• The Journal of Korean Academic Society of Nursing Education
• /
• v.9 no.2
• /
• pp.222-233
• /
• 2003

The purpose of this study was to identify the relationship between existential spiritual well-being, hope and self-empowerment in middle aged women. The subjects were 190 women who lived in Taegu, Korea and ranged in age from 35 to 59. The data was collected during the period from October 2nd to October 18th, 2002. The instruments were the revised existential spiritual well-being scale developed by Paloutzian and Ellison (1982), hope scale developed hope scale developed Nowotny(1989) and empowerment scale by Spreitzer(1995). The data was analyzed using descriptive statistics, pearson correlation coefficients and stepwise multiple regression. The results of this study were as follows : 1. Mean score of existential spiritual well-being was 4.18. Mean score of hope was 2.80. Mean score of empowerment was 3.73. 2. The score of existential spiritual well-being showed significantly positive correlation with the score of hope(r=.508, P=.000), self-empowerment(r=.458, P=.000). 3. There were significant differences in existential spiritual well-being according to age, presence of religion, leisure time activity. 4. There were significant differences in hope according to leisure time activity. 5. The most powerful predictor of existential spiritual well-being was hope and the variance explained was 25.8%. A combination of competence, leisure time activity, meaning, impact for 37.2% of the variance in existential spiritual well-being of middle aged women. Further studies need to be done to identify the effect of competence through the repeated studies and to develop a hope promoting program which can cause positive effects on a existential spiritual well-being.

• The Journal of Korean Association of Computer Education
• /
• v.7 no.1
• /
• pp.79-88
• /
• 2004

Since computer integrated technology was introduced to the field of education, it has offered an expanding range of interactive possibilities which are remarkably powerful and helpful for the learners, especially constructing the cyber learning environments. Interactivity, the critical element in cyber learning, is categorized into three dimensions: student-to-contents, student-to-student and student-to-instructors. Six surrogate variables are introduced, and two quantitative model are developed for evaluating the degree of interactivity. The first model, which is called Data Envelopment Analysis model, is a linear programming based technique for measuring the relative performance of organizational units where the presence of multiple inputs and outputs makes comparison difficult. DEA model allows each unit to adopt a set of weight that shows it in the most favorable light in comparison to the other unit. The Second model employes the weighted average of standardized input variables for evaluation. Actual data have been collected from the Cyber IT university and these two models are applied for comparison. The analysis shows that the results from these two models are very much similar to each other, and are highly correlated to the level of class satisfaction.

• The Journal of Korean Association of Computer Education
• /
• v.18 no.1
• /
• pp.21-33
• /
• 2015

The purpose of this study has been found to be effective using web-based instruction than traditional teaching-learning method on academic achievement applying the meta-analysis method. The results of this study were as follows: First, The 85% subject of analysis of web-based instruction selected in this study turned out to be clear effective than traditional teaching-learning method in academic achievement of students. Second, Web-based instruction is more effective for academic achievement of elementary school students and university students than for middle school students and high school students relatively. Third, Web-based instruction is a most effective method in social subject and physical education but less effective in language subject. The overall results of this study concluded more powerful and big decisions which have integrated each different effects on academic achievement of studies web-based instruction method applying meta-analysis. Through this study, make better results were obtained and suggested the base line data and direction for follow up studies.

• Genomics & Informatics
• /
• v.10 no.4
• /
• pp.256-262
• /
• 2012

Most common complex traits, such as obesity, hypertension, diabetes, and cancers, are known to be associated with multiple genes, environmental factors, and their epistasis. Recently, the development of advanced genotyping technologies has allowed us to perform genome-wide association studies (GWASs). For detecting the effects of multiple genes on complex traits, many approaches have been proposed for GWASs. Multifactor dimensionality reduction (MDR) is one of the powerful and efficient methods for detecting high-order gene-gene ($G{\times}G$) interactions. However, the biological interpretation of $G{\times}G$ interactions identified by MDR analysis is not easy. In order to aid the interpretation of MDR results, we propose a network graph analysis to elucidate the meaning of identified $G{\times}G$ interactions. The proposed network graph analysis consists of three steps. The first step is for performing $G{\times}G$ interaction analysis using MDR analysis. The second step is to draw the network graph using the MDR result. The third step is to provide biological evidence of the identified $G{\times}G$ interaction using external biological databases. The proposed method was applied to Korean Association Resource (KARE) data, containing 8838 individuals with 327,632 single-nucleotide polymorphisms, in order to perform $G{\times}G$ interaction analysis of body mass index (BMI). Our network graph analysis successfully showed that many identified $G{\times}G$ interactions have known biological evidence related to BMI. We expect that our network graph analysis will be helpful to interpret the biological meaning of $G{\times}G$ interactions.

• Human Ecology Research
• /
• v.52 no.5
• /
• pp.483-494
• /
• 2014

The purpose of this study was to investigate the causal relationship of early adolescents' personal variables and social support on their self-esteem by grade. Information on 226 6th graders from elementary schools and 226 1st year students from middle schools in Busan was collected. Early adolescents' prosocial behavior, academic achievement, social support, and self-esteem were assessed using their self-reports. For the data analysis, Cronbach's ${\alpha}$, t -test, Pearson's correlation coefficient, and multiple regression were used. The collected data were analyzed by the SPSS ver. 21.0 program for Windows. The major findings were as follows: first, early adolescents' prosocial behavior, academic achievement, social support demonstrated a significant difference between grades. Second, peers' social support was the most powerful determinant of self-esteem in both the 6th graders from elementary schools and the 1st year middle school students. Third, prosocial behavior had the greatest total effect on self-esteem in the case of both groups of students. The middle schoolers' academic achievement had no causal effect on their self-esteem. The findings from this study indicate that early adolescents' personal variables and social support are important elements that affect their self-esteem differently depending on their grade. Further, the findings of this study can be used as fundamental data to develop a teaching plan and provide counseling for early adolescents in order to increase their self-esteem.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
• /
• v.7 no.2
• /
• pp.77-90
• /
• 2012

As the influence of service industry into domestic economy is increasing, it also has been influenced more powerfully at the domestic GDP(Gross Domestic Product) relative importance and employment relative importance continuously. By means of these reason, the Korean government announced the synthetic countermeasure for strengthening the competitive power of service industry in December, 2006. After then, it announced phase I of 'service industry advancing plan' which is concrete execution plan in April, 2008. Also, it is announced to announce phase II plans in september, 2008 and phase III plan in December, 2008 additionally. Service quality is the most powerful competitive means at service marketing and a key point for improving service productivity. The improvement of service quality has considerable influence on survival and profitability of service industry. Therefore, the study of objective service quality measurement in service industry is very important issue. The purpose of this study is to suggest a measurement model of service quality using fuzzy theory and AHP which measuring service quality objectively in subjective environment. It is expected that this study will help the improvement of competition power of service industry as well as establishment of effective decision-making.

• Journal of the Korean Society of Costume
• /
• v.57 no.3 s.112
• /
• pp.165-175
• /
• 2007

Religion affects all the dimension of human beings, and at the same time it forms one dimension of human beings. Costume Is considered as a result that reflects the phases of the time and the characteristics of a wearer. Costume, also, has been influenced by religion that has led one's belief, social spirit and culture for a long period of time. The Eastern aesthetics has expanded the area of thoughts with the concepts that originated from Buddhism, Taoism, and Confucianism. Among the concepts, Non-Dualistic Theory is the core idea of Buddhism.'rho theory contains the moaning that one should not lean to one side between existence and nonexistence and should not be obsessed with the center. It was the most powerful Buddhistic idea that had an influence on Asian aesthetics. Korean traditional costume is not an exception. This study has a significance that it was conducted to understand the relation between religious principle and traditional custom through mainly using documentary records. The formative characteristics of Korean traditional costume influenced by Non-Dualistic Theory ran be summarized as non-structure like, indeterminate forms, amorphousness and anti-decoration such as plainness, temperance and achromatic color. Aesthetic value was expressed through 'the aesthetic of emptiness', 'the aesthetic of hiding', and 'the aesthetic of nature'. Although the appearance of a religious symbol can change, an essential element in religion lasts as human society remains. Although our clothing culture has converted to western style, Korean traditional aesthetics is placed deep inside of 'the Koreans' spirit and has a consistent effect on our overall culture of clothing.

• Molecules and Cells
• /
• v.40 no.11
• /
• pp.823-827
• /
• 2017

Genome editing using programmable nucleases such as CRISPR/Cas9 or Cpf1 has emerged as powerful tools for gene knock-out or knock-in in various organisms. While most genetic diseases are caused by point mutations, these genome-editing approaches are inefficient in inducing single-nucleotide substitutions. Recently, Cas9-linked cytidine deaminases, named base editors (BEs), have been shown to convert cytidine to uridine efficiently, leading to targeted single-base pair substitutions in human cells and organisms. Here, we first report on the generation of Xenopus laevis mutants with targeted single-base pair substitutions using this RNA-guided programmable deaminase. Injection of base editor 3 (BE3) ribonucleoprotein targeting the tyrosinase (tyr) gene in early embryos can induce site-specific base conversions with the rates of up to 20.5%, resulting in oculocutaneous albinism phenotypes without off-target mutations. We further test this base-editing system by targeting the tp53 gene with the result that the expected single-base pair substitutions are observed at the target site. Collectively, these data establish that the programmable deaminases are efficient tools for creating targeted point mutations for human disease modeling in Xenopus.

• Natural Product Sciences
• /
• v.19 no.4
• /
• pp.290-296
• /
• 2013

In preliminary tests, we examined the effect of several fractions isolated from fermented pine needle extract on pacemaker potentials in cultured interstitial cells of Cajal (ICCs) from the mouse colon using a whole cell patch clamp technique. Among these fractions, Fraction 3 (F3) elicited the most powerful depolarization of membrane. Therefore, the aim of the present study was to investigate the effect of F3 obtained from fermented extract of Pinus densiflora needle on pacemaker potentials in ICCs and to establish its mechanism of action. Colonic ICCs generated spontaneous periodic pacemaker potentials in the current-clamp mode. F3 depolarized the membrane and decreased the frequency and amplitude of pacemaker potentials in a dose-dependent fashion. The F3-induced effects on pacemaker potentials were blocked by methoctramine, a muscarinic $M_2$ receptor antagonist, and by glycopyrrolate, a muscarinic $M_3$ receptor antagonist. The F3-induced effects on pacemaker potentials were blocked by external $Na^+$-free solution and by flufenamic acid, a non-selective cation channel blocker, as well as by the removal of external $Ca^{2+}$ and in the presence of thapsigargin, a $Ca^{2+}$-ATPase inhibitor in the endoplasmic reticulum. Taken together, these results suggest that F3 of pine needle extract modulates the pacemaker activity of colonic ICCs by the activation of non-selective cation channels via muscarinic $M_2$ and $M_3$ receptors. And external $Ca^{2+}$ influx and intracellular $Ca^{2+}$ release are involved in F3 actions on ICCs.

• Journal of Marine Bioscience and Biotechnology
• /
• v.9 no.1
• /
• pp.1-7
• /
• 2017

Perfluorooctane sulfonate (PFOS) is one of the most widely distributed environmental pollutants and causes neurotoxicities. Fucoidan is a main bioactive constituent of the brown sea-weed and has many functions in a variety of physiological conditions. The present study attempted to investigate the potential role of fucoidan as neuroprotective marine polypeptide in environmental pollutant-induced apoptosis of neuronal cells in culture. MTT assay showed that cell viability was significantly reduced to 68 % at $30{\mu}M$ PFOS, which was recovered up to 77% and 92% in the presence of fucoidan 25 and $50{\mu}g/ml$, respectively. Cytotoxicity assay showed that LDH release was significantly increased to 160% at $30{\mu}M$ PFOS but was reduced to 150% and 122% in the presence of fucoidan 25 and $50{\mu}g/ml$, respectively. Caspase-3 activity, a hallmark of apoptosis, was measured to determine the cytotoxicity of PFOS and the cytoprotective effects of fucoidan. PFOS induced a 250% increase of caspase-3 activity at $30{\mu}M$ but the increase was dampened to 180% and 130% in the presence of fucoidan 25 and $50{\mu}g/ml$, respectively. PFOS $30{\mu}M$ induced 180 % increase in ROS accumulation, which was effectively blocked by $50{\mu}g/ml$ fucoidan (120% of control). Our results demonstrated that PFOS is a powerful neurotoxicant and fucoidan may be a protective marine bioactive polypeptide against the neurotoxic environmental pollutants. It may contribute to establishing the potential role of fucoidan as a neuroprotective polypeptide that prevents the risk of neurological disorders from the possible neurotoxic pollutants.