• BMB Reports
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• v.56 no.2
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• pp.71-77
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• 2023

Cancers are one of the most dreaded diseases in human history and have been targeted by numerous trials including surgery, chemotherapy, radiation therapy, and anti-cancer drugs. Adult stem cells (ASCs), which can regenerate tissues and repair damage, have emerged as leading therapeutic candidates due to their homing ability toward tumor foci. Stem cells can precisely target malicious tumors, thereby minimizing the toxicity of normal cells and unfavorable side effects. ASCs, such as mesenchymal stem cells (MSCs), neural stem cells (NSCs), and hematopoietic stem cells (HSCs), are powerful tools for delivering therapeutic agents to various primary and metastatic cancers. Engineered ASCs act as a bridge between the tumor sites and tumoricidal reagents, producing therapeutic substances such as exosomes, viruses, and anti-cancer proteins encoded by several suicide genes. This review focuses on various anti-cancer therapies implemented via ASCs and summarizes the recent treatment progress and shortcomings.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2022.04a
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• pp.251-252
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• 2022

The microfluidic controlled droplet manufacturing system is one of the most powerful methods for capsule manufacturing. The microfluidic control method can control the type and size of the capsule by changing the size and configuration of the channel. In addition, by increasing the number of channels, capsules of uniform size can be mass-produced. In this paper, a capsule manufacturing system including flow-focusing and T junction method was designed. In addition, the effectiveness of this system was verified by manufacturing multi-emulsion capsules with a size of 2.2 to 3 mm.

• Proceedings of the Korea Information Processing Society Conference
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• 2020.05a
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• pp.523-525
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• 2020

In recent years, deep learning has been widely used in news recommendation systems. In the previous personalized news recommendation, a large number of CF-based methods, content-based or hybrid methods have been proposed. But most of the works are only modeling the user's interaction history, ignoring the hidden meaning of the user's continuous behaviors. In this paper, we propose to adopt the powerful Transformer model in order to understand the hidden meaning of the user's continuous behaviors in news recommendations. The experimental results prove the superiority of the transformer, and the AUC has been significantly improved as compared to the original model.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.2
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• pp.40.4-40.4
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• 2019

Interplanetary coronal mass ejections (ICMEs) are regarded as one of the most powerful sources of space weather disturbances observed near the Earth orbit (1 AU). In this study, we aim at investigating the relation between these disturbances and the physical properties of an ICME. Toward this end, we used an spheromak-type ICME and performed a series of three-dimensional magnetohydrodynamic (MHD) simulations with different sets of ICME parameters. The ICME is injected into the background solar wind generated from near-Sun data and interplanetary scintillation (IPS) data via an MHD-IPS tomography method. We will compare simulation results to in situ observations near the Earth and discuss how the physical properties of an ICME affect the space weather disturbances at 1 AU.

• Journal of Information Science Theory and Practice
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• v.10 no.spc
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• pp.123-134
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• 2022

Existing network cryptography systems are threatened by recent developments in quantum computing. For example, the Shor algorithm, which can be run on a quantum computer, is capable of overriding public key-based network cryptography systems in a short time. Therefore, research on new cryptography systems is actively being conducted. The most powerful cryptography systems are quantum key distribution (QKD) and post quantum cryptograph (PQC) systems; in this study, a network based on both QKD and PQC is proposed, along with a quantum key management system (QKMS) and a Q-controller to efficiently operate the network. The proposed quantum cryptography communication network uses QKD as its backbone, and replaces QKD with PQC at the user end to overcome the shortcomings of QKD. This paper presents the functional requirements of QKMS and Q-Controller, which can be utilized to perform efficient network resource management.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2022.11a
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• pp.247-248
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• 2022

The microfluidic controlled droplet production system is one of the most powerful methods for capsule manufacturing. However, stable production is not possible when the powder is included. We solved the above problem by developing an off-chip droplet production system. we checked the droplet creation mechanism and created a simple repair model. It was possible to produce a uniform and stable droplet regardless of the powder content.

• Journal of the Daesoon Academy of Sciences
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• v.16
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• pp.167-182
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• 2003

The societies of HuiDaoMen, appeared upon the scene of history in the later feudal age of china, were religious secret organizations whose adherents resisted their government or powerful families. Generally, HuiDaoMens are grouped into political ones and religious ones. This distinction, however, comes from on which characteristics they laid emphasis, because both of regional and political goal appear in most of HuiDaoMens. Although those contemporary governments ordinarily called them Dow-Bees, which were groups of burglars without any political goal or regional ideal, HuiDaoMens are quite distinguishable from them. So, it is possible to say that the requisites of HuiDaoMen were to be a secret society, to be popular, to be religious, to be political. That is, HuiDaoMens should not be understood as mere superstitious secret group, but religious societies giving comforts to people as popular societies in feudal age. It is very important to have correct understandings on these HuiDaoMens, because they firstly appeard in the middle years of Ming(明) dynasty, and considerably affected the progress of Chinese history. Now I expect upcoming researches on them to bring into focus various aspects related to contemporary and social circumstances.

• Journal of Digestive Cancer Research
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• v.2 no.1
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• pp.5-7
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• 2014

Screening and early diagnosis of cancer is important. Screening lead to detect disease earlier, and earlier treatment of disease cause to yield a better outcome than treatment at the onset of symptoms. Some studies suggest that gastric cancer screening may be associated with a reduced risk of mortality from gastric cancer, although there are no definitive data from large controlled trials. Regular colorectal cancer screening or testing is one of the most powerful weapons for preventing colorectal cancer, because some polyps, or growths can be found and removed before they have the chance to turn into cancer. Screening can also result in finding colorectal cancer early, when it is highly curable. In conclusion, to increase utilization of screening is important to decrease gastric and colorectal cancer morbidity and mortality.

• Journal of Korean Neuropsychiatric Association
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• v.57 no.4
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• pp.276-286
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• 2018

Circadian rhythm is a periodic and continuous change in physiological, behavioral, and mental characteristics that occurs in most organisms on the Earth, because the Earth rotates in a 24-hour cycle. The circadian system regulates daily rhythms of physiology and behavior, such as the sleep/wake cycle, body temperature, hormonal secretion, and mood. The influence of circadian rhythm is very powerful, but limited research has addressed its effects. However, many recent studies have shown that circadian dysregulation may play an important role in the pathogenesis of bipolar disorder. This review study examined current and noteworthy studies, including the authors' own works, and proposes a possible clinical application of bipolar disorder based on evidence that circadian rhythm dysregulation in bipolar disorder may be a key pathogenetic mechanism.

• Structural Engineering and Mechanics
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• v.88 no.3
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• pp.201-208
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• 2023

In this work, the effect of the correction fibers direction on the efficiency of repairing damaged composite plates was highlighted. The composite plates studied in this work consist of eight layers of graphite/epoxy, while the patch used in this repair consists of four layers of the same type. The results obtained in this work, whether with regard to the experimental or analytical side, showed that the fibers orientation affects the repair efficiency, so the closer the angle of fibers inclination is to the tensile strength direction, the performance of the composite material is ideal. Hence, we conclude that the composite materials with longitudinal fibers (Parallel to tensile strength) is the most powerful and efficient material in performance.