Journal of Korean Neuropsychiatric Association (신경정신의학)

Korean Neuropsychiatric Association (대한신경정신의학회)
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Is the Circadian Rhythm Dysregulation a Core Pathogenetic Mechanism of Bipolar Disorder?

일주기리듬의 조절이상이 양극성장애의 핵심 발병 기전일까?

  • Lee, Heon-Jeong (Department of Psychiatry and Biomedical Sciences, Korea University College of Medicine, Korea University Chronobiology Institute)
  • 이헌정 (고려대학교 의과대학 정신건강의학교실 및 의과학과, 고려대학교 시간생물학연구소)
  • Received : 2018.10.30
  • Accepted : 2018.11.07
  • Published : 2018.11.30
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Abstract

Circadian rhythm is a periodic and continuous change in physiological, behavioral, and mental characteristics that occurs in most organisms on the Earth, because the Earth rotates in a 24-hour cycle. The circadian system regulates daily rhythms of physiology and behavior, such as the sleep/wake cycle, body temperature, hormonal secretion, and mood. The influence of circadian rhythm is very powerful, but limited research has addressed its effects. However, many recent studies have shown that circadian dysregulation may play an important role in the pathogenesis of bipolar disorder. This review study examined current and noteworthy studies, including the authors' own works, and proposes a possible clinical application of bipolar disorder based on evidence that circadian rhythm dysregulation in bipolar disorder may be a key pathogenetic mechanism.

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Acknowledgement

본 논문은 한국연구재단의 바이오의료기술개발사업 연구비 지원(2017M3A9F1031220) 및 보건산업진흥원 정신건강기술개발사업단 연구비 지원(HM14C2606)에 의하여 이루어짐.