemical tumor promoters, oncogenes, connexin knock-out mice and roles of genetically-engineered tumor and normal cells with connexin and anti-sense connexin genes, respectively, seems to provide evidence which is consistent with the roles of both stem cells and gap junctional communication playing a major role in carcinogenesis. The integrative hypothesis provides new strategies for chemoprevention and chemotherapy which focuses on modulating connexin gene expression or gap junctional intercellular communication in the premalignant and malignant cells, respectively.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2619-2623
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• 2014

Aim: To investigate signaling pathways for reversal of EGF-mediated multi-drug resistance (MDR) in hepatocellular carcinoma (HCC) models. Materials and Methods: HCC MDR cell strain HepG2/adriamycin (ADM) and SMMC7721/ADM models were established using a method of exposure to medium with ADM between low and high concentration with gradually increasing concentration. Drug sensitivity and reversal of multi-drug resistance by EGF were determined and the cell cycle distribution and apoptosis were analyzed by flow cytometry. Phosphorylation of ERK1, ERK2, ERK5 and expression of Bim were detected by Western blotting. Results: The results showed that HepG2/ADM and SMMC7721/ADM cells were resistant not only to ADM, but also to multiple anticancer drugs. When used alone, EGF had no anti-tumor activity in HepG2/ADM and SMMC7721/ADM cells in vitro, while it increased the cytotoxicity of ADM. EGF induced cell apoptosis and G0/G1 phase cell cycle arrest in HepG2/ADM And SMMC7721/ADM cells, while enhancing activity of p-ERKs and up-regulated expression of BimEL. Conclusions: EGF might enhance the chemosensitivity of HepG2/ADM and SMMC7721/ADM cells via up-regulating p-ERKs and BimEL protein.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.5
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• pp.1063-1070
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• 2015

In this paper, we propose a distributed user scheduling with transmit power control based on the amount of generating interference to other base stations (BSs) in multi-cell multi-input multi-output (MIMO) networks. Assuming that the time-division duplexing (TDD) system is used, the interference channel from users to other cell BSs is obtained at each user. In the proposed scheduling, each user first generates a transmit beamforming vector by using singular value decompositon (SVD) over MIMO channels and reduces the transmit power if its generating interference to other BSs is larger than a predetermined threshold. Each BS selects the user with the largest effective channel gains among users, which reflects the adjusted power of users. Simulation results show that the proposed technique significantly outperforms the existing user scheduling algorithms.

• The Transactions of the Korean Institute of Power Electronics
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• v.8 no.6
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• pp.478-487
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• 2003

In this paper, a type and special feature of Multi-level inverter used in medium-voltage and high-capacity motor driver is introduced. Especially, a power quality and structural advantages of H-Bridge Multi-level inverter is described. It presented the specific structure of power circuit, design method, controller composition and PWM techniques of the cascaded H-Bridge Multi-level inverter which is developed. The feasibility of the developed product based on 3,300V lMVA 7-level H-bridge inverter was studied by experiments and we get conclusion that 1)generate of near-sinusoidal output voltage; 2)is low dv/dt at output voltage; 3)reduce the harmonic injection at input; Experiment demonstrate that it is very economical in productivity because of using the existing production technique and examination equipment, and has the reliability and a good maintenance due to the structure of Power Cell unit combination as well as low cost IGBT.

• Proceedings of the IEEK Conference
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• 2001.06b
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• pp.281-284
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• 2001

This paper describes an analog multi-phase delay-locked loop (DLL) to solve the harmonic lock problem using current-starved inverter and shunt-capacitor delay cell. The DLL can be used not only as an internal clock buffer of microprocessors and memory It's but also as a multi-phase clock generator for gigabit serial interfaces. The proposed circuit was simulated in a 0.25${\mu}{\textrm}{m}$ CMOS technology to solve harmonic lock problem and to realize fast lock-on time and low-jitter we verified time interval less than 40 ps as the simulation results.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.25 no.8
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• pp.70-81
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• 2011

In this paper, a multi-agent control system for DC-coupled photovoltaic (PV), fuel cell (FC), ultracapacitor(UC) and battery hybrid power system is studied for commercial buildings & apartment buildings microgrid. In this proposed system, the PV system provides electric energy to the electrolyzer to produce hydrogen for future use and transfer to the load side, if possible. Whenever the PV system cannot completely meet load demands, the FC system provides power to meet the remaining load. A multi-agent system based-power management and control algorithm is proposed for the hybrid power system by taking into account the characteristics of each power source. The main works of this paper are hybridization of alternate energy sources with FC systems using long and short storage strategies to build the multi-agent control system with pragmatic design, and a dynamic model proposed for a PV/FC/UC/battery bank hybrid power generation system. A dynamic simulation model for the hybrid power system has been developed using Matlab/Simulink, SimPowerSystems and Stateflow. Simulation results are also presented to demonstrate the effectiveness of the proposed multi-agent control and management system for building microgrid.